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Patent # Description
2016/0102167 COMB-LIKE POLYURETHANE AND METHODS FOR PREPARING AND USING THE SAME
A method for preparing a comb-like polyurethane, including: 1) adding a diol to a reaction vessel, stirring, heating, vacuum dehydrating, and cooling the diol;...
2016/0102166 NATURAL OIL POLYOLS DERIVED FROM POST-CONSUMER RECYCLE OILS
Disclosed embodiments include an open cell, molded polyurethane foam comprising the reaction product of a reaction mixture comprising: an isocyanate mixture;...
2016/0102165 HMF-BASED PHENOL FORMALDEHYDE RESIN
A HMF-based phenol formaldehyde resin is provided. The HMF-based phenol formaldehyde resin has the formula ##STR00001## In the formula, A includes...
2016/0102164 HIGH FLOW, HYDROGENATED STYRENE-BUTADIENE-STYRENE BLOCK COPOLYMERS AND APPLICATIONS
The invention relates to unique applications for the novel high melt flow, low viscosity, selectively hydrogenated styrene-butadiene-styrene (hSBS) or...
2016/0102163 FLAME RETARDANT ACRYLIC/PLA COPOLYMER
A flame retardant acrylic/polylactic acid (PLA) copolymer is synthesized which contains a FR-PMMA block that includes either a poly(MMAP) block or a...
2016/0102162 COPOLYMER, AQUEOUS INK, AND INK CARTRIDGE
A copolymer includes structural units having the following formulae (1) and (2): ##STR00001## wherein each of R1 and R2 independently represents a hydrogen atom...
2016/0102161 Titanium Phosphinimide and Titanium Iminoimidazolidide Catalyst Systems With Activator-Supports
Catalyst compositions containing activator-supports and half-metallocene titanium phosphinimide complexes or half-metallocene titanium iminoimidazolidide...
2016/0102160 HEXAHYDROTRIAZINE, DITHIAZINE, AND THIOETHER FUNCTIONALIZED MATERIALS
Synthetic schemes for preparation of polymers and polymer precursors having various functional groups is provided. These synthetic schemes are used to prepare...
2016/0102159 Olefin Polymerization Catalyst and a Combined Catalyst Containing the Same
The present disclosure provides an olefin polymerization catalyst and a combined catalyst containing the same. The catalyst comprises a reaction product of a...
2016/0102158 POLYMER COMPRISING REPEAT UNITS WITH PHOTOACID-GENERATING FUNCTIONALITY AND BASE-SOLUBILITY-ENHANCING...
A polymer includes repeat units, most of which are photoacid-generating repeat units. Each of the photoacid-generating repeat units includes ...
2016/0102157 POLYMER COMPRISING REPEAT UNITS WITH PHOTOACID-GENERATING FUNCTIONALITY AND BASE-SOLUBILITY-ENHANCING...
A polymer includes repeat units, at least half of which are photoacid-generating repeat units. Each of the photoacid-generating repeat units includes...
2016/0102156 PROCESS FOR PREPARING SPHERICAL POLYMERIZATION CATALYST COMPONENTS FOR USE IN OLEFIN POLYMERIZATIONS
A method of making a solid catalyst component for production of a polyolefin, including the steps of: a) dissolving a halide-containing magnesium compound in a...
2016/0102155 LOW DENSITY ETHYLENE-BASED POLYMERS WITH BROAD MOLECULAR WEIGHT DISTRIBUTIONS AND LOW EXTRACTABLES
The invention provides an ethylene-based polymer comprising the following properties: a) a melt index (I2).gtoreq.2.0 dg/min; b) a Mw(abs) versus I2...
2016/0102154 HYBRID COOPERATIVE COMPLEXES OF HYALURONIC ACID
Describes cooperative hybrid complexes of hyaluronic acid, a simple and economical method for production thereof and use thereof in the area of medicine,...
2016/0102153 PROCESS FOR MANUFACTURING LITHIUM CARBOXYMETHYL CELLULOSE
Prepare lithium carboxymethyl cellulose by treating sodium carboxymethyl cellulose with a weak acid to form an acid from of carboxymethyl cellulose and then...
2016/0102152 IMMUNOGLOBULIN VARIABLE REGION CASSETTE EXCHANGE
The invention provides methods for generating human antibodies with the specificity of a reference antibody by replacement of portions of the V.sub.H and...
2016/0102151 COMPOSITIONS AND METHODS FOR TREATMENT AND DETECTION OF CANCERS
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to globo H, SSEA3, and SSEA-4 are disclosed herein, as well as...
2016/0102150 PLASMA KALLIKREIN BINDING PROTEINS
Plasma kallikrein binding proteins and methods of using such proteins are described.
2016/0102149 OPTIMIZING THE PRODUCTION OF ANTIBODIES
A general method is provided for the production of purified antibodies by separation of an antibody molecule from an antibody variant by chromatographic...
2016/0102148 MODIFIED ANTIBODY IN WHICH MOTIF COMPRISING CYSTEINE RESIDUE IS BOUND, MODIFIED ANTIBODY-DRUG CONJUGATE...
The present invention relates to an antibody in which a motif composed of an amino acid or peptide sequence including one or more cysteine residues is bound to...
2016/0102147 Stabilized Formulations Containing Anti-Interleukin-4 Receptor (IL-4R) Antibodies
The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human interleukin-4 receptor (hIL-4R). The...
2016/0102146 ANTI-LGR5 ANTIBODIES AND IMMUNOCONJUGATES
The invention provides anti-LgR5 antibodies and immunoconjugates and methods of using the same.
2016/0102145 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT CACHEXIA, WEAKNESS, FATIGUE, AND/OR FEVER
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat...
2016/0102144 Use of Reslizumab To Treat Moderate to Severe Eosinophilic Asthma
Disclosed herein are methods of treating moderate to severe eosinophilic asthma in a patient comprising: 1) identifying a patient having moderate to severe...
2016/0102143 MODULATING REGULATORY T CELL ACTIVITY VIA INTERLEUKIN 35
Methods for regulating T cell function in a subject, particularly regulatory T cell activity are provided. Methods of the invention include administering to a...
2016/0102142 Antibodies Targeting M-CSF
This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are...
2016/0102141 CELL CULTURE MEDIA AND METHODS OF ANTIBODY PRODUCTION
Cell culture media are provided herein as are methods of using the media for cell culture and antibody production from cells. Compositions comprising...
2016/0102140 METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
The present invention provides methods of delivering a protein to the brain of a mammal, comprising administering to the mammal a therapeutic fusion protein...
2016/0102139 Inflammatory Disease Treatment Composition Including Anti-Myosin Regulatory Light-Chain Polypeptide Antibody
Provided is a means for inhibiting a function of CD69, whereby allowing suppression of an inflammatory response. That is, provided are: a composition for...
2016/0102138 TREATMENT OF TAUOPATHIES BY PASSIVE IMMUNIZATION TARGETING THE N-TERMINAL PROJECTION DOMAIN OF TAU
A method of treating tau pathologies, such as Alzheimer's disease, involving the administration of antibodies specific to the amino terminal region of human...
2016/0102137 CROSSLINKED ANTI-HIV-1 COMPOSITIONS FOR POTENT AND BROAD NEUTRALIZATION
An anti-HIV-1 spike composition includes a first anti-HIV-1 antibody Fab and a second anti-HIV-1 antibody Fab linked by a DNA or protein linker molecule to...
2016/0102136 SINGLE-DOMAIN VHH ANTIBODIES DIRECTED TO NOROVIRUS GI.1 AND GII.4 AND THEIR USE
Isolated V.sub.HH monoclonal antibodies are disclosed that specifically bind to a Norovirus polypeptide. In some embodiments, the Norovirus is a Genogroup I...
2016/0102135 HETEROMULTIMERS WITH REDUCED OR SILENCED EFFECTOR FUNCTION
Provided herein are heteromultimer constructs with reduced or silenced effector function. In an embodiment is provided a heteromultimer construct comprising an...
2016/0102134 CROSSLINKED HUMAN OR ANIMAL TISSUE PRODUCTS AND THEIR METHODS OF MANUFACTURE AND USE
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and...
2016/0102133 MUTANT FACTOR VIII COMPOSITIONS AND METHODS
In one aspect, present invention provides a recombinant mutant human factor VIII having increased expression and/or secretion as compared to wild-type factor...
2016/0102132 MONOMERIC RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS
The present invention provides, in particular embodiments, for modified recombinant T cell receptor (TCR) ligands (RTLs) comprising a MHC class I or MHC class...
2016/0102131 Consumable Cryopreserved Cells Transiently Overexpressing Gene(s) Encoding Drug Transporter Protein(s) and/or...
The present invention discloses cryopreserved recombinant cells for screening drug candidates that transiently overexpress one or more drug transporter...
2016/0102130 WATER SOLUBLE G-PROTEIN COUPLED RECEPTOR
Described herein are recombinant integral membrane proteins having multiple transmembrane domains that have been engineered to be less hydrophobic, through...
2016/0102129 Stable GLP-1 Based GLP-1/Glucagon Receptor Co-Agonists
New GLP-1 derivatives, compositions thereof and their use in medicine.
2016/0102128 CODON OPTIMIZED IL-15 AND IL-15R-ALPHA GENES FOR EXPRESSION IN MAMMALIAN CELLS
The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for...
2016/0102127 TARGETED MODULATION OF MACROPHAGES
An immunomodulatory fusion protein (IFP) for converting pro-inflammatory M macrophages to anti-inflammatory M2 like phenotypes of macrophagesthe IFP having at...
2016/0102126 Novel Peptides Involved in Energy Homeostasis
The expression of a mRNA encoding a putative 76 amino acid, secreted protein ("Enho1") was found to negatively correlate with fasting triglyceride and...
2016/0102125 EXPRESSION SYSTEMS AND ASSOCIATED METHODS
A method of producing synthetic spider silk, including: transforming Escherichia coli with an expression vector; fermenting the transformed E. coli in a...
2016/0102124 VMP-LIKE SEQUENCES OF PATHOGENIC BORRELIA SPECIES AND STRAINS
The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to...
2016/0102123 STABILIZED SOLUBLE PREFUSION RSV F POLYPEPTIDES
Described are stable pre-fusion respiratory syncitial virus (RSV) F polypeptides, immunogenic compositions comprising the polypeptides and uses thereof for the...
2016/0102122 Immunomodulators
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2016/0102121 Peptide Inhibitors of Sodium Channels
The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium...
2016/0102120 Galactose Cluster-Pharmacokinetic Modulator Targeting Moiety for siRNA
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator...
2016/0102119 INHIBITORS OF IAP
Novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies and have the general formula I: ##STR00001## wherein R.sup.1, R.sup.2,...
2016/0102118 SOLID PHASE PEPTIDES SYNTHESIS PROCESSES AND ASSOCIATED SYSTEMS
Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino...
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