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Patent # Description
2016/0168595 TWO-PHASE FERMENTATION PROCESS FOR THE PRODUCTION OF AN ORGANIC COMPOUND
The invention relates to a two phase fermentation process for producing an organic compound, in particular an isoprenoid and to a bioreactor comprising a two...
2016/0168594 ONCOGENIC MODELS BASED ON DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS
The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of...
2016/0168593 METHODS AND COMPOSITIONS FOR ENHANCING TARGETED TRANSGENE INTEGRATION
Disclosed herein are methods and compositions for enhancing insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or...
2016/0168592 Multiplex RNA-Guided Genome Engineering
Methods of multiplex genome engineering in cells using Cas9 is provided which includes a cycle of steps of introducing into the cell a first foreign nucleic...
2016/0168591 CONSTRUCTION OF FULLY-DELETED ADENOVIRUS-BASED GENE DELIVERY VECTORS AND USES THEREOF
The embodiments disclosed herein relate to the construction of fully-deleted Adenovirus-based gene delivery vectors packaged without helper Adenovirus, and...
2016/0168590 METHODS OF IMPROVING TITER IN TRANSFECTION-BASED PRODUCTION SYSTEMS USING EUKARYOTIC CELLS
The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using...
2016/0168589 METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous...
2016/0168588 METHODS OF PRODUCING LONG ACTING CTP-MODIFIED POLYPEPTIDES
Disclosed herein is a method for manufacturing a recombinant polypeptide of interest modified by a CTP extension in a mammalian cells culture system.
2016/0168587 Methods and Compositions for Plant Pest Control
The present invention comprises methods and compositions for controlling nematode parasitism in host plant. The present invention comprises novel ...
2016/0168586 Corn Plant Event MON87460 and Compositions and Methods for Detection Thereof
The present invention provides a transgenic corn event MON87460, and cells, seeds, and plants comprising DNA diagnostic for the corn event. The invention also...
2016/0168585 GENERATION OF PLANTS WITH ALTERED PROTEIN, FIBER, OR OIL CONTENT
The present disclosure is directed to plants that display an improved oil quantity phenotype or an improved meal quality phenotype due to altered expression of...
2016/0168584 Gene Expression or Activity Enhancing Elements
The present invention relates to transgenic nucleic acids, expression cassettes, vectors, plant cells, plant organs and plants. The invention also relates to...
2016/0168583 Plant Produced Human Papillomavirus Pseudovirion
The present invention relates to a method of producing HPV pseudovirions in plant cells, the plant produced pseudovirions per se, a neutralisation assay using...
2016/0168582 ENHANCED PROTEIN EXPRESSION IN BACILLUS
The present invention provides cells that have been genetically manipulated to have an altered capacity to produce expressed proteins. In particular, the...
2016/0168581 ENZYMES AND USES THEREOF
The present invention relates to novel enzymes and the uses thereof. The invention also relates to methods of producing such enzymes, coding nucleic acid...
2016/0168580 EXPRESSION VECTOR FOR CYANOBACTERIA
The present disclosure discloses a vector that can be used for both cyanobacteria and E. coli, which contains, sequentially, a pUC replication origin as a...
2016/0168579 ENCODING TEXT INTO NUCLEIC ACID
Methods and apparatus are disclosed herein for encoding human readable text conveying a non-genetic message into nucleic acid sequences with a substantially...
2016/0168578 METHODS AND DEVICES FOR ELECTROMAGNETIC LIGATION OF NUCLEIC ACIDS AND ELECTROMAGNETIC TRANSFORMATION OF CELLS
Described herein are methods and devices for ligating nucleic acids or nucleic acid fragments as well as methods for transforming or transfecting cells with...
2016/0168577 Clusterin Antisense Therapy for Treatment of Cancer
A method for providing antisense therapy which reduces the expression of clusterin to provide therapeutic benefits in the treatment of cancer comprising...
2016/0168576 ANTISENSE DESIGN
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
2016/0168575 ANTISENSE DESIGN
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
2016/0168574 TREATMENT OF INSULIN GENE (INS) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN INSULIN...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Insulin gene (INS), in particular, by...
2016/0168573 LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND...
There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo...
2016/0168572 DELIVERY OF THERAPEUTIC AGENT
A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method...
2016/0168571 CpG-OLIGODEOXYNUCLEOTIDE, IMMUNOGENIC COMPOSITION COMPRISING THE SAME, AND METHODS FOR PREPARING THE...
CpG-oligodeoxynucleotides (CpG-ODN), as potent immune stimuli developed for using as adjuvant in different species, are disclosed herein. TLR9 is the cellular...
2016/0168570 MODULATION OF EXON RECOGNITION IN PRE-MRNA BY INTERFERING WITH THE SECONDARY RNA STRUCTURE
The invention relates to oligonucleotides for inducing skipping of exon 53 of the dystrophin gene. The invention also relates to methods of inducing exon 53...
2016/0168569 Phased Small RNAs
This invention discloses recombinant DNA constructs encoding phased small RNAs useful in regulating expression of one or more genes of interest. Also disclosed...
2016/0168568 TREATMENT OF ADIPONECTIN (ADIPOQ) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO AN...
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of an Adiponectin (ADIPOQ), in particular, by...
2016/0168567 UNA SINGLE STRANDED OLIGOMERS FOR THERAPEUTICS
The present invention is directed to RNA oligonucleotides or complexes of RNA oligonucleotides, denoted herein together as RNA complexes, containing at least...
2016/0168566 Methods and Compositions using miR-3151 in the Diagnosis and Treatment of Thyroid Cancer
Compositions comprising therapeutic oligonucleotide miR-3151 compounds that target the expression of genes associated with tumorigenesis or cell transformation...
2016/0168565 MOLECULAR TARGETS FOR THE PREVENTION AND/OR TREATMENT OF FIBROSIS, HYPERTROPHIC SCARS OR KELOIDS
The present invention relates to a therapeutic compound comprising: an agent that inhibits the activity of at least one gene selected from the group consisting...
2016/0168564 Methods for the Production of Long Length Clonal Sequence Verified Nucleic Acid Constructs
Methods and compositions relate to the production of high fidelity nucleic acids using high throughput sequencing.
2016/0168563 EFFICIENT METHOD FOR DISPLAYING PROTEIN MULTIMER
The invention provides a method of producing a protein multimer-nucleic acid complex comprising a protein multimer and any one target component of the protein...
2016/0168562 DEVICE HAVING A FILTER LAYER AND METHOD FOR EXTRACTING NUCLEIC ACIDS FROM FORMALIN-FIXED AND PARAFFIN-EMBEDDED...
The invention relates to a device (1) for extracting nucleic acid from a formalin-fixed and paraffin-embedded sample comprising a hollow body (2) having an...
2016/0168561 ORGANIC DEVICES FOR THE PHOTOINHIBITION OF EXCITABLE CELLS
Devices are provided for inhibiting the electrical activity of an excitable cell through the application of a pulse of light which includes a substrate and a...
2016/0168560 CELL CULTURING METHOD, CELL CULTURING APPARATUS AND KIT
The present invention relates to a cell culturing method as well as a cell culturing apparatus and kit for use in said culturing method. This cell culturing...
2016/0168559 BIOCATALYTICAL COMPOSITION
The present invention relates to means and methods for protecting proteins and protein-type compounds in industrial and other applications. In particular, the...
2016/0168558 Compositions, Methods and Kits for Real-Time Nucleic Acid Analysis in Live Cells
The present invention includes compositions, methods and kits for the real-time detection of transcription and translation in live cells, tissues and...
2016/0168557 MODIFIED BETA-LACTAMASES AND METHODS AND USES RELATED THERETO
The present invention relates to pharmaceuticals and modified beta-lactamases. Specifically, the invention relates to novel recombinant beta-lactamases and...
2016/0168556 UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEIN
Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin...
2016/0168555 MUTANT XYLANASE, MANUFACTURING METHOD AND USE THEREFOR, AND METHOD FOR MANUFACTURING SACCHARIFIED LIGNOCELLULOSE
What is aimed at is provision of an inexpensive and efficient saccharification method for lignocellulose using a thermostable xylanase and provision of a...
2016/0168554 BACTERIAL HYALURONIDASE AND PROCESS FOR ITS PRODUCTION
The present invention relates to a hyaluronidase from S. koganeiensis, applications thereof and a method for the production thereof.
2016/0168553 THERMOSTABLE BETA-GLUCOSIDASE
A thermostable .beta.-glucosidase including a .beta.-glucosidase catalytic domain, the .beta.-glucosidase catalytic domain including: (A) a polypeptide...
2016/0168552 CELLULASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
This invention relates to molecular and cellular biology and biochemistry. In one aspect, the invention provides polypeptides having cellulase activity, e.g.,...
2016/0168551 Polypeptides Having Cellulolytic Enhancing Activity And Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2016/0168550 VARIANT ENZYMES
Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the...
2016/0168549 THERMOSTABLE CELLOBIOHYDROLASE
A thermostable cellobiohydrolase, having a cellobiohydrolase catalytic domain including: (A) a polypeptide including the amino acid sequence represented by SEQ...
2016/0168548 THERMOSTABLE BETA-XYLOSIDASE
A thermostable .beta.-xylosidase, having a .beta.-xylosidase catalytic domain including: (A) a polypeptide including the amino acid sequence represented by SEQ...
2016/0168547 Polypeptides Having Lipase Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also...
2016/0168546 Reconstituted Histone Methyltransferase Complex and Methods of Identifying Modulators Thereof
The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase)...
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