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Patent # Description
2016/0115190 METHODS OF PREPARING SUBSTITUTED NUCLEOSIDE ANALOGS
Disclosed herein are methods of preparing a nucleoside analog, which are useful in treating diseases and/or conditions such as viral infections, and...
2016/0115189 PARASITICIDAL COMPOUNDS, METHODS, AND FORMULATIONS
Provided are compounds of formula I useful for controlling parasites both in animals and agriculture. Further provided are methods for controlling parasite...
2016/0115188 NOVEL alpha-GALACTOSYL CERAMIDE ANALOGS AND USES THEREOF
The present invention is directed to compounds of formula (I) and pharmaceutical compositions comprising compounds of formula (I) and pharmaceutically...
2016/0115187 Chelates of Lead (II) and Bismuth (III) Based on Trans-Di-N-Picolinate Tetraazacycloalkanes
The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand...
2016/0115186 PHOSPHORIC ACID/PHOSPHONIC ACID DERIVATIVES AND MEDICINAL USES THEREOF
The present invention relates to phosphoric acid/phosphonic acid derivatives shown by formula (I), wherein, R.sub.1 or R.sub.2 represents the following...
2016/0115185 PHOSPHATE ESTERS OF NORIBOGAINE
Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical...
2016/0115184 PHOSPHONIUM COMPOUND, EPOXY RESIN COMPOSITION INCLUDING THE SAME AND SEMICONDUCTOR DEVICE PREPARED FROM THE SAME
A phosphonium compound, an epoxy resin composition, a method of preparing a phosphonium compound, and a semiconductor device encapsulated with the epoxy resin...
2016/0115183 METHODS AND SYSTEMS FOR CAMPTOTHECIN ANALOG SYNTHESIS
Methods and systems for making camptothecin analogs and intermediates are provided. Aspects include safer and lower cost methodologies for making camptothecin...
2016/0115182 ONE STEP PROCESS FOR REGIOSELECTIVE SYNTHESIS OF ALPHA-ACYLOXY CARBONYLS
A regioselective N-Heterocyclic Carbene (NHC) catalyzed one step process for high yield synthesis of .alpha.-acyloxy carbonyl compounds is disclosed.
2016/0115181 NOVEL PYRROLE COMPOUNDS WITH SILICON INCORPORATION
The present invention discloses novel Silicon incorporated pyrrole compounds of Formula I having potential anti-bacterial properties. The invention further...
2016/0115180 Novel Super-Resolution Imaging Compositions and Methods Using Same
The invention provides compositions that may be used for imaging intracellular structures. The invention further provides methods of imaging intracellular...
2016/0115179 SPIRO-OXAZINES, INDOLINONES AND PREPARATION THEREOF
The present invention relates to novel spiro-oxazine analogues of Formula-I and Indolinone compounds of Formula-II or positional isomers, or stereoisomers, or...
2016/0115178 SOLID FORMS OF A MACROCYCLIC KINASE INHIBITOR
This invention relates to crystalline solvates of (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2- ...
2016/0115177 HIGHLY POTENT INHIBITORS OF PORCUPINE
The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such...
2016/0115176 CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
Described herein are certain crystalline forms of Compound 3, as well as pharmaceutical compositions employing the crystalline forms. Also provided are...
2016/0115175 ANTIVIRAL COMPOUNDS
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
2016/0115174 DIHYDROETORPHINES AND THEIR PREPARATION
The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, ##STR00001## wherein R.sup.1 and...
2016/0115173 METHODS AND COMPOSITIONS FOR STUDYING, IMAGING, AND TREATING PAIN
Saxitoxin analogue compounds, compositions, pharmaceutical compositions, methods of synthesis of saxitoxin analogues, methods of imaging, methods of treatment,...
2016/0115172 METHOD FOR PRODUCNG TRICYCLIC COMPOUND, AND TRICYCLIC COMPOUND CAPABLE OF BEING PRODUCED BY SAID PRODUCTION METHOD
An object of the present invention is to provide a method for reproducibly producing a pyrrolopyrimidine ring-containing tricyclic compound in high yield with...
2016/0115171 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO[1,5-A]PYRAZIN-3(2H)-ONE DERIVATIVES AS INHIBITORS OF BETA-SECRETASE (BACE)
The present invention relates to novel 5,6-dihydroimidazo[1,5-a]pyrazin-3(2H)-one derivatives as inhibitors of beta-secretase, also known as beta-site amyloid...
2016/0115170 4-AMINO-6-PHENYL-5,6-DIHYDROIMIDAZO[1,5-A]PYRAZINE DERIVATIVES AS INHIBITORS OF BETA-SECRETASE (BACE)
The present invention relates to novel 5,6-dihydroimidazo[1,5-a]pyrazinyl derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving...
2016/0115169 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
2016/0115168 NOVEL FUSED PYRIMIDINE COMPOUND OR SALT THEREOF
Provided is a novel compound having BTK inhibitory action and a cell proliferation suppressing effect. Also provided is a medicine useful for the prevention...
2016/0115167 BMP INHIBITORS AND METHODS OF USE THEREOF
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation,...
2016/0115166 PYRROLO[2, 1-F] [1,2,4]TRIAZINE DERIVATIVE AND USE THEREOF FOR TREATING TUMORS
Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative...
2016/0115165 CRYSTALLINE FORM OF N,N-DICYCLOPROPYL-4-(1,5-DIMETHYL-1H-PYRAZOL-3-YLAMINO)-6-ETHYL-1-METHYL-- ...
Crystalline form, Form HI.5-4, of N,N-di-cyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl- ...
2016/0115164 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS
The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
2016/0115163 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, ELECTROPHOTOGRAPHIC APPARATUS, AND IMIDE COMPOUND
An electrophotographic photosensitive member includes, in the following order, a support member, an undercoat layer adjacent to the support member, and a...
2016/0115162 Radiosynthesis of Tau Radiopharmaceuticals
This disclosure relates to a one-step method for preparing the tau radiopharmaceutical, [18F]T807, using an unprotected or protected precursor (e.g.,...
2016/0115161 ISOINDOLINE COMPOUNDS AND METHODS OF THEIR USE
Provided herein are isoindoline compounds, pharmaceutical compositions comprising one or more of such compounds, and methods of their use for treating,...
2016/0115160 2, 3-Butanediamide Epoxide Compound and Preparation Method and Use Thereof
Provided are a compound of formula I which can be used as a drug against small RNA virus infections, and optical isomers, pharmaceutically acceptable salts,...
2016/0115159 MACROCYCLIC FACTOR VIIA INHIBITORS
The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These...
2016/0115158 N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS
A compound of formula (I), or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor...
2016/0115157 SUBSTITUTED ALIPHANES, CYCLOPHANES, HETERAPHANES, HETEROPHANES, HETERO-HETERAPHANES AND METALLOCENES USEFUL FOR...
The present disclosure provides substituted aliphanes, cyclophanes, heteraphanes, heterophanes, hetero-heteraphanes and metallocenes, of Formula I D-M-D ...
2016/0115156 PYRIMIDIN-4-YL)OXY)-1H-INDOLE-1-CARBOXAMIDE DERIVATIVES AND USE THEREOF
This invention relates to certain metabolites of N-(1-methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6-((methyl-amino)met- ...
2016/0115155 A PHENYL TRIAZOLE DERIVATIVE AND ITS USE FOR MODULATING THE GABAA RECEPTOR COMPLEX
This invention relates to a novel phenyl triazole derivative, pharmaceutical compositions containing this compound, and methods of treatment therewith. The...
2016/0115154 Quinoline Inhibitor of the Macrophage Stimulating 1 Receptor MSTR1
The compound N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-5-ethyl-1-(pyrimid- in-5-yl)-1H-pyrazole-4-carboxamide ##STR00001## and pharmaceutically...
2016/0115153 LANTHIONINE SYNTHETASE C-LIKE 2-BASED THERAPEUTICS
Provided are compounds that target the lanthionine synthetase C-like protein 2 pathway. The compounds can be used to treat a number of conditions, including...
2016/0115152 Novel Compounds
There is provided inter alia a compound of formula (I): ##STR00001## wherein R.sup.1, J, Ar, L, X, R.sup.3 and R.sup.4 are as defined in the specification, for...
2016/0115151 AMINOTRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present invention provides novel compounds having a P2X.sub.3 and/or P2X.sub.2/3 receptor antagonistic activity. A compound of Formula (I): ##STR00001## ...
2016/0115150 PROCESS FOR THE PREPARATION OF (R,S)-NICOTINE
A method of preparing (R,S)-nicotine, comprising reacting a nicotinate ester with N-vinyl-2-pyrrolidinone in the presence of a base and a solvent to form a...
2016/0115149 SULPHAMOYLTHIOPHENAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
Inhibitors of HBV replication of formula (I) ##STR00001## including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R.sup.1...
2016/0115148 N-SUBSTITUTED HYDROXYLAMINE DERIVATIVES WITH CARBON-BASED LEAVING GROUPS
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds,...
2016/0115147 PRO-DRUG COMPOUNDS
The present invention provides neuronal gap junction blocking compounds according to formula (I) or a hydrate, solvate, or pharmaceutically acceptable salt...
2016/0115146 3-CARBOXY SUBSTITUTED COUMARIN DERIVATIVES WITH A POTENTIAL UTILITY FOR THE TREATMENT OF CANCER DISEASES
The present invention relates to novel compounds. The present invention also relates to the compounds for use as a medicine, more in particular for the...
2016/0115145 ROSEOBACTICIDES AND USES THEREOF
Embodiments of the invention relate to compounds and methods for controlling algal growth, for example, in bodies of water or surfaces exposed to algae....
2016/0115144 NOVEL ACID DIANHYDRIDE, METHOD FOR PREPARING SAME, AND POLYIMIDE PREPARED THEREFROM
The present invention relates to a novel acid dianhydride, a method for preparing the same, and a polyimide prepared therefrom. More specifically, the acid...
2016/0115143 METHODS FOR PRODUCING FUELS, GASOLINE ADDITIVES, AND LUBRICANTS
The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to...
2016/0115142 PROCESS FOR THE SYNTHESIS OF 5-HYDROXYMETHYLFURFURAL FROM SACCHARIDES
This invention relates to a process for the synthesis of 5-hydroxymethylfurfural (HMF) from saccharides. In particular this invention relates to a process for...
2016/0115141 CARBOXYLIC ACID DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISORDERS
Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders,...
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