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Patent # Description
2016/0122409 ERYTHROFERRONE AND ERFE POLYPEPTIDES AND METHODS OF REGULATING IRON METABOLISM
Disclosed herein are polypeptides which are capable of modulating the amount of hepcidin in subjects. Also disclosed are compositions and methods for treating...
2016/0122408 Galectin-3 Inhibitor (Gal-3M) is Associated with Additive Anti-Myeloma and Anti-Solid Tumor Effects, Decreased...
The present invention includes a method for the treatment of myeloma comprising identifying a patient with myeloma and administering to the patient a...
2016/0122407 Galectin-3 Inhibitor (Gal-3M) is Associated with Additive Anti-Myeloma and Anti-Solid Tumor Effects, Decreased...
The present invention includes a method for the treatment of myeloma comprising identifying a patient with myeloma and administering to the patient a...
2016/0122406 ANALOGS OF PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AND METHODS FOR THEIR USE
This invention relates to analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide...
2016/0122405 HOMEODOMAIN FUSION PROTEINS AND USES THEREOF
Provided herein are fusion proteins comprising a homeodomain fusion protein domain and a transcription modulator domain for treatment of various diseases or...
2016/0122404 COMPOSITIONS AND METHODS FOR MODULATION OF IMMUNE FUNCTION
Compositions and methods for modulating immune cell function and Nedd-4 family member signaling are disclosed.
2016/0122403 GHRELIN SPLICE VARIANT FOR TREATING NEURONAL DAMAGE,NEURODEGENERATIVE DISEASE, PARKINSONS DISEASE, ALZHEIMERS...
The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof, or a ghrelin splice variant-like compound for the...
2016/0122402 RETRO POLYPEPTIDES FOR ACTIVATION IMMUNITY TO CANCER AND VIRAL INFECTION
A polypeptide that drives T cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide....
2016/0122401 AGENTS FOR PREVENTING AND TREATING HIV AND OTHER VIRAL INFECTIONS
An agent for preventing and/or treating HIV and other viral infections. The agent in particular comprises at least one peptide, including an amino acid...
2016/0122400 POLYPEPTIDES WITH PERMEASE ACTIVITY
The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the...
2016/0122399 DIG-303 INSECTICIDAL CRY TOXINS
DIG-303 insecticidal toxins, polynucleotides encoding such toxins, use of such toxins to control pests, and transgenic plants that produce such toxins are...
2016/0122398 RECOMBINANT RSV ANTIGENS
This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions...
2016/0122397 REPLIKIN-BASED COMPOUNDS FOR PREVENTION AND TREATMENT OF INFLUENZA AND METHODS OF DIFFERENTIATING INFECTIVITY...
The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing,...
2016/0122396 THERAPEUTIC HPV16 VACCINES
Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
2016/0122395 Immunogenic compositions and a process for producing same
The present invention provides a modified HIV envelope glycoprotein (Env) antigen or a lipid containing vehicle comprising same. The Env antigen comprises one...
2016/0122394 FC RECEPTOR (FcRn) BINDING PEPTIDES AND USES THEREOF
The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking...
2016/0122393 POLYPEPTIDES HAVING NUCLEIC ACID BINDING ACTIVITY
Polynucleotides having nucleic acid binding activity are provided. Methods of stabilizing a nucleic acid duplex are provided. Methods of promoting the...
2016/0122392 POLYPEPTIDES FOR USE IN SELF-ASSEMBLING PROTEIN NANOSTRUCTURES
Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures...
2016/0122391 SHORT BETA-DEFENSIN-DERIVED PEPTIDES
The invention is directed to .beta.-defensin-derived peptides and their use in modulating the activity of hematopoietic cells, particularly hematopoietic stem...
2016/0122390 A BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND...
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related...
2016/0122389 PEPTIDES WITH ANTAGONISTIC ACTIVITIES AGAINST NATURAL CXCR4
A peptide effective in blocking the CXC-chemokine receptor 4 (CXCR4) mediated HIV-1 NL4-3 (X4-tropic) infection with an IC.sub.50 value of less than 50 .mu.M.
2016/0122388 CONOTOXIN PEPTIDES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
The present disclosure describes analog conotoxin peptides of the .alpha.-contoxin peptide RgIA. These analog conotoxin peptides block the .alpha.9.alpha.10...
2016/0122387 Angiotensin Peptide and Pharmaceutical Compositions for Disease Treatment
The present invention relates to the peptide (arg0) n-angiotensin-(1-7) [(arg0) n-Ang-(1-7)], where n is 1 to 10 (Xaa-Asp-Arg-Val-Tyr-Ile-His-Pro; SEQ ID NO:1...
2016/0122386 V1A RECEPTOR AGONISTS
Compounds of formula (I), salts thereof, and compositions and uses thereof are described. The compounds are useful as V1a vasopressin agonists, for the...
2016/0122385 METHODS OF INCREASING PROTEIN PURITY USING PROTEIN A BASED CHROMATOGRAPHY
The present invention provides methods for increasing purity of an Fc-containing protein by removing protein aggregates during the Protein A chromatography...
2016/0122384 Method For Purifying Antibody
The present invention relates to a method of purifying an antibody with high purity and high quality by removing impurities by sequential use of a...
2016/0122383 Peptide Ligation
The invention relates to a process for introducing a thiol group a to a carbonyl group in a side chain of a protected a-amino acid, said protected a-amino acid...
2016/0122382 PROCESSES FOR THE PREPARATION OF DEHYDROEPIANDROSTERONE AND ITS INTERMEDIATES
The present application relates to a regioselective and stereoselective processes for the preparation of dehydroepiandrosterone (DHEA) and processes for its...
2016/0122381 METHOD OF PREPARATION OF ANTIVIRAL COMPOUNDS AND USEFUL INTERMEDIATES THEREOF
The invention is directed to processes for synthesizing bicyclic nucleoside antiviral compounds and for synthesizing the intermediates used in the process. The...
2016/0122380 CYCLIC PHOSPHONATE SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL...
The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts...
2016/0122379 Renewable aromatics from lignocellulosic lignin
The present invention provides novel and improved processes for treating a lignocellulosic biomass or technical lignin using ionic liquids to obtain lignin...
2016/0122378 METHOD FOR PRODUCING BETA-HEMATIN CRYSTAL COMPRISING STEP OF HEATING
This invention provides a method of preparing a .beta.-hematin crystal comprising a step of heating, the .beta.-hematin crystal obtained by such method, and a...
2016/0122377 LIPID-BASED PLATINUM-N-HETEROCYCLIC CARBENE COMPOUNDS AND NANOPARTICLES
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to carbene...
2016/0122376 RUTHENIUM- OR OSMIUM-BASED COMPLEX CATALYSTS
The present invention provides novel ruthenium or osmium based complex structures with a unique combination of ligands comprising a Schiff-base type ligand, a...
2016/0122375 IMMOBILIZED METATHESIS TUNGSTEN CATALYSTS AND USE THEREOF IN OLEFIN METATHESIS
Compound of formula (I) wherein M is W; R.sup.1 is H, aryl, heteroaryl, alkyl, or heteroalkyl, optionally substituted, respectively; R.sup.2 and R.sup.3 can be...
2016/0122374 METHODS FOR TREATING FILOVIRIDAE VIRUS INFECTIONS
Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and...
2016/0122373 AN EFFICIENT PROCESS FOR SEPARATION OF DIASTEREOMERS OF ...
The present invention relates to an efficient process for the separation of diastereomers of ...
2016/0122372 TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM
The present invention provides novel tricyclic nucleosides and oligomeric compounds prepared therefrom. Incorporation of one or more of the tricyclic...
2016/0122371 LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERAZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME
This disclosure relates to a ligand compound, a catalyst system for olefin oligomerization, and a method for olefin oligomerization using the same. The...
2016/0122370 BIMETALLIC COMPLEX COMPRISING CYCLOPENTADIENYL AND AMIDINE LIGANDS
The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal R.sup.1 means is a substituent comprising a...
2016/0122369 NOVEL AMINO-SILYL AMINE COMPOUND, METHOD FOR PREPARING THE SAME AND SILICON-CONTAINING THIN-FILM USING THE SAME
Provided are a novel amino-silyl amine compound, a method for preparing the same, and a silicon-containing thin-film using the same, wherein the amino-silyl...
2016/0122368 CHROMATOGRAPHIC MATERIAL AND METHOD FOR PREPARATION THEREOF
A chromatographic material comprising a zwitterionic ligand covalently bound to a substrate, the ligand preferably has a formula II: ##STR00001## wherein ...
2016/0122367 ANTIBACTERIAL POWDERS BASED ON ANIONIC SILICON OR TITANIUM DIOXIDE ADSORBED WITH PHARMACEUTICALLY ACTIVE CATIONS
The present invention relates to a dioxide silicon or titanium derivative of formula (I): (MO.sub.2).sup.-(A.sup.m+).sub.y, as active ingredient for the...
2016/0122366 BORONIC ACID INHIBITORS OF HIV PROTEASE
Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to...
2016/0122365 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
2016/0122364 NOVEL GAK MODULATORS
The present invention relates to a class of novel isothiazolo[4,3-b]pyridine derivatives and a method for their preparation, as well as to pharmaceutical...
2016/0122363 NOVEL 6-BRIDGED HETEROARYLDIHYDROPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the description...
2016/0122362 INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS
Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type 1 are identified and methods of use as anti-parasitic compounds are provided.
2016/0122361 PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of...
2016/0122360 TETRAHYDRO-2H-PYRANO[3,2-C]ISOCHROMENE-6-ONES AND ANALOGS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
The present invention relates to 2,3,4,4a-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyra- no[3,2-c]isochromen-6(10bH)-one analogs of the...
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