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Patent # Description
2016/0144062 USE OF HER2 BINDERS
A method of use of an isolated polypeptide conjugated with a radionuclide, wherein the isolated polypeptide binds specifically to HER2, or a variant thereof is...
2016/0144061 Compositions and Imaging Methods Comprising Detectably Labeled Phosphatidylethanolamine-Binding Peptides
Disclosed are surprising discoveries concerning the role of anionic phospholipids and aminophospholipids in tumor vasculature and in viral entry and spread,...
2016/0144060 Imaging of Meningiomas Using Phenylbenzothiazole, Stilbene, or Biphenylalkyne Derivatives
Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative,...
2016/0144059 MICROBUBBLE TETHER FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
The present disclosure relates to a composition of albumin microbubbles to which are bound one or more moieties that exhibit a binding preference for the...
2016/0144058 IR DYES FOR FLUORESCENCE IMAGING
A method for organ imaging, comprising: administering to a subject a diagnostic effective amount of ...
2016/0144057 Methods for Expressing a Polynucleotide of Interest in the Retina of a Subject
The present invention relates to methods for expressing a polynucleotide of interest in the retina of a subject. In particular, the present invention relates...
2016/0144056 Materials and Methods for the Treatment of Pathological Neovascularization in the Eye
The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of...
2016/0144055 GENE THERAPY VECTOR FOR TREATMENT OF STEROID GLAUCOMA
The presently disclosed subject matter provides an inducible vector comprising a therapeutic gene. In some embodiments a method is provided for treating...
2016/0144054 Vector(S) Containing an Inducible Gene Encoding a CDK4/CDK6 Inhibitor Useful for Treating Neurodegenerative...
Described are vectors containing (a) a gene encoding (i) a CDK4/CDK6 inhibitor, preferably p16INK4a, or (ii) an RNA interfering with CDK4 and/or CDK6...
2016/0144053 TREATMENT OF INTRACELLULAR BACTERIAL INFECTION
An intracellular bacterial infection in a plant or animal is treated by administration to a plant cell or animal cell of a particle to which an infectious...
2016/0144052 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF
A conjugate of formula (A): ##STR00001##
2016/0144051 LOGIC ELEMENT COMPLEX BASED ON BIOMOLECULES (VARIANTS)
The invention relates to the field of logic elements, specifically to logic elements based on biomolecules. The essence of the invention consists in a logic...
2016/0144050 PRODRUGS ACTIVATED BY CASPASE
Described are prodrug conjugates that release a chemotherapeutic agent upon activation by caspase, and methods using such prodrug conjugates to induce...
2016/0144049 CARRIERS FOR IMPROVED DRUG DELIVERY
The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that...
2016/0144048 Pegylated Hemoglobin and Albumin and Uses Thereof
The present invention provides PEGylated hemoglobins and PEGylated albumins comprising polyethylene glycol (PEG) conjugated to hemoglobin or to albumin,...
2016/0144047 N-OPTIONALLY SUBSTITUTED ARYL-2-OLIGOMER-3-ALKOXYPROPIONAMIDES
The invention relates to (among other things) N-optionally substituted aryl-2-oligomer-3-alkoxypropionamides and compositions comprising the same. A compound...
2016/0144046 POLYMERIC ALPHA-HYDROXY ALDEHYDE AND KETONE REAGENTS AND CONJUGATION METHOD
Provided herein are polymeric .alpha.-hydroxy aldehyde or .alpha.-hydroxy ketone reagents which can be conjugated to amine-containing compounds to form stable...
2016/0144045 MULTI-ARM POLYMERIC ALKANOATE CONJUGATES
Among other aspects, provided herein are multi-armed polymer conjugates comprising an alkanoate-linker, compositions comprising such conjugates, and related...
2016/0144044 Carboxymethylcellulose-Peptide Conjugates and Methods for Using the Same
Provided are compositions for repairing an injured tissue. The composition includes carboxymethylcellulose conjugated to an extracellular matrix derived...
2016/0144043 METHOD FOR CROSSLINKING HYALURONIC ACID; METHOD FOR PREPARING AN INJECTABLE HYDROGEL; HYDROGEL OBTAINED; USE OF...
The present invention relates to a method for crosslinking hyaluronic acid, a method for preparing an injectable hydrogel, the hydrogel thus obtained and its use.
2016/0144042 DESIGN AND DEVELOPMENT OF MASKED THERAPEUTIC ANTIBODIES TO LIMIT OFF-TARGET EFFECTS
In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a...
2016/0144041 CARRIER FOR DELIVERY OF SUBSTANCE TO PHAGOCYTES
An object of the present invention is to provide a low-cost and safe approach to efficient delivery of a substance to phagocytes. In particular, the present...
2016/0144040 DRUG SUSTAINED RELEASE AGENT BASED ON OLEANOLIC ACID AND A PREPARATION METHOD THEREOF
The present invention relates to the technical field of oleanolic acid drugs and provides a drug sustained release agent based on oleanolic acid and a...
2016/0144039 METHODS FOR ENHANCING STABILITY OF POLYORTHOESTERS AND THEIR FORMULATIONS
Disclosed herein are methods of enhancing the stability of a sustained pharmaceutical composition comprising an active agent and a polymer and methods of...
2016/0144038 WATER-SOLUBLE SUPRAMOLECULAR COMPLEXES
Water-soluble supramolecular complexes formed from a water soluble block copolymer and at least one associative gelling adjuvant. The copolymer includes at...
2016/0144037 ADJUVANT COMPOSITIONS AND RELATED METHODS
The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition...
2016/0144036 TIGECYCLINE COMPOSITIONS AND METHODS OF PREPARATION
The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these...
2016/0144035 FORMULATIONS OF BENDAMUSTINE
Methods of treatment using bendamustine formulations designed for small volume intravenous administration are disclosed. The methods conveniently allow shorter...
2016/0144034 FORMULATIONS OF BENDAMUSTINE
Methods of treatment using bendamustine formulations designed for small volume intravenous administration are disclosed. The methods conveniently allow shorter...
2016/0144033 CONCENTRATED ACETAMINOPHEN SOLUTION
A concentrated acetaminophen solution is provided that is dissolved in polyethylene glycol (PEG) with trace water. The acetaminophen is present in the PEG at a...
2016/0144032 COMPOSITION FOR NEW BONE FORMATION, AND NEW BONE FORMATION SYSTEM
Provided are a composition for new bone formation and a new bone formation system, which when used to fill a bone treatment site does not effuse from the...
2016/0144031 Photo-Responsive Compounds
The presently-disclosed subject matter provides photo-responsive compounds and methods of use thereof. The photo-responsive compounds comprise a photolabile...
2016/0144030 TECHNIQUES FOR RELEASE OF MATERIAL INTO AN ENVIRONMENT
Systems and methods for releasing a material into an environment. The material may be encapsulated in a receptacle or otherwise packaged for movement into the...
2016/0144029 Anti-ErbB3 Antibodies and Uses Thereof
The present invention provides antibodies that bind to ErbB3 and methods of using same. According to certain embodiments of the invention, the antibodies are...
2016/0144028 COMBINATION THERAPY USING DUAL INHIBITOR OF C-MET AND EGFR AND IGF-1R INHIBITOR
A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met and EGFR (hereinafter, `c-Met/EGFR dual...
2016/0144027 COMBINATION THERAPY USING C-MET INHIBITOR AND IGF-1R INHIBITOR
A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met (hereinafter, `c-Met inhibitor`) and an IGF-1R...
2016/0144026 Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
The invention provides a system that comprises pharmaceutical agents for use in immunotherapy for reducing the side-effects of an antigen-recognizing receptor...
2016/0144025 METHODS AND FORMULATIONS FOR TREATING VASCULAR EYE DISEASES
The present invention provides methods for treating, preventing or reducing the severity of an eye disease. The methods of the present invention comprise...
2016/0144024 Methods and Compositions for Preserving the Viability of Photoreceptor Cells
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells...
2016/0144023 DRY SOLID ALUMINUM ADJUVANT-CONTAINING VACCINES AND RELATED METHODS THEREOF
Described herein are dry vaccine compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry...
2016/0144022 MODIFIED MATRIX PROTEINS OF VESICULAR STOMATITIS VIRUS
The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic...
2016/0144021 Vaccine Composition And Method Of Use
Described herein is a vaccine composition and methods of use. In one embodiment, the vaccine composition includes RSV-F protein in combination with an...
2016/0144020 JOHNSON GRASS ALLERGENIC POLLEN PROTEINS, ENCODING NUCLEIC ACIDS AND METHODS OF USE
Allergenic Johnson Grass proteins, antibodies thereto and encoding nucleic acids are provided, which may be used for the diagnosis and/or therapy of...
2016/0144019 Novel Therapeutic and Diagnostic Means
Disclosed is a method for treatment of HIV related diseases comprising targeting complexes between on the one hand the C5 domain of gp120 and on the other hand...
2016/0144018 METHODS OF PREPARING ANTI-HUMAN PAPILLOMAVIRUS ANTIGEN T CELLS
Disclosed are methods of preparing an isolated population of human papillomavirus (HPV)-specific T cells comprise dividing an HPV-positive tumor sample into...
2016/0144017 Synthetic Antigen Constructs Against Campylobacter Jejuni
The invention relates to immunogenic synthetic constructs capable of inducing an immune response against Campylobacter jejuni (C. jejuni) in a subject...
2016/0144016 SYNTHETIC OLIGOSACCHARIDES FOR P. AERUGINOSA VACCINE
The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P....
2016/0144015 BORDETELLA OUTER-MEMBRANE PROTEIN ANTIGENS AND METHODS OF MAKING AND USING THE SAME
An isolated protein or peptide selected from the group consisting of Bordetella colonization factor A (BcfA) protein and antigenic fragments thereof is...
2016/0144014 COMPOSITIONS CONTAINING COMBINATIONS OF BIOACTIVE MOLECULES DERIVED FROM MICROBIOTA FOR TREATMENT OF DISEASE
Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery...
2016/0144013 Compositions and Methods for Preventing and Treating Salmonella Typhi and Salmonella Paratyphi Infection
The invention provides compositions and methods for preventing, treating and diagnosing infection by Salmonella enterica serovar typhi (S. typhi) and/or S....
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