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| Patent # | Description |
|---|---|
| 2012/0095063 |
METHODS AND COMPOSITIONS FOR TREATMENT OF ISCHEMIC CONDITIONS AND
CONDITIONS RELATED TO MITOCHONDRIAL FUNCTION The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In... |
| 2012/0095062 |
TRICYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS The present invention is directed to compounds of Formula I: ##STR00001## or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and... |
| 2012/0095061 |
Fluorinated Derivatives of Deferiprone The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or... |
| 2012/0095060 |
METHODS AND COMPOSITIONS OF MITOGEN-ACTIVATED PROTEIN KINASE (MAPK)
PATHWAY INHIBITORS FOR TREATING PULMONARY... Methods and compositions of inhibitors of MAPK kinases 1 and 2 (MEK1 and MEK2, or together, MEK1/2), such as ARRY142886, and their use in inhibiting MEK1/2... |
| 2012/0095059 |
Compositions and Methods for Treating Type II Diabetes and Related
Disorders The present invention relates to methods and compositions for treating type II diabetes. This invention discloses an orally administrable pharmaceutical... |
| 2012/0095058 |
Method of preventing survival of retrovirally cells and of inhibiting
formation of infectious retroviruses The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced... |
| 2012/0095057 |
PYRAZOLE COMPOUND Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. A compound represented by the formula ##STR00001## ... |
| 2012/0095056 |
2,5-DISUBSTITUTED TETRAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC
ACETYLCHOLINE RECEPTOR MODULATORS This invention relates to novel tetrazole derivatives of formula (I), which are found to be modulators of the nicotinic acetylcholine receptors. Due to their... |
| 2012/0095055 |
HEXAHYDROCYCLOPENTYL[f]INDAZOLE 5-HYDROXYMETHYL ETHANOLS AND DERIVATIVES
THEREOF AS SELECTIVE GLUCOCORTICOID... The present invention encompasses compounds of Formula (I): or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective... |
| 2012/0095054 |
POLYMORPHS OF ESOMEPRAZOLE SALTS The present invention relates to a high assayed esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention further... |
| 2012/0095053 |
AMINOTETRAHYDROINDAZOLOACETIC ACIDS The invention is concerned with the compounds of formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are... |
| 2012/0095052 |
PAR-1 ANTAGONISM IN FED OR ANTACID-DOSED PATIENTS Disclosed are methods of inhibiting a PAR-1 receptor in a patient who has recently ingested food or an antacid comprising the step of administering an effective... |
| 2012/0095051 |
CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES This invention provides a compound having the structure ##STR00001## wherein .alpha., .beta., X, Y, and R.sub.1-R.sub.11 are defined herein. This invention also... |
| 2012/0095050 |
STABILIZED AND PRESERVED KETOTIFEN OPHTHALMIC COMPOSITIONS Ophthalmic compositions comprising ketotifen, a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v),... |
| 2012/0095049 |
NOCICEPTIN ANALOGS A compound of the formula (I), (II), (III) or (IV) ##STR00001## wherein Z, A, B, C, R, R.sub.1, R.sub.2, Q, and n are as described herein. |
| 2012/0095048 |
ALLOSTERIC BINDING COMPOUNDS The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical... |
| 2012/0095047 |
Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the... |
| 2012/0095046 |
Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for
the Treatment of Metabolic Syndrome... The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole... |
| 2012/0095045 |
INJECTABLE ANTICANCER COMPOSITION FOR LOCAL ADMINISTRATION CONTAINING
HYDROXYCHLOROQUINE The present invention relates to an injectable anticancer composition for local administration comprising hydroxychloroquine. The anticancer composition shows... |
| 2012/0095044 |
TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR
TREATING VASCULAR CALCIFICATION Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate... |
| 2012/0095043 |
TRIGLYCERIDE-LOWERING AGENT AND HYPERINSULINISM-AMELIORATING AGENT The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating... |
| 2012/0095042 |
Organic Compounds Having Cooling Properties Provided are compounds of formula (I) ##STR00001## wherein m is 0, 1 or 2; R.sup.I is a mono- or bicyclic heterocyclic ring system including one, two or three... |
| 2012/0095041 |
REVERSIBLE NONDEPOLARIZING NEUROMUSCULAR BLOCKADE AGENTS AND METHODS FOR
THEIR USE The invention provides neuromuscular blockade agents of the non-depolarizing type with few if any circulatory effects. Compounds of the invention include... |
| 2012/0095040 |
CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND
THERAPEUTIC USE THEREOF The invention relates to compounds of the general formula (I) where: R.sub.2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl,... |
| 2012/0095039 |
HETEROCYCLIC COMPOUNDS WITH AFFINITY TO MUSCARINIC RECEPTORS The present invention relates to heterocyclic compounds of formula (I) having affinity to muscarinic receptors, a pharmaceutical composition containing the... |
| 2012/0095038 |
SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a... |
| 2012/0095037 |
SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a... |
| 2012/0095036 |
NOVEL SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE
MODULATORS The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3,... |
| 2012/0095035 |
CRYSTALS OF PRASUGREL HYDROBROMATE The present application discloses crystals of 2-acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd- rothieno[3,2-c]pyridine hydrobromate,... |
| 2012/0095034 |
PIPERIDINE DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS This invention relates to imidazo[1,2-a]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals, in the treatment... |
| 2012/0095033 |
Selective Glycosidase Inhibitors and Uses Thereof The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including... |
| 2012/0095032 |
METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS
FOR IDENTIFYING AGENTS FOR TREATING SAME The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia.... |
| 2012/0095031 |
CYCLOPROPANE COMPOUND A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has... |
| 2012/0095030 |
METHODS AND KITS TO PREDICT THERAPEUTIC OUTCOME OF TYROSINE KINASE
INHIBITORS Methods of using specific microRNA to identify subjects with non-small cell lung cancer likely or unlikely to respond to treatment with tyrosine kinase... |
| 2012/0095029 |
IPP COMPLEX AS MARKER FOR ERLOTINIB TREATMENT The present invention provides biomarkers which are predictive for the clinical benefit of erlotinib hydrochloride treatment in cancer patients. |
| 2012/0095028 |
3-OXA-7-AZABICYCLO[3.3.1]NONANES Compounds of Formula (I) that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the... |
| 2012/0095027 |
SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a... |
| 2012/0095026 |
INHIBITORS OF BRUTON'S TYROSINE KINASE Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the... |
| 2012/0095025 |
SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM
CHANNEL MODULATORS This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines useful as modulators of potassium channels. In other aspects the invention relates... |
| 2012/0095024 |
TOLUIDINE SULFONAMIDES AND THEIR USE The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor... |
| 2012/0095023 |
Novel Heterocyclic Compounds as Pesticides The present application relates to novel amides and thioamides, to processes for preparation thereof and to the use thereof for controlling animal pests, in... |
| 2012/0095022 |
DERIVATIVES OF
10-AMINO-1,2,3,4-TETRAHYDROPYRIDO[2,1-A]ISOINDOL-6(10BH)-ONES, METHOD FOR
PREPARATION... The present invention relates to compounds having the following general formula (I): ##STR00001## wherein: A represents a SO.sub.2 or CX group, X ... |
| 2012/0095021 |
SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR
AGENTS The present disclosure provides a compound of general formula A useful as potential anti-tubercular agents. ##STR00001## |
| 2012/0095020 |
Cathepsin S Inhibitor Compounds The present invention provides a compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. Also, the present invention provides a... |
| 2012/0095019 |
METHODS AND FORMULATIONS OF TREATING THROMBOSIS WITH BETRIXABAN AND A
P-GLYCOPROTEIN INHIBITOR This invention is directed to methods of inhibiting coagulation or treating thrombosis using a factor Xa inhibitor and a P-glycoprotein (Pgp) inhibitor. The... |
| 2012/0095018 |
5-HT1A RECEPTOR SUBTYPE AGONIST The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor... |
| 2012/0095017 |
PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE
DERIVATIVES WITH PROTEASE INHIBITORS This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is... |
| 2012/0095016 |
THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABA.sub.A receptor... |
| 2012/0095015 |
TRIAZOLE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO
MODULATION OF THE DOPAMINE D3 RECEPTOR The invention relates to compounds of formula (I), wherein n is 1 or 2, Ar is a C-bound 1,2,4-triazol radical which carries a radical R.sup.1 on the remaining... |
| 2012/0095014 |
AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions... |
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