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Patent # Description
2016/0158232 COMBINATIONS OF HISTONE DEACETYLASE INHIBITORS AND BENDAMUSTINE
The invention relates to pharmaceutical combinations comprising an HDAC inhibitor and bendamustine; pharmaceutical compositions comprising the same; and...
2016/0158231 PYRIMIDINE HYDROXY AMIDE COMPOUNDS FOR TREATING PERIPHERAL NEUROPATHY
The invention relates to HDAC inhibitors for the treatment of peripheral neuropathy in a subject in need thereof. Also provided herein are methods for treating...
2016/0158230 2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER
Provided are compounds of formula (I), wherein: ring A and ring B are each independently an optionally substituted 5-6 membered monocyclic aryl or heteroaryl;...
2016/0158229 Mixtures of Heteropolycycles
A mixture of heteropolycycles has preferably two particular heteropolycycles and more preferably, no more than 10 wt. %, 5 wt. %, 2.5 wt. %, 1 wt. %, 0.5 wt....
2016/0158228 SUSTAINED-RELEASE FORMULATION FOR INJECTION
The present invention relates to a composition comprising N-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]-(2R,3R)-2,3-tetramethyle- ...
2016/0158227 TABLET COMPRISING 7-[4-(4-BENZO[B]THIOPHEN-4-YL-PIPERAZIN-1-YL)BUTOXY)-1H-QUINOLIN-2-ONE OR A SALT THEREOF
This invention relates to a tablet containing, as an active ingredient, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl) butoxy]-1H-quinolin-2-one or a salt...
2016/0158226 ANTITUBERCULAR COMPOSITION COMPRISING RIFAMPICIN, ISONIAZID, ETHAMBUTOL AND PYRAZINAMIDE AND ITS PROCESS OF...
The present invention relates to a monolayer tablet for use in the treatment of tuberculosis comprising a mixture of: granules comprising isoniazid,...
2016/0158225 SUSTAINED RELEASE FORMULATION OF NALTREXONE
A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with...
2016/0158224 CONTROLLED RELEASE HYDROCODONE FORMULATIONS
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a...
2016/0158223 CONTROLLED RELEASE HYDROCODONE FORMULATIONS
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a...
2016/0158222 COMBINATIONS OF OPIOID/TLR4 ANTAGONIST AND A CYCLOOXYGENASE (COX) INHIBITOR FOR USE IN THE TREATMENT OF PAIN
Disclosed are compositions for treatment of pain comprising a first compound and a second compound, the first compound is an opioid antagonist that treats pain...
2016/0158221 SUSTAINED RELEASE FORMULATION OF NALTREXONE
A sustained-release oral dosage form of naltrexone or a pharmaceutically acceptable salt thereof is provided. The oral dosage form may be administered with...
2016/0158220 BENZOQUINOLINE INHIBITORS OF VESICULAR MONOAMINE TRANSPORTER 2
The present invention relates to new benzoquinoline inhibitors of vesicular monoamine transporter 2 (VMAT2), pharmaceutical compositions thereof, and methods...
2016/0158219 USE OF AN H4 AGONIST MOLECULE TO TREAT ACUTE LEUKEMIA
The present invention relates to the use of new chemical substances, the levogyre and dextrogyre enantiomers of (AMINO-7 TRIETHOXY-4, 5, 6 OXO-1 DIHYDRO-1, 3...
2016/0158218 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases...
2016/0158217 Quinoline Carboxamide and Quinoline Carbonitrile Derivatives as mGluR2-Negative Allosteric Modulators,...
The present invention provides quinoline carboxamide and quinoline carbonitrile compounds of formula (I) ##STR00001## wherein ring A, R.sup.Q, -L-, R.sup.1, n,...
2016/0158216 CRYSTALS OF LAQUINIMOD SODIUM AND IMPROVED PROCESS FOR THE MANUFACTURE THEREOF
The subject invention provides a mixture of crystalline laquinimod sodium particles, wherein (i) 90% or more of the total amount by volume of the laquinimod...
2016/0158215 TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE
The invention pertains to methods that include administering to a subject a transoral dosage form comprising a pharmaceutical carrier and sufentanil, and...
2016/0158214 HEPATITIS B ANTIVIRAL AGENTS
Provided herein are compounds useful for the treatment of HBV infection in man.
2016/0158213 USE OF FLECAINIDE AS AN ANTI-CONNEXIN AGENT AND METHOD FOR POTENTIATING THE EFFECTS OF A PSYCHOTROPIC DRUG
The present invention relates to the use of flecainide as an anti-connexin agent. This anti-connexin agent is advantageously used to potentiate the therapeutic...
2016/0158212 EXTENDED RELEASE AQUEOUS SUSPENSION OF METHYLPHENIDATE OR SALTS THEREOF
An extended release aqueous suspension composition of methylphenidate or salts thereof, is provided. The extended release aqueous suspension of methylphenidate...
2016/0158211 Dosage and Use of an A2A Antagonist
The present invention relates to specific dosages of an A.sub.2A antagonist for use as a medicament and in particular useful for the treatment of Parkinson...
2016/0158210 CORNEAL ENDOTHELIUM ECM THERAPEUTIC MEDICAMENTS
The present invention provides medicaments for treating or preventing a disease, disorder, or condition associated with extracellular matrix (ECM) abnormality...
2016/0158209 Compounds for Treatment of Alzheimer's Disease
The invention is directed to the use of a compound of formula I, as defined herein, to a pharmaceutically acceptable salt thereof; to a pharmaceutical...
2016/0158208 METHODS OF USE OF CYCLOPAMINE ANALOGS
The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: ##STR00001##
2016/0158207 THERAPEUTIC COMPOUNDS AND USES THEREOF
The present invention relates to compounds of formula (I) or formula (II): ##STR00001## and to salts thereof, wherein R.sup.1-R.sup.4 of formula (I) and ...
2016/0158206 Reversing Intestinal Inflammation by Inhibiting Retinoic Acid Metabolism
An agent that increases local concentration of retinoic acid (RA) in the intestine through modifying enzymatic pathways involved in RA metabolism is...
2016/0158205 COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS
Disclosed herein are methods of treating conditions, which may be associated with elevated levels of eosinophils and/or basophils, with a therapeutically...
2016/0158204 PHARMACOLOGICAL STIMULATION TO FACILITATE AND RESTORE STANDING AND WALKING FUNCTIONS IN SPINAL CORD MOTOR DISORDERS
The invention relates to the selective targeting of specific .alpha.2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in...
2016/0158203 METHODS OF TREATMENT WITH BIOAVAILABLE COMPOSITIONS OF METAXALONE COMPRISING NONVOLATILE LIQUIDS
Pharmaceutical compositions comprising metaxalone which demonstrate improved dissolution and bioavailability characteristics compared to the commercially...
2016/0158202 Low Dose Pharmaceutical Composition
This invention provides a low dose pharmaceutical composition comprising deferasirox or a pharmaceutically acceptable derivative thereof and one or more...
2016/0158201 CHEMICAL COMPOUNDS
Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods...
2016/0158200 Combinations of Hepatitis C Virus Inhibitors
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function...
2016/0158199 METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS
Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha-2...
2016/0158198 COMPOSITIONS AND METHODS FOR AMELIORATING CACHEXIA
The invention provides preparations, formulations, kits and other products of manufacture (e.g., blister packs) comprising combinations of beneficial...
2016/0158197 Novel 1-Aryl-3-Azabicyclo[3.1.0]Hexanes: Preparation And Use To Treat Neuropsychiatric Disorders
The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as...
2016/0158196 A MODIFIED-RELEASE ORAL PHARMACEUTICAL FORMULATION CONTAINING GLICLAZIDE
Sustained-release Gliclazide tablets devoid of calcium phosphate dibasic, and containing only soluble excipients. The mixing of two high viscosity HPMC with a...
2016/0158195 REDUCTION OF EPILEPTIC SEIZURES
Compositions for use in a method of treatment, particularly for use in a method of treatment of epilepsy or an epilepsy-related disorder, are provided. Uses of...
2016/0158194 Methods and Treatments for the Learning and Memory Deficits Associated with Noonan Syndrome
Disclosed herein are methods and compositions for treating learning and memory deficits associated with Noonan Syndrome.
2016/0158193 ADJUVANTS IN ANTI-CANCER CHEMOTHERAPY
The present invention provides a 1,2,4-trioxane or a pharmaceutically acceptable salt, ester, solvate, tautomer or stereoisomer thereof for use as an adjuvant...
2016/0158192 Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising...
2016/0158191 Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising...
2016/0158190 Methods and Compositions for Inhibition of ATR and FANCD2 Activation
This invention is announcing a composition of flavonoid skeleton in the formula I or formula II compound, wherein each of the substituents is given the...
2016/0158189 SENSITIZATION OF CANCER CELLS TO APOPTOSIS INDUCTION BY FLAVAGLINES AND 5-HYDROXY-FLAVONES
The present invention relates to a combined preparation for simultaneous, separate or sequential use comprising at least one flavagline or a pharmaceutically...
2016/0158188 NOVEL USE FOR PAI-1 INHIBITOR
Provided is a novel use of a plasminogen activator inhibitor-1 inhibitor (PAI-1 inhibitor) that is used as an active ingredient of an agent for controlling a...
2016/0158187 TIGLIEN-3-ONE DERIVATIVES
The present invention relates to tiglien-3-one compounds and their use in methods of treating or preventing protozoal infections, bacterial infections,...
2016/0158186 USE OF DIANHYDROGALACTITOL AND ANALOGS AND DERIVATIVES THEREOF TO TREAT RECURRENT MALIGNANT GLIOMA OR...
Methods and compositions suitable for the treatment of malignancies such as recurrent glioma and progressive secondary brain tumor are disclosed. These methods...
2016/0158185 SARMS AND METHOD OF USE THEREOF
This invention is directed to substituted acylanilide compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter...
2016/0158184 SELF-EMULSIFYING COMPOSITION OF OMEGA3 FATTY ACID
A self-emulsifying composition which comprises, when taking the total amount of the self-emulsifying composition as 100 mass %, 70 to 90 mass % of at least one...
2016/0158183 COMPOSITIONS AND METHODS COMPRISING MEDIUM CHAIN TRIGLYCERIDES FOR TREATMENT OF EPILEPSY
The invention provides compositions and methods for treatment of epilepsy in an animal. In one embodiment, a dietary regime suitable for enhancing the effect...
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