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Patent # Description
2016/0130251 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS
The present invention relates to compounds of Formula (I): ##STR00001## wherein X.sup.1, X.sup.2, X.sup.3, X.sup.4, X.sup.5, X.sup.6, X.sup.7, X.sup.8, R.sup.1,...
2016/0130250 SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
The present invention relates to a compound of the formula I ##STR00001## wherein R.sup.1 to R.sup.6, A, B, n and m are as defined herein. Such novel sulfonyl...
2016/0130249 Quinazoline Derivatives as VEGF Inhibitors
The invention relates to quinazoline derivatives of formula (I), wherein m is an integer from 1 to 3; R.sup.1 represents halogeno or C.sub.1-3alkyl; X.sup.1...
2016/0130248 (+)-5-(3,4-DIFLUOROPHENYL)-5-[(3-METHYL-2-OXOPYRIDIN-1(2H)-YL)METHYL]IMIDA- ZOLIDINE-2,4-DIONE AND DRUG...
Provided is (+)-5-(3,4-difluorophenyl)-5-[(3-methyl-2-oxopyridin-1(2H)-yl)methyl]imid- azolidine-2,4-dione or a salt thereof. Also provided is a drug...
2016/0130247 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2016/0130246 THIOUREA COMPOUNDS AND THEIR USE AS INHIBITORS OF SIRT2 OR SIRT5
A compound useful as a Sirt2 or Sirt5 inhibitor having the formula (1) wherein: R.sub.1 is a hydrocarbon group having at least two carbon atoms connected by...
2016/0130245 6,8-SUBSTITUTED NARINGENIN DERIVATIVE AND USE THEREOF
Disclosed in the present invention are a 6,8-substituted naringenin derivative as shown in formula (I): ##STR00001## in which A.sub.6 and A.sub.8 in formula...
2016/0130244 OXIDATION PROCESS TO PRODUCE A PURIFIED CARBOXYLIC ACID PRODUCT VIA SOLVENT DISPLACEMENT AND POST OXIDATION
Disclosed is a process to produce a dry purified carboxylic acid product comprising furan-2,5-dicarboxylic acid (FDCA). The process comprises oxidizing at...
2016/0130243 EPOXY COMPOUND, EPOXY RESIN, CURABLE COMPOSITION, CURED PRODUCT THEREOF, SEMICONDUCTOR SEALING MATERIAL, AND...
There is provided an epoxy compound whose melt viscosity is low and which exhibits heat resistance and flame retardancy of a cured product; an epoxy resin...
2016/0130242 PROCESS AND APPARATUS FOR PRODUCING DIVINYLARENE DIOXIDE
A process for preparing a divinylarene dioxide including the steps of: (a) feeding one or more feed streams of the following reactants into a reactor system:...
2016/0130241 THIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
2016/0130240 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes...
2016/0130239 SODIUM CHANNEL MODULATORS FOR THE TREATMENT OF PAIN AND DIABETES
Provided herein are sodium channel modulating Compounds, in particular NaV1.7 modulating compounds of Formula I or compounds of Formula I': ##STR00001## In...
2016/0130238 New Process to make non nucleosidal reverse transcriptase inhibitors (NNRTI) for the treatment of HIV
A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical...
2016/0130237 PYRIMIDINE FGFR4 INHIBITORS
Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.
2016/0130236 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0130235 CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING
The present disclosure is directed, in part, to compounds and methods for imaging myocardial perfusion, comprising administering to a patient a contrast agent...
2016/0130234 PHARMACEUTICAL COMPOSITIONS BASED ON PHOTOCHEMICALLY STABLE SILVER COMPLEXES, CHLOREXIDINE AND CATIONIC SURFACTANTS
The present invention generally relates to silver complexes of formula (I) and (II), having high stability and showing antimicrobial activity. The invention...
2016/0130233 COMPOUND, DISPERSANT AND TONER
The present invention provides a dispersant excellent in the solubility to a solvent, the adsorption power to a coloring material, and the coloring material...
2016/0130232 4-ALKYNYL IMIDAZOLE DERIVATIVE AND MEDICINE COMPRISING SAME AS ACTIVE INGREDIENT
There are provided 4-alkynylimidazole derivatives represented by the following general formula (I) or phamaceutically acceptable salts thereof; the derivatives...
2016/0130231 ROR MODULATORS AND THEIR USES
The invention relates to ROR modulators; compositions comprising an effective amount of a ROR modulator; and methods for treating or preventing diseases...
2016/0130230 SUBSTITUTED DICYANOPYRIDINES AND USE THEREOF
The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of...
2016/0130229 ACETYL-COA CARBOXYLASE MODULATORS
Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the...
2016/0130228 Novel Heterocyclic Compounds as Bromodomain Inhibitors
The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
2016/0130227 PRODRUGS OF ANTI-PLATELET AGENTS
The invention relates to the compounds of formula II, formula Ia, formula IIa or its pharmaceutical acceptable salts, as well as polymorphs, solvates,...
2016/0130226 SPIRO-SUBSTITUTED OXINDOLE DERIVATIVES HAVING AMPK ACTIVITY
The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are...
2016/0130225 COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ORGANIC ELECTROLUMINESCENT ELEMENT, AND ELECTRONIC...
A compound is represented by a formula (1) below, in which k is an integer of 0 or more, m is an integer of 1 or more, n is an integer of 2 or more. L is a...
2016/0130224 Novel Pyrrole Derivatives
There are provided inter alia novel N-phenyl substituted pyrrole derivativesand theiruse in therapy, especially in the treatment of bacterial (e.g....
2016/0130223 Electrophilic Reagents for Monohalomethylation, Their Preparation and Their Uses
The invention provides a compound of formula A, B, C or D, methods for making them, intermediates therefor, and their use in making organic biologically active...
2016/0130222 INHIBITORS OF THE MITF MOLECULAR PATHWAY
Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the...
2016/0130221 PROCESS FOR THE PREPARATION OF ISOBUTYLIDENE DIUREA
Disclosed herein is mixed fertilizer according to the process comprising: reacting isobutyraldehyde with an aqueous solution of urea in the presence of a phase...
2016/0130220 PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS
Disclosed herein are novel antioxidant inflammation modulators, including those of the formula: ##STR00001## wherein the variables are defined herein. Also...
2016/0130219 METABOLITES AND OXIMES WITH VASODILATOR AND HYPOTENSIVE ACTIVITY
Semi-synthetic oximes derived from metabolites extracted from medicinal plants, Senecio nutans and Xenophyllum poposum, the method of preparation thereof and...
2016/0130218 4-BENZYL-1-PHENETHYL-PIPERAZINE-2,6-DIONE PREPARATION METHOD, AND INTERMEDIATE AND PREPARATION METHOD THEREOF
The present invention provides a key new intermediate (a compound of formula III) of 4-benzyl-1-phenethyl-piperazine-2,6-dione (formula IV compound), a...
2016/0130217 OLIGO-BENZAMIDE COMPOUNDS AND THEIR USE
The present invention includes bis- and tris-benzamide compounds that block AR signaling and have anticancer activity. Uses for these compounds, and...
2016/0130216 COMPOUNDS FOR PROMOTING LIPOSOMAL AND CELLULAR ADHESION AND COMPOSITIONS AND METHODS OF USE THEREOF
The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal...
2016/0130215 CYCLOPROPANEAMINE COMPOUND
The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or...
2016/0130214 1,3-DIAMINOCYCLOPENTANE CARBOXAMIDE DERIVATIVES
Compounds of the formula I ##STR00001## in which R.sup.1, R.sup.4, R.sup.6, R, X.sup.1, X.sup.2, X.sup.3, X.sup.4, q and W have the meanings indicated in claim...
2016/0130213 INHIBITION OF AMINE OXIDATION
In an embodiment, an amine-oxidation inhibitor, such as a free radical scavenger and/or antioxidant, is added to an oxidation-sensitive amine, such as an amine...
2016/0130212 COMPOUND, RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN
A compound represented by formula (I), a resin including a structural unit derived from the compound and a resist composition including the resin: ...
2016/0130211 ANTIOXIDANT-BASED POLY(ANHYDRIDE-ESTERS)
Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof....
2016/0130210 COMPOUND, RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN
A compound represented by formula (I), a resin including a structural unit derived from the compound and a resist composition including the resin: ...
2016/0130209 METHOD FOR SYNTHESISING GLYCOLIC ACID
The invention relates to a method for synthesising glycolic acid or one of the salts thereof, including the following step: placing glycerol and an oxidising...
2016/0130208 SYNTHESIS OF ALPHA,BETA-UNSATURATED CARBOXYLIC ACID (METH)ACRYLATES FROM OLEFINS AND CO2
The invention relates to a method for producing .alpha.,.beta.-unsaturated carboxylic acids or salts thereof, comprising a step in which a metallalactone is...
2016/0130207 METHOD FOR PRODUCING CARBONYL COMPOUND
To provide a production method for suppressing the reduction in production rate of a carbonyl compound due to transferring a noble metal component into liquid...
2016/0130206 PROCESS FOR THE PREPARATION OF LIGHTLY-BRANCHED HYDROPHOBES AND THE CORRESPONDING SURFACTANTS AND APPLICATIONS...
Processes to prepare lightly branched surfactant products comprise combining at least one olefin and a coordination-insertion catalyst under conditions such...
2016/0130205 CATALYTIC SYSTEM FOR CROSS-COUPLING REACTIONS
The present invention concerns a process for creating a Carbon-Carbon bond (C--C) or a Carbon-Heteroatom bond (C--HE) by reacting a compound carrying a leaving...
2016/0130204 PROCESS AND PLANT FOR PREPARATION OF ONE OR MORE REACTION PRODUCTS
A process for preparing one or more reaction products, in which a first methane-rich feed stream is subjected to a partial oxidation process and/or an...
2016/0130203 NOVEL PHENYLNAPHTHOL DERIVATIVES
Phenylnaphthol derivatives represented by the following general formula (1), ##STR00001## wherein, R.sup.1 to R.sup.3 are hydrogen atoms, alkyl groups or aryl ...
2016/0130202 Systems and Methods for the Depolymerization of a Biopolymer
Methods for the production and isolation of a monomer from a biopolymer are described. The method includes extracting a biopolymer from a biopolymer source and...
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