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Prokaryotic Expression of Soluble, Active Dkk
Dickkopf (Dkk) proteins inhibit the canonical Wnt signaling pathway. Each of the members of the Dkk family has been previously cloned and expressed as a soluble...
SYSTEM FOR ANTIBODY EXPRESSION AND ASSEMBLY
The present invention provides methods and compositions for expression and production of recombinant antibodies in a host cell system, such as prokaryotic and...
Rage Fusion Proteins And Methods Of Use
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE...
METHOD OF PREPARING PROTEIN HAVING HIGH CONTENT OF SPECIFIC AMINO ACID BY
CO-EXPRESSION WITH TRNA OF SPECIFIC...
The present invention relates to a method of increasing the expression of a target protein by co-expression of a gene encoding a target protein having a high...
Mammalian Sweet Taste Receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor...
ISOLATED MAMMALIAN MEMBRANE PROTEIN GENES; RELATED REAGENTS
Nucleic acids encoding various lymphocyte cell proteins from mammalian, including primate, reagents related thereto, including specific antibodies, and purified...
PENTOSE PHOSPHATE PATHWAY UPREGULATION TO INCREASE PRODUCTION OF
NON-NATIVE PRODUCTS OF INTEREST IN TRANSGENIC...
Coordinately regulated over-expression of the genes encoding glucose 6-phosphate dehydrogenase ["G6PDH"] and 6-phospho-gluconolactonase ["6PGL"] in transgenic...
METHODS AND ARTICLES FOR DETECTING HEMOLYTIC MICROORGANISMS
A thin film culture plate device useful for detecting hemolysin-producing microorganisms is included. The device can further include selective agents and/or...
Filtration method for detecting microbial contamination
Disclosed is a convenient sample preparation method for a medium suspected of containing contaminants, the method comprising a) passing a known volume of said...
ApoIII and the Treatment and Diagnosis of Diabetes
The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic .beta. cells...
Method for investigating the thrombocyte function of the blood
A method for investigating the thrombocyte function of the blood, and particularly of platelet aggregation, wherein the following steps are carried out: a)...
USE OF NEUREGULIN- AS AN INDICATOR AND/OR TARGET
The invention relates, inter alia, to the use of neuregulin-.beta. as a target in a screening method for active compounds, in particular for exerting an...
EGFR DEPENDENT MODULATION OF CHEMOKINE EXPRESSION AND INFLUENCE ON THERAPY
AND DIAGNOSIS OF TUMORS AND SIDE...
The invention relates to diagnosis and therapy of tumors utilizing the epidermal growth factor (EGFR) by means of chemical inhibitors or monoclonal antibodies....
Method for In Vitro Blood Testing
Method for determining the presence of a malady in a patient by measuring the degree of reaction of individual types of white blood cells (basophils,...
BIOMARKERS OF INFLAMMATION IN BRUCH'S MEMBRANE OF THE HUMAN RETINA
A method of diagnosing a patient with age-related macular degeneration (AMD), by detecting biomarkers in the patient's Bruch's membrane, and diagnosing the...
System and Method for Anti-Cancer Drug Candidate Evaluation
The disclosure provides a method of evaluating the ability of an anti-cancer drug candidate to induce apoptosis in a known cancer cell line by placing a...
HORMONE RESPONSIVE TISSUE CULTURE SYSTEM AND USES THEREOF
The invention provides tissue culture system for primary cells (e.g. normal mammalian primary epithelial progenitors). This system includes: a) a serum-free,...
CANCER STEM CELLS
Cancer stem cell populations characterized by expression of CD44.sup.hi, ABCG2, .beta.-catenin, CD117, CD133, ALDH, VLA-2, CD166, CD201, IGFR, and/or EGF1R, and...
Gel electrophoresis method useful for resolution and characterization of
nerve tissue ultra high molecular...
The instant disclosure describes an electrophoretic procedure capable of resolving and isolating ultra high molecular weight (MW) protein aggregates from nerve...
METHODS OF ENZYMATIC HYDROLYSIS
In one embodiment the instant invention generally pertains to a method for producing glucose for fermentation. The method comprises first treating a biomass...
TYROSINE KINASE-INDUCIBLE DOMAINS
The present invention relates to a tyrosine kinase-inducible domain (pKID) and uses thereof. An isolated polypeptide comprising the pKID, and an isolated...
METHOD FOR JUDGING SUSCEPTIBILITY OF CANCER CELLS TO ANTHRACYCLINE
ANTICANCER AGENT AND COMPUTER PROGRAM
The present invention provides a method for judging susceptibility of cancer cells contained in a biological sample to an anthracycline anticancer agent...
HIV REVERSE TRANSCRIPTASE COMPOSITIONS AND METHODS
The present invention provides engineered novel variants of human immunodeficiency virus reverse transcriptase (HIV-RT) capable of being expressed in large...
METHOD FOR TESTING ALZHEIMER'S DISEASE BY MEASURING DEGRADATION RATE OF
-AMYLOID IN BLOOD AND DIAGNOSTIC REAGENT
Provided is a method of testing Alzheimer's disease using serum or plasma as a sample. It is found that a .beta.-amyloid peptide added to a blood sample is...
REAGENTS, METHODS AND KITS FOR THE UNIVERSAL RAPID IMMUNO-DETECTION
Novel immuno-detection methods, kits and reagents are provided. The Combination of this invention, combining at least two of the following reagents of a...
CELL-BASED DETECTION OF APF THROUGH ITS INTERACTION WITH CKAP4 FOR
DIAGNOSIS OF INTERSTITIAL CYSTITIS
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide,...
IMMUNOASSAYS FOR CITRULLINATED PROTEINS
Methods and kits are provided for assessing radiation injury and exposure in a mammal. The methods comprise the steps of: obtaining one or more test samples...
PEPTIDES DERIVED FROM HUMAN BPLP PROTEIN, POLYNUCLEOTIDES CODING FOR SAID
PEPTIDES AND ANTIBODIES DIRECTED...
The invention relates to an in vitro method for prognosis, diagnosis or determination of the evolution of a condition involving an altered production of Basic...
DETECTION AND MONITORING OF LIVER DAMAGE
A method of detecting liver damage in a subject comprises measuring the level of caspase-3 generated cytokeratin-18 fragments in the bodily sample. The level of...
METHOD FOR THE EARLY DETECTION OF RENAL INJURY
A method and kit for detecting the immediate or early onset of renal disease and injury, including renal tubular cell injury, utilizing NGAL as an immediate or...
CHITIN-INDUCED IMMUNE RESPONSE BASED METHOD FOR DIAGNOSING ALLERGIC ASTHMA
A method of diagnosing allergic asthma in patients, including the steps of: obtaining from a subject a first sample of peripheral blood immune cells and a...
METHODS FOR TESTING BINDING OF A LIGAND TO A G PROTEIN-COUPLED RECEPTOR
The present invention relates to methods for testing for the binding of a ligand to a G Protein-Coupled Receptor. In particular, the methods of the invention...
METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF DIABETES
Methods, assays and compositions for the diagnosis and treatment of diabetes, in which the glutamate transporters and/or receptors expressed in pancreatic islet...
ANTI-TUNA VASA ANTIBODY
An object of the present invention is to provide a means for distinguishing between a germ cell derived from a donor (tuna) and a germ cell derived from a...
METHOD OF DIAGNOSING ALZHEIMER'S DISEASE USING GIANT MAGNETORESISTANCE
SENSOR AND MAGNETIC BEAD-POLYPROTEIN...
Provided are a method of diagnosing Alzheimer's disease using a giant magnetoresistance sensor and a magnetic bead-polyprotein complex for diagnosing...
ASSESSMENT OF PROTEIN DEGRADATION BY MEASUREMENT OF COLLAGEN FRAGMENTS
A method of assay measuring in a biological sample fragments of a protein that contain an N-terminal neo-epitope and a C-terminal neo-epitope, each generated by...
ASSESSMENT OF SUBCHONDRAL BONE REMODELLING BY MEASURING CATHEPSIN K
FRAGMENTS OF COLLAGEN TYPE II
A method of assay to determine the extent of collagen type II resorption activity comprising measuring the level of fragments of collagen type II that contain a...
COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES
Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from...
METHOD OF DIAGNOSIS AND KIT THEREFOR
The invention provides kits and methods for detecting or monitoring the number of cells in sample. The cell comprises a cell surface associated protein (CSAP)...
Plasmon Resonant Particles, Methods and Apparatus
A method and apparatus for interrogating a target having a plurality of plasmon resonant particles (PREs) distributed in the target are disclosed. In the...
Methods and Compositions for Treating Bleeding Disorders
Aspects of the invention include methods for enhancing blood coagulation in a subject. In practicing methods according to certain embodiments, an amount of a...
ANTIBODY-SECRETING CELL ASSAY
An improved assay is described where a surface is provided with immobilized anti-Ig antibodies rather than antigen and where specific antibody-secreting cells...
METHOD FOR EVALUATION OF QUALITY OF BLOOD SAMPLE
A method for evaluating the quality of a blood sample, comprising the steps of: mixing labeled anti-cortisol antibodies with a blood sample to be subjected, to...
MN Gene and Protein
Identified herein is the location of the MN protein binding site, and MN proteins/polypeptides that compete for attachment to vertebrate cells with immobilized...
Rapid screening of biologically active nucleases and isolation of
Disclosed herein are methods and compositions for rapidly identifying active nucleases and cells having nuclease-mediated genomic modifications.
Methods and materials for observing apoptosis
The invention provides methods and materials for observing protein fragments generated during apoptosis in order to observe this process in mammalian cells....
Cancer stem cell immortalization
The present invention relates to the preparation and use of immortalized cancer stem cells. The immortalized cancer stem cells of the invention may be used in...
SCREENING METHOD AND VECTOR, VECTOR LIBRARY, AND ASSAY KIT USED THEREFOR
According to one embodiment, a method of screening an enhancer and/or a promoter, includes culturing a host cell into which an amplifiable vector is introduced,...
ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE
CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO...
The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is...
METHOD FOR QUANTIFYING INITIAL CONCENTRATION OF NUCLEIC ACID FROM
REAL-TIME NUCLEIC ACID AMPLIFICATION DATA
Provided is a method for quantifying an initial concentration of a nucleic acid from a real-time nucleic acid amplification data. Nucleic acid (DNA or RNA)...