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Patent # Description
2016/0115490 Bacterial Mutants with Improved Transformation Efficiency
Provided herein are Bacillus mutants having improved transformation efficiency, comprising a disruption of an endogenous epsA-O operon. Also described are...
2016/0115489 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and...
2016/0115488 CRISPR-CAS COMPONENT SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and...
2016/0115487 CELL-FREE SYNTHETIC INCORPORATION OF NON-NATURAL AMINO ACIDS INTO PROTEINS
The present disclosure provides methods for incorporating at least one non-natural amino acid into a polypeptide using a cell-free protein synthesis which...
2016/0115486 NUCLEASE-MEDIATED DNA ASSEMBLY
Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end...
2016/0115485 MODULATION OF NLGn4 EXPRESSION, NK CELL ACTIVITY IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)
The present invention provides a method of treating, attenuating or preventing a liver disorder by inhibiting NGn4 expression and thereby modulating the...
2016/0115484 INHIBITION OF MAP4K4 THROUGH RNAI
RNAi constructs directed to MAP4K4 that demonstrate unexpectedly high gene silencing activities, and uses thereof are disclosed. The blunt-ended constructs...
2016/0115483 SILENCING OF POLO-LIKE KINASE EXPRESSION USING INTERFERING RNA
The present invention provides compositions comprising interfering RNA (e.g., siRNA, aiRNA, miRNA) that target polo-like kinase 1 (PLK-1) expression and...
2016/0115482 RNA INTERFERENCE IN OCULAR INDICATIONS
The present invention relates to ocular administration of sd-rxRNA and rxRNAori molecules.
2016/0115481 PROSTATE CANCER-SPECIFIC ALTERATIONS IN ERG GENE EXPRESSION AND DETECTION AND TREATMENT METHODS BASED ON THOSE...
Alterations in ERG gene expression can be observed in patients with prostate cancer. Specific ERG isoforms are associated with, or involved in, prostate...
2016/0115480 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER
Some embodiments of the present invention relate to methods and compositions for treating cancer. More embodiments include methods and compositions for...
2016/0115479 Predictive Biomarker for Cancer Therapy
The present invention relates generally to the identification of patients suffering from cancer whether they will respond to specific therapies. More...
2016/0115478 DERMATOLOGICAL, PHARMACEUTICAL COMPOSITION SUITABLE FOR OLIGONUCLEOTIDES
The invention relates to a cosmetic and/or dermatological and/or pharmaceutical composition for the topical use and application of oligonucleotides, in...
2016/0115477 LIPID ENCAPSULATING INTERFERING RNA
Rich tooling is provided for REST application development that integrates the exploration of a REST API, modeling of data types and the REST API, and the...
2016/0115476 COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter...
2016/0115475 Treatment of Insulin Resistance Through Inhibitors of Transcription Factor TSC22D4
The present invention relates to modulators, in particular inhibitors, of TSC22D4 activity or expression and their uses for the prevention, treatment, and/or...
2016/0115474 TARGETED TRANSPOSITION FOR USE IN EPIGENETIC STUDIES
Disclosed herein are compositions, methods and kits useful for epigenetic analysis based on the use of transposons that are targeted to specific regions of...
2016/0115473 MULTIFUNCTIONAL OLIGONUCLEOTIDES
Provided herein is technology relating to the manipulation and characterization of nucleic acids and particularly, but not exclusively, to methods and...
2016/0115472 NON-DISRUPTIVE DNA ISOLATION FROM CORN SEEDS
This invention relates to systems and process for isolating DNA from biological materials such as seeds while retaining a viable seed for further use. The seed...
2016/0115471 ENRICHMENT OF SMALL NUCLEIC ACIDS
Provided herein is technology related to processing samples of nucleic acids and particularly, but not exclusively, to methods for enriching samples for small...
2016/0115470 CELL FUSION DEVICE AND CELL FUSION METHOD
A cell fusion device includes a chamber including a first input/output portion and a second input/output portion and providing a space through a fluid...
2016/0115469 DEVICE FOR ELECTRICALLY DISINTEGRATING CELL CLUSTERS
A device (1) for electrically disintegrating cell clusters, comprising: an electrode unit (11) which has an electrode head (13) and an electrode body (15); a...
2016/0115468 ALBUMIN-BINDING ARGININE DEIMINASE FOR CANCER TARGETING TREATMENT AND DETECTION OF ARGININE
The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase (AAD) fusion protein for treating cancer or other...
2016/0115467 CHIMERIC FVII-XTEN MOLECULES AND USES THEREOF
The present invention provides chimeric FVII molecules comprising FVII, an XTEN polypeptide, and an antibody C and antigen-binding molecules thereof which...
2016/0115466 ENZYME AND USES THEREOF
The present invention relates generally to methods and materials relating to newly characterised enzymes from Pusillimonas noertemannii, or variants thereof,...
2016/0115465 COMPOSITIONS AND METHODS OF USE
The present compositions and methods relate to a beta-mannanase from Bacillus hemicellulosilyticus, polynucleotides encoding the beta-mannanase, and methods of...
2016/0115464 CARBOHYDRATE BINDING MODULES WITH REDUCED BINDING TO LIGNIN
Provided is a modified Family 1 carbohydrate binding module (CBM) comprising amino acid substitutions at one or more of positions 10, 11, 12, 14, 17, 21, 24,...
2016/0115463 Codon Modified Amylase From Bacillus Akibai
The present invention relates to an isolated synthetic polynucleotide encoding the mature amylase AX856 from Bacillus akibai, using codon modified...
2016/0115462 SULFOLOBAL PHOSPHOTRIESTERASE-LIKE (PLL) LACTONASES ACTIVITY HAVING ENHANCED PROPERTIES AND THE USES THEREOF
Mutated hyperthermophilic PTE having a lactonase activity derived from a hyperthermophilic phosphotriesterase corresponding to the consensus sequence of SEQ ID...
2016/0115461 Polymerases
Modified DNA polymerases have an affinity for DNA such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate...
2016/0115460 Mutant DNA Polymerases and Methods of Use
The present invention provides mutant DNA polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and...
2016/0115459 CHIMERAS OF BRUCELLA LUMAZINE SYNTHASE AND BETA SUBUNIT OF AB5 TOXINS
Chimeric polypeptides useful as immunogens for inducing protective immune responses and neutralizing antibodies against Shiga toxin (Stx) in mammals. More...
2016/0115458 TUMOR THERAPY WITH REPLICATION COMPETENT SINDBIS VIRAL VECTORS
Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal...
2016/0115457 MULTI-LAYERED CELL CONSTRUCTS AND METHODS OF USE AND PRODUCTION USING ENZYMATICALLY DEGRADABLE NATURAL POLYMERS
The present disclosure relates generally to the fields of tissue engineering and regenerative medicine. More particularly, the present disclosure generally...
2016/0115456 METHODS FOR REPROGRAMMING SOMATIC CELLS
The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes,...
2016/0115455 REPROGRAMMED CELLS AND METHODS OF PRODUCTION AND USE THEREOF
The present invention relates generally to a secondary reprogramming technique and its uses. More particularly, it concerns immortalized secondary somatic...
2016/0115454 ISOLATION, EXPANSION AND USE OF CLONOGENIC ENDOTHELIAL PROGENITOR CELLS
A hierarchy of endothelial colony forming cells (EPCs) was identified from mammalian cord blood, umbilical vein and aorta. A newly isolated cell named high...
2016/0115453 DIFFERENTIATION AND EXPANSION OF ENDOTHELIAL CELLS FROM PLURIPOTENT STEM CELLS AND THE IN VITRO FORMATION OF...
The disclosure is concerned among others with means and methods for obtaining endothelial cells and to means and methods for in vitro cell culture comprising...
2016/0115452 Non-Simian Cells for Growth of Porcine Reproductive and Respiratory Syndrome (PRRS) Virus
Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a...
2016/0115451 In Vitro Growth of Tissues Suitable to the Formation of Bone and Bone Forming Tissue Formed Thereby
The present invention is directed to a device for the growth of new bone or bone-like tissue under in vitro cell culture conditions.
2016/0115450 HEMANGIO-COLONY FORMING CELLS
Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods...
2016/0115449 Novel Method for Producing Differentiated Cells
The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present...
2016/0115448 CORTICAL INTERNEURONS AND OTHER NEURONAL CELLS PRODUCED BY THE DIRECTED DIFFERENTIATION OF PLURIPOTENT AND...
Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the...
2016/0115447 COMPOSITIONS AND METHODS FOR IMPROVING INDUCED NEURON GENERATION
The present inventions relate to methods and compositions useful for improving the efficiency of inducing the generation of neurons from non-neuronal cell...
2016/0115446 Technologies, Methods, and Products of Small Molecule Directed Tissue and Organ Regeneration from Human...
Pluripotent human embryonic stem cells (hESCs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and...
2016/0115445 EXPANDABLE CELL POPULATIONS FROM BRAIN BIOPSIES OF LIVING SUBJECTS
The present invention relates to a method of producing expandable cultured brain cells. The brain cells are neurotrophic factor (NTF) positive. The expandable...
2016/0115444 AGE-MODIFIED CELLS AND METHODS FOR MAKING AGE-MODIFIED CELLS
Provided are age-modified cells and method for making age modified cells using progerin or a progerin-like protein. The aging and/or maturation process can be...
2016/0115443 VP16-CREB FUSION GENE
The present application describes a cell that has integrated into its genome fusion molecule V16-CREB.
2016/0115442 COMPOSITION FOR CULTURING SANAL AND SANAL CULTURING METHOD USING THE SAME
Provided are a sanal culturing composition and a method for culturing sanal using the same.
2016/0115441 NOVEL GRAFT POLYMER, TEMPERATURE-RESPONSIVE SUBSTRATE FOR CELL CULTURE USING THE SAME AND PRODUCTION METHOD...
By using a graft polymer comprising a dendritic polymer with a styrene skeleton and a hydrophilic polymer grafted to a terminal thereof, a ...
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