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Patent # Description
2016/0122759 DOSAGES AND METHODS FOR DELIVERING LIPID FORMULATED NUCLEIC ACID MOLECULES
Methods, kits and devices for dosing a subject to reduce a hypersensitivity response to a lipid-formulated nucleic acid (e.g., RNA) molecule are disclosed.
2016/0122758 AGENTS FOR DOWNREGULATION OF THE ACTIVITY AND/OR AMOUNT OF BCL-XL AND/OR BCL-W
A method of treating an inflammatory or fibrotic disease in a subject is disclosed. The method comprises administering to the subject a therapeutically...
2016/0122757 siRNA TARGETING HSR1
The invention provides siRNA molecules and LNA antisense oligonucleotides, which target Heat Shock RNA (HSR1) and effectively inhibit stress response in a...
2016/0122756 COMPOSITIONS AND METHODS FOR DIRECTIONAL NUCLEIC ACID AMPLIFICATION AND SEQUENCING
The invention provides methods and compositions, including kits, for directional nucleic acid amplification and sequencing. The invention further provides...
2016/0122755 Compositions, Methods and Apparatus for Oligonucleotides Synthesis
Aspects of the invention relate to methods, compositions for synthesizing oligonucleotides having a predefined sequence.
2016/0122754 Arrays and Methods of Use
Methods are provided for producing a molecular array comprising a plurality of molecules immobilized to a solid substrate at a density which allows individual...
2016/0122753 HIGH-THROUGHPUT RNA-SEQ
The present invention relates generally to methods for single-cell nucleic acid profiling, and nucleic acids useful in those methods. For example, it concerns...
2016/0122752 Methods for Obtaining Information from Single Cells Within Populations Using DNA Origami Nanostructures Without...
Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha...
2016/0122751 NUCLEIC ACID-TAGGED COMPOSITIONS AND METHODS FOR MULTIPLEXED PROTEIN-PROTEIN INTERACTION PROFILING
Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by...
2016/0122750 ACCELERATED DIRECTED EVOLUTION OF MICROBIAL CONSORTIA FOR THE DEVELOPMENT OF DESIRABLE PLANT PHENOTYPIC TRAITS
The disclosure relates to methods for the screening, identification, and/or application of one or more microorganisms of use in imparting one or more...
2016/0122749 SCREENING FOR INHIBITORS OF RIBOSOME BIOGENESIS
The invention relates to a method and a prokaryotic cell for identifying a compound, which interferes with ribosome biogenesis, assembly and/or degradation....
2016/0122748 SCALABLE METHOD FOR ISOLATION AND SEQUENCE-VERIFICATION OF OLIGONUCLEOTIDES FROM COMPLEX LIBRARIES
A novel method for preparing sequence-verified oligonucleotides is disclosed. In particular, the invention relates to a simple, affordable, and scalable method...
2016/0122747 TARGET ANTIGEN DISCOVERY, PHENOTYPIC SCREENS AND USE THEREOF FOR IDENTIFICATION OF TARGET CELL SPECIFIC TARGET...
The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically...
2016/0122746 METHOD OF NONSPECIFIC TARGET CAPTURE OF NUCLEIC ACIDS
Methods for capturing a target nucleic acid from a sample by using a capture probe that binds nonspecifically to the target nucleic acid and binds specifically...
2016/0122745 METHOD AND SYSTEM FOR AQUACULTURE OR REDUCING BIOFOULING
An aquaculture method and a method for reducing biofouling of vessels or submerged structures, the method comprising broadcasting into the marine environment...
2016/0122744 BIOMOLECULE DRYING PROCESS FOR LONG-TERM STORAGE
The present invention relates to a method for producing a storable dry composition of biomolecule. First a composition is dispensed on a surface. The...
2016/0122743 METHODS FOR REMOVING VIRAL CONTAMINANTS FROM PANCREATIC EXTRACTS
Methods for screening pancrelipase for RNA virus contamination comprise removing free viral RNA from the pancrelipase, denaturing any viruses in the...
2016/0122742 PROTEIN INVOLVED IN DNA REPLICATION, AND MODULATION OF ITS ACTIVITY
A composition including at least a protein consisting of an amino acid sequence as set forth in SEQ ID NO: 1, or a salt or a solvate thereof, in association...
2016/0122741 Molecules Associated with Fatty Acid Biosynthetic Pathways and Uses Thereof
The present disclosure relates in part to recombinant microorganisms that include non-native genes encoding PUFA-PKS polypeptides, and to methods of making and...
2016/0122740 FACTOR IX POLYPEPTIDE MUTANT, ITS USES AND METHOD FOR ITS PRODUCTION
Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or...
2016/0122739 FACTOR IX VARIANTS AND METHODS OF USE THEREFOR
Modified Factor IX (FIX) polypeptides, nucleic acid encoding the same, and methods of generating modified Factor IX polypeptides are provided. Also provided...
2016/0122738 NOVEL METALLOPROTEASES
Aspects of the present compositions and methods relate to novel metalloproteases, polynucleotides encoding the novel metalloproteases, and compositions and...
2016/0122737 XYLANASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to xylanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2016/0122736 CHEMICALLY MODIFIED SOPHOROLIPIDS AND USES THEREOF
The present disclosure provides a sophorolipid composition that can be used for inducing protein expression in a fermentation host. The sophorolipid...
2016/0122735 VARIANTS OF CELLOBIOHYDROLASES
Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding...
2016/0122734 VARIANTS OF CELLOBIOHYDROLASES
Disclosed are a number of homologs and variants of Hypocrea jecorina Cel7A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding...
2016/0122733 METHOD OF TREATING GLYCOGEN STORAGE DISEASE
The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and...
2016/0122732 HIGH ACTIVITY MUTANTS OF COCAINE ESTERASE FOR COCAINE HYDROLYSIS
The Bacterial cocaine esterase (CocE) mutants disclosed herein each have enhanced catalytic efficiency for (-)-cocaine, as compared to CocE mutants in the...
2016/0122731 THERAPEUTIC STRATEGIES TO TREAT CNS PATHOLOGY IN MUCOPOLYSACCHARIDOSES
The invention provides for nucleotide sequences encoding for a chimeric sulfatase, viral vectors expressing such sequences for gene therapy and pharmaceutical...
2016/0122730 NOVEL MOLECULES OF THE CARD-RELATED PROTEIN FAMILY AND USES THEREOF
Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11...
2016/0122729 RECOMBINANT PHAGE AND METHODS
This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage...
2016/0122728 IPN VACCINE
The present invention relates to a live avirulent infectious pancreatic necrosis virus which has been shown to be genetically stable in biological studies....
2016/0122727 MESSENGER RNA BASED VIRAL PRODUCTION
The present invention provides methods for producing recombinant viral particles based on the use of exogenous mRNAs to supply various helper factors for...
2016/0122726 INFLUENZA VIRUS REASSORTMENT
The invention provides reassortant influenza strains.
2016/0122725 USE OF BACTERIOPHAGES
We disclose the use of a strain of bacteriophages in the manufacturing of a preparation for improving the state of health of patients infected with ...
2016/0122724 Recombinant Baculovirus Expression Vector and Cell
A recombinant baculovirus expression vector or cell comprising an engineered baculovirus fp25k gene with one to three modified or mutated spots, the modified...
2016/0122723 ENGINEERED THREE-DIMENSIONAL SKIN TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME
Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer...
2016/0122722 TISSUE STRUCTURE AND PREPARATION METHOD THEREOF
A tissue structure for enabling comprehensive understanding of gene patterns of mature cells and a method of preparing the tissue structure are provided. A...
2016/0122721 USE OF RNA FOR REPROGRAMMING SOMATIC CELLS
The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the...
2016/0122720 METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
The invention provides a method of producing iPS cells, which comprises the steps of (i) introducing reprogramming factors into somatic cells; (ii) culturing...
2016/0122719 METHODS AND COMPOSITIONS FOR PREPARING CARDIOMYOCYTES FROM STEM CELLS AND USES THEREOF
The present invention discloses novel compositions and methods for enhancing cardiac differentiation efficiency of stem cells or promoting ventricular and...
2016/0122718 CULTURE MEDIUM COMPOSITION FOR MATURATING CARDIOMYOCYTES DERIVED FROM PLURIPOTENT MAMMALIAN STEM CELLS
The current disclosure relates to a culture medium, different methods to generate adult-like cardiomyocytes from pluripotent embryonic stem cells (ESC) and/or...
2016/0122717 DIFFERENTIATION OF PLURIPOTENT STEM CELLS AND CARDIAC PROGENITOR CELLS INTO STRIATED CARDIOMYOCYTE FIBERS USING...
The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The...
2016/0122716 METHOD OF EFFICIENTLY INDUCING CARDIOMYOCYTES
The present invention provides a method for efficiently producing cardiomyocytes from pluripotent stem cells, which method comprises the steps of dissociating...
2016/0122715 GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF
An in-vitro method of activating T cells is disclosed. The method comprises incubating T cells with pathogenic cells in the presence of a multimeric peptide...
2016/0122714 SERUM-FREE MEDIUM CONTAINING PDGF FOR DS CELLS
The problem to be solved by the present invention is to provide a serum-free medium suitable for culturing of DS cells. The present invention relates to a...
2016/0122713 GENETICALLY-MODIFIED MICRO-ORGAN SECRETING A THERAPEUTIC PEPTIDE AND METHODS OF USE THEREOF
Provided herein is a genetically-modified micro-organ that provides a sustained delivery of a therapeutic peptide. The genetically-modified micro-organ may...
2016/0122712 CELL PROGRAMMING
The present invention is concerned with methods for reprogramming of mammalian somatic cells and in particular to reprogramming of mature mammalian somatic...
2016/0122711 CHEMICAL DIFFERENTIATION OF PLURIPOTENTSTEM CELLS INTO RETINAL EPITHELIAL CELLS
The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human...
2016/0122710 METHOD AND PHARMACEUTICAL COMPOSITION FOR CONTINUOUSLY MAINTAINING GROWTH OF A MOTOR NEURON PROGENITOR CELL
This present invention provides a method for continuously maintaining growth of a motor neuron progenitor cell and a pharmaceutical composition. Wherein, the...
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