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Patent # Description
2016/0152606 HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof,...
2016/0152605 Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof
The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors...
2016/0152604 SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS
The present invention relates to substituted bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
2016/0152603 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2016/0152602 COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
2016/0152601 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and...
2016/0152600 SYNTHESIS OF (2S,5R)-5-ETHYNYL-1-PYRROLIDINE-2-CARBONITRILE
A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl- )glycyl}pyrrolidine-2-carbonitrile and salts thereof, and...
2016/0152599 INDOLE AND PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Compounds of formula (I): ##STR00001## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, R.sub.5, A.sub.1, A.sub.2, T and W are as defined in the...
2016/0152598 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
The present invention provides a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity and useful as an agent for the...
2016/0152597 COMPOSITIONS AND METHODS FOR TREATING SCHIZOPHRENIA
The disclosure provides a novel polymorph of Compound (I): ##STR00001## 2-((1-(2-(4-Fluorophenyl)-2-oxoethyl)piperidin-4-yl)methyl)isoindolin-1-o- ne...
2016/0152596 Nuclear Transport Modulators and Uses Thereof
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds...
2016/0152595 INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
2016/0152594 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
2016/0152593 PROCESS FOR THE PREPARATION OF 3-(3-CHLORO-1H-PYRAZOL-1-YL)PYRIDINE
3-(3-Chloro-1H-pyrazol-1-yl)pyridine is prepared by cyclizing 3-hydrazinopyridine-dihydrochloride with commercially available 3-ethoxyacrylonitrile to provide...
2016/0152592 IMIDAZOLE DIKETONE COMPOUND AND USE THEREOF
Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione...
2016/0152591 THE 5,6-DIMETHOXY-1,1-DIOXOBENZO[B]THIOPHENE-2-METHYLOXYCARBONYL (DM-BSMOC) AND RELATED AMINO-PROTECTING GROUPS
Amino acid protecting groups are provided for use in peptide synthesis. Particular compounds disclosed include 5,6-dimethoxy-1,1-dioxobenzo[b]thiophi...
2016/0152590 Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors
Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved...
2016/0152589 LIQUID CRYSTAL COMPOUND HAVING 2, 6-DIFLUOROPHENYL ETHER STRUCTURE AND LIQUID CRYSTAL COMPOSITION THEREOF
The present invention relates to a compound having 2,6-difluorophenyl ether structure and useful as an organic electronic material and a medicine/agrochemical,...
2016/0152588 FORMATION OF CHIRAL 4-CHROMANONES USING CHIRAL PYRROLIDINES
The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane...
2016/0152587 LIQUID-CRYSTALLINE MEDIUM
The invention relates to a liquid-crystalline medium which comprises at least one compound of the formula I, ##STR00001## in which R.sup.1, R.sup.1*, Z.sup.1,...
2016/0152586 PROCESS FOR STARTING UP A GAS PHASE OXIDATION REACTOR
A process for preparing carboxylic acids and/or carboxylic anhydrides by gas phase oxidation of aromatic hydrocarbons, in which a gas stream comprising at...
2016/0152585 PROCESS FOR THE PRODUCTION OF FURANIC COMPOUNDS COMPRISING AT LEAST ONE AMINE FUNCTION
Disclosed is a process for the production of furanic compound comprising at least one amine function, comprising reacting a furanic compound having at least...
2016/0152584 PIPERAZINE SUBSTITUTED BRIDGED SPIRO[2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AGONISTS
The present invention relates to a piperazine substituted bridged spiro[2.4]heptane derivative of formula (I), ##STR00001## its preparation and its use as...
2016/0152583 COMPOSITE CONTAINING CATALYTIC METAL NANOPARTICLES, AND USE FOR SAME
Provided is a material that, when compared with SAPd, exhibits the similar activity in cross-coupling (CC) reactions, can decrease the amount of catalytic...
2016/0152582 THERAPEUTIC COMPOUNDS
Compounds of formula I': ##STR00001## or salts thereof are provided. Pharmaceutical compositions comprising a compound of formula I', processes for preparing...
2016/0152581 5,6-DIHYDRO-2H-[1,4]OXAZIN-3-YL-AMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE)
The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-ylamine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid...
2016/0152580 PROCESS FOR PREPARING HEONONE (METH)ACRYLATE
The invention relates to a process for preparing heonone (meth)acrylate by transesterification of alkyl (meth)acrylate with heonone, which comprises the steps:...
2016/0152579 OXAZOLIDINONE DERIVATIVES AS PPAR LIGANDS
The present invention relates to a family of differently substituted oxazolidinones and to the pharmaceutically acceptable salts, esters, prodrugs, tautomers,...
2016/0152578 CRYSTALLINE MODIFICATIONS OF PROTHIOCONAZOLE
There is disclosed a crystalline DMSO solvate of prothioconazole as well as amorphous prothioconazole. Methods for making these solid forms, microbicidal...
2016/0152577 2,4-Diaminoquinazolines for Spinal Muscular Atrophy
2,4-Diaminoquinazolines of formulae I-IV and VI ##STR00001## are useful for treating spinal muscular atrophy (SMA).
2016/0152576 AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the...
2016/0152575 AMORPHOUS FORM OF AN AKT INHIBITING PYRIMIDINYL-CYCLOPENTANE COMPOUND, COMPOSITIONS AND METHODS THEREOF
Disclosed is (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cy- ...
2016/0152574 HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
The present invention provides compounds, including pharmaceutically acceptable salts thereof, comprising the Formula I: ##STR00001## Also provided are methods...
2016/0152573 BIOORTHOGONAL METHODS AND COMPOUNDS
The invention provides a new bioorthogonal deprotection method for preparing heterocyclic compounds by bond cleavage using palladium. The methods have general...
2016/0152572 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS
The invention relates to the compounds of formula I, formula II, formula III and formula IV or its pharmaceutical acceptable polymorphs, solvates, enantiomers,...
2016/0152571 Electrically Conducting Oligo(pyrazoles)
An electrically conducting organic oligomer comprising 3-amino-1H-pyrazole-4-carbonitrile, 3-amino-1H-pyrazole-4-carboxylic acid, 3-amino-4-nitro-1H-pyrazole,...
2016/0152570 PPAR-SPARING COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
The present invention relates to hydroxamate compounds and pharmaceutical compositions that are useful for treating and/or preventing metabolic inflammation...
2016/0152569 PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING
The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the...
2016/0152568 METAL-ORGANIC MATERIALS AND METHOD FOR PREPARATION
The present invention provides metal-organic materials, more specifically organometallic polymers, comprising polypyridyl organic ligands such as ...
2016/0152567 NOVEL ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF
The present invention relates generally to novel allosteric regulators of proteasome activity, methods for preparation and use, and pharmaceutical compositions...
2016/0152566 TRICYCLIC PYRROLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
The invention refers to compounds of general formula (I) ##STR00001## wherein the variables take the various meanings, pharmaceutical compositions containing...
2016/0152565 AMORPHOUS TECOVIRIMAT PREPARATION
Disclosed are methods for the preparation of amorphous N-[(aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-eth- ...
2016/0152564 METHOD FOR STEPWISE SEPARATING AMINO ACID ACTIVE INGREDIENTS OF CAMELLIA NITIDISSIMA CHI
The present invention relates to the technical field of Camellia nitidissima Chi processing and application, and provides a method for stepwise separating...
2016/0152563 SOLID SUPPORTED TRITHIOL COMPOUNDS FOR REMOVING HEAVY METALS FROM SOLUTION, AND FILTRATION SYSTEMS UTILIZING...
Solid-supported trithiol compounds are prepared. The solid-supported trithiol compounds have formula (I): ##STR00001## in which R is a linker moiety, X is a...
2016/0152562 POLYMORPHS OF N- (2 -METHOXYBENZOYL) -4- [ (METHYLAMINOCARBONYL) AMINO] BENZENESULFONAMIDE
The present invention relates to solid forms of herbicide safeners, to processes for their preparation, compositions comprising the solid forms and methods of...
2016/0152561 SULFONAMIDES AS MODULATORS OF SODIUM CHANNELS
The invention relates to compounds of formula I or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: (I). The invention also...
2016/0152560 Compounds for the treatment of hypertension and hypertensive end stage renal disease
This disclosure relates to compounds and compositions useful for the treatment of hypertension and hypertensive renal disease.
2016/0152559 PROCESS FOR THE PREPARATION OF URETHANES
Urethanes are prepared by oxidative carbonylation of at least one amino compound in the presence of carbon monoxide, oxygen and organic, at least one...
2016/0152558 METHOD FOR PRODUCING ISOCYANATES
The invention relates to a method for producing an isocyanate by reacting the corresponding primary amine with phosgene in a reactor (100) which comprises at...
2016/0152557 QUINONE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER
A quinone derivative represented by general formula (1), ##STR00001## where, in the general formula (1), R.sub.1 and R.sub.2 each represent, independently of one...
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