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Patent # Description
2016/0145262 NEW POLYMORPHIC FORMS OF ICOTINIB PHOSPHATE AND USES THEREOF
Disclosed is Icotinib phosphate (i.e., the compound of Formula (I)) and polymorph forms thereof, and methods of preparing and using them. ##STR00001##
2016/0145261 FREE BASE CRYSTALS
The present invention relates to crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluor- ...
2016/0145260 STABLE PEMETREXED ARGININE SALT AND COMPOSITIONS COMPRISING IT
The present invention relates to arginine salt of pemetrexed of formula (1), particularly to a stable solid form thereof, and to pharmaceutical compositions...
2016/0145259 CXCR7 ANTAGONISTS
Compounds having formula I, ##STR00001## or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and...
2016/0145258 Inhibitor Crystalline Form and Preparation Method and Use Thereof
The present invention relates to a new crystalline forms of the inhibitor, 5-fluoro-3-phenyl-2-[(S)-1-(9H-purin-6-ylamino)-propyl]-3H-quinazoline-4-- one;...
2016/0145257 SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
2016/0145256 PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaz- a-spiro[4.5]decan-2-one...
2016/0145255 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
Compounds of Formula I: ##STR00001## are HIV reverse transcriptase inhibitors, wherein R.sup.1, R.sup.2, R.sup.E, L, M and Z are defined herein. The compounds of...
2016/0145254 TRIAZOLOPYRIDINE COMPOUND, AND ACTION THEREOF AS PROLYL HYDROXYLASE INHIBITOR OR ERYTHROPOIETIN...
The present invention provides a triazolopyridine compound having a prolyl hydroxylase inhibitory action and an erythropoietin production-inducing ability. The...
2016/0145253 SALTS OF AZA-BICYCLIC DI-ARYL ETHERS AND METHODS TO MAKE THEM OR THEIR PRECURSORS
The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane, to methods for making them or their...
2016/0145252 HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.
2016/0145251 INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE...
Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related...
2016/0145250 ANTI-CANCER COMPOUNDS
Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit Skp2 are provided....
2016/0145249 ALXR AGONIST COMPOUND
The present invention provides a compound having ALXR agonist activity. Specifically, the invention provides a compound having ALXR agonist activity...
2016/0145248 NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2016/0145247 Aminomethyl-Biaryl Derivatives Complement Factor D inhibitors and uses thereof
The present invention provides a compound of formula (I), a method for manufacturing the compounds of the invention, and its therapeutic uses. The present...
2016/0145246 NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the...
2016/0145245 KAPPA OPIOID AGONISTS AND USES THEREOF
Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The compounds of Formula I described herein relate to and/or...
2016/0145244 CERTAIN PROTEIN KINASE INHIBITORS
Provided are certain ALK inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
2016/0145243 Novel Anti-Cancer Agents
The present invention provides a compound of Formula (I), or a pharmaceutical acceptable derivative, salt or prodrug thereof. Further provided is a method of...
2016/0145242 PHENYLIMIDAZOLE DERIVATIVE, AND THERAPEUTIC MEDICINE OR PREVENTIVE MEDICINE FOR INFLAMMATORY DISEASE, ETC.
A medicinal active ingredient is provided which is useful for the treatment or prevention of inflammatory diseases, diseases caused by lipid oxidation,...
2016/0145241 STABLE CRYSTAL FORM OF TIPIRACIL HYDROCHLORIDE AND CRYSTALLIZATION METHOD FOR THE SAME
An objective of the present invention is to obtain a stable crystal form of 5-chloro-6-(2-iminopyrrolidin-1-yl)methyl-2,4(1H,3H)-pyrimidinedione hydrochloride....
2016/0145240 HETEROARYLAMINE DERIVATIVES AS PROTEIN KINASE INHIBITORS
A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for...
2016/0145239 DIAMINOHETEROARYL SUBSTITUTED PYRAZOLES
Compounds of formula (I), and their use as pharmaceuticals. ##STR00001##
2016/0145238 HETEROARYL SUBSTITUTED PYRAZOLES
Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals. ##STR00001##
2016/0145237 PROTEIN TYROSINE KINASE MODULATORS AND METHODS OF USE
Heterocyclic pyrimidine compounds that modulate mutant-selective epidermal growth factor receptor (EGFR) and ALK kinase activity are disclosed. More...
2016/0145236 4-(3-CYANOPHENYL)-6-PYRIDINYLPYRIMIDINE MGLU5 MODULATORS
The disclosures herein relate to novel compounds of formula wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and n are defined here, and their use in treating,...
2016/0145235 ARYL SULFIDE DERIVATIVES AND ARYL SULFOXIDE DERIVATIVES AS ACARICIDES AND INSECTICIDES
The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests...
2016/0145234 METHOD FOR PRODUCING CYCLIC CARBONATE
Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide, the method being capable of efficiently producing a...
2016/0145233 METHODS OF MAKING ALKYLENE CARBONATES AND METHODS OF CONVERTING CO2
Embodiments of the present disclosure provide for a method of making an alkylene carbonate, catalysts, methods of converting CO.sub.2 to an alkylene carbonate,...
2016/0145232 2-OXO-1,3-DIOXOLANE-4-ACYL HALIDES, THEIR PREPARATION AND USE
The present invention suggests 2-oxo-1,3-dioxolane-4-acyl halides of formula (I), ##STR00001## wherein X is selected from F, Cl, Br, I and mixtures thereof,...
2016/0145231 RESIST COMPOSITION, METHOD FOR FORMING RESIST PATTERN, POLYPHENOLIC COMPOUND FOR USE IN THE COMPOSITION, AND...
A resist composition containing a compound represented by the general formula (1) or (2), a method for forming a resist pattern using the composition, a...
2016/0145230 AGENT CONTAINING FLAVONOID DERIVATIVES FOR TREATING CANCER AND INFLAMMATION
A pharmaceutical composition for the prevention and treatment of cancer with specific flavanoid-based compounds selected from among the groups of Flavone,...
2016/0145229 EXTRACTION SEPARATION METHOD OF A FLAVONE COMPONENT BASED ON GRAPHENE
The present invention refers to the technical field of flavone component extraction, and provides an extraction separation method of a flavone component based...
2016/0145228 FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES IN THE PRESENCE OF UREAS OR THIOUREAS
The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane...
2016/0145227 PROCESSES FOR CONVERSION OF BIOLOGICALLY DERIVED MEVALONIC ACID
The invention relates to a process comprising reacting mevalonic acid, or a solution comprising mevalonic acid, to yield a first product or first product...
2016/0145226 PROCESS FOR PREPARING PHTHALIC ANHYDRIDE
The present invention relates to a process for preparing phthalic anhydride by gas phase oxidation of aromatic hydrocarbons, in which a gas stream comprising...
2016/0145225 PRODRUGS OF PHENOLIC TRPV1 AGONISTS
Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate...
2016/0145224 PROCESS FOR THE PREPARATION OF AN ANTIDEPRESSANT AND THE INTERMEDIATES THEREOF
The present invention relates to a process for the preparation of 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine of formula (I), also known as...
2016/0145223 Bicyclyl-Substituted Isothiazoline Compounds
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula I ##STR00001## wherein the variables are as defined in the claims and...
2016/0145222 Methods for Controlling Pests in Soybean
The present invention relates to agricultural methods for controlling pests on soybean plants and soybean crops and the general use of isothiazoline compounds...
2016/0145221 METHOD FOR PRODUCING POLYISOCYANATES COMPRISING IMINOOXADIAZINEDIONE GROUPS AND USE OF THESE
The present invention relates to a method for producing polyisocyanates comprising iminooxadiazinedione groups, wherein at least one monomeric di- and/or...
2016/0145220 NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND
The present invention provides a nitrogen-containing saturated heterocyclic compound of the formula [I]: ##STR00001## wherein R.sup.1 is a cycloalkyl group and...
2016/0145219 STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI
The present invention relates to novel strobilurine type compounds, to compositions comprising at least one such compound, to methods for combating...
2016/0145218 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE MODULATORS OF GPR139
The present invention provides a method for treating a disease, disorder or condition associated with GPR139 using compounds of formula 1: ##STR00001## which are...
2016/0145217 METHOD FOR PREPARING NITROGEN-CONTAINING AROMATIC COMPOUND BY CATALYTIC PYROLYSIS OF ORGANIC MATERIAL
Provided is a method for preparing a nitrogen-containing aromatic compound through catalytic pyrolysis from organic materials. The method comprises: feeding...
2016/0145216 AMORPHOUS LETERMOVIR AND SOLID PHARMACEUTICAL FORMULATIONS THEREOF FOR ORAL ADMINISTRATION
The present invention provides for amorphous Letermovir and orally administrable solid pharmaceutical formulations thereof (immediate release formulation)....
2016/0145215 PROCESS FOR PREPARING A PYRIMIDINE INTERMEDIATE
The present invention relates to a process for preparing a pyrimidine intermediate, namely the compound of formula I-2 or a salt thereof. Said compound of...
2016/0145214 New Family of Discriminating Molecules for Neutron and Gamma Rays and Ionic Liquids
The invention concerns a new family of discriminating molecules for neutron rays and gamma rays, and method for preparing the same. These molecules are also...
2016/0145213 HETEROCYCLIC COMPOUNDS AND METHODS OF THEIR USE
The present invention relates generally to compounds that are useful in antagonizing the angiotensin II type 2 (AT.sub.2) receptor. More particularly, the...
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