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Patent # Description
2016/0108032 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
2016/0108031 INHIBITORS OF NHR2 AND/OR RUNX1/ETO-TETRAMERIZATION
The invention relates to inhibitors of the NHR2 tetramerization and their use as tumor therapeutics (e.g. against acute myeloid leukemia (AML)), cytostatics,...
2016/0108030 THERAPEUTIC COMPOUNDS
Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for...
2016/0108029 METHODS FOR THE PREPARATION OF HIV ATTACHMENT INHIBITOR PIPERAZINE PRODRUG COMPOUND
A method for making the compound ##STR00001## is set forth utilizing the starting material ##STR00002##
2016/0108028 1,2,5-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS
The present invention relates to compounds of Formula (I), ##STR00001## and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A,...
2016/0108027 SUBSTITUTED BENZOXAZOLES
The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or...
2016/0108026 ALDOSTERONE SYNTHASE INHIBITORS
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2 and R.sup.3, are as...
2016/0108025 POLYCYCLIC HERG ACTIVATORS
The present invention provides a compound of formula I, in which R.sup.1, R.sup.2, X and R.sup.3 are defined in the Summary of the Invention, or a ...
2016/0108024 BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1)...
The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to...
2016/0108023 Novel Compound
There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the...
2016/0108022 TRIAZOLE COMPOUNDS AND THEIR USE AS GAMMA SECRETASE MODULATORS
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof. The invention also relates to pharmaceutical...
2016/0108021 PYRIDONE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
This invention relates to pyridone derivatives, processes for their preparation, phamaceutical compositions, and their use in therapy.
2016/0108020 QUINAZOLINEDIONE DERIVATIVES AS PARP INHIBITORS
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of...
2016/0108019 INHIBITORS OF KRAS G12C MUTANT PROTEINS
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): ##STR00001## or a...
2016/0108018 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
2016/0108017 PROCESS FOR PREPARING AN 1,2-ALKYLENE CARBONATE
The invention relates to a process for preparing an 1,2-alkylene carbonate comprising (i) contacting carbon dioxide, an 1,2-alkylene oxide and a carbonation...
2016/0108016 Novel Cannabinergic Compounds and Uses Thereof
Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various...
2016/0108015 Carbofluorescein Lactone Ion Indicators and Their Applications
Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for...
2016/0108014 NOVEL ACID DIANHYDRIDE, METHOD FOR PREPARING SAME, AND POLYIMIDE PREPARED THEREFROM
The present invention relates to a novel acid dianhydride, a method for preparing the same, and a polyimide prepared therefrom. More specifically, the acid...
2016/0108013 PROCESSES FOR SELECTIVE EXTRACTION OF UNSAPONIFIABLE MATERIALS FROM RENEWABLE RAW MATERIALS BY REACTIVE...
A method for extracting an unsaponifiable fraction from a renewable raw material, includes the reactive trituration of the raw material dehydrated in the...
2016/0108012 PROSTAGLANDIN CONJUGATES AND DERIVATIVES FOR TREATING GLAUCOMA AND OCULAR HYPERTENSION
Prostaglandin conjugates and derivatives and methods for their use to treat glaucoma and/or lower intraocular pressure are disclosed. Additionally, ophthalmic...
2016/0108011 Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors
The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical...
2016/0108010 HUMIC ACID DERIVATIVES AND METHODS OF PREPARATION AND USE
Disclosed are antioxidative natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds...
2016/0108009 Novel formulation of metaxalone
The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone,...
2016/0108008 Substituted N-(Tetrazol-5-yl)- and N-(Triazol-5-yl)arylcarboxamide Compounds and Their Use as Herbicides
N-(tetrazol-5-yl)- and N-(triazol-5-yl)arylcarboxamides of formula I and their use as herbicides, ##STR00001## The invention relates to N-(tetrazol-5-yl)- and ...
2016/0108007 SYNTHESIS OF SYRBACTIN PROTEASOME INHIBITORS
The disclosure relates generally to methods for the preparation of a family of natural compounds, the syrbactins and their analogs.
2016/0108006 Synthesis Method of Organometallic Complex, Synthesis Method of Pyrazine Derivative, 5,6-Diaryl-2-Pyrazyl...
Provided is a 5,6-diaryl-2-pyrazyl triflate, its synthetic method, and a method for synthesizing an organometallic complex having a triarylpyrazine ligand from...
2016/0108005 TREATMENT OR PREVENTION OF DEPRESSION USING MENTHOL AND/OR ICILIN
Compositions for treatment or prevention of depression are provided, and the compositions contain a therapeutically effective amount of a compound selected...
2016/0108004 TREATMENT OR PREVENTION OF NEURODEGENERATIVE DISORDERS USING MENTHOL, LINALOOL AND/OR ICILIN
Compositions for treatment or prevention of neurodegenerative disorders are provided, and the compositions contain a therapeutically effective amount of a...
2016/0108003 SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMID- AZOL-2-AMINE,...
The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imid- azol-2-amine and pharmaceutically...
2016/0108002 UNIVERSAL READER MOLECULE FOR RECOGNITION TUNNELING
Some embodiments of the present disclosure are directed to a compound 5(6)-mercapto-1H-benzo[d]imidazole-2-carboxamide ("BIA") which yields enhanced signals...
2016/0108001 PROCESS FOR THE STEREOSELECTIVE PREPARATION OF A PYRAZOLE-CARBOXAMIDE
The present invention relates to a process for the enantioselective preparation of the compound of formula (Ib), which process comprises a) reducing the (E)-...
2016/0108000 PROCESS FOR PREPARING 3,5-BIS(FLUOROALKYL)PYRAZOLE DERIVATIVES FROM a,a-DIHALOAMINES
The present invention relates to a novel process for preparing 3,5-bis(fluoroalkyl)pyrazole derivatives from .alpha.,.alpha.-dihaloamines.
2016/0107999 SUBSTITUTED AZADIBENZOCYCLOOCTYNE COMPOUNDS AND THEIR USE IN METAL-FREE CLICK REACTIONS
The invention relates to a substituted azadibenzocyclooctyne compound according to Formula (5): The invention also relates to a conjugate wherein a substituted...
2016/0107998 A PROCESS FOR PREPARING IVABRADINE
The invention refers to a process for preparing ivabradine, in particular a process for preparing an ivabradine salt.
2016/0107997 CXCR7 RECEPTOR MODULATORS
The present invention relates to derivatives of formula (I) ##STR00001## wherein (R.sup.1).sub.n, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, R.sup.4, L.sup.1,...
2016/0107996 Mitochondrial Aldehyde Dehyrogenase-2 Modulators and Methods of Use Thereof
The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of...
2016/0107995 HISTONE DEMETHYLASE INHIBITORS
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
2016/0107994 HETEROCYCLIC AMPHOTERIC COMPOUNDS
Disclosed are a variety of amphoteric compounds having a heterocyclic quaternary nitrogen group. The heterocycle includes pyridines, piperidines, and...
2016/0107993 POLYMORPHIC FORMS OF ST-246 AND METHODS OF PREPARATION
Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocy- cloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as...
2016/0107992 INTERMEDIATES USEFUL FOR THE PREPARATION OF SAXAGLIPTIN
Intermediates useful for the synthesis of saxagliptin and their preparationare described.
2016/0107991 PROCESSES AND INTERMEDIATES FOR PREPARING INDOLE PHARMACEUTICALS
The invention described herein pertains to processes and intermediates for preparing indole containing pharmaceuticals, particularly to processes and...
2016/0107990 4-(5-(4-CHLOROPHENYL)-2-(2-CYCLOPROPYLACETYL)-1,4-DIMETHYL-1H-PYRROL-3-YL)- BENZENESULFONAMIDE AS ALPHA 7 NACHR...
Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yl- jbenzenesulfonamide, its...
2016/0107989 A PROCESS FOR PREPARATION OF PYRROLES HAVING HYPOLIPIDEMIC HYPOCHOLESTEREMIC ACTIVITIES
The present invention provides pyrroles having hypolipidemic hypocholesteremic activities. The invention provides saroglitazar and its pharmaceutically...
2016/0107988 Tetracycline Compounds
The present invention is directed to a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. The variables for...
2016/0107987 METHOD FOR PREPARING URETHANE (METH)ACRYLATES
Described is a process for preparing urethane (meth)acrylates. In a first step, a hydroxyalkyl (meth)acrylate is reacted with a lactone (B) in the presence of...
2016/0107986 IMPROVED METHOD FOR PRODUCING SPECIFIC OXIMES AND OXIMETHERS
Method for preparing certain oximes and oxime O-methyl ethers by reacting poorly water-soluble carbonyl compounds with salts of hydroxylamine or hydroxylamine...
2016/0107985 Compositions and Methods Relating to Ionic Salts of Peptides
The present invention relates to compounds of Formula I, compositions containing same, and methods of use.
2016/0107984 MODULATOR
The present disclosure relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein Z is selected from OH, NHCH.sub.2CH.sub.2F,...
2016/0107983 AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE AND SALT THEREOF
The present invention relates to an industrially feasible and economically viable process for the preparation of 3-aryloxy-3-phenylpropylarnine and salt of...
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