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Patent # Description
2011/0300183 METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPY
In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing...
2011/0300182 NUCLEIC ACID DRUG FOR TREATMENT OF ALLERGIC DISEASE
This invention provides double-stranded (ds) RNA capable of suppressing the expression of STAT6 related to allergic diseases mediated by Th2-type cytokines via...
2011/0300181 PURIFICATION OF VACCINIA VIRUS- AND RECOMBINANT VACCINIA VIRUS-BASED VACCINES
The present invention relates to methods for purification of Vaccinia viruses (W) and/or Vaccinia virus (W) particles, which can lead to highly pure and stable...
2011/0300180 PLANT-DERIVED VACCINES AGAINST RESPIRATORY SYNCYTIAL VIRUS
A plant-derived vaccine against respiratory syncytial virus (RSV) is disclosed. The vaccine includes an immunogenic complex that includes plant cells...
2011/0300179 Novel Compositions and Uses Thereof
The present invention provides a cellular vaccine for therapeutic or prophylactic treatment of a pathological condition, the vaccine comprising or consisting of...
2011/0300178 HPV TYPES AND VARIANTS ASSOCIATED WITH CERVICAL CANCER AND THE USES THEREOF
The invention relates to identification of novel sequences associated with cervical cancer, probes and kits for the identification of said sequences, and...
2011/0300177 TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF
The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent...
2011/0300176 Microorganisms for therapy
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in...
2011/0300175 COMPOSITION FOR PROMOTING CONTROL OF TOTAL AND LDL CHOLESTEROL, AND/OR WEIGHT LOSS AND/OR THERMOGENESIS
A composition for promoting control of total and LDL cholesterol and/or weight loss and/or thermogenesis in individuals, the composition including green tea...
2011/0300174 CONJUGATES FOR THE PREVENTION OR TREATMENT OF NICOTINE ADDICTION
The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): ##STR00001## wherein m, n, W, -(spacer)-, X* and Y are...
2011/0300173 Capsule composition for use as immunogen against Campylobacter jejuni
Immunogenic compositions, and method of using the compositions to elicit an immune response against Campylobacter jejuni. The compositions are isolated...
2011/0300172 FUSION PROTEINS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR TREATMENT AND/OR PREVENTION OF ATHEROSCLEROSIS
A fusion protein comprising an antigenic fragment of apoB-100 and a suitable carrier and related compositions methods and systems.
2011/0300171 FACTOR H BINDING PROTEIN IMMUNOGENS
The invention relates to immunization against pathogenic bacterial strains which express or can express multiple factor H binding proteins. Certain aspects of...
2011/0300170 HCV VACCINES
Disclosed are methods and compositions for inducing immune responses against Hepatatis C virus (HCV). The compositions comprise one or more epitope from a...
2011/0300169 PHARMACEUTICAL COMPOSITION COMPRISING AN ANTIGEN
The invention relates to immunogenic compositions. In certain embodiments, the invention provides pharmaceutical compositions comprising an antigen, an...
2011/0300168 COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST INFLUENZA ANTIGENS
This disclosure provides compositions and methods for inducing an immune response against influenza antigens, for example in elderly populations, as well as a...
2011/0300167 CXCR5 RECEPTOR COMPOUNDS
The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and...
2011/0300166 Vaccine Compositions for Inducing Immune Responses Against Components of Drusen
Disclosed are compositions and methods for treating or preventing the formation of drusen in a patient in need thereof. The compositions include an effective...
2011/0300165 SUBSTITUTED ISOXAZOLE COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## or pharmaceutically acceptable salts thereof, wherein Q is ##STR00002## R.sup.1 is alkyl or aryl, said aryl...
2011/0300164 IMMUNOSTIMULATORY DNA:RNA OLIGONUCLEOTIDES
Immunostimulatory sequence-specific RNA oligonucleotides corresponding to 3' terminal sequences of single-stranded minus-sense RNA genomic RNAs are provided....
2011/0300163 IgE CH3 Peptide Vaccine
The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier, compositions...
2011/0300162 DRUG CONJUGATE COMPOSITION
The invention provides a liquid composition and a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody...
2011/0300161 Methods for the Treatment and the Prognostic Assessment of Malignant Pleural Mesothelioma
The present invention relates to methods for the treatment and the prognostic assessment of malignant pleural mesothelioma.
2011/0300160 SULFATION OF WNT PATHWAY PROTEINS
Provided is a protein comprising an antibody binding site that binds to a sulfated epitope of a Wnt pathway protein that is not Wnt5A, Wnt11, or Wnt3a. Also...
2011/0300159 Sulfonated Sclerostin, antibodies, epitopes and methods for identification and use therefor
Provided are antibodies that bind to: a sulfonated epitope of the protein Sclerostin, to Sclerostin portions comprising a sulfonated amino acid and to dimerized...
2011/0300158 ANTI-SERUM ALBUMIN BINDING VARIANTS
The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-14, as well as ligands and drug conjugates...
2011/0300157 METALLOPROTEINASE 9 AND METALLOPROTEINASE 2 BINDING PROTEINS
Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described.
2011/0300156 HUMAN ANTIBODIES AGAINST TISSUE FACTOR
Isolated human monoclonal antibodies which bind to human TF and related antibody-based compositions and molecules, are disclosed. Also disclosed are...
2011/0300155 MODULATING XRN2
The present invention relates to a method for modulating miRNA, said method being characterized in that a modulator of XRN2 is used. Also provided are uses of...
2011/0300154 TREATMENT OF AIRWAY HYPERREACTIVITY
The invention provides strategies for treating and preventing airway hyperreactivity and non-allergic asthma comprising antagonizing IL-17 activity and/or...
2011/0300153 ANTIBODY PRODUCED USING OSTRICH AND METHOD FOR PRODUCTION THEREOF
Disclosed is an antibody produced using an ostrich. Also disclosed is a method for producing the antibody. By using an ostrich, it becomes possible to produce...
2011/0300152 COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED...
Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of ...
2011/0300151 USES AND COMPOSITIONS FOR TREATMENT OF HIDRADENITIS SUPPURATIVA (HS)
The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating...
2011/0300150 COMPOSITIONS AND METHODS FOR TREATMENT OF AUTOIMMUNE AND OTHER DISEASE
Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of autoimmune disease, inflammatory disease, or cancer. Also...
2011/0300149 LJUNGAN VIRUS
The present invention relates to a new group of Ljungan viruses, proteins expressed by the viruses, antibodies to the viruses and proteins, vaccines against the...
2011/0300148 IL-4-DERIVED PEPTIDES FOR MODULATION OF THE CHRONIC INFLAMMATORY RESPONSE AND TREATMENT OF AUTOIMMUNE DISEASES
The present invention relates to small peptides derived from a cytokine, interleukin-4 (IL-4), capable of binding to the IL-4 receptors and inhibiting...
2011/0300147 Inhibiting tumor cell invasion, metastasis and angiogenesis
The present invention relates to new compositions and methods useful for preventing, treating and diagnosing metastatic and/or invasive cancer and undesirable...
2011/0300146 ANTI-CMET ANTAGONISTS
The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.
2011/0300145 Interferon Alpha Antibodies And Their Uses
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological...
2011/0300144 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CANCER
The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and...
2011/0300143 PRENATAL ENZYME REPLACEMENT THERAPY
The invention contemplates transplacental enzyme replacement therapy (ERT) for deficiency of a polypeptide such as a tissue-nonspecific alkaline phosphatase...
2011/0300142 USE OF ZEBURALINE FOR THE TREATMENT OF AUTOIMMUNE DISEASES OR IMMUNE REJECTION OF TRANSPLANTS
The invention relates to the use of 1-(.beta.-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one derivative or mimetic or an analogue, derivatives, metabolites,...
2011/0300141 Novel Alphabeta-Binding protein and its peptide derivatives and uses thereof
A protein kinase C inhibitor that binds B-amyloid and its peptide derivatives with the same function are disclosed. These may be useful in the treatment of...
2011/0300140 ANTIGEN BINDING POLYPEPTIDES
The invention relates to a platform technology for production of antigen binding polypeptides having specificity for a desired target antigen which is based on...
2011/0300139 GENERATION, EXPRESSION AND CHARACTERIZATION OF THE HUMANIZED K33N MONOCLONAL ANTIBODY
The present invention provides humanized antibodies that immunospecifically recognize human 9 integrin. Some of these antibodies inhibit the biological...
2011/0300138 HUMAN ANTI TSHR ANTIBODIES
According to one aspect there is provided an isolated human antibody molecule which binds to the TSHR and which reduces ligand-induced stimulation of the TSHR...
2011/0300137 Use of lumefantrine and related compounds in the treatment of cancer
The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.
2011/0300136 THERAPY OF AUTOIMMUNE DISEASE IN A PATIENT WITH AN INADEQUATE RESPONSE TO A TNF-ALPHA INHIBITOR
The present application describes therapy with antagonists which bind to B cell surface markers, such as CD20. In particular, the application describes the use...
2011/0300135 METHOD AND FORMULATION FOR REDUCING AGGREGATION OF A MACROMOLECULE UNDER PHYSIOLOGICAL CONDITIONS
The invention provides a method for reducing aggregation and inhibiting flocculation of a macromolecule, such as a protein, under physiological conditions, by...
2011/0300134 REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
The present invention relates to novel "reverse amide" compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and...
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