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Patent # Description
2016/0115240 USE OF SEMAPHORIN-4D INHIBITORY MOLECULES IN COMBINATION WITH AN IMMUNE MODULATING THERAPY TO INHIBIT TUMOR...
Provided herein are methods for inhibiting, delaying, or reducing tumor growth and metastases of plexin-B1-expressing cancer cells in a subject, comprising...
2016/0115239 CD138-TARGETED INTERFERON DEMONSTRATES POTENT APOPTOTIC AND ANTI-TUMOR ACTIVITIES
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs...
2016/0115238 CD20 Antibodies and Uses Thereof
CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells from peripheral blood as well as lymphoid tissues. CD20...
2016/0115237 CELL SENESCENCE MARKERS AS DIAGNOSTIC AND THERAPEUTIC TARGETS
Provided are methods and agents for depleting senescent cells endogenous to a subject, involving administering to the subject a binding agent that is...
2016/0115236 NEUTRALIZATION OF CD95 ACTIVITY BLOCKS INVASION OF GLIOBLASTOMA CELLS IN VIVO
The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to...
2016/0115235 MONOCLONAL ANTIBODY DIRECTED AGAINST CXCR5
The invention relates to monoclonal antibodies against human CXCR5 and to their use in the treatment of autoimmune or inflammatory diseases, as well as cancers.
2016/0115234 Anti-GPIIB/IIIA Antibodies or Uses Thereof
The present invention provides antibodies and antigen-binding molecules thereof which specifically bind the .alpha. and/or .beta. subunits of the non-active...
2016/0115233 HIGH FUNCTIONAL BISPECIFIC ANTIBODY
[Problem] The purpose of the present invention is to provide a bispecific antibody that is structurally stable, and can show alone a sufficient effect without...
2016/0115232 TARGETING AGENT ANTIBODY CONJUGATES AND USES THEREOF
Methods, compositions and uses are provided for bispecific antibodies comprising one or more unnatural amino acids. The bispecific antibodies may bind to two...
2016/0115231 TREATMENT OF MAST CELL RELATED PATHOLOGIES
Methods of inhibiting activation of a mast cell and/or treating a disease induced by activation of a mast cell in a subject are provided. Accordingly there is...
2016/0115230 NOVEL ANTIBODY USEFUL IN NEUROLOGICAL OR NEURODEGENERATIVE DISORDERS
The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of...
2016/0115229 Hybridoma Clones, Monoclonal Antibodies, and Methods of Use
The present invention is directed to a monoclonal antibody that recognizes human CD63 in its native form. The invention is also directed to a hybridoma cell...
2016/0115228 ANTAGONISTS OF IL-6 TO PREVENT OR TREAT THROMBOSIS
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2016/0115227 Administration of an Anti-Interleukin 12/23 Antibody for Treatment of Autoimmune Disease
The present invention provides a method for treating or delaying the onset of an autoimmune condition in a human subject. An effective oral dose of ustekinumab...
2016/0115226 SINGLE DOMAIN ANTIBODIES DIRECTED AGAINST TNF-ALPHA
This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The...
2016/0115225 Methods of Reducing Methylglyoxal (MGO) Modification of Recombinant Proteins in Cell Culture
Methods are provided for controlling the levels of acidic species when a protein of interest is expressed by host cells. One particular example of an acidic...
2016/0115224 FORM-SPECIFIC ANTIBODIES FOR NAG-1 (MIC-1, GDF-15), H6D AND OTHER TGF-BETA SUBFAMILY AND HEART DISEASE AND...
A method of producing form-specific anti-peptide antibodies for a wild type protein and its one amino acid mutated protein using a peptide antigen, by...
2016/0115223 POLYPEPTIDES COMPRISING A MODIFIED BACTERIOPHAGE G3P AMINO ACID SEQUENCE WITH REDUCED IMMUNOGENICITY
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate...
2016/0115222 IMMUNOGLOBULINS AND VARIANTS DIRECTED AGAINST PATHOGENIC MICROBES
Anti-SpA murine, chimeric and humanized monoclonal antibodies, and variant antibodies having a heavy chain with at least one amino acid substitution are...
2016/0115221 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNODEFICIENCY
The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the...
2016/0115220 PROTEOLYTIC RELEASE OF CELL SURFACE ANTIGENS FOR PHAGE BIOPANNING
The invention described herein features methods of isolating monoclonal antibodies or polypeptides that bind to a cell surface expressed antigen. The method of...
2016/0115219 FACTOR VIII GLYCOFORMS
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides...
2016/0115218 Anti-Sense Oligonucleotides Targeted Against Exon 9 of IL-23R-alpha Gene and Method of Using Same to Induce...
The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23R.alpha. gene. Exon 9 skipping of the IL23R.alpha....
2016/0115217 COMPOSITIONS OF HUMANIZED NOTCH FUSION PROTEINS AND METHODS OF TREATMENT
This invention provides a fusion protein comprising a signal peptide, an extracellular domain of human Notch receptor protein and an Fc portion of an antibody...
2016/0115216 Method for Making Mature Insulin Polypeptides
This invention relates to an improved method for making mature human insulin or an analogue thereof by cultivating fungi cell comprising a DNA sequence...
2016/0115215 Glucagon Analogs Exhibiting GIP Receptor Activity
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity....
2016/0115214 CHEMOKINE-IMMUNOGLOBULIN FUSION POLYPEPTIDES, COMPOSITIONS, METHOD OF MAKING AND USE THEREOF
This application is directed to chemokine-immunoglobulin fusion polypeptides and chemokine-polymer conjugates. The fusion polypeptides and conjugates can be...
2016/0115213 Modified FGF-21 Polypeptides and Uses Thereof
Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides...
2016/0115212 TUMOR-ASSOCIATED PEPTIDES BINDING PROMISCUOUSLY TO HUMAN LEUKOCYTE ANTIGEN (HLA) CLASS II MOLECULES
The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention...
2016/0115211 COMPOSITIONS AND METHODS FOR REGULATING ANGIOGENESIS AND CHOLESTEROL AND TREATING DYSLIPIDEMIA,...
The invention provides pharmaceutical compounds and formulations comprising nucleic acids and polypeptides for regulating (including upregulating or...
2016/0115210 COLORIMETRIC AND FLUORESCENT PROTEINS
The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a...
2016/0115209 CERBERUS/COCO DERIVATIVES AND USES THEREOF
The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and...
2016/0115208 USE OF AN IMMUNOMODULATORY PROTEIN FROM GANODERMA IN PROMOTING NEURITE OUTGROWTH
The inventors surprisingly found that an immunomodulatory protein from Ganoderma can promote neurite outgrowth, suggesting that the immunomodulatory protein...
2016/0115207 GENETICALLY MODIFIED FILAMENTOUS FUNGI AND USES THEREOF
The present invention relates to a filamentous fungus comprising a genetic modification in one more hydrophobin genes and the use of the same as host cell for...
2016/0115206 Treponema Pallidum Triplet Antigen
A Treponema pallidum triplet antigen construct is disclosed which includes three Treponema pallidum antigens (TP15, TP17, and TP47), as well as a ten amino...
2016/0115205 POLYVALENT HIV-1 IMMUNOGEN
The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and...
2016/0115204 METHODS FOR PREPARING PURIFIED POLYPEPTIDE COMPOSITIONS
The present invention relates to purified peptidomimetic macrocycles. The invention additionally provides methods of preparing and using such macrocycles, for...
2016/0115203 HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to...
2016/0115202 CHEMICAL SYNTHESIS AND SCREENING OF BICYCLIC PEPTIDE LIBRARIES
Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds,...
2016/0115201 PEPTIDES BINDING TO PARALLEL-STRANDED G-QUADRUPLEXES
This invention relates to a peptide comprising or consisting of the amino acid sequence of SEQ ID NO:1 or a derivative thereof. The present invention also...
2016/0115200 New Use for JNK Inhibitor Molecules for Treatment of Various Diseases
The present invention relates to the use of novel JNK inhibitor molecules and their use in a method of treatment of the human or animal body by therapy.
2016/0115199 Cell Penetrating Peptides for Intracellular Delivery of Molecules
A cell-penetrating peptide characterized in that it comprises an amino acid sequence consisting of XWXRLXXXXXX (SEQ ID No: 5), wherein X in position 1 is...
2016/0115198 METHODS OF MAKING CARFILZOMIB AND INTERMEDIATES THEREOF
Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation...
2016/0115197 SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
2016/0115196 SELF-ASSEMBLED MICRO-AND NANOSTRUCTURES
The present invention discloses self-assembled bioadhesive anti-microbial, anti-fouling and/or anti-oxidant micro- and nano-structures comprising a plurality...
2016/0115195 PURIFICATION PROCESS FOR MONOCLONAL ANTIBODIES
The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired...
2016/0115194 PROTEIN PURIFICATION PROCESS
A method of purifying a target protein includes contacting a cell culture harvest or a protein preparation including at least one target protein with at least...
2016/0115193 NOVEL PURIFICATION OF ANTIBODIES USING HYDROPHOBIC INTERACTION CHROMATOGRAPHY
Disclosed herein are compositions and methods for purifying antibody products from a sample matrix. In particular, the present invention relates to...
2016/0115192 ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTICANCER DERIVATIVES OF TRIPTOLIDE AND NANOSPHERES THEREOF
This invention relates to uses of conjugates of triptolide nanoprodrugs in cancer immunotherapy, specifically compound such as D-I or D-II wherein X.sub.1 is a...
2016/0115191 Novel Polymorph of Regadenoson
The invention provides a novel polymorph of Regadenoson. More particularly, the invention provides propylene glycol solvate of Regadenoson. The invention also...
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