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Patent # Description
2012/0095063 METHODS AND COMPOSITIONS FOR TREATMENT OF ISCHEMIC CONDITIONS AND CONDITIONS RELATED TO MITOCHONDRIAL FUNCTION
The present invention relates to compositions and methods for prophylactic and/or therapeutic treatment of conditions related to mitochondrial function. In...
2012/0095062 TRICYCLIC COMPOUNDS, COMPOSITIONS, AND METHODS
The present invention is directed to compounds of Formula I: ##STR00001## or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and...
2012/0095061 Fluorinated Derivatives of Deferiprone
The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or...
2012/0095060 METHODS AND COMPOSITIONS OF MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) PATHWAY INHIBITORS FOR TREATING PULMONARY...
Methods and compositions of inhibitors of MAPK kinases 1 and 2 (MEK1 and MEK2, or together, MEK1/2), such as ARRY142886, and their use in inhibiting MEK1/2...
2012/0095059 Compositions and Methods for Treating Type II Diabetes and Related Disorders
The present invention relates to methods and compositions for treating type II diabetes. This invention discloses an orally administrable pharmaceutical...
2012/0095058 Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced...
2012/0095057 PYRAZOLE COMPOUND
Provided is a compound having a superior acid secretion suppressive action, antiulcer activity and the like. A compound represented by the formula ##STR00001## ...
2012/0095056 2,5-DISUBSTITUTED TETRAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
This invention relates to novel tetrazole derivatives of formula (I), which are found to be modulators of the nicotinic acetylcholine receptors. Due to their...
2012/0095055 HEXAHYDROCYCLOPENTYL[f]INDAZOLE 5-HYDROXYMETHYL ETHANOLS AND DERIVATIVES THEREOF AS SELECTIVE GLUCOCORTICOID...
The present invention encompasses compounds of Formula (I): or pharmaceutically acceptable salts or hydrates thereof, which are useful as selective...
2012/0095054 POLYMORPHS OF ESOMEPRAZOLE SALTS
The present invention relates to a high assayed esomeprazole magnesium dihydrate substantially free of its trihydrate form. The present invention further...
2012/0095053 AMINOTETRAHYDROINDAZOLOACETIC ACIDS
The invention is concerned with the compounds of formula I: ##STR00001## and pharmaceutically acceptable salts and esters thereof, wherein Q, R1-R3 and n are...
2012/0095052 PAR-1 ANTAGONISM IN FED OR ANTACID-DOSED PATIENTS
Disclosed are methods of inhibiting a PAR-1 receptor in a patient who has recently ingested food or an antacid comprising the step of administering an effective...
2012/0095051 CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
This invention provides a compound having the structure ##STR00001## wherein .alpha., .beta., X, Y, and R.sub.1-R.sub.11 are defined herein. This invention also...
2012/0095050 STABILIZED AND PRESERVED KETOTIFEN OPHTHALMIC COMPOSITIONS
Ophthalmic compositions comprising ketotifen, a source of hydrogen peroxide providing an amount of hydrogen peroxide of from about 0.001 to about 0.1% (w/v),...
2012/0095049 NOCICEPTIN ANALOGS
A compound of the formula (I), (II), (III) or (IV) ##STR00001## wherein Z, A, B, C, R, R.sub.1, R.sub.2, Q, and n are as described herein.
2012/0095048 ALLOSTERIC BINDING COMPOUNDS
The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical...
2012/0095047 Novel Heteropyrrole Analogs Acting on Cannabinoid Receptors
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or the...
2012/0095046 Amido-Isothiazole Compounds and Their Use as Inhibitors of 11Beta-HSD1 for the Treatment of Metabolic Syndrome...
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-isothiazole...
2012/0095045 INJECTABLE ANTICANCER COMPOSITION FOR LOCAL ADMINISTRATION CONTAINING HYDROXYCHLOROQUINE
The present invention relates to an injectable anticancer composition for local administration comprising hydroxychloroquine. The anticancer composition shows...
2012/0095044 TISSUE NON-SPECIFIC ALKALINE PHOSPHATASE INHIBITORS AND USES THEREOF FOR TREATING VASCULAR CALCIFICATION
Disclosed herein are compounds that are tissue-nonspecific alkaline phosphatase inhibitors. The disclosed compounds are used to treat, prevent, or abate...
2012/0095043 TRIGLYCERIDE-LOWERING AGENT AND HYPERINSULINISM-AMELIORATING AGENT
The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating...
2012/0095042 Organic Compounds Having Cooling Properties
Provided are compounds of formula (I) ##STR00001## wherein m is 0, 1 or 2; R.sup.I is a mono- or bicyclic heterocyclic ring system including one, two or three...
2012/0095041 REVERSIBLE NONDEPOLARIZING NEUROMUSCULAR BLOCKADE AGENTS AND METHODS FOR THEIR USE
The invention provides neuromuscular blockade agents of the non-depolarizing type with few if any circulatory effects. Compounds of the invention include...
2012/0095040 CYCLOPENTA[C]PYRROLE-2-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
The invention relates to compounds of the general formula (I) where: R.sub.2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl,...
2012/0095039 HETEROCYCLIC COMPOUNDS WITH AFFINITY TO MUSCARINIC RECEPTORS
The present invention relates to heterocyclic compounds of formula (I) having affinity to muscarinic receptors, a pharmaceutical composition containing the...
2012/0095038 SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a...
2012/0095037 SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a...
2012/0095036 NOVEL SUBSTITUTED INDAZOLE AND AZA-INDAZOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS
The present invention is concerned with novel substituted indazole and aza-indazole derivatives of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3,...
2012/0095035 CRYSTALS OF PRASUGREL HYDROBROMATE
The present application discloses crystals of 2-acetoxy-5-(.alpha.-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahyd- rothieno[3,2-c]pyridine hydrobromate,...
2012/0095034 PIPERIDINE DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS
This invention relates to imidazo[1,2-a]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals, in the treatment...
2012/0095033 Selective Glycosidase Inhibitors and Uses Thereof
The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including...
2012/0095032 METHODS FOR TREATING LEUKEMIA AND MYELODYSPLASTIC SYNDROME, AND METHODS FOR IDENTIFYING AGENTS FOR TREATING SAME
The present disclosure relates to methods for treating leukemia, pre-leukemic conditions, as well as myelodysplastic syndrome and acute myelogenous leukemia....
2012/0095031 CYCLOPROPANE COMPOUND
A cyclopropane compound represented by the following formula (A) or a pharmaceutically acceptable salt thereof has orexin receptor antagonism, and therefore has...
2012/0095030 METHODS AND KITS TO PREDICT THERAPEUTIC OUTCOME OF TYROSINE KINASE INHIBITORS
Methods of using specific microRNA to identify subjects with non-small cell lung cancer likely or unlikely to respond to treatment with tyrosine kinase...
2012/0095029 IPP COMPLEX AS MARKER FOR ERLOTINIB TREATMENT
The present invention provides biomarkers which are predictive for the clinical benefit of erlotinib hydrochloride treatment in cancer patients.
2012/0095028 3-OXA-7-AZABICYCLO[3.3.1]NONANES
Compounds of Formula (I) that modulate the activity of the G-protein-coupled receptor GPR119 and their uses in the treatment of diseases linked to the...
2012/0095027 SYNTHESIS AND ANTI-PROLIFERATIVE EFFECT OF BENZIMIDAZOLE DERIVATIVES
This invention provides for compounds, compositions, and methods that involve anti-proliferative and anti-neoplastic activity in cancer cells. In particular, a...
2012/0095026 INHIBITORS OF BRUTON'S TYROSINE KINASE
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the...
2012/0095025 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS
This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines useful as modulators of potassium channels. In other aspects the invention relates...
2012/0095024 TOLUIDINE SULFONAMIDES AND THEIR USE
The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor...
2012/0095023 Novel Heterocyclic Compounds as Pesticides
The present application relates to novel amides and thioamides, to processes for preparation thereof and to the use thereof for controlling animal pests, in...
2012/0095022 DERIVATIVES OF 10-AMINO-1,2,3,4-TETRAHYDROPYRIDO[2,1-A]ISOINDOL-6(10BH)-ONES, METHOD FOR PREPARATION...
The present invention relates to compounds having the following general formula (I): ##STR00001## wherein: A represents a SO.sub.2 or CX group, X ...
2012/0095021 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS
The present disclosure provides a compound of general formula A useful as potential anti-tubercular agents. ##STR00001##
2012/0095020 Cathepsin S Inhibitor Compounds
The present invention provides a compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof. Also, the present invention provides a...
2012/0095019 METHODS AND FORMULATIONS OF TREATING THROMBOSIS WITH BETRIXABAN AND A P-GLYCOPROTEIN INHIBITOR
This invention is directed to methods of inhibiting coagulation or treating thrombosis using a factor Xa inhibitor and a P-glycoprotein (Pgp) inhibitor. The...
2012/0095018 5-HT1A RECEPTOR SUBTYPE AGONIST
The present invention relates to a method of treating a patient suffering from a disorder of the central nervous system associated with 5-HT.sub.1A receptor...
2012/0095017 PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is...
2012/0095016 THERAPEUTIC 5,6,5-TRICYCLIC ANALOGS
The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABA.sub.A receptor...
2012/0095015 TRIAZOLE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR
The invention relates to compounds of formula (I), wherein n is 1 or 2, Ar is a C-bound 1,2,4-triazol radical which carries a radical R.sup.1 on the remaining...
2012/0095014 AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions...
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