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Patent # Description
2011/0201673 LPL VARIANT THERAPEUTICS
The invention provides for the use of a therapeutic derived from a truncated lipoprotein lipase protein (LPL S447X), including nucleic acids encoding such...
2011/0201672 SEMI-SOFT C-CLASS IMMUNOSTIMULATORY OLIGONUCLEOTIDES
The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the...
2011/0201671 Compositions And Methods For Inhibiting Expression Of A Gene From The Ebola Virus
The invention relates to a double-stranded ribonucleic acid (dsRNA) FOR INHIBITING THE expression of a gene from the Ebola virus.
2011/0201670 OLIGORIBONUCLEOTIDES AND METHODS OF USE THEREOF FOR TREATMENT OF FIBROTIC CONDITIONS AND OTHER DISEASES
The invention relates to a double-stranded compound, preferably an oligoribonucleotide (siRNA), which down-regulates the expression of a human TGaseII gene at...
2011/0201669 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER
The present invention relates to the diagnosis and treatment of cancer, and in particular breast cancer. Specifically, in some embodiments the invention relates...
2011/0201668 REGULATION OF NEUROTRANSMITTER RELEASE THROUGH ANION CHANNELS
A novel use of anion channels, preferably Ca2+-activated anion channels (CAACs), in regulating release of neurotransmitters from neurons and/or astrocytes is...
2011/0201667 COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene...
2011/0201666 COMPOUNDS FROM MYCELIUM OF ANTRODIA CINNAMOMEA AND USE THEREOF
The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating...
2011/0201665 Compositions, Methods, and Kits for Treating Influenza Viral Infections
The present invention provides compositions, methods, and kits for treating or preventing a viral infection (e.g., an infection caused by an influenza virus).
2011/0201664 Methods and Compositions for Treatment of Prostate Intraepithelial Neoplasia
Provided herein are methods of treatment of prostate intraepithelial neoplasia (PIN) by administering bexarotene. Also provided are pharmaceutical compositions...
2011/0201663 BENZO (F) ISOINDOL-2-YLPHENYL ACETIC ACID DERIVATIVES AS EP4 RECEPTOR AGONISTS
A compound of formula (I) or a pharmaceutically acceptable derivative thereof, ##STR00001## wherein, R.sup.1 R.sup.2 R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and Y...
2011/0201662 METHOD FOR PRODUCING XPS MOULDED PIECES PROVIDED WITH INSECTICIDE
Process for the production of insecticide-modified extruded polystyrene foam (XPS) preforms, comprising the steps (a) heating polystyrene (PS) until a polymer...
2011/0201661 Spiro Derivatives of Parthenin as Novel Anticancer Agents
The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides,...
2011/0201660 Method for Controlling Plant Disease
The combination of ethaboxam and transgenic plants provides enhanced plant protection in controlling plant disease. According to the present invention, an...
2011/0201659 AGENT FOR PREVENTING OR TREATING ZOSTER-ASSOCIATED PAIN
The present invention relates to a pharmaceutical composition and method for preventing or treating a zoster-associated pain. The inventors found that an...
2011/0201658 Pharmaceutical package
The present invention relates to a pharmaceutical package including a pharmaceutical preparation containing ...
2011/0201657 AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose)...
2011/0201656 NOVEL DIPHENYL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
This invention relates to novel diphenyl 1,2,3-triazole derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their...
2011/0201655 PHARMACEUTICAL COMPOSITION IMPROVING INTESTINAL ABSORPTION
An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented...
2011/0201654 THERAPEUTIC COMBINATION
This invention relates to pharmaceutical combinations of amlodipine or a pharmaceutically acceptable acid addition salt thereof and atorvastatin or a...
2011/0201653 METHOD FOR INHIBITING AND/OR PREVENTING FORMATION OF CANCER METASTASES AND SECONDARY MALIGNANT CANCER
The invention relates to a method for inhibiting and/or preventing formation of cancer metastases and secondary malignant cancers by administration to a subject...
2011/0201652 2,4-Disubstituted Pyrrolidine Orexin Receptor Antagonists
The present invention is directed to 2,4-disubstituted pyrrolidine amide compounds which are antagonists of orexin receptors, and which are useful in the...
2011/0201651 MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides...
2011/0201650 CYCLOHEXANE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
A compound has a strong analgesic action against both nociceptive pain and neuropathic pain and has less side effects, and is medically useful. The compound...
2011/0201649 AGRICULTURAL COMPOSITION
Provided is an agricultural composition comprising a compound represented by the formula (I) or a salt thereof or a hydrate thereof, for controlling a plant...
2011/0201648 POLY-HETEROARYL DERIVATIVES FOR THE TREATMENT OF CANCER
The present invention relates to Penta-hexa-, hepta-, octa-, nona- and, deca-heteroaryl derivatives, comprising a combination of heterocycle 1 (Het-1).sub.a...
2011/0201647 [4-(5-AMINOMETHYL-2-FLUORO-PHENYL)-PIPERIDIN-1-YL]-[7-FLUORO-1-(2-METHOXY-- ...
The present invention is directed to an indole benzylamine compound of formula I: ##STR00001## useful as an inhibitor of tryptase. In addition, the present...
2011/0201646 OPTICAL ISOMERS OF AN ILOPERIDONE METABOLITE
The present invention relates to novel isomers of a metabolite of Iloperidone, their preparation, their use as pharmaceuticals and pharmaceutical compositions...
2011/0201645 Method Of Treating Attention Deficit Disorders With D-Threo Methylphenidate
Methods for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS while...
2011/0201644 CRYSTALLINE FORM OF A BENZIMIDAZOLE-CARBOXAMIDE MEDICINAL COMPOUND
The invention provides crystalline forms of the novel benzimidazole-carboxamide 5-HT.sub.4 receptor agonist compound, ...
2011/0201643 NOVEL N-SUBSTITUTED TETRAHYDROISOQUINOLINE/ISOINDOLINE HYDROXAMIC ACID COMPOUNDS
Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and...
2011/0201642 Bioactive Compounds
The invention relates to bioactive compounds derived from an endophytic Aspergillus sp. fungus strain isolated from a Malaysian medicinal plant Garcinia...
2011/0201641 INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS
The compound (+) {7R-[[(4-fluorophenyl)sulfonyl] (methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts...
2011/0201640 TRICYCLIC COMPOUND
Provided is a tricyclic compound having a PPAR .gamma. agonist activity, which is represented by the general formula (I) wherein Z represents a single bond or...
2011/0201639 STABILIZED TACROLIMUS COMPOSITION
The invention relates to a stable pharmaceutical composition comprising comprising a solid dispersion of tacrolimus in a vehicle further comprising a...
2011/0201638 PHENANTHROINDOLIZIDINE COMPOUND AND NFkB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
A novel compound having an excellent NF.kappa.B inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1)...
2011/0201637 PHENANTHROINDOLIZIDINE DERIVATIVE AND NFKB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
A novel compound having an excellent NF.kappa.B inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or...
2011/0201636 USE OF 14,15-DIHYDRO-20,21-DINOREBURNAMENIN-14-OL FOR THE TREATMENT AND/OR PREVENTION OF SERIOUS DEPRESSION AND...
The invention relates to a novel therapeutic use of 14,15-dihydro-20,21-dinoreburnamenin-14-ol for the treatment of serious depression in humans, particularly...
2011/0201635 SUBSTITUTED SPIROINDOLINONES
There is provided a compound of the formula ##STR00001## wherein X, Y, W, R.sub.1, R.sub.2 and R.sub.3 are as described herein. The compounds have activity as...
2011/0201634 DIHYDROPYRIDIMIDINONE COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND PROCESS FOR PREPARING THE SAME
The present invention relates to a dihydropyrimidinone compound of formula (I) wherein X represents O, S, etc. and R' represents alkyl, alkoxy, thioalkyl,...
2011/0201633 ALFUZOSIN TABLETS AND SYNTHESIS
A monolithic composition includes alfuzosin in a polymeric matrix adapted to release 13-33% of the alfuzosin within 2 hours, 40-60% of the alfuzosin within 7...
2011/0201632 2,5-Disubstituted Piperidine Orexin Rceptor Antagonists
The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the...
2011/0201631 PHARMACEUTICAL FORMULATIONS COMPRISING PEMETREXED
Pharmaceutical formulations comprising amorphous pemetrexed or its salts, and processes to prepare the formulations.
2011/0201630 Fused Pyridine Derivatives as Kinase Inhibitors
A series of heteroaryl-substituted fused pyridine derivatives, in particular heteroaryl-substituted thieno[3,2-6]pyridine derivatives, being selective...
2011/0201629 CYCLOHEXYL AMIDE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS
There are described cyclohexyl amide derivatives of Formula I, ##STR00001## which are useful as corticotropin releasing factor (CRF) receptor antagonists and as...
2011/0201628 HETEROCYCLIC JAK KINASE INHIBITORS
The present invention relates to compounds of Formula (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation....
2011/0201627 FREEZE-DRIED REPARATION OF TETRODOTOXIN AND THE PRODUCING METHOD THEREOF
A stable freeze-dried powder preparation of tetrodotoxin and the producing method thereof. The freeze-dried powder preparation has tetrodotoxin as the main...
2011/0201626 4,6-DIAMINOPYRIMIDINE STIMULATORS OF SOLUBLE GUANYLATE CYCLASE
The present invention relates to new 4,6-diaminopyrimidine stimulators of soluble guanylate cyclase, pharmaceutical compositions thereof, and methods of use...
2011/0201625 Organic Comopunds
A compound of Formula I ##STR00001## or a hydrate or solvate thereof, where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, and...
2011/0201624 Pharmaceutical Composition for Prevention and Treatment of Diabetes or Obesity Comprising a Compound that...
The present invention relates to a pharmaceutical composition for the prevention and treatment of diabetes or obesity comprising as active ingredients a...
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