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Patent # Description
2016/0130351 Anti-IL-6/IL-6R Antibodies and Methods of Use Thereof
This invention provides fully human monoclonal antibodies that recognize the IL-6/IL-6R complex. The invention further provides methods of using such...
2016/0130350 ANTI-CXCL9, ANTI-CXCL10, ANTI-CXCL11, ANTI-CXCL13, ANTI-CXCR3 AND ANTI-CXCR5 AGENTS FOR INHIBITION OF INFLAMMATION
Methods for preventing or inhibiting inflammation in a subject are disclosed. In one aspect, the method comprises administering to a subject diagnosed with an...
2016/0130349 MODIFIED ANTIBODIES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
Provided herein are modified antibodies, compounds used to make them, and intermediates in their synthesis; compositions; formulations and methods, including...
2016/0130348 ANTIBODIES AND OTHER MOLECULES THAT BIND B7-H1 AND PD-1
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1...
2016/0130347 Fc-free antibodies comprising two Fab-fragments and methods of use
The present invention relates to bispecific antibodies comprising at least two Fab fragments, wherein the first Fab fragment comprises at least one antigen...
2016/0130346 KIR3DL2 IS A BIOMARKER AND A THERAPEUTIC TARGET USEFUL FOR RESPECTIVELY PREVENTING AND TREATING A SUBSET OF...
The present invention relates to a ligand molecule that specifically binds to KTR3DL2 at the surface of KTR3DL2 expressing malignant T-cells for the treatment...
2016/0130345 COMBINATION OF VACCINATION AND INHIBITION OF THE PD-1 PATHWAY
The present invention relates to a vaccine/inhibitor combination comprising an RNA vaccine comprising at least one RNA comprising at least one open reading...
2016/0130344 ANTI-GCC ANTIBODY MOLECULES AND METHODS FOR USE OF SAME
Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing...
2016/0130343 ANTI-ILT7 ANTIBODY
An antibody binding to IPC was obtained by using an animal cell in which a cell membrane protein associatable with ILT7 was co-expressed as an immunogen. The...
2016/0130342 NOVEL P2X7 EPITOPES
The invention relates to purinergic (P2X) receptors, to generation of antibodies and to use of antibodies and immunogens for detection and treatment of a...
2016/0130341 ANTIBODIES TO HUMAN RESISTIN
The present invention relates to the field of pulmonary, cardiac and inflammatory disorders. More specifically, the present invention provides methods and...
2016/0130340 DOSING REGIMENS USING ANTI-IL-6 ANTIBODIES FOR THE TREATMENT OF RHEUMATOID AND PSORIATIC ARTHRITIS
The present invention relates to therapeutic methods of using an antibody, or antigen-binding fragment thereof, which selectively binds IL-6 for the treatment...
2016/0130339 Isolation and Purification of Anti-IL-13 Antibodies Using Protein A Affinity Chromatography
Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an...
2016/0130338 Antibody Neutralizers of Human Granulocyte Macrophage Colony Stimulating Factor
The present invention relates to a human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF.
2016/0130337 METHODS FOR TREATING OCULAR DISEASES
A method is provided for reducing the treatment burden for patients who have an intraocular neovascular disorder, the method comprising administering a...
2016/0130336 ANTI-VEGF ANTIBODIES AND USE THEREOF
An anti-VEGF antibody, or a binding fragment thereof, includes a heavy-chain variable region that comprises: (1) a CDRH1 sequence selected from SEQ ID NO: 17,...
2016/0130335 NOVEL ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME
The present invention relates to anti-Nodal antibodies and use of the anti-Nodal antibodies for diagnosing, preventing, and treating a Nodal-related disorder...
2016/0130334 NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF OBESITY
The present invention is directed to methods of treating or preventing obesity by administering agents that inhibit the NOTCH signaling pathway. Antibodies...
2016/0130333 Chimeric and Humanized Anti-Histone Antibodies
The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific CDR sequences, disclosed herein....
2016/0130332 ANTIBODIES TO HUMAN SIGNAL PEPTIDE-CONTAINING PROTEINS
The invention provides a human signal peptide-containing proteins (SIGP) and polynucleotides which identify and encode SIGP. The invention also provides...
2016/0130331 MULTIVALENT DLL3 ANTIBODIES
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
2016/0130330 MAMMALIAN RECEPTORS AS TARGETS FOR ANTIBODY AND ACTIVE VACCINATION THERAPY AGAINST MOLD INFECTIONS
The present invention provides therapeutic compositions and methods for treating and preventing fungal disease or conditions including mucormycosis. The...
2016/0130329 COMPOSITIONS AND METHODS RELATED TO RECOMBINANT ANTIBODIES TO HISTONE POSTTRANSLATIONAL MODIFICATIONS
Embodiments concern compositions and methods involving recombinant antibodies to histone post-translational modifications. The invention provides compositions...
2016/0130328 Pathogen Binding Agents Conjugated to Radioisotopes and Uses in Imaging and Therapeutic Applications
This disclosure relates to binding agents specific for the envelope protein of a virus, e.g., lentivirus, wherein the binding agent is conjugated to a molecule...
2016/0130327 CMV NEUTRALIZING ANTIGEN BINDING PROTEINS
The present invention is directed to antigen binding proteins including, but not limited to, monoclonal antibodies and antigen binding fragments thereof, that...
2016/0130326 NOVEL ANTIBODY FRAMEWORKS
The present invention relates to novel antibody frameworks with advantageous properties.
2016/0130325 METHOD FOR PRODUCING HYPO-METALLATED REDOX-ACTIVE METALLOTHIONEIN PROTEIN AND PHARMACEUTICAL COMPOSITION...
The present invention relates to method for producing hypo-metallated redox-active metallothionein (MT) proteins, pharmaceutical compositions containing the...
2016/0130324 C1 Inhibitor Fusion Proteins and Uses Thereof
The present invention provides, among other things, methods and compositions for treating complement mediated disease, in particular, chronic diseases...
2016/0130323 NOVEL PEPTIDES THAT BIND TO TYPES OF MHC CLASS II AND THEIR USE ON DIAGNOSIS AND TREATMENT
It is provided novel peptides from human alpha-enolase, collagen type II and vimentin that bind to types of MHC class II that is associated with rheumatoid...
2016/0130322 A GROWTH HORMONE SECRETAGOGUE RECEPTOR BASED PROTEIN, NUCLEIC ACIDS AND METHODS AND USES THEREOF
Ghrelin is a peptide hormone that binds its receptor, growth hormone secretatgogue receptor 1a (GHS-R1 a, ghrelin receptor), to promote adiposity and obesity...
2016/0130321 USE OF A VEGF ANTAGONIST IN TREATING MACULAR EDEMA
The present invention relates to the use of a non-antibody VEGF antagonist in the treatment of macular edema secondary to diseases or conditions other than...
2016/0130320 MODIFIED CHIMERIC POLYPEPTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES
The present invention provides VEGF antagonists with improved pharmacokinetic properties. According to certain embodiments, a fusion polypeptide capable of...
2016/0130319 HIGH-STABILITY T-CELL RECEPTOR AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention provides a high-stability T cell receptor. The T cell receptor has mutations in its hydrophobic core domain causing the enhancement of...
2016/0130318 Interleukin 15 (IL-15) Antagonists and Uses Thereof for the Treatment of Autoimmune Diseases and Inflammatory...
The present relates to interleukin 15 (IL-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases....
2016/0130317 IL-12 Immunotherapy for Cancer
Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably...
2016/0130316 New uranium-chelating peptides derived from EF-hand calcium-binding motif useful for uranium biodetection and...
Uranium-chelating polypeptides comprising at least one helix-loop-helix calcium-binding (EF-hand) motif which comprises a deletion of at least two amino acid...
2016/0130315 TUMOR TISSUE-PENETRATING PEPTIDE SPECIFIC TO NEUROPILIN AND FUSION PROTEIN HAVING SAME PEPTIDE FUSED THEREIN
A tumor tissue-penetrating peptide specifically binding to neuropilin, or a fusion protein, a small molecule drug, a nanoparticle, or a liposome having the...
2016/0130314 OPTIMIZED NON-CANONICAL ZINC FINGER PROTEINS
Disclosed herein are zinc fingers comprising CCHC zinc coordinating residues. Also described are zinc finger proteins and fusion proteins comprising these CCHC...
2016/0130313 Bis-Met Histones
The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal...
2016/0130312 Bis-Met Histones
The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal...
2016/0130311 T CELL EPITOPES DERIVED FROM ALT A 1 OR ALT A 5 FOR THE TREATMENT OF ALTERNARIA ALTERNATA ALLERGY
The application discloses peptides capable of preventing or treating fungal disease, including fungal allergy disease.
2016/0130310 NOVEL RHTB PROTEIN VARIANTS AND THE METHOD OF PRODUCING O-PHOSPHOSERINE USING THE SAME
The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export ...
2016/0130309 MONOCINS AND METHODS OF USE
The disclosure relates to the identification, cloning, and expression of a genetic locus within a Listeria monocytogenes genome that encodes a phage tail-like...
2016/0130308 Nucleic Acid Molecules Encoding Novel Herpes Antigens, Vaccine Comprising The Same, And Methods Of Use Thereof
Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of herpes virus antigens, as well as genetic constructs/vectors and...
2016/0130307 HEPATITIS B VIRUS PRE-S1 DERIVED SYNTHETIC POLYPEPTIDES AND USES THEREOF
The invention relates to a group of synthetic polypeptides, derived from the pre-S1 region of HBV, that efficiently interfere with early steps of an HBV...
2016/0130306 Human Adaptation of H7 HA
The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention,...
2016/0130305 DENGUE VIRUS (DV) POLYPEPTIDE SEQUENCES, T CELL EPITOPES AND METHODS AND USES THEREOF
Dengue virus (DV) peptides, including T cell epitopes, structural and non-structural (NS) polypeptide sequences, subsequences and modifications thereof,...
2016/0130304 NOVEL CYCLOSPORIN ANALOGUES FOR PREVENTING OR TREATING HEPATITIS C INFECTION
The present invention relates to novel cyclosporine analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More...
2016/0130303 GLYCOGEN SYNTHASE KINASE-3 INHIBITORS
Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive...
2016/0130302 COMPOSITIONS AND METHODS FOR SPECIFIC REGULATION OF PYRUVATE DEHYDROGENASE KINASE
A peptide composition is provided which specifically inhibits the ability of .delta.-protein kinase C (.delta.PKC) to phosphorylate pyruvate dehydrogenase...
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