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Patent # Description
2016/0137757 METHOD FOR SEPARATION OF A POLYMER FROM A POLYMER SOLUTION OR DISPERSION
The present invention relates to a method for separation of a polymer from a polymer solution or dispersion, wherein (i) a solution or dispersion of a polymer...
2016/0137756 Water Based Concentrated Product Forms of Photoinitiators Made by a Heterophase Polymerization Technique
The invention relates to a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising g) a polymer carrier...
2016/0137755 SURFACTANT COMPOSITION
A reactive surfactant composition comprising one or more kinds of reactive surfactants is disclosed that may be used as an emulsifier for emulsion...
2016/0137754 NEW PROCESSES FOR THE PRODUCTION OF CHEMICALLY-MODIFIED HEPARINS
The present invention relates to a process for the production of heparin derivatives having an average molecular weight of from about 4.6 to about 6.9 kDa and...
2016/0137753 METHOD OF EXTRACTING CERAMIDE AND/OR PECTIN FROM WHOLE APPLES OR APPLE JUICE RESIDUE
The object of the invention is to provide a method of extracting useful ingredients: ceramide and/or pectin from whole apples and/or apple juice residues. In...
2016/0137752 PACKAGING FORMULATION FOR PREVENTING THE INSOLUBILITY OF CHITOSAN-CONTAINING COMPOSITIONS
Formulations, methods, and products for preventing or decreasing insolubilization of chitosan-containing compositions are provided. By employing embodiments...
2016/0137751 METHOD FOR PRODUCING MODIFIED CELLULOSE NANOFIBERS
Provided are modified cellulose nanofibers that can be easily formed into a composite with a resin containing a solvent and a resin composition that contains...
2016/0137750 METHOD OF TREATING A PATHOLOGICAL SYNDROME
A method of treating disorder or condition that relates to intracellular signal transmission of a neurotransmitter, comprising administration of an...
2016/0137749 Compositions and Methods Related to Antibodies to Staphylococcal Protein A
Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects...
2016/0137748 ADAM22 FOR USE AS A PROGNOSTIC VARIABLE, AND TARGET FOR THERAPY, OF A METASTATIC BREAST CANCER DISEASE
A method of diagnosing metastatic potential of a breast cancer in an individual with breast cancer is described. The method comprises a step of assaying a...
2016/0137747 Antibodies Against Human CD39 and Use Thereof for Inhibiting T Regulatory Cells Activity
The invention relates to antibodies against human CD39 and use thereof for inhibiting T regulatory cells (Treg) activity. More particularly CD39 antibodies may...
2016/0137746 METHODS FOR TREATING HIGH CARDIOVASCULAR RISK PATIENTS WITH HYPERCHOLESTEROLEMIA
The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to a high cardiovascular...
2016/0137745 METHODS FOR TREATING PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA (heFH)
The present invention provides methods for treating hypercholesterolemia. The methods of the present invention comprise administering to patients with...
2016/0137744 MET-BINDING AGENTS AND USES THEREOF
The present invention relates to binding agents that specifically bind human MET, binding agents that specifically bind one or more components of the WNT...
2016/0137743 GLYCAN-INTERACTING COMPOUNDS
The present invention provides glycan-interacting antibodies useful in the treatment and prevention of human disease, including cancer. Such glycan-interacting...
2016/0137742 HIGHLY CONCENTRATED PHARMACEUTICAL FORMULATIONS
The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-CD20 antibody, such as e.g....
2016/0137741 Muscle Specific Tyrosine Kinase-Fluorophore Conjugate Compositions, Kits and Methods of Using
Provided herein is a method of diagnosing muscle specific tyrosine kinase specific autoimmune myasthenia gravis in an individual. Generally, in the method a...
2016/0137740 HUMANIZED ANTI-OX40 ANTIBODIES AND USES THEREOF
The disclosure provides humanized anti-OX40 antibodies. Also provided are methods of making such antibodies, and methods of use, e.g., treatment of cancer.
2016/0137739 ONCOSTATIN M RECEPTOR ANTIGEN BINDING PROTEINS
The invention provides anti-oncostatin M receptor-.beta. (OSMR) antigen binding proteins. e.g., antibodies and functional fragments, derivatives, muteins, and...
2016/0137738 MONOSPECIFIC AND BISPECIFIC ANTI-IGF-1R AND ANTI-ERBB3 ANTIBODIES
Provided are monospecific and bispecific antibodies that are useful as anti-neoplastic agents and that bind specifically to human IGF-1R and human ErbB3....
2016/0137737 INTEGRIN ALPHA-V BETA8 NEUTRALIZING ANTIBODY
The present invention relates to .alpha.v.beta.8 antagonists, anti-.alpha.v.beta.8 antibodies or immunoconjugates for reducing TGF.beta. activation in an...
2016/0137736 ANTI-CTLA4, ANTI-GLUT2 PROTEIN FOR THE TREATMENT OF TYPE 1 DIABETES
The disclosure relates to a protein composed of a first polypeptide or polypeptide domain having a first specific binding activity for Cytotoxic T-lymphocyte...
2016/0137735 METHOD OF TREATING MULTIPLE MYELOMA USING COMBINATION THERAPIES BASED ON ANTI-CS1 ANTIBODIES
Compositions and methods for treating MM are provided herein.
2016/0137734 THERAPEUTIC CD47 ANTIBODIES
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and...
2016/0137733 THERAPEUTIC CD47 ANTIBODIES
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and...
2016/0137732 FC VARIANTS WITH IMPROVED COMPLEMENT ACTIVATION
The present disclosure relates to polypeptide variants having modified Fc domains with improved potency and efficacy in activation of complement-dependent...
2016/0137731 HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFOR
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to...
2016/0137730 ANTIBODY DRUG CONJUGATES
This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding...
2016/0137729 ANTI CD37 ANTIBODIES
Chimeric and humanized anti-CD37 antibodies and pharmaceutical compositions containing them are useful for the treatment of B cell malignancies and autoimmune...
2016/0137728 ANTIBODY SPECIFICALLY BINDING TO INSULIN-LIKE GROWTH FACTOR-1
Isolated antibodies that specifically bind to an epitope comprised in the stretch of amino acids ranging from amino acid 76 to amino acid 84 of human...
2016/0137727 ANTIBODY FORMULATIONS
The invention provides stable aqueous pharmaceutical formulations comprising a therapeutic antibody, trehalose, a buffer, and optional surfactant, and having a...
2016/0137726 SINGLE DOMAIN BINDING MOLECULE
The present invention provides a single domain specific binding molecule having the structure FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 in which the Framework...
2016/0137725 Methylation and Acetylation Sites
The disclosure features over 5000 methylation and acetylation sites identified in human cell line, human serum and mouse tissues, peptides (including AQUA...
2016/0137724 ANTIBODIES FOR PREVENTION AND TREATMENT OF DISEASES CAUSED BY CLOSTRIDIUM DIFFICILE
The present invention relates to an antibody having specificity for an immunogenic determinant consisting of the pentasaccharide repeating unit of the...
2016/0137723 MONOCLONAL ANTIBODIES THAT REACT WITH THE CAPSULE OF BACILLUS ANTHRACIS
The present disclosure relates to monoclonal antibodies that bind poly-.gamma.-D-glutamic acid (.gamma.DPGA), which is present on the surface of Bacillus...
2016/0137722 HUMANIZED MONOCLONAL ANTIBODIES THAT SPECIFICALLY BIND AND/OR NEUTRALIZE JAPANESE ENCEPHALITIS VIRUS (JEV) AND...
Disclosed herein are isolated humanized monoclonal antibodies that specifically bind Japanese encephalitis virus (JEV) with a binding affinity of about 1.0 nM...
2016/0137721 ANTIBODIES AGAINST INFLUENZA VIRUS HEMAGGLUTININ AND USES THEREOF
Provided herein are antibodies that cross-react with hemagglutinin from strains of influenza virus of the same subtype or different subtypes, host cells for...
2016/0137720 METHOD FOR REFINING PROTEIN INCLUDING SELF-CUTTING CASSETTE AND USE THEREOF
The present invention relates to a self-cleaving fusion protein including a target protein, a peptide consisting of amino acid sequence represented by LPXTG, a...
2016/0137719 PROCESS FOR PRODUCING HIGH PURITY FIBRINOGEN AND THROMBIN FOR FIBRIN SEALANT
The present invention relates to a fibrin sealant kit comprising purified fibrinogen and thrombin. The invention particularly relates to an improved...
2016/0137718 Stabilized Receptor Polypeptides and Uses Thereof
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A,...
2016/0137717 USE OF A VEGF ANTAGONIST IN TREATING CHOROIDAL NEOVASCULARISATION
The present invention relates to the use of a non-antibody VEGF antagonist, in the treatment of choroidal neovascularisation secondary to diseases other than...
2016/0137716 THERAPEUTIC DELIVERY VESICLES
The present invention pertains to inter alia therapeutic delivery vesicles, for instance exosomes or microvesicles, comprising polypeptide constructs, methods...
2016/0137715 T CELL RECEPTORS
The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from .alpha. Fetoprotein...
2016/0137714 PEPTIDES WITH ENHANCED STABILITY AND THEIR USE IN METHODS FOR TREATING DISEASES
The invention provides peptides that are useful for treating or preventing, or preventing the progression of a disorder associated with aberrant TDF...
2016/0137713 FCRN-SPECIFIC HUMAN ANTIBODY AND COMPOSITION FOR TREATMENT OF AUTOIMMUNE DISEASES
The present invention relates to a human antibody specific for FcRn that is a receptor with a high affinity for IgG, a production method thereof, a composition...
2016/0137712 Fusion Proteins With Dual Receptor Agonist Activities
The present disclosure relates to heterodimeric fusion proteins comprising two polypeptides, the first polypeptide comprising a first peptide (P1), a linker...
2016/0137711 GLUCAGON-LIKE PEPTIDE-2 COMPOSITIONS AND METHODS OF MAKING AND USING SAME
The present invention relates to compositions comprising GLP-2 protein or variants thereof linked to extended recombinant polypeptide (XTEN), isolated nucleic...
2016/0137710 PEPTIDOMIMETIC MACROCYCLES
The present invention provides peptidomimetic macrocycles capable of modulating growth hormone levels and methods of using such macrocycles for the treatment...
2016/0137709 ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The...
2016/0137708 IL-1 FAMILY VARIANTS
The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
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