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Patent # Description
2016/0096864 CATIONIC STEROIDAL ANTIMICROBIAL PRODRUG COMPOSITIONS AND USES THEREOF
Prodrugs or pharmaceutically acceptable salts, stereoisomers, solvates, or polymorphs thereof include a pharmaceutically and/or diagnostically active cationic...
2016/0096863 METHODS OF PREPARING INTERMEDIATE OF FLUTICASONE PROPIONATE
A method of preparing a thioic acid intermediate of fluticasone propionate includes: treating a 17.beta.-[(N,N-dimethyl carbamoyl)thio]carbonyl compound in a...
2016/0096862 TGR5 Modulators and Methods of Use Thereof
The invention relates to compounds of Formula A: ##STR00001## or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of...
2016/0096861 Novel galactoside inhibitor of galectins
Provided is a compound of the general formula (I): ##STR00001## The compound of formula (I) is suitable for treating pulmonary fibrosis, such as Idiopathic...
2016/0096860 PREPARATION METHOD OF TRIHYDROXYETHYL RUTOSIDE
The present invention relates to a preparation method of trihydroxyethyl rutoside. In the method, rutin is firstly prepared into 7-monohydroxyethyl rutoside...
2016/0096859 ARBEKACIN DERIVATIVE, AND PRODUCTION AND USE THEREOF
It has been found that adding carbon dioxide or the like to a solution containing arbekacin free base makes it possible to produce arbekacin derivatives...
2016/0096858 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions...
2016/0096857 Aldose-Ketose Transformation for Separation and/or Chemical Conversion of C6 and C5 Sugars from Biomass Materials
Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to...
2016/0096856 METHOD OF PURIFYING IDRAPARINUX SODIUM
A method for the purification of idraparinux sodium includes: passing a solution including a crude idraparinux sodium through a column including a sodium ion...
2016/0096855 Method of Treating Colorectal Cancer
The present invention relates to the use of certain platinum compounds including [PtCb(cis-1,4-diaminocyclohexane)], or combinations of these compounds with a...
2016/0096854 METHOD FOR SUPPRESSING HEAT DISCOLORATION OF LECITHIN
[PROBLEM] To provide a novel method for suppressing heat discoloration of lecithin and a novel lecithin or lecithin preparation having resistance to heat...
2016/0096853 SYNTHETIC BLEND F-POSS COMPOSITIONS FORMED FROM MULTIPLE FEEDSTOCK MATERIALS
The present disclosure relates, in exemplary embodiments, to compositions of matter comprising synthetic blends of at least two feedstocks that produce a...
2016/0096852 Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and Analogs
4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of...
2016/0096851 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF
The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide,...
2016/0096850 ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): ##STR00001## wherein Q, A.sup.1-A.sup.8, R.sup.4 and R.sup.5 and each has the meaning as described herein. ...
2016/0096849 CARBAZOLE DIOXAZINE PIGMENTS
The present disclosure relates to a benzoyl substituted carbazole-dioxazine pigment and its preparation. The process involves benzoylation of...
2016/0096848 SELECTIVE INHIBITORS FOR PROTEIN KINASES AND PHARMACEUTICAL COMPOSITION AND USE THEREOF
The present invention provides a compound of formula (I) or the salt thereof: ##STR00001## wherein R is at least one selected from the group consisting of...
2016/0096847 SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS
Disclosed are azaindazole compounds of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is...
2016/0096846 FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including...
2016/0096845 SUPEROLEOPHOBIC AND/OR SUPERHYDROPHOBIC MATERIAL, PROCESS FOR PREPARING SAME AND APPLICATIONS THEREOF
The invention relates to a multilayer superoleophobic and/or superhydrophobic material comprising: on the one hand, a first constituent that is a conductive...
2016/0096844 ORIDONIN ANALOGS, COMPOSITIONS, AND METHODS RELATED THERETO
Certain embodiments are directed to oridonin analogs or derivatives. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents.
2016/0096843 PYRAZOLO-PYRROLIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the ...
2016/0096842 ANTI-INFLUENZA COMPOSITIONS AND METHODS
Disclosed are novel compounds comprising an imino-ribose derivative covalently linked to a carbocycle or heterocycle. Pharmaceutical compositions comprising...
2016/0096841 SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
Provided herein are Aminopurine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined herein,...
2016/0096840 PROCESS FOR CONVERTING LUPANINE INTO SPARTEINE
The present invention relates to processes for preparing enantiopure Lupanine and Sparteine.
2016/0096839 PYRIMIDINONES AS FACTOR XIA INHIBITORS
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the...
2016/0096838 CRYSTALLINE FORM OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-- ...
Crystalline form, Form T2H1.5-4, of N,Ndicyclopropyl-4-(1,5-dimethyl-1 Hpyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3- ...
2016/0096837 SUBSTITUTED 1,2,3,4-TETRAHYDROPYRIDO[3,4-E] PYRROLO[1,2-A]PYRIMIDINES AS KINASE INHIBITORS
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
2016/0096836 SPIROCYCLIC COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS
The present invention is directed to spirocyclic compounds which are inhibitors of tryptophan hydroxylase (TPH), particularly isoform 1 (TPH1), that are useful...
2016/0096835 TRIAZOLOPYRIDINE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
The invention relates to a compound of Formula I or IA and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
2016/0096834 HETEROARYL COMPOUNDS AS BTK INHIBITORS AND USES THEREOF
The present invention relates to imidazo pyridine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
2016/0096833 SUBSTITUTED 6-ARYL-IMIDAZOPYRIDINE AND 6-ARYL-TRIAZOLOPYRIDINE CARBOXAMIDE ANALOGS AS NEGATIVE ALLOSTERIC...
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds;...
2016/0096832 KINASE INHIBITORS
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
2016/0096831 MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce...
2016/0096830 INHIBITORS OF LYSINE GINGIPAIN
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and...
2016/0096829 Substituted Isoxazole Derivatives
The present invention relates to compounds of the formula I ##STR00001## wherein the substituents are defined in the claims and the specification.
2016/0096828 Indole-1-Carboxamides as Kinase Inhibitors
This invention is directed to a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2016/0096827 TANK-BINDING KINASE INHIBITOR COMPOUNDS
Compounds having the following formula (I) and methods of their use and preparation are disclosed: ##STR00001##
2016/0096826 CO-CRYSTALS OF LAPATINIB MONOACID SALTS
The present invention refers to co-crystals of monoacid salts of the pharmaceutical active ingredient named Lapatinib and to processes for the preparation...
2016/0096825 Furanone Compounds as Kinase Inhibitors
The present disclosure provides novel furanone compounds, or pharmaceutically acceptable salts, solvates or prodrugs thereof, as Raf kinase, especially BRAF...
2016/0096824 Heterocyclic Compounds Useful for Kinase Inhibition
Provided herein are compounds useful for kinase inhibition.
2016/0096823 AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGF.beta.R1),...
2016/0096822 Novel Cannabinergic Nitrate Esters and Related Analogs
Biologically active cannabinergic nitrate esters and related analogs, process of preparation, pharmaceutical compositions and their methods of use as...
2016/0096821 Chiral Synthesis of Pyrrolidine Core Compounds en route to Neuronal Nitric Oxide Synthase Inhibitors
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore...
2016/0096820 INHIBITORS OF INV(16) LEUKEMIA
This invention describes the development of targeted small molecule inhibitors of the inv(16) fusion, the causative agent in .about.12% of acute myeloid...
2016/0096819 PROCESS FOR PREPARING N-SUBSTITUTED 1H-PYRAZOLE-5-CARBOXYLIC ACID COMPOUNDS AND DERIVATIVES THEREOF
The present invention relates to a process for preparing N-substituted 1H-pyrazole-5-carboxylic acid compounds of the formula I-A and derivatives thereof, in...
2016/0096818 SUBSTITUTED 2-(2,6-DIOXOPIPERIDIN-3-YL)-PHTHALIMIDES AND -1-OXOISOINDOLINES AND METHOD OF REDUCING TNFALPHA LEVELS
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in...
2016/0096817 TREATMENT OF INFLAMMATORY BOWEL DISEASE
Disclosed herein is a method comprising administering a compound to a mammal suffering from an inflammatory bowel disease for the treatment of said disease,...
2016/0096816 METHOD OF PREPARING INTERMEDIATE OF SALMETEROL
A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with...
2016/0096815 T-TYPE CALCIUM CHANNEL INHIBITOR
The present invention provides a T-type calcium channel inhibitor which is a compound represented by formula (1), a pharmaceutically acceptable salt of this...
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