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Patent # Description
2016/0108132 Antitumor Peptide Derived From A Complementarity Determining Region of a Humanized Monoclonal Antibody to...
Described herein is novel isolated or synthetic peptides derived from a complementarity determining region hypervariable domain amino acid sequence of a...
2016/0108131 ANTI-CEACAM5 ANTIBODIES AND USES THEREOF
The present invention discloses antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells...
2016/0108130 RSPO3 Binding Agents and Uses Thereof
The present invention relates to RSPO-binding agents, particularly RSPO3-binding agents and methods of using the agents for treating diseases such as cancer....
2016/0108129 CYTOTOXIC BENZODIAZEPINE DERIVATIVES
The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula...
2016/0108128 ANTIBODIES THAT BIND TO JAGGED 1
The present invention provides antibodies which bind to the Delta/Serrate/LAG-2 consensus sequence (DSL) domain of human Jagged 1 via novel epitopes comprising...
2016/0108127 Methods of Controlling the Formation of Disulfide Bonds in Protein Solutions
Disclosed herein are methods that have been developed to control the formation of disulfide bonds between polypeptides of a multimeric protein produced by a...
2016/0108126 CD20 Antibodies and Uses Thereof
CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells from peripheral blood as well as lymphoid tissues. CD20...
2016/0108125 FORMULATIONS WITH REDUCED OXIDATION
The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides...
2016/0108124 ANTI-DEspR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS...
Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof, including fully human, composite engineered human, humanized,...
2016/0108123 ANTIBODY MOLECULES TO PD-L1 AND USES THEREOF
Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The...
2016/0108122 THERAPEUTIC OR PROPHYLACTIC AGENT FOR IMMUNODEFICIENCY VIRUS INFECTION
Disclosed is a novel means that enables complete cure of not only acute and chronic virus infections, but also latent retrovirus infections in which...
2016/0108121 T Cell Regulation
Combinations of anti-cancer antibodies and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The inhibitory antibodies may be...
2016/0108120 ANTI-ROBO4 ANTIBODY
Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an...
2016/0108119 PROTEIN PURIFICATION
The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange...
2016/0108118 Anti-TNF-alpha/CXCL10 Double-Targeting Antibody and Use Thereof
The present invention relates to a TNF-.alpha. (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG...
2016/0108117 Anti-CXCL1, CXCL7 and CXCL8 Antibodies and their Applications
The invention provides an isolated antibody or a fragment thereof, which is directed to the human chemokines CXCL1, CXCL7 and CXCL8, said antibody or fragment...
2016/0108116 VEGF-SPECIFIC ANTAGONISTS FOR ADJUVANT AND NEOADJUVANT THERAPY AND THE TREATMENT OF EARLY STAGE TUMORS
Disclosed herein are methods of treating benign, pre-cancerous, or non-metastatic tumors using an anti-VEGF-specific antagonist. Also disclosed are methods of...
2016/0108115 ANTI-C5 ANTIBODIES HAVING IMPROVED PHARMACOKINETICS
The disclosure provides antibodies that are useful for, among other things, inhibiting terminal complement (e.g., the assembly and/or activity of the C5b-9...
2016/0108114 Compositions And Methods For Macular Degeneration
The present invention pertains to methods of inhibiting angiogenesis (e.g., ocular angiogenesis choroidal neovasculariztion) in an individual in need thereof...
2016/0108113 ANTI-ALPHA-SYNUCLEIN ANTIBODIES AND METHODS OF USE
The present invention relates to anti-alpha-synuclein (anti-.alpha.-synuclein) antibodies and methods of using the same.
2016/0108112 METHODS OF REPLICATING A LARGE SCALE ECULIZUMAB PRODUCTION CELL CULTURE
Provided herein are methods of replicating a large scale eculizumab production cell culture in a small scale culture.
2016/0108111 METHODS OF SHIFTING AN ISOELECTRIC PROFILE OF A PROTEIN PRODUCT AND USES THEREOF
Provided herein are methods shifting the isoelectric profile of a recombinant protein product and the use of such methods in the manufacture of recombinant...
2016/0108110 ANGIOPOETIN-LIKE 4 (ANGPTL4) ANTIBODIES AND METHODS OF USE
The present invention relates to monoclonal antibodies binding to human angiopoetin-like protein 4 (hereinafter, sometimes referred to as "ANGPTL4"), and...
2016/0108109 ANTIBODY TO PEPTIDE ENCODED BY Exon-21 OF PERIOSTIN, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT...
The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is...
2016/0108108 INFLAMMATORY DISEASE DIAGNOSIS AND METHODS OF TREATMENT USING LIPOPOLYSACCHARIDES-RESPONSIVE BEIGE-LIKE ANCHOR
Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine...
2016/0108107 DEAMIDATED ANTI-GLUTEN ANTIBODY AND USES THEREOF
The present invention relates to a monoclonal antibody that is capable of bonding to deamidated gluten proteins and has no cross-reaction with the ...
2016/0108106 GENERATION OF HIGHLY POTENT ANTIBODIES NEUTRALIZING THE LUKGH (LUKAB) TOXIN OF STAPHYLOCOCCUS AUREUS
The subject relates to an isolated Staphylococcus aureus leukocidin antigen comprising a LukGH complex, an antibody specifically binding to the Luk GH complex,...
2016/0108105 HUMAN IGG4 FC POLYPEPTIDE VARIANT
Disclosed is a human IgG4 Fc polypeptide variant, including a modified CH2 domain of human IgG4 Fc, wherein the modification contains a replacement of a 6-20...
2016/0108104 APOLIPOPROTEIN E POLYPEPTIDES AND THEIR USE
Disclosed herein are several apoplipoprotein E (ApoE) polypeptides, and nucleic acids encoding these polypeptides, that can be used to treat or prevent a...
2016/0108103 IMMUNOGENIC PEPTIDES AND THEIR USE IN TRANSPLANTATION
The present invention relates to the use of immunogenic peptides comprising a T-cell epitope derived from an allograft antigen and a redox motif such as...
2016/0108102 Novel GLP-1 Derivatives
Novel polypeptide derivatives having protracted profile of action.
2016/0108101 RECOMBINANT CANCER THERAPEUTIC CYTOKINE
Recombinant therapeutic cytokines ("therakines") for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24...
2016/0108100 Interference Peptides and Use Thereof
A purified and isolated peptide comprises an amino acid sequence of SEQ ID NOs: 1 to 8. A method is also provided for preventing interaction, e.g. binding, of...
2016/0108099 VECTORS ENCODING ROD-DERIVED CONE VIABILITY FACTOR
The present invention relates to nucleic acids coding for and capable of expressing a rod-derived cone viability factor (RdCVF) and viral vectors containing...
2016/0108098 THERAPEUTIC PEPTIDES
The present invention relates to novel analogs of PYY that have an improved therapeutic profile when compared to native human PYY. These novel PYY analogs are...
2016/0108097 MONOMERIC GRIFFITHSIN TANDEMERS
The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the...
2016/0108096 FUSION PROTEINS, RECOMBINANT BACTERIA, AND METHODS FOR USING RECOMBINANT BACTERIA
Fusion proteins containing a targeting sequence, an exosporium protein, or an exosporium protein fragment that targets the fusion protein to the exosporium of...
2016/0108095 POLYPEPTIDES
The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that...
2016/0108094 IMMUNOGENIC BACTERIAL VESICLES WITH OUTER MEMBRANE PROTEINS
Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can...
2016/0108093 CYCLIZED TRANSTHYRETIN PEPTIDE AND METHODS OF USE THEREFOR
The present disclosure describes cyclized peptides that inhibit A.beta. toxicity and therefore can be used as therapeutic agents to treat Alzheimer's Disease.
2016/0108092 Selectin Inhibitors, Composition, and Uses Related Thereto
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that...
2016/0108091 CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE
The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a...
2016/0108090 DYNORPHIN A ANALOGS WITH BRADYKININ RECEPTORS SPECIFICITY FOR MODULATION OF NEUROPATHIC PAIN
Described are Dynorphin A analog compounds and uses thereof for treating pain in humans and lower animals by administering to a human or lower animal in need...
2016/0108089 BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES
The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The...
2016/0108088 ANTI-ANGIOGENIC MOLECULES, NANOSTRUCTURES AND USES THEREOF
The disclosure is generally directed toward the design and synthesis of peptide amphiphile (PA) molecules that comprises a peptide configured to inhibit...
2016/0108087 THERAPEUTICS FOR THE INDUCTION OF ENDOGENOUS STEROIDOGENESIS AND METHODS ASSOCIATED WITH THEIR IDENTIFICATION
The present disclosure provides agents capable of promoting endogenous steroid production (such as endogenous testosterone production) without altering the...
2016/0108086 PEPTIDE STIMULATOR OF CELL SURVIVAL AND PROLIFERATION
The invention provides a novel peptide, and derivatives thereof, which is stable in aqueous solution and which stimulates proliferation and survival of...
2016/0108085 TUBULYSINS AND PROCESSES FOR PREPARING
Processes are described for the preparation of tubulysins. The processes are useful for preparing predetermined mixtures of tubulysins, preparing single...
2016/0108084 Purification Of Recombinantly Produced Polypeptides
Described herein is a method for separating a recombinantly produced polypeptide from host cell protein. The method includes a step of loading a clarified cell...
2016/0108083 PROCESS FOR THE PREPARATION OF 7 alpha -(METHOXYCARBONYL)-3-OXO-17alpha-PREGN-4,9(11)-DIEN-21,17-CARBOLACTONE,...
An improved process for the preparation of intermediate (V) through the elimination of a molecule of water from intermediate (IV) is described. ##STR00001## ...
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