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Patent # Description
2016/0159782 INHIBITORS OF EZH2
The present invention relates to compounds that inhibit activity of the histone lysine N-methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical...
2016/0159781 CHEMICAL COMPOUNDS
The invention relates to pyrrolone compounds of the formula (I) wherein X, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification. Furthermore,...
2016/0159780 STRIGOLACTONE FORMULATIONS AND USES THEREOF
Disclosed herein plant propagation materials, methods of manufacturing, formulations and uses thereof. The plant propagation materials disclosed herein may...
2016/0159779 CO-CRYSTAL OF THE PAR-1 RECEPTOR ANTAGONISTS VORAPAXAR AND ASPRIN
This invention relates to a co-crystal of vorapaxar and aspirin. The inventive co-crystal antagonizes the PAR-1 receptor. This invention also provides for...
2016/0159778 NOVEL UREIDO DERIVATIVES OF NAPHTHALENESULFONIC ACIDS
Objects of the present invention are novel ureido derivatives of naphthalensulfonic acids, pharmaceutical compositions comprising such derivatives, a process...
2016/0159777 CROSSLINKING REAGENTS, METHODS, AND COMPOSITIONS FOR STUDYING PROTEIN-PROTEIN INTERACTIONS
The invention provides reagents, methods, and compositions for studying protein-protein interactions. The inventive system and methods allow the analysis of...
2016/0159776 BENZIMIDAZOLE-2-PIPERAZINE HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME, PREPARATION...
The present invention relates to a class of benzimidazole-2-piperazine heterocyclic derivatives, a preparation method and medical use thereof. Specifically,...
2016/0159775 BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders,...
2016/0159774 HETEROARYL COMPOUNDS AND USES THEREOF
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
2016/0159773 HETEROCYCLIC COMPOUND
The present invention provides an agent for the prophylaxis or treatment of autoimmune diseases (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel...
2016/0159772 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of...
2016/0159771 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described...
2016/0159770 Herbicidal Azines
The present invention relates to diaminotriazine compounds of the formula (I) ##STR00001## wherein A and R.sup.1-R.sup.5 are as defined herein, and their use as ...
2016/0159769 Pyrimidine Compounds for the Treatment of Hepatitis C
The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The...
2016/0159768 ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME
Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of...
2016/0159767 CHEMICAL COMPOUNDS
The invention relates to pyrrolone compounds of the formula (I) wherein X, R.sup.1, R.sup.2, R.sup.3 and A are as defined in the specification. Furthermore,...
2016/0159766 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO
This document discloses molecules having the following formula ("Formula One"): ##STR00001## and processes related thereto.
2016/0159765 LIQUID CRYSTAL COMPOUND HAVING 2, 6-DIFLUOROPHENYLETHER STRUCTURE, AND LIQUID CRYSTAL COMPOSITION CONTAINING...
The present invention relates to a compound having a 2,6-difluorophenylether structure useful as organic electronic materials, pharmaceuticals and...
2016/0159764 METHOD FOR PRODUCING ELLAGIC ACID COMPOSITION
Provided is a production method for an ellagic acid composition excellent in solubility in water. The production method for an ellagic acid composition...
2016/0159763 POLYMERIZABLE COMPOUNDS AND THE USE THEREOF IN LIQUID-CRYSTAL DISPLAYS
The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical,...
2016/0159762 PROCESS FOR PRODUCING FURAN FROM FURFURAL FROM BIOMASS
A process is described for producing furan from furfural from biomass, wherein furfural in an aqueous mass or stream from the liquefaction of biomass or a...
2016/0159761 ASSEMBLY FOR PRODUCING ALKYLENE OXIDES AND GLYCOL ETHERS
There is provided a manufacturing assembly for the production of an alkylene oxide and a stream of glycol ethers. The manufacturing assembly produces the...
2016/0159760 ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS
Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical...
2016/0159759 OXATHIAZINE DERIVATIVES AS ANTIBACTERIAL AND ANTICANCER AGENTS
New oxathiazin-like compounds and their derivatives are useful as antineoplastic and antimicrobial agents. Compositions and methods of using oxathiazin-like...
2016/0159758 3-(2-AMINO-ETHYL)-ALKYLIDENE)-THIAZOLIDINE-2,4-DIONE AND 1-(2-AMINO-ETHYL)-ALKYLIDENE-1,3-DIHYDRO-INDOL-2-ONE...
3-(2-amino-ethyl)-5-[3-(4-substituted-phenyl)-alkylidene)-thiazolidine-2,- 4-dione and 1-(2-amino-ethyl)-3-alkylidene-1,3-dihydro-indol-2-one and derivatives...
2016/0159757 OXAZINE DERIVATIVES
The present invention provides, for example, a compound mentioned below as a medicament for treating or preventing the diseases induced by production,...
2016/0159756 FORMULATION OF METAXALONE
Dosage forms of metaxalone containing submicron particles of metaxalone and uses thereof are described. The submicron dosage forms have improved ...
2016/0159755 TETRAZOLINONE COMPOUND AND USE THEREOF
A tetrazolinone compound represented by formula (1): ##STR00001## Wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.11 each represents a halogen atom, a C1-C6 alkyl...
2016/0159754 COMPOUNDS FOR TREATMENT OF CYSTIC FIBROSIS
Described herein are compounds, compositions, and methods of their use for the treatment of cystic fibrosis.
2016/0159753 Methods for the synthesis of activated ethylfumarates and their use as intermediates
Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed...
2016/0159752 PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS
The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease,...
2016/0159751 NOVEL QUINAZOLINES AS BIOGENIC AMINE TRANSPORT MODULATORS
The present disclosure relates to certain amine derivatives of fused bicyclic heterocycles that inhibit the amine reuptake function of the biogenic amine...
2016/0159750 POLYMER FILM, RETARDATION FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND COMPOUND
Provided is a polymer film containing at least one of a compound represented by formula (1) of hydrates, solvates, or salts thereof. Y is a methine group or...
2016/0159749 METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES
The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.
2016/0159748 Novel Solid Forms Of Bendamustine Hydrochloride
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.
2016/0159747 METHOD FOR PREPARATION OF BENZIMIDAZOLE DERIVATIVES
The present invention provides a method for preparing a compound with a benzimidazole structure with an excellent yield using a low-cost starting material, not...
2016/0159746 HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING
In certain embodiments hydantoin compounds are provided herein that are effective to inhibit BACE activity against APP. Without being bound to a particular...
2016/0159745 PREPARATION OF (-)-HUPERZINE A
The present invention relates to a method for preparing (-)-huperzine A. The method involves: allowing a mixture of (.+-.)-huperzine A obtained from chemical...
2016/0159744 Quinoline Carboxamide and Quinoline Carbonitrile Derivatives as mGluR2-Negative Allosteric Modulators,...
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) ##STR00001## wherein ring A, R.sup.Q, -L-, R.sup.1, n,...
2016/0159743 FUSED HETEROCYCLIC COMPOUND
There is provided a compound having an excellent controlling effect on pests represented by the formula (1): ##STR00001## wherein, A.sup.1 represents...
2016/0159742 PROCESS FOR THE PREPARATION OF 4-AMINO-5-FLUORO-3-CHLORO-6-(SUBSTITUTED)PICOLINATES
4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a C.sub.1-C.sub.4 alkyl propiolate and a...
2016/0159741 METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS
Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the...
2016/0159740 INDOLE-3-CARBINOL DERIVATIVES
The present invention relates to novel stable indole-3-carbinol derivatives of Formula-I and its pharmaceutical composition and biological activity. The...
2016/0159739 AZACYCLIC CONSTRAINED ANALOGS OF FTY720
Small molecules comprised of azacyclic constrained analogs of FTY720 are provided. Formulations and medicaments are also provided that are directed to the...
2016/0159738 COVALENT INHIBITORS OF KRAS G12C
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods...
2016/0159737 PROCESS FOR THE PREPARATION OF A POLYUNSATURATED KETONE COMPOUND
The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of...
2016/0159736 Deuterated Rigosertib
This invention relates to novel substituted styryl benzylsulfones that are multikinase inhibitors and pharmaceutically acceptable acid addition salts thereof....
2016/0159735 COMPLEXES OF AGOMELATINE AND SULPHONIC ACIDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS...
Complexes of agomelatine and sulphonic acids of formula (I): ##STR00001## Medicinal products containing the same which are useful in treating disorders of the...
2016/0159734 PROCESS FOR OBTAINING ORGANIC ISOCYANATES FROM DISTILLATION RESIDUES FROM ISOCYANATE PREPARATION
The present invention relates to a process for obtaining organic isocyanate from a phosgenation product comprising the isocyanate, comprising the following...
2016/0159733 REACTION ACCELERATOR AND METHOD OF PRODUCING URETHANE COMPOUND, THIOURETHANE COMPOUND, AMIDE COMPOUND, OR UREA...
A reaction accelerator is provided which is used in a reaction of a compound including an isocyanate group that is not directly bonded to an aromatic ring in a...
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