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Patent # Description
2016/0130601 NUCLEIC ACID SEQUENCES ENCODING TRANSCRIPTION FACTORS REGULATING ALKALOID BIOSYNTHESIS AND THEIR USE IN...
Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment,...
2016/0130600 Soybean Seed and Oil Compositions and Methods of Making Same
Methods for obtaining soybean plants that produce seed with low linolenic acid levels and moderately increased oleic levels are disclosed. Also disclosed are...
2016/0130599 MODIFIED DIATOMS FOR BIOFUEL PRODUCTION
The invention provides engineered diatoms and methods of producing oil using diatoms. The invention also provides methods of modifying the lipids quantity...
2016/0130598 PEPPER WITH INCREASED TOTAL CONTENT OF TERPENOIDS
The present invention relates to a pepper plant (Capsicum annuum L.) which may comprise at least one QTL selected from QTL1, QTL2 and QTL3, which when present...
2016/0130597 Regulation of Gene Expression
The invention provides isolated polynucleotides comprising sequences encoding a u ORF peptides and variants and fragments thereof. The invention also provides...
2016/0130596 METHOD OF PRODUCING LEAFY BIOMASS
A method for producing leafy biomass from undifferentiated plant cells, the method comprising providing undifferentiated plant cells, contacting them with an...
2016/0130595 SYNTHETIC BI-DIRECTIONAL PLANT PROMOTER
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a minimal core...
2016/0130594 SYNTHETIC BI-DIRECTIONAL PLANT PROMOTER
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a minimal core...
2016/0130593 ARTIFICIAL DNA SEQUENCE WITH OPTIMIZED LEADER FUNCTION IN 5'(5'-UTR) FOR THE OVER-EXPRESSION OF RECOMBINANT...
Artificial DNA of a 5'-UTR leader region, which artificial DNA is effective in increasing the expression of recombinant proteins in plants, and comprises,...
2016/0130592 Soybean Transformation Using HPPD Inhibitors as Selection Agents
The invention relates to methods for Agrobacterium-mediated transformation of soybean organogenic tissue using a gene or genes for tolerance to HPPD inhibitors...
2016/0130591 METHOD FOR IDENTIFYING SUBSTANCES WHICH PRIME CELLS FOR A STRESS RESPONSE AND CELLS FOR USE IN THIS METHOD
The present invention relates to a transgenic eukaryotic cell or non-human organism comprising one or more genetic modifications providing the activation of...
2016/0130590 BACTERIAL XYLOSE ISOMERASES ACTIVE IN YEAST CELLS
Specific polypeptides were identified as bacterial xylose isomerases that are able to provide xylose isomerase activity in yeast cells. The xylose isomerase...
2016/0130589 FILAMENTOUS FUNGAL MUTANTS WITH IMPROVED HOMOLOGOUS RECOMBINATION EFFICIENCY
The present invention relates to a method for increasing the efficiency of targeted integration of a polynucleotide to a pre-determined site into the genome of...
2016/0130588 METHOD FOR THE GENERATION OF POLYCYSTRONIC VECTORS
The present invention provides a method for generating polycystronic nucleic acid vectors, said method comprising the steps of a) providing a first nucleic...
2016/0130587 INTERFERING RNA MOLECULES
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand...
2016/0130586 PREVENTIVE OR THERAPEUTIC AGENT FOR FIBROSIS
Provided is siRNA effective for the treatment of fibrosis and a pharmaceutical containing the siRNA.
2016/0130585 APTAMERS FOR THE TREATMENT OF SICKLE CELL DISEASE
The present invention provides polynucleotide aptamers that selectively bind to and inhibit polymerization of sickle hemoglobin (HbS), pharmaceutical...
2016/0130584 TREATMENT OF ALPHA-L-IDURONIDASE (IDUA) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IDUA
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Alpha-L-Iduronidase (IDUA), in particular, by...
2016/0130583 DOUBLE-STRANDED ANTISENSE NUCLEIC ACID WITH EXON-SKIPPING EFFECT
Disclosed are double-stranded antisense nucleic acid complexes that can efficiently alter the processing of RNA in a cell via an antisense effect, and methods...
2016/0130582 OLIGONUCLEOTIDE MODULATORS OF B-CELL CLL/LYMPHOMA 11A (BCL11A) AND USES THEREOF
The present invention provides, among other things, oligonucleotide modulators (e.g., inhibitors) of B cell lymphoma/leukemia 11A (BCL11A) and improved methods...
2016/0130581 TARGETING DOMAIN AND RELATED SIGNAL ACTIVATED MOLECULAR DELIVERY
Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain,...
2016/0130580 RNA AMIDATES AND THIOAMIDATES FOR RNAI
The present disclosure relates to RNA amidates and thioamidates useful for RNA interference applications. The RNA amidates and thioamidates contain at least...
2016/0130579 ADIPOCYTE-TARGETING NON-VIRAL GENE DELIVERY SYSTEM
The present invention relates to a gene delivery system for targeting adipocytes and a treatment system for obesity and obesity-derived metabolic syndromes...
2016/0130578 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS
The present invention relates to methods for in vivo administration of sd-rxRNA molecules.
2016/0130577 NUCLEOTIDE SEQUENCE MOTIFS DIRECTING NUCLEIC ACID LOCATION TO EXTRACELLULAR VESICLES
The present invention discloses the use of isolated short sequence motifs capable of directing or packaging regulatory nucleic acids, preferably RNAs, into...
2016/0130576 COMPOSITIONS AND METHODS FOR DIRECTIONAL NUCLEIC ACID AMPLIFICATION AND SEQUENCING
The invention provides methods and compositions, including kits, for directional nucleic acid amplification and sequencing. The invention further provides...
2016/0130575 SCREENING OF NUCLEIC ACID AGENTS VIA PARTICLE DISPLAY
The present disclosure provides a method for identifying one or more nucleic acid agents, e.g., aptamers, having a desired property from a mixture of candidate...
2016/0130574 METHODS OF MEASURING GENE EXPRESSION IN FACS-SORTED CELLS
Improved methods of measuring gene expression in intracellularly immunostained FACS-sorted cell populations are provided. Exemplary methods involve fixing...
2016/0130573 Method of Controlling a Polypeptide Modification Reaction
The invention relates to a method of controlling a polypeptide modification reaction, in particular but not exclusively, a method of controlling the activation...
2016/0130572 ALPHA AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to variants of alpha amylase. The present invention also relates to polynucleotides encoding the variants; nucleic acid...
2016/0130571 Alpha-Amylase from Bacillaceae Family Member
Disclosed are compositions and methods relating to an alpha-amylase from a Bacillaceae family member. The compositions and methods are useful, for example, for...
2016/0130570 METHOD FOR TREATING ONCOLOGICAL DISEASES
A method to treat cancer and other malignant diseases, said method comprising parenterally administering an agent which destroys blood extracellular DNA into...
2016/0130569 A LAGLIDADG HOMING ENDONUCLEASE CLEAVING THE T CELL RECEPTOR ALPHA GENE AND USES THEREOF
Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives,...
2016/0130568 THERMOPHILIC AND THERMOACIDOPHILIC GLYCOSYLATION GENES AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS AND...
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
2016/0130567 MESSENGER UNA MOLECULES AND USES THEREOF
This invention provides a range of translatable messenger UNA (mUNA) molecules. The mUNA molecules can be translated in vitro and in vivo to provide an active...
2016/0130566 BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF ARMODAFINIL
The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods...
2016/0130565 Method to Produce Virus in Cultured Cells
A method for improving virus production in a host cell infected with the virus is provided.
2016/0130564 VACCINIA VIRUS FOR GENE-DIRECTED ENZYME PRODRUG THERAPY
Methods of making vaccinia viruses for gene-directed prodrug therapy are disclosed and their use in the treatment of disease is provided. In particular, the...
2016/0130563 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2...
2016/0130562 Attenuated African Swine Fever Virus Vaccine Based in the Deletion of MGF Genes
African swine fever virus (ASFV) is the etiological agent of a contagious and often lethal viral disease of domestic pigs. Control of ASF has been hampered by...
2016/0130561 PLURIPOTENT STEM CELLS DERIVED FROM NON-CRYOPROTECTED FROZEN TISSUE AND METHODS FOR MAKING AND USING THE SAME
In some embodiments the present invention provides cells, such as pluripotent stem cells and differentiated cells, derived from tissue samples that have been...
2016/0130560 METHODS FOR IN VITRO MATURATION OF OVARIAN FOLLICLES
The invention relates to methods to be used in the maturation of ovarian follicles and oocytes. More specifically, the invention concerns the use of inhibitors...
2016/0130559 CELL POPULATIONS, METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic...
2016/0130558 MATRIX AND IMPLANT FOR TISSUE ENGINEERING
A porous matrix for tissue engineering has a first biodegradable and biocompatible polymer component forming a three-dimensional primary structure with primary...
2016/0130557 Formulations Containing and Kit for Using Adipose-Derived Stem Cells and Use Thereof
Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction...
2016/0130556 ENHANCED DIFFERENTIATION OF MESENCHYMAL STEM CELLS
Isolated populations of mesenchymal stem cells (MSCs) are provided, including mammalian mesenchymal stem cells (MSCs) characterized by the lack of CD54...
2016/0130555 METHODS FOR MATURING CARDIOMYOCYTES AND USES THEREOF
Described herein are methods and compositions useful for inducing maturation of a cardiomyocyte to a mature (e.g., adult) phenotype, such that the function and...
2016/0130554 Reprogramming Mesenchymal Stromal Cells Into Hematopoietic Cells
Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into...
2016/0130553 PREPARATION OF FETAL NUCLEATED RED BLOOD CELLS (NRBCs) FOR DIAGNOSTIC TESTING
The disclosure relates to methods of preparation of fetal nucleated red blood cells (NRBCs) from biological samples for diagnostic testing.
2016/0130552 METHOD FOR OBTAINING IMMUNO-SUPPRESSIVE DENDRITIC CELLS
The present invention relates to methods for producing immuno-suppressive dendritic cells. The present invention further relates to the use of such cells for...
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