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Patent # Description
2012/0088817 TREATMENT OF ANTIVIRAL GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN ANTIVIRAL GENE
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Antiviral gene, in particular, by targeting...
2012/0088816 Head-And-Neck Tumor Proliferation Inhibitor
It is to provide a novel head-and-neck tumor proliferation inhibitor, head-and-neck tumor metastasis inhibitor and pharmaceutical composition for treating a...
2012/0088815 Modified Oligonucleotide and Its Preparation and Application
The present invention relates to a modified oligonucleotide, its preparation and application. The invention enables stabilizing the oligonucleotide by...
2012/0088814 METHODS OF MODULATING AN IMMUNE RESPONSE TO A VIRAL INFECTION
Disclosed herein are methods for treating respiratory disorders via administration of antisense compounds targeting IL-4R.alpha.. Provided herein, for example,...
2012/0088813 ANTI VIRAL THERAPY
The present invention provides a method of identifying host cell molecules which may be modulated to inhibit viral replication and method of testing antiviral...
2012/0088812 COMPOSITIONS FOR PROMOTING EPIGENETIC DNA DEMETHYLATION AND METHODS OF USE THEREFORE
The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to...
2012/0088811 METHOD FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA
The invention is in the field of molecular medicine and provides methods for the treatment of acute myeloid leukemia. These methods are based on the observation...
2012/0088810 THIOXANTHONE RING SYSTEM DERIVATIVES
A thioxanthone ring system derivative compound is provided. The thioxanthone ring system derivative compound is represented by a formula (I): ##STR00001## ...
2012/0088809 1-(2-ALKYL-2,3-DIHYDRO-BENZOFURAN-4-YL)-PYRROLIDIN-3-YLAMINE ACYL COMPOUNDS
This invention provides new 1-(2-alkyl-2,3-dihydro-benzofuran-4-yl)-pyrrolidin-3-ylamine acyl compounds, their use for the treatment or prevention of...
2012/0088808 CRYSTAL FORMS OF SAXAGLIPTIN
The present invention relates to novel polymorphic forms of Saxagliptin Hydrochloride. The present invention also relates to methods of making polymorphic forms...
2012/0088807 INTERLACED METHOD FOR TREATING CANCER OR A PRECANCEROUS CONDITION
The present invention provides a method for treating a disease or condition in a mammal which comprises the steps of; administering a therapeutically effective...
2012/0088806 SEED TREATMENT FORMULATIONS AND METHODS OF USE
The present invention generally relates to aqueous seed treatment formulations comprising a pesticidal agent, a polyvinyl alcohol (PVA), a graft copolymer, and...
2012/0088805 COMPOUND HAVING DETRUSOR MUSCLE-CONTRACTING ACTIVITY AND URETHRAL SPHINCTER MUSCLE-RELAXING ACTIVITY
Since a compound represented by formula (I) wherein all of the symbols are the same as defined in the specification, a salt thereof, a solvate thereof, a...
2012/0088804 CLEVIDIPINE EMULSION FORMULATIONS CONTAINING ANTIMICROBIAL AGENTS
Pharmaceutical formulations comprising clevidipine and an antimicrobial agent exhibit a reduced propensity for microbial growth and provide increased...
2012/0088803 CONTROL AGENT FOR SOFT ROT AND CONTROL METHOD FOR THE SAME
Provided is a novel control agent for soft rot and a novel control method for the same. The control agent for soft rot of a plant contains ...
2012/0088802 TRICYCLIC COMPOUNDS, COMPOSITIONS AND METHODS
The present invention is directed to compounds of Formula I: ##STR00001## or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and...
2012/0088801 Pirfenidone Therapy and Inducers of Cytochrome P450
The present invention relates to methods involving avoiding adverse drug interactions with pirfenidone and CYP inducers, such as smoking.
2012/0088800 2-(SUBSTITUTED) (ARYLMETHYL, ARYLOXY and ARYLTHIO))-N-(SUBSTITUTED PYRIDIN-2-YL)-2-(SUBSTITUTED ARYL) COMPOUNDS...
The invention provides compounds represented by the formula (I), each of which compounds may have sphingosine-1-phosphate receptor agonist and or antagonist...
2012/0088799 SEROTONIN REUPTAKE INHIBITORS
In one aspect, the invention relates to compounds of formula I: ##STR00001## where X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.4, and n are as defined in the...
2012/0088798 Intramolecular Hydrogen-Bonded Nitric Oxide Synthase Inhibitors
Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of...
2012/0088797 1-HETEROCYCLYLSULFONYL, 3-AMINOMETHYL, 5- (HETERO-) ARYL SUBSTITUTED 1-H-PYRROLE DERIVATIVES AS ACID SECRETION...
The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present...
2012/0088796 COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITION AND USE THEREOF
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds...
2012/0088795 FACTOR XA INHIBITORS
The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor...
2012/0088794 AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides aminotetralin compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, n, and m are...
2012/0088793 Bicyclic Compounds and Methods of Making and Using Same
Disclosed herein are compounds that may be modulators of 5-HT receptors, and methods of making and using same.
2012/0088792 Pyridin-2-YL Methylamine Derivatives for Treating Opiate Dependence
The invention concerns the use of compounds of general formula (I) ##STR00001## for treating opioid drug dependence, hyperalgesia induced by opiate drug ...
2012/0088791 AMIDOBIPIPERIDINECARBOXYLATE M1 ALLOSTERIC AGONISTS, ANALOGS AND DERIVATIVES THEREOF, AND METHODS OF MAKING AND...
In one aspect, the invention relates to compounds having a general structure: Formula (I) which are useful as allosteric agonists of the M.sub.1 muscarinic...
2012/0088790 PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY
The present invention relates to phenalkylamine derivatives of the formula (I) or (II) ##STR00001## or a physiologically tolerated salt thereof. The invention...
2012/0088789 CHROMEN-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS
The present applications discloses novel 8-aza-bicyclo[3.2.1]oct-3-yloxy)-chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake...
2012/0088788 SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor...
2012/0088787 3-CARBOXYPROPYL-AMINOTETRALIN DERIVATIVES AND RELATED COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 are ...
2012/0088786 IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITIONS COMPRISING OXYCODONE AND NALOXONE
The present invention pertains to oral immediate release pharmaceutical compositions suitable for treating patients suffering from pain comprising oxycodone and...
2012/0088785 NEW USES FOR QUATERNARY AMMONIUM ANTICHOLINERGIC MUSCARINIC RECEPTOR ANTAGONISTS IN PATIENTS BEING TREATED FOR...
A method for treating the adverse effects of acetyl-cholinesterase inhibitors used in the treatment of cognitive disorders such as acute delirium and cognitive...
2012/0088784 Substituted Aromatic Compounds and Pharmaceutical Uses thereof
The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the...
2012/0088783 CHROMAN DERIVATIVES
The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I ##STR00001## wherein the substituents are as...
2012/0088782 LPA RECEPTOR ANTAGONIST
A compound of the general formula (I): ##STR00001## (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in...
2012/0088781 Famciclovir for the Treatment of Recurrent genital Herpes Labialis with a one day application
A method for the treatment of recurrent herpes labialis in mammals, including humans, which method comprises administering to the mammal in need of such...
2012/0088780 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention...
2012/0088779 HETEROCYCLIC SULFONAMIDES
Certain substituted sulfonamide derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the...
2012/0088778 AZOLE DERIVATIVES AND FUSED BICYCLIC AZOLE DERIVATIVES AS THERAPEUTIC AGENTS
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human...
2012/0088777 5-HT1A RECEPTOR SUBTYPE AGONIST
The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor...
2012/0088776 TREATMENT OF MAMMALIAN DISORDERS MEDIATED BY ALPHA-ANHYDRASE ISOFORMS
The present invention pertains to 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-- 2-ylamino)phenyl]-benzamide or a pharmaceutically...
2012/0088775 Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof
The present invention provides new pyrazolo-[1,5-a]-pyrimidone derivates and pharmaceutical compositions comprising said compounds and one or more ...
2012/0088774 ACTIVE PHARMACEUTICAL INGREDIENT ADSORBED ON SOLID SUPPORT
The present invention belongs to the field of pharmaceutical industry and relates to dosage forms comprising active pharmaceutical ingredients (API) such as...
2012/0088773 Circadian rhythm modulation
A method and composition is herein described to modulate the circadian rhythm to effect summer metabolism and the metabolic syndrome. The method entails the...
2012/0088772 NOVEL PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF ATTENTION DEFICIT/HYPERACTIVITY DISORDER
The present invention is to provide a therapeutic agent for attention deficit/hyperactivity disorder having a novel mechanism of action which is different from...
2012/0088771 TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP): A THERAPEUTIC TARGET FOR ARTERIAL CALCIFICATION
This invention relates generally to the field of mineralization, and specifically to the role of TNAP in regulating the levels of extracellular inorganic...
2012/0088770 ALPHA HELIX MIMETICS AND METHODS RELATING THERETO
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the...
2012/0088769 SALTS OF ARYLSULFONAMIDE CCR3 ANTAGONISTS
Provided herein are arylsulfonamide salts, e.g., a salt of a compound of Formula I, which are useful for modulating CCR3 activity, and their pharmaceutical...
2012/0088768 PINANE-SUBSTITUTED PYRIMIDINEDIAMINE DERIVATIVES USEFUL AS AXL INHIBITORS
Pinane-substituted pyrimidinediamine derivatives and pharmaceutical compositions containing the derivatives are disclosed as being useful in inhibiting the...
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