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Patent # Description
2016/0152706 RNA-CODED ANTIBODY
The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of...
2016/0152705 USE OF A CD6 BINDING PARTNER AND METHOD BASED THEREON
The present disclosure relates to methods for treatment and prevention of disease conditions mediated by T-helper 17 (Th17) and/or T-helper 1 (Th1) T...
2016/0152704 CADHERIN 15 AGONISTS
CDH15 has been identified as a receptor for a peptide which has an inhibitory effect of the migration of T cells. Agonists of this receptor have applications...
2016/0152703 ANTI-CDH3 HUMANIZED ANTIBODY, DRUG CONJUGATE THEREOF, AND USE THEREOF
It is an object of the present invention to produce an anti-CDH3 humanized antibody having lower immunogenicity, and to provide an anti-CDH3 humanized antibody...
2016/0152702 METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention...
2016/0152701 INDUCIBLE EXPRESSION SYSTEM
The present invention is an inducible coexpression system, capable of controlled induction of expression of each gene product.
2016/0152700 Antigen Binding Proteins Capable of Binding Thymic Stromal Lymphopoietin
The present disclosure provides compositions and methods relating to antigen binding proteins which bind to human thymic stromal lymphopoietin (TSLP),...
2016/0152699 PAN-ELR+ CXC CHEMOKINE ANTIBODIES
Antibodies are provided that specifically bind seven human ELR.sup.+ CXC chemokines. The antibodies of the invention are useful for treating various...
2016/0152698 ANTI-NGF ANTIBODIES AND METHODS USING SAME
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use...
2016/0152697 METHODS, COMPOSITIONS AND APPARATUSES FOR FACILITATING REGENERATION
A polypeptide having at least 70% homology, in particular 80%, 90% or 95% homology to the polypeptide of SEQ ID No 2 representing the wild-type of the protein...
2016/0152696 ANTIBODIES TO 2-GLYCOPROTEIN I AND THERAPEUTIC USES THEREOF
Human recombinant antibodies or fragments thereof having specificity for the .beta.2-glycoprotein I (.beta.2GPI), pharmaceutical compositions containing same...
2016/0152695 METHODS AND DEVICE TO NEUTRALIZE SOLUBLE TOXIC AGENTS IN THE BRAIN
Methods, agents and devices for treating a patient to reduce accumulation of certain proteins in the brain are described. Such proteins include amyloid beta...
2016/0152694 ANTIBODIES AGAINST CLOSTRIDIUM DIFFICILE TOXINS AND USES THEREOF
Antibodies that specifically bind to toxins of C. difficile, antigen binding portions thereof, and methods of making and using the antibodies and antigen...
2016/0152693 AMINO ACID SEQUENCES DIRECTED AGAINST ENVELOPE PROTEINS OF A VIRUS AND POLYPEPTIDES COMPRISING THE SAME FOR THE...
The present invention relates in part to amino acid sequences that are directed against and/or that can specifically bind to an envelope protein of a virus, as...
2016/0152692 INFLUENZA VIRUS-NEUTRALIZING ANTIBODY AND SCREENING METHOD THEREFOR
Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized...
2016/0152691 RNA-CODED ANTIBODY
The present application describes an antibody-coding, non-modified or modified RNA and the use thereof for expression of this antibody, for the preparation of...
2016/0152690 PROCESS FOR INCREASED YIELD OF IMMUNOGLOBULIN FROM HUMAN PLASMA
The present invention discloses a preparation method for large scale production of human immunoglobulins (IgG) with high yields by an improved ...
2016/0152689 COMPOSITIONS AND METHODS FOR INHIBITING THROMBOGENESIS
The invention is directed to a composition comprising an (one or more) isolated peptide comprising a BF01 peptide, variants of a BF01 peptide and/or mutants of...
2016/0152688 TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR
The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain...
2016/0152687 ALBUMIN FUSION PROTEINS
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by...
2016/0152686 FIBRONECTIN BASED SCAFFOLD DOMAINS LINKED TO SERUM ALBUMIN OR MOIETY BINDING THERETO
Provided herein are fusion proteins comprising a first moiety comprising a fibronectin based scaffold and a second moiety comprising serum albumin or a...
2016/0152685 SMALL MOLECULE-DEPENDENT INTEINS AND USES THEREOF
Elucidating the function of proteins in mammalian cells is particularly challenging due to the inherent complexity of these systems. Methods to study protein...
2016/0152684 IMMUNOGLOBULIN FC CONJUGATE WHICH MAINTAINS BINDING AFFINITY OF IMMUNOGLOBULIN FC FRAGMENT TO FCRN
The present invention relates to a physiologically active polypeptide-immunoglobulin Fc fragment conjugate, which comprises a physiologically active...
2016/0152683 NOVEL ACTIVIN RECEPTOR AND USES THEREOF
The present invention provides novel activin IIB5 receptor polypeptides capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11....
2016/0152682 ILT3 Polypeptides and Uses Thereof
This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all...
2016/0152681 ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS
Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E6.sub.29-38. Related...
2016/0152680 TARGETED THERAPEUTIC PROTEINS
Targeted therapeutics that localize to a specific subcellular compartment such as the lysosome are provided. The targeted therapeutics include a therapeutic...
2016/0152679 RELAXIN-LIKE COMPOUNDS AND USES THEREOF
The present invention is directed to novel relaxin-like compounds having at least one intramolecular or intramolecular bridge that is a bioisosteric...
2016/0152678 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF ONCOLOGY-RELATED PROTEINS AND PEPTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of oncology-related polynucleotides, oncology-related...
2016/0152677 SINGLE DOMAIN TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and...
2016/0152676 HELIX-GRAFTED PROTEINS AS INHIBITORS OF DISEASE-RELEVANT PROTEIN-PROTEIN INTERACTIONS
The disclosure provides helix grafted proteins, methods of producing helix grafted proteins and methods of use of helix grafted proteins as inhibitors of...
2016/0152675 COMPOSITIONS AND METHODS RELATED TO TAUOPATHY
Disclosed herein are isolated polypeptides, antibody preparations, treatment methods, diagnostic methods, and screening methods related to tauopathy....
2016/0152674 TDF-RELATED COMPOUNDS AND ANALOGS THEREOF
The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and...
2016/0152673 Dopaminergic Neuronal Survival-Promoting Factors and Uses Thereof
In general, the invention features substantially purified MANF and substantially purified nucleic acids encoding the same. The invention also features a...
2016/0152672 Reagents and Methods for Treating Dental Disease
The present invention provides reagents and methods for treating dental disease.
2016/0152671 CHLOROTOXIN POLYPEPTIDES AND CONJUGATES AND USES THEREOF
Reduced lysine chlorotoxin polypeptides that may be used to generate single species conjugates of chlorotoxin. Conjugates comprising such chlorotoxin...
2016/0152670 SELECTIVE DELIVERY MOLECULES AND METHODS OF USE
Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells...
2016/0152669 NOVEL POLYPEPTIDE, AND USE THEREOF
This invention provides a novel means that allows efficient secretion and production of a target protein in a host cell. This invention concerns a novel...
2016/0152668 Mutated Immunoglobulin-Binding Protein
The present invention relates to an immunoglobulin-binding protein, wherein at least one asparagine residue has been mutated to an amino acid other than...
2016/0152667 COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad repeat domain in a stabilized .alpha.-helical...
2016/0152666 RECOMBINANT VIRAL VECTORS
The present relation relates to recombinant vesicular stomatitis virus for use as prophylactic and therapeutic vaccines for infectious diseases of AIDS. The...
2016/0152665 Compositions and Methods of Treatment of Cancers
Described herein are compositions and methods useful to treat cancers. In addition, the present invention provides screening assays, diagnostic assays, methods...
2016/0152664 NOVEL a4B7 PEPTIDE MONOMER AND DIMER ANTAGONISTS
The invention relates to peptide dimer compounds and peptide monomer compounds that potently inhibit binding of .alpha.4.beta.7 to the mucosal addressin cell...
2016/0152663 USE OF RUTHENIUM COMPLEXES FOR FORMATION AND/OR HYDROGENATION OF AMIDES AND RELATED CARBOXYLIC ACID DERIVATIVES
A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular...
2016/0152662 LIGAND FUNCTIONAL SUBSTRATES
A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the...
2016/0152661 PROCESS FOR ISOLATION AND PURIFICATION OF A TARGET PROTEIN FREE OF PRION PROTEIN (PRPSC)
A process for isolation and purification of a target protein by chromatography wherein the chromatography removes or depletes prions (PrP.sup.Sc), comprising...
2016/0152660 AN ARRANGEMENT FOR A COLUMN, A METHOD FOR SUBSTITUTING A TUBULAR HOUSING IN SUCH AN ARRANGEMENT FOR A COLUMN...
An arrangement for a column comprising a stand provided with a platform adapted to receive a second end of a tubular housing and for supporting the arrangement...
2016/0152659 NOVEL SOLANIDINE-DERIVED COMPOUNDS
Novel solanidine-derived compounds, the synthesis method thereof and the uses of same in the fields of phytosanitary protection and health. In particular, the...
2016/0152658 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Described herein are neuroactive steroids of the Formula (I): (Formula (I)) or a pharmaceutically acceptable salt thereof; wherein R.sup.1a and R.sup.1b are as...
2016/0152657 Steroids as Agonists for FXR
The invention relates to compounds of formula (I): ##STR00001## wherein R is ethyl, propyl or allyl, and pharmaceutically acceptable salts, solvates or amino...
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