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Patent # Description
2011/0243968 THERAPEUTIC APPLICATIONS OF P53 ISOFORMS IN REGENERATIVE MEDICINE, AGING AND CANCER
The present invention provides methods and compositions for modulating cell senescence and cell proliferation using isoforms of the p53 tumor suppressor...
2011/0243967 MOLECULAR COMPLEXES WHICH MODIFY IMMUNE RESPONSES
Extracellular domains of transmembrane heterodimeric proteins, particularly T cell receptor and major histocompatibility complex proteins, can be covalently...
2011/0243966 SINGLE CHAIN Fc (ScFc) REGIONS, BINDING POLYPEPTIDES COMPRISING SAME, AND METHODS RELATED THERETO
The present invention features inter alia polypeptides comprising an Fc region comprising genetically-fused Fc moieties. In addition, the instant invention...
2011/0243965 ANTIBODIES AGAINST DOMAINS OF LAMININ-332
Antibodies against various domains of laminin-332 are discussed herein. The antibodies reduce the adhesion and matrix binding properties of laminin-332,...
2011/0243964 TREATMENT OF ORTHOPEDIC CONDITIONS
Methods, compounds, compositions, kits and articles of manufacture comprising anti-connexin agents for treatment of orthopedic disorders, diseases, or...
2011/0243963 ANTIBODIES TO LRP6
Anti-LRP6 antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are...
2011/0243962 THERAPEUTIC USE OF SPECIFIC LIGAND IN MSRV ASSOCIATED DISEASES
The present invention deals with a ligand comprising each of the complementary-determining regions (CDRs) set forth in SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3...
2011/0243961 METHODS FOR TREATING BONE CANCER BY ADMINISTERING A NERVE GROWTH FACTOR ANTAGONIST ANTIBODY
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by...
2011/0243960 METHODS AND COMPOSITIONS FOR TREATING P. ACNES
The disclosure provides an antigenic composition useful for immunization against P. acnes, K. pneumoniae, S. aureus, or Streptococcus pyogenes. The disclosure...
2011/0243959 MODULATING NEURONAL PLASTICITY AND TREATMENT OF NEURONAL LOSS BY MODULATIONG WNT7A OR WNT7B MODULATION
The present invention relates to a method of treating or preventing a disease characterized by a loss or imbalance of neuronal connections, wherein said disease...
2011/0243958 ANTIMICROBIAL AGENTS THAT TARGET BACTERIAL VKOR
Aspects of the invention relate to a method for inhibiting the growth of a microbe that expresses bacterial vitamin K epoxide reductase (bVKOR). The method...
2011/0243957 MATERIALS AND METHODS FOR PREVENTING OR TREATING NEURODEGENERATIVE CONDITIONS ASSOCIATED WITH ABETA PEPTIDE...
The subject invention concerns methods for preventing and/or treating neurodegenerative conditions associated with Abeta peptide accumulation in neural tissue...
2011/0243956 METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY
Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by...
2011/0243955 ANTIBODY AND USES THEREOF
Described are specific binding members e.g. antibodies which may be used in the treatment of diseases associated with cathepsin S activity. The specific binding...
2011/0243954 PEPTIDES CAPABLE OF BINDING TO SERUM PROTEINS AND COMPOUNDS, CONSTRUCTS AND POLYPEPTIDES COMPRISING THE SAME
Provided are pharmaceutical compositions, preparations or formulations including a compounds or constructs that include at least one amino acid sequence that is...
2011/0243953 NEUTRALIZING ANTIBODIES AGAINST GDF-8 AND USES THEREFOR
The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including...
2011/0243952 COMPOUND AND METHOD FOR REGULATING PLASMINOGEN ACTIVATION AND CELL MIGRATION
The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for...
2011/0243951 IMMUNOMODULATING TUMOR NECROSIS FACTOR RECEPTOR 25 (TNFR25) AGONISTS, ANTAGONISTS AND IMMUNOTOXINS
It is an object of the invention to provide novel compositions and methods utilizing immunomodulating agents that can either stimulate or indirectly augment the...
2011/0243950 MSP2 ANTIGENIC PEPTIDES AND THEIR USE
This invention relates generally to the field of P. falciparum antigens and their use, for example, for the preparation of a vaccine against said pathogen. More...
2011/0243949 COMPOSITION FOR PRODUCING ANTI-AMYLOID BETA PEPTIDE ANTIBODIES WITH D-PEPTIDES
The present invention relates to a composition comprising D-peptides or antibodies for use as a therapeutic and/or for disease prevention, wherein a) the...
2011/0243948 Monoclonal Antibodies Against ANGPTL3
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided....
2011/0243947 ANTIBODIES AGAINST CSF-1R
The invention provides a human antibody that binds human CSF-1R with high affinity. Antibodies of the present invention have significant advantages over the...
2011/0243946 Remedies for pemphigus containing anti Fas ligand antibodies
The present invention refers to the use of FasL antagonists, e.g. of humanized antibodies directed against human Fas ligands (also named CD95L or Apo1L and...
2011/0243945 Anti-Inflammatory Agents
This invention is in the field of treating or preventing inflammation in humans and animals and relates to pharmaceutical compositions and methods for treating...
2011/0243944 Fusion Protein Inhibiting Osteoclast Formation, Preparation Method and Medicine Compositions Thereof
The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits...
2011/0243943 TREATMENT USING RELAXIN-FUSION PROTEINS WITH EXTENDED IN VIVO HALF-LIVES
Disclosed are human relaxin-Fc fusion proteins having an increased serum half-life, polynucleotides encoding the same, and intermediates formed during the...
2011/0243942 RELAXIN-FUSION PROTEINS WITH EXTENDED IN VIVO HALF-LIVES
Disclosed are human relaxin-Fc fusion proteins having an increased serum half-life, polynucleotides encoding the same, and intermediates formed during the...
2011/0243941 Identification and Engineering of Antibodies with Variant Fc Regions and Methods of Using Same
The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region,...
2011/0243940 BICYCLIC PYRANONE DERIVATIVES AND METHODS OF USE THEREOF
The present invention relates to Bicyclic Pyranone Derivatives, their compositions and uses for treating or preventing a metabolic disorder, dyslipidemia, a...
2011/0243939 MODIFICATION OF NUCLEIC ACID VECTORS WITH POLYMERS COMPRISING CHARGED QUATERNARY AMINO GROUPS
The present invention provides a polymer modified nucleic acid vector in which the nucleic acid vector is covalently linked to a polymer, which polymer...
2011/0243938 Methods to Reduce B-Helper T Cells to Treat Autoimmune Diseases
The present invention includes compositions and methods for the treatment of autoimmune diseases by administering to a subject having an autoimmune disorder an...
2011/0243937 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment...
2011/0243936 TNFalpha-NEUTRALIZING ANTIBODIES
The invention provides monoclonal antibodies that neutralize TNF.alpha. activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal...
2011/0243935 Compositions and Methods for Immunotherapy
The invention relates to immunotherapeutic compounds, compositions that include such compounds, and methods of using the compounds, for example, to treat an...
2011/0243934 EPHA3 ANTIBODIES FOR THE TREATMENT OF MULTIPLE MYELOMA
The invention provides methods and compositions comprising anti-EphA3 antibodies for the treatment of multiple myeloma.
2011/0243933 Perifosine and Capecitabine as a Combined Treatment for Cancer
Treatment regimens comprising co-treatment of cancer with perifosine and capecitabine are disclosed herein, as well as pharmaceutical compositions and unit...
2011/0243932 ANTI-CD40 ANTIBODIES
The present invention relates to new humanized antagonistic anti-CD40 antibodies and therapeutic and diagnostic methods and compositions for using the same.
2011/0243931 COMBINATION THERAPY WITH TYPE I AND TYPE II ANTI-CD20 ANTIBODIES
The present application is directed to the combination therapy of a type I and a type II anti-CD20 antibody for the treatment of cancer, especially of CD20...
2011/0243930 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune...
2011/0243929 ANTI-ICOS ANTIBODIES AND THEIR USE IN TREATMENT OF ONCOLOGY, TRANSPLANTATION AND AUTOIMMUNE DISEASE
The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions,...
2011/0243928 CHIMERIC AND HUMANISED MONOCLONAL ANTIBODIES AGAINST INTERLEUKIN-13
The present invention concerns immunoglobulins, particularly antibodies which specifically bind human Interleukin 13 (hIL-13). Antibodies of the invention may...
2011/0243927 METHODS OF INHIBITING TUMOR GROWTH USING BETA 5 INTEGRIN ANTAGONISTS
The present invention relates to methods for treating cancer by administering to a mammalian subject a therapeutically effective amount of a selective...
2011/0243926 ANTI-P-SELECTIN ANTIBODIES AND METHODS OF USING THE SAME TO TREAT INFLAMMATORY DISEASES
The invention features antibodies, e.g., chimeric and humanized antibodies, that recognize (i.e., bind) P-selectin. The P-selectin antibodies prevent P-selectin...
2011/0243925 Gene Expression Profiles Being Predictive for the Response of Tumors to Pharmaceutically Effective Compounds
The present invention relates to a method for providing a gene expression profile being predictive for the specific response of an individual tumor to a...
2011/0243924 NOVEL METHODS
The invention provides methods of inhalation treatment of a respiratory disease or condition in a patient in need to such treatment without producing in said...
2011/0243923 ORGANIC COMPOUNDS
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7,...
2011/0243922 Genetic Alterations Associated with Type I Diabetes and Methods of Use Thereof for Diagnosis and Treatment
Compositions and methods for the detection and treatment of T1D are provided.
2011/0243921 PREVENTION AND TREATMENT OF CUTANEOUS LUPUS ERYTHEMATOSUS
Disclosed herein, in certain embodiments, are methods and compositions for the prevention and treatment of autoimmune disease. Further disclosed herein, in...
2011/0243920 COMPOSITIONS AND METHODS FOR TREATING COLLAGEN-MEDIATED DISEASES
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product...
2011/0243919 Compositions and Methods for Treating Collagen-Mediated Diseases
A drug product comprising a combination of highly purified collagenase I and collagenase II from Colostridium histolyticum is disclosed. The drug product...
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