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Patent # Description
2016/0153006 OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0153005 DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0153004 DELIVERY, ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR TARGETING AND MODELING DISEASES...
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0153003 Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing
Many studies have shown that CRISPR-Cas nucleases can tolerate up to five mismatches and still cleave; it is hard to predict the effects of any given single or...
2016/0153002 METHOD FOR CELL MEMBRANE PERMEATION FOR COMPOUND
The present invention discloses a cell-penetrating method for compounds, comprising the following steps of: (1) preparing raw materials, i.e., the compounds...
2016/0153001 METHODS FOR TRANSFORMING YEAST
This invention is directed to the transformation of yeast, and mutants thereof, by electroporation, which result in stably transformed yeast host cells that...
2016/0153000 NON-TOXIC HSV VECTORS FOR EFFICIENT GENE DELIVERY APPLICATIONS AND COMPLEMENTING CELLS FOR THEIR PRODUCTION
The invention provides a herpes simplex virus (HSV) vector that does not express toxic HSV genes in non-complementing cells and which comprises a genome...
2016/0152999 RHIZOMANIA-RESISTANT GENE
The present invention provides a new nucleic acid molecule which encodes a polypeptide that is able to convey a resistance to a pathogen, in particular to...
2016/0152998 Transgenic Expression Of Archaea Superoxide Reductase
This invention provides a stably transformed plant, plant part and/or plant cell, comprising a heterologous polynucleotide encoding a superoxide reductase...
2016/0152997 Enhanced Oil Production And Stress Tolerance In Plants
Provided are plants that express, or overexpress, type III G.gamma. protein AGG3. Such plants exhibit faster vegetative and reproductive growth, accompanied by...
2016/0152996 PLANT HEAT-RESISTANCE GENE JAZ5A AND USE THEREOF
The present invention provides a heat-resistance plant gene JAZ5a and use thereof. The inventors of the present invention isolated for the first time a heat...
2016/0152995 METHODS AND COMPOSITIONS TO IMPROVE THE SPREAD OF CHEMICAL SIGNALS IN PLANTS
Compositions and methods are provided which employ a chemical-gene switch which may comprise at least three components. The first component comprises a...
2016/0152994 METHODS CONTROLLING GENE EXPRESSION
The present invention is in the field of genetics, especially plant genetics, and provides agents capable of controlling gene expression. The present invention...
2016/0152993 Promoters for Expressing Genes in a Fungal cell
The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides...
2016/0152992 PROMOTER EXHIBITING HIGH EXPRESSION ACTIVITY IN MORTIERELLA MICROORGANISMS
The present invention aims to provide a promoter showing high expression activity in microorganisms belonging to the genus Mortierella. The present invention...
2016/0152991 RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode...
2016/0152990 Polypeptide Containing DNA-Binding Domain
The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting...
2016/0152989 MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF (2-HYDROXY-3METHYL-4-OXOBUTOXY) PHOSPHONATE
The invention provides non-naturally occurring microbial organisms having a (2-hydroxy-3-methyl-4-oxobutoxy)phosphonate pathway, p-toluate pathway, and/or...
2016/0152988 COMPOSITIONS AND METHODS FOR EFFICACIOUS AND SAFE DELIVERY OF SIRNA USING SPECIFIC CHITOSAN-BASED NANOCOMPLEXES
There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through...
2016/0152987 COMPOSITIONS AND METHODS FOR CONTROLLED DELIVERY OF INHIBITORY RIBONUCLEIC ACIDS
Polymeric nanoparticles encapsulating inhibitory ribonucleic acids (RNAs) and methods of their manufacture and use are provided. Advantageous properties of the...
2016/0152986 METHODS AND MATERIALS FOR TREATING CANCER
This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate,...
2016/0152985 COMPOSITIONS AND METHODS FOR TREATING CANCER
This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic...
2016/0152984 ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of...
2016/0152983 NOVEL RIG-I LEGANDS AND METHODS FOR PRODUCING THEM
The present invention relates to new triphosphate-modified oligonucleotides which may act as RIG-I ligands as well as a new method allowing the synthesis and...
2016/0152982 APTAMERS AGAINST GLIOMA CELLS
Provided are aptamers able to bind to ligands associated with cancer cells. The ligands may particularly be associated with brain cancers, such as gliomas. The...
2016/0152981 APTAMERS AND USE OF THE APTAMERS IN THE DIAGNOSIS AND TREATMENT OF CANCER
The present invention relates to an aptamer comprising a nucleotide sequence SEQ ID NO: 1, a composition comprising an aptamer, and the use of the aptamer in...
2016/0152980 METHOD OF REGULATING GENE EXPRESSION
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs...
2016/0152979 NOVEL COMPOUNDS
Disclosed herein are novel compounds having the general formula (I): Q-L-A1 (I) wherein Q is a Q10 moiety, such as ubiquinone; L, which is optionally included,...
2016/0152978 SELECTIVE REDUCTION OF THE DELETERIOUS ACTIVITY OF EXTENDED TRI-NUCLEOTIDE REPEAT CONTAINING GENES
Aspects of the invention include methods of selectively reducing the deleterious activity of mutant extended trinucleotide repeat containing genes in a cell,...
2016/0152977 ANALYZING METHOD FOR MICRO RNA ID AND BIOMARKERS RELATED TO COLON CANCER THROUGH THIS METHOD
The present invention relates to an analysis method for the mi-RNA ID. More specifically, the invention relates to improve the analysis capabilities of the...
2016/0152976 COMPOUND ADMINISTRATION PRECURSOR AND MEDICAMENT CARRIER PREPARATION
The present invention provides a compound drug-delivery precursor for membrane permeation, and a drug carrier preparation based on this precursor. The compound...
2016/0152975 METHOD FOR RECOMBINANT PROTEIN PRODUCTION IN MAMMALIAN CELLS
Some embodiments relate to methods for the recombinant expression of a protein of interest in a mammalian host cell, use of an sh RNA or an si RNA directed...
2016/0152974 COMPOUNDS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION FOR IMPROVING A DIABETIC PROFILE
Provided herein are improved compounds, compositions and associated methods for reducing expression of ApoCIII mRNA and protein in a subject having, or at risk...
2016/0152973 CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID MOLECULES THAT MEDIATE RNA INTERFERENCE
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond...
2016/0152972 METHODS FOR ASSEMBLING AND READING NUCLEIC ACID SEQUENCES FROM MIXED POPULATIONS
The disclosure relates to methods for obtaining nucleic acid sequence information by constructing a nucleic acid library and reconstructing longer nucleic acid...
2016/0152971 Method for Selecting Polynucleotides Encoding Antigen-Specific Immunoglobulin Subunits
The present invention relates to a high efficiency method of expressing immunoglobulin molecules in eukaryotic cells. The invention is further drawn to a...
2016/0152970 METHOD FOR NUCLEI STROAGE
A method of performing data management in a high-speed data environment. The method includes collecting time-series information including multiple data types...
2016/0152969 NUCLEIC ACID EXTRACTION DEVICE
A nucleic acid extraction device includes a tube part in which a first plug of an oil, a second plug of a cleansing liquid not miscible with the oil for...
2016/0152968 HIGH POTENCY PANCREATIN PHARMACEUTICAL COMPOSITIONS
The present invention provides high potency pharmaceutical compositions comprising high activity pancreatin enzymes. The invention is also directed to a...
2016/0152967 PSICOSE EPIMERASE MUTANT AND METHOD FOR PREPARING PSICOSE BY USING SAME
The present invention relates to: a D-psicose 3-epimerase mutant from Agrobacterium tumefaciens with improved thermal stability; a recombinant vector...
2016/0152966 LEUCINE BETA ROLL DOMAINS AND USES THEREOF
In one aspect, the invention relates to a peptide that forms a calcium-dependent hydrogel using a rationally engineered beta roll peptide. In the absence of...
2016/0152965 TRANSGENIC FACTOR VII HAVING A SPECIFIC N-GLYCOSYLATION AND SUBSTANTIALLY HOMOGENOUS ISOELECTRIC POINT
The present invention relates to a factor VII composition having a substantially homogeneous isoelectric point and to a method for formulating such a...
2016/0152964 RECOMBINANT AUTO-ACTIVATING PROTEASE PRECURSORS
A recombinant serine protease precursor that auto-activates in an aqueous buffer to form a mature active enzyme is disclosed. A contemplated precursor contains...
2016/0152963 Protease Variants and Polynucleotides Encoding Same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2016/0152962 SUBTILASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2016/0152961 Polypeptides Having Endoglucanase Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2016/0152960 GLUCOAMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to glucoamylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
2016/0152959 PEPTIDE LINKERS FOR POLYPEPTIDE COMPOSITIONS AND METHODS FOR USING SAME
Disclosed herein are novel peptide linkers and polypeptide compositions comprising the linkers (e.g., chimeric polypeptides) and methods of using the...
2016/0152958 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION
Disclosed are mutant DNA polymerases having increased 3'-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are...
2016/0152957 Methods of Producing 6-Carbon Monomers From 8-Carbon Compounds
This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a monooxygenase to form a 7-hydroxyoctanoate intermediate, which can be...
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