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Patent # Description
2016/0113940 METHODS OF TREATING BIOFILMS
A method of treating or preventing a condition caused by a biofilm in a subject is carried out by: providing a subject having, or susceptible to, a condition...
2016/0113939 Treating Patients with Compounds or Biological Agents That Pass the Safety Tests
The invention discloses a method of treatment for various severe disorders which is not treated well by current FDA approved drugs. The therapeutic agents by...
2016/0113938 ANIMAL TRAINING USING COGNITIVE ENHANCEMENT
Methods are disclosed to enhance the training potential of a domestic animal during training, thereby shortening the training period and/or increasing the...
2016/0113937 DISCOVERY OF FDA-APPROVED DRUGS AS INHIBITORS OF FATTY ACID BINDING PROTEIN 4 USING MOLECULAR DOCKING SCREENING
Using molecular docking screening, a few therapeutical compounds including trovafloxacin and levofloxacin have been first identified as potential inhibitors of...
2016/0113936 METHODS FOR MODULATING MONOCYTE FUNCTION
It has been discovered that HSP90 inhibitors can inhibit both the pro-inflammatory and pro-coagulatory potential of monocytes, in particular activated...
2016/0113935 COMPOSITION INCLUDING ATM INHIBITOR FOR REDUCING CELLULAR SENESCENCE AND USE OF THE COMPOSITION
A composition including an ataxia telangiectasia mutated (ATM) inhibitor for reducing cellular senescence, a method of reducing cellular senescence in a...
2016/0113934 PRESERVATIVE FREE BIMATOPROST AND TIMOLOL SOLUTIONS
The present invention is directed to preservative-free solutions of bimatoprost and timolol for lowering intra-ocular pressure and treatment of glaucoma.
2016/0113933 TREATMENT OF OBESITY AND PULMONARY ARTERIAL HYPERTENSION
Disclosed are methods and compositions for treating pulmonary arterial hypertension and/or obesity using inhibitors of prostaglandin transporter (PGT) activity.
2016/0113932 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS
Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders. Provided...
2016/0113931 Method of treating and/or preventing neurodegenerative diseases
The present disclosure provides a method of treating and/or preventing neurodegenerative diseases, such as Parkinson disease, Alzheimer disease, Huntington's...
2016/0113930 COMPOUNDS FOR USE IN TREATING RETT SYNDROME
Provided herein are compounds and pharmaceutically acceptable salts thereof that are useful therapeutics for Rett syndrome.
2016/0113929 METHODS AND COMPOSITIONS FOR TREATING VIRAL OR VIRALLY-INDUCED CONDITIONS
Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The...
2016/0113928 HETEROCYCLIC COMPOUNDS AS HEDGEHOG SIGNALING PATHWAY INHIBITORS
This invention relates to novel compounds of formula (I). The compounds of the invention are hedgehog pathway antagonists. Specifically, the compounds of the...
2016/0113927 LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of...
2016/0113926 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM
A process of production of trazodone or trazodone hydrochloride that comprises: (a) preparing an organic phase comprising trazodone in at least one organic...
2016/0113925 METHODS OF TREATING CANCER WITH A COMBINATION OF GLUCOSE MODULATORS AND BCL-2 INHIBITORS
This disclosure relates to treating or preventing cancers, such as hematological malignancies, by administering a compound that binds BCL2 and one or more...
2016/0113924 METHOD OF TREATING NASOPHARYNGEAL CARCINOMA USING PERILLYL ALCOHOL DERIVATIVE
A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH)...
2016/0113923 PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
The present invention provides a compound of formula I: ##STR00001## wherein X.sup.-, R.sup.1, and R.sup.2 are as defined herein, and compositions thereof.
2016/0113922 Group of Alkaloids, the Novel Autophagic Enhancers for Treatment of Cancers and Neurodegenerative Conditions...
The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine,...
2016/0113921 COMBINATION THERAPY COMPRISING OXAZOLIDINONE-QUINOLONES FOR USE IN TREATING BACTERIAL INFECTIONS
The present invention provides a combination of at least one oxazolidinone-quinolone hybrid with at least one further antibacterial compound and the use...
2016/0113920 COMPOSITIONS AND METHODS FOR INHIBITING BACTERIAL AND VIRAL PATHOGENS
Compositions and methods including Amodiaquine (AQ) or N-Desethy Amodiaquine (DEAQ) are provided for treating, inhibiting, or preventing cathepsin B dependent...
2016/0113919 CHLOROQUINE STEREOISOMER FOR TREATING TUBERCULOSIS RELATED DISEASES
This disclosure provides a method of treating a subject infected with a mycobacteria of the M. tuberculosis complex or infected with an atypical mycobacterium....
2016/0113918 Heterocyclic GSK-3 Allosteric Modulators
The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme....
2016/0113917 MEDICINAL COMPOSITION FOR INHIBITING FORMATION AND/OR ENLARGEMENT OF CEREBRAL ANEURYSM OR SHRINKING SAME
Provided is a pharmaceutical composition which enables the inhibition of formation and/or enlargement of cerebral aneurysm or the regression of cerebral...
2016/0113916 PHARMACEUTICAL INTERVENTION AND METHOD FOR TREATING AN APRAXIA OF SPEECH IN CHILDREN
A pharmaceutical intervention and therapeutic method for treating an apraxia of speech in children. The child can also be diagnosed with gait abnormalities or...
2016/0113915 COMPOSITIONS AND METHODS FOR MODULATING METABOLIC PATHWAYS
Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or...
2016/0113914 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted ...
2016/0113913 CONTROLLED-RELEASE DRUG FORMULATION
The present invention provides a controlled-release solid preparation containing pioglitazone or a salt thereof as an active ingredient, and having superior...
2016/0113912 AN IMPROVED PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF
The present invention relates to an improved process for the preparation of apixaban and intermediates thereof. In particular, the invention relates to an...
2016/0113911 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
The methods and uses described herein relate to the role of KDM4A in, e.g. cancer, and permit, e.g. the diagnosis, prognosis, and treatment of cancer and graft...
2016/0113910 Treating Infections with Ceftolozane/Tazobactam in Subjects Having Impaired Renal Function
Disclosed are methods of administering cephalosporin/tazobactam to human patients with end stage renal disease undergoing hemodialysis and suffering from a...
2016/0113909 METHODS AND COMPOSITIONS TO TREAT CANCER
Embodiments provided herein relate to methods and compositions for treating cancer. Some embodiments include treating lung cancers and renal cancers.
2016/0113908 Transdermal Therapeutic System for Extended Dosing of Pramipexole in Treating Neurological Disorders
This disclosure relates to a transdermal therapeutic system (TTS) containing pramipexole or related compounds and methods of making the system as well as its...
2016/0113907 SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR...
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D ...
2016/0113906 METHODS OF PREPARING EXTRUDATES
Compositions and methods of preparing amorphous drug formulations through hot melt extrusion which result in decreased decomposition of the desired drug are...
2016/0113905 Polymer composition and polymer material
A polymer composition including a polymer having a hydroxyl group and a histidine or a histidine derivative grafted to the polymer having a hydroxyl group. A...
2016/0113904 SKIN CARE PRODUCTS COMPRISING SUBSTITUTED HYDROXYPROLINE WITH UNSATURATED FATTY ACIDS DERIVATIVES
Disclosed is a method for treating or preventing pathological or non-pathological skin conditions, disorders or diseases comprising administering a conjugate...
2016/0113903 SirT INHIBITORS THAT BIND TO NAD
Compound of formula (I) ##STR00001## and methods of treating disorders by administering a compound of formula (I) are described herein. Examples of disorders...
2016/0113902 Glycopyrrolate Salts
Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including...
2016/0113901 Cyclic Peptidomimetic Compounds as Immunomodulators
The present invention relates to cyclic peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling...
2016/0113900 INHIBITORS OF MITOCHONDRIAL STAT3 AND USES THEREOF IN MODULATION OF MAST CELL EXOCYTOSIS
The invention provides composition of matter comprising at least one STAT3 inhibiting moiety or any vehicle, matrix, nano- or micro-particle comprising the...
2016/0113899 Method of Treating Cancer That Overexpresses TopBP1
The present invention provides a method of treating cancer that overexpresses TopBP1 by administering to a patient suffering from the cancer with an effective...
2016/0113898 TAXANE ANALOGS FOR THE TREATMENT OF BRAIN CANCER
Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a...
2016/0113897 METHOD OF MANAGING HEPATIC FIBROSIS, HEPATITIS C VIRUS AND ASSOCIATED CONDITION
The present disclosure relates to management of Hepatitis C Virus (HCV) and associated condition. The present disclosure also relates to management of Hepatic...
2016/0113896 COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR...
An exemplary embodiment relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases...
2016/0113895 Novel Use of Adapalene in Treating Esophageal Cancer and Gastrointestinal Stromal Tumor
A novel use of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthalenecarboxylic acid or a pharmaceutically acceptable salt or functional derivative thereof in ...
2016/0113894 TREATING CRITICALLY ILL PATIENTS WITH INTRAVENOUS IBUPROFEN
Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to...
2016/0113893 NEW THERAPEUTIC USES OF ENZYME INHIBITORS
The invention relates to use of compounds which inhibit VAP-1/SSAO activity for the treatment of muscular dystrophy.
2016/0113892 Method For Enhancing Folding and Transport of Misfolded Glucocerebrosidase
Therapeutic compositions and methods for treatment of late-onset Gaucher disease are described herein. The compositions comprise compounds having activity as...
2016/0113891 INJECTABLE PHARMACEUTICAL COMPOSITIONS COMPRISING ADRENALINE AND CITRIC ACID
The present invention relates to injectable pharmaceutical compositions showing improved storage stability said compositions comprising adrenaline and citric...
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