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Patent # Description
2016/0129001 SUBSTITUTED [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS BRD4 INHIBITORS
Method for treating AML and MM by administration of a compound of the formula (I) ##STR00001## wherein the groups R.sup.1 to R.sup.3 have the meanings given...
2016/0129000 METHOD OF TREATMENT FOR MENTAL DISORDERS
The invention relates to a medicament or a method for treating mental disorders, in detail, ADHD comprising lurasidone, or a combination of lurasidone and a...
2016/0128999 MASITINIB FOR TREATING HEPATIC CANCER
A method for treating hepatic cancer in a subject in need thereof, which includes the administration to the subject a therapeutically effective amount of a...
2016/0128998 Compositions and Methods Comprising Bupropion or Related Compounds for Sustained Delivery of Dextromethorphan
Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically,...
2016/0128997 SUSTAINED-RELEASE BUPRENORPHINE FORMULATIONS
The disclosure is directed to sustained-release buprenorphine formulations that provide long-term, therapeutic levels of buprenorphine for the treatment of...
2016/0128996 BICYCLIC AZA COMPOUNDS AS MUSCARINIC M1 RECEPTOR AGONISTS
This invention relates to compounds (Formula (1)) that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1...
2016/0128995 METHODS FOR TREATING HEARTBURN AND/OR PREVENTING GASTRIC BLEEDING OR HEMORRHAGE IN PATIENTS RECEIVING...
The present invention relates to methods of treating heartburn in a patient receiving clopidogrel therapy. In another aspect, the present invention relates to...
2016/0128994 PPAR GAMMA MODULATORS FOR TREATING CYSTIC DISEASES
Compositions and methods are described herein for the treatment of cystic diseases using PPAR.gamma. modulators. In particular, compositions and methods are...
2016/0128993 1,2,4-THIAZOLIDIN-3-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
According to the invention there is provided a compound of formula (I) wherein: A represents C(.dbd.N--W-D) or S; B represents S or C(--NH--W-D); when: A...
2016/0128992 Methods for limiting acute kidney injury
Method of limiting development of acute kidney injury (AKI) and treating AKI using pyridoxamine are described, together with methods for monitoring efficacy of...
2016/0128991 INDAZOLE INHIBITORS OF THE WNT SIGNAL PATHWAY AND THERAPEUTIC USES THEREOF
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
2016/0128990 METHODS OF USING RIFAXIMIN IN POSITION EMISSION TOMOGRAPHY (PET) SCANS
The present invention provides new methods and kits for the reduction, prevention or inhibition of substrate uptake by non-metastatic, metabolically active...
2016/0128989 PYRAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF BLADDER CANCER
The invention relates to the use of compounds corresponding to formula (I), or a pharmaceutically acceptable salt thereof, for preparing a medicament for the...
2016/0128988 COMBINATIONS FOR THE TREATMENT OF CANCER COMPRISING A MPS-1 KINASE INHIBITOR AND A MITOTIC INHIBITOR
The present invention relates to a combination comprising an Mps-1 kinase inhibitor and a mitotic inhibitor. The present invention also relates to the use of...
2016/0128987 METHODS AND COMPOSITIONS RELATED TO SYNTHETIC NANOCARRIERS WITH RAPAMYCIN IN A STABLE, SUPER-SATURATED STATE
Disclosed are compositions and methods that provide synthetic nanocarriers that comprise hydrophobic polyester carrier material and rapamycin that is in a...
2016/0128986 METHODS AND COMPOSITIONS RELATED TO THE USE OF LOW HLB SURFACTANTS IN THE PRODUCTION OF SYNTHETIC NANOCARRIERS...
Disclosed are compositions and methods related to synthetic nanocarriers comprising a hydrophobic carrier material, a rapalog, and a non-ionic surfactant with...
2016/0128985 Methods and Compositions for the Treatment of Body Weight Related Disorders
The present invention relates to methods for reducing body weight in an animal in need thereof via administration of a therapeutically effective amount of a...
2016/0128984 ISOXAZOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective...
2016/0128983 CYTOTOXIC SUBSTANCE FOR USE IN COMBINATION WITH RADIOTHERAPY IN CANCER TREATMENT
The present invention provides a substance comprising a preparation of at least one chemotherapeutic or cytotoxic substance for the use in treatment of a...
2016/0128982 ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE
Antimicrobial compositions include at least one antimicrobial azole compound, particularly imidazole, triazole or thiazole compounds, and at least one...
2016/0128981 CONTROLLED RELEASE ORAL DOSAGE FORMS OF POORLY SOLUBLE DRUGS AND USES THEREOF
Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the...
2016/0128980 METHODS OF TREATING CKD USING PREDICTORS OF FLUID RETENTION
The disclosure relates to methods of treating chronic kidney disease and diabetic nephropathy using predictors of fluid retention to minimize the risk of...
2016/0128979 MODIFIED RELEASE FORMULATION
Drug products in the form of modified release formulations comprising the drug substance ...
2016/0128978 PHARMACEUTICAL FOR IMPROVING DYSPHAGIA
A dysphagia improving composition characterized in that a substance having an inhibitory action on an angiotensin converting enzyme, which is a degrading...
2016/0128977 STABILIZED STATIN FORMULATIONS
The present invention is directed to statin formulations having improved solubility and/or stability and methods for the same.
2016/0128976 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides...
2016/0128975 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF LUNG CANCER
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides...
2016/0128974 ANTI-CXCR4 AS A SENSITIZER TO CANCER THERAPEUTICS
Inhibition of CXCR4 can inhibit tumor growth and metastasis during certain therapeutic windows. Disclosed are novel methods for treating and preventing cancer...
2016/0128973 INHIBITION OF CANCER CELL MOTILITY
Provided herein are compositions and methods for inhibiting cancer cell motility and/or metastasis. In particular embodiments, KBU2046 (or an analog thereof)...
2016/0128972 METHOD FOR PREVENTING INFLUENZA VIRUS INFECTION BY ADMINISTERING A DRY POWDER PHARMACEUTICAL COMPOSITION
A method for preventing an influenza virus infection by administering by inhalation to a patient a pharmaceutically effective amount of a dry powder...
2016/0128971 Nanoparticle Compositions
The present invention relates to compositions and methods of formulating nanoparticle drugs for cancer treatment in particular for intravenous administration...
2016/0128970 COMPOSITION AND METHOD FOR TREATING NOSEBLEEDS
A composition and method for treating nosebleed, that is, epistaxis. The composition comprises bismuth subgallate and a vasoconstriction agent, preferably...
2016/0128969 SOLID FORMS OF SELECTIVE ANDROGEN RECEPTOR MODULATORS
The present invention relates to solid forms of (S)--N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2- -methylpropanamide and process for...
2016/0128968 METHOD OF TREATING ANDROGEN RECEPTOR (AR) -POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR...
This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer;...
2016/0128967 PROCESS AND COMPOSITION FOR STABILIZATION OF VULNERABLE PLAQUE UTILIZING A COMBINATION OF A STATIN AND OMEGA 3...
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels...
2016/0128966 METHODS FOR TREATING LEUKOPENIA AND THROMBOCYTOPENIA
The disclosure provides methods for treating, controlling or mitigating leukopenia (e.g. neutropenia) and/or thrombocytopenia, for example in the context of...
2016/0128965 GEL COMPOSITIONS
Novel aqueous topical gel compositions comprising ingenol-3-angelate.
2016/0128964 GEL COMPOSITIONS
Aqueous topical liposome gel compositions comprising ingenol-3-angelate.
2016/0128963 METHOD FOR TREATING OVERACTIVE BLADDERS AND A DEVICE FOR STORAGE AND ADMINISTRATION OF TOPICAL OXYBUTYNIN...
The invention relates to a method for treating overactive bladders and a device for storing and administering non-occluded oxybutynin topical compositions.
2016/0128962 LOW DOSE ORAL PHARMACEUTICAL COMPOSITION OF ISOTRETINOIN
The present invention provides a low dose oral pharmaceutical composition of isotretinoin having reduced food effect. The present invention further relates to...
2016/0128961 DIETARY OMEGA-3 FATTY ACID DERIVED GLYCEROPHOSPHOLIPIDS TO TREAT NEUROPATHIC PAIN
Disclosed are methods and dietary compositions for the treatment and prevention of neuropathic pain and for pain prognosis. Some embodiments may include the...
2016/0128960 AMINO ACID SUPPLEMENTATION FOR A HEALTHY MICROBIOTA ECOSYSTEM
A nutritional composition is used to reconstitute an optimal healthy microbiota ecosystem in humans or animals. In particular, an ingestible carrier contains...
2016/0128959 COMPOSITION AND METHOD FOR COMPOUNDED THERAPY
A method of producing a compounded medication may include formulating a compounded transdermal cream that includes combining a diclofenac sodium solution and a...
2016/0128958 Ornithine Aminotransferase Inhibition with GABA Analogues for Treatment of Hepatocellular Carcinoma
Therapeutic methods relating to the use of GABA-AT inhibitor compounds for the treatment of hepatocellular carcinoma.
2016/0128957 Transdermal Drug Delivery using an Osmolyte and Vasoactive Agent
A formulation and method for delivery of bioactive substances when applied to, or within, the skin or other exterior region of a mammal. for example, a...
2016/0128956 Nutritional Intervention for Improving Muscular Function and Strength
The present invention provides a composition comprising HMB and Vitamin D. Methods of administering HMB and Vitamin D to an animal are also described. Vitamin...
2016/0128955 INJECTABLE SUPERSATURATED ACETAMINOPHEN SOLUTION FOR SPINAL ADMINISTRATION
The present invention relates to an acetaminophen injectable aqueous solution for use in the treatment or in the prevention of pain by spinal administration,...
2016/0128954 Methods of Treating Huntington's Disease Using Cysteamine Compositions
The present disclosure relates in general to methods for the treatment of neurodegenerative disease, such as Huntington's Disease, using compositions...
2016/0128953 TRANS-CLOMIPHENE AND ITS ANALOGUES AS AGENTS THAT INCREASE BONE MINERAL DENSITY
The present invention relates to the administration of compositions comprising trans-clomiphene or an analogue or salt thereof, for inhibiting bone resorption...
2016/0128952 Pharmaceutical Combination
A combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) Paracetamol or a derivative thereof, a...
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