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Patent # Description
2016/0168245 TRPM4 CHANNEL INHIBITORS FOR STROKE TREATMENT
The present invention relates to methods for treating ischemic stroke including extension of the therapeutic time window for reperfusion. More particularly,...
2016/0168244 ANTAGONIST ANTIBODIES DIRECTED AGAINST CALCITONIN GENE-RELATED PEPTIDE AND METHODS USING SAME
The invention features methods for preventing or treating CGRP associated disorders such as vasomotor symptoms, including headaches (e.g., migraine, cluster...
2016/0168243 Antagonists to IL-6 to Raise Albumin and/or Lower CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
2016/0168242 ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
2016/0168241 BINDING AGENTS
Compositions and methods relating to epitopes of sclerostin protein, and sclerostin binding agents, such as antibodies capable of binding to sclerostin, are...
2016/0168240 USE OF VEGF ANTAGONIST IN TREATING CHORIORETINAL NEOVASCULAR AND PERMEABILITY DISORDERS IN PAEDIATRIC PATIENTS
The present invention relates to the use of a VEGF antagonist in the treatment of chorioretinal neovascular or permeability disorders in children. In...
2016/0168239 Combination Therapies for the Treatment of Alzheimer's Disease and Related Disorders
The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising...
2016/0168238 HUMANIZED, ANTI-N2 ANTIBODIES AND METHODS OF TREATING ISCHEMIA-REPERFUSION INJURY
The present invention encompasses humanized antibodies that specifically bind N2 peptide, methods for the preparation thereof and methods for the use thereof.
2016/0168237 METHOD FOR TREATING A COMPLEMENT MEDIATED DISORDER CAUSED BY AN INFECTIOUS AGENT IN A PATIENT
The present disclosure relates to, inter alia, a method of treating a complement mediated disorder caused by an infectious agents in a patient, comprising...
2016/0168236 ANTI-GALECTIN-1 MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF
The present invention is based, in part, on the discovery of anti-galectm-1 (Gal 1.) monodonai antibodies useful for diagnostic and prognostic applications, as...
2016/0168235 TRANSTHYRETIN AMYLOID-SELECTIVE AND POLYREACTIVE CATABODIES
The present invention provides transthyretin amyloid-selective and polyreactive catabodies and method of use thereof.
2016/0168234 HUMANIZED ANTIBODY IGG1
The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of...
2016/0168233 CELLULAR FACTORS INVOLVED IN THE CYTOTOXICITY OF STAPHYLOCOCCUS AUREUS LEUKOCIDINS: NOVEL THERAPEUTIC TARGETS
The present invention relates to methods for treating and preventing Staphylococcus aureus infection and/or a condition resulting from a S. aureus infection in...
2016/0168232 GRAM-POSITIVE BACTERIA SPECIFIC BINDING COMPOUNDS
The present invention provides improved binding compounds capable of specifically binding Gram-positive bacteria. Binding compounds are provided that are fully...
2016/0168231 ANTIBODIES WITH ULTRALONG COMPLEMENTARITY DETERMINING REGIONS
The present disclosure provides antibodies, including antibodies comprising ultralong CDR3 and uses thereof.
2016/0168230 ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
2016/0168229 AFFINITY CHROMATOGRAPHY MATRIX
The invention relates to an affinity chromatography matrix, as a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a...
2016/0168228 GENERATION OF HEMOGLOBIN-BASED OXYGEN CARRIERS USING ELASTIN-LIKE POLYPEPTIDES
Described herein is the use of elastin-like polypeptides to generate hemoglobin-based oxygen carriers as a means of preventing and treating conditions caused...
2016/0168227 COMPOSITION AND VACCINE FOR TREATING LUNG CANCER
The present invention relates to a composition comprising at least one mRNA encoding a combination of antigens capable of eliciting an (adaptive) immune...
2016/0168226 PROCESS FOR PRODUCTION OF INSULIN AND INSULIN ANALOGUES
A process for production of insulin or insulin analogues by expression of Insulin or Insulin analogues through an expression vector in a host cell is provided....
2016/0168225 EXENDIN-4 PEPTIDE ANALOGUES AS DUAL GLP-1/GLUCAGON RECEPTOR AGONISTS
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including...
2016/0168224 PROCESS FOR PREPARING AMPHIPHILIC PEPTIDE DERIVATIVES
The present invention relates to novel derivatives of hydrophilic bioactive peptides which have been modified by introducing a lipophilic substituent through...
2016/0168223 FGF MUTANTS AND USES THEREOF
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21...
2016/0168222 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168221 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168220 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168219 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168218 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168217 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168216 METHODS OF USING COMPOSITIONS COMPRISING VARIANTS AND FUSIONS OF FGF19 POLYPEPTIDES FOR REDUCING GLUCOSE LEVELS...
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168215 COMPOSITIONS COMPRISING VARIANTS AND FUSIONS OF FGF19 POLYPEPTIDES
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
2016/0168214 BIOLOGICAL DEVICES AND METHODS OF USE THEREOF FOR THE STUDY AND CONTROL OF ALZHEIMER'S DISEASE
Described herein are devices and methods for simultaneously expressing amyloid precursor protein and TonB protein. For example, the biological devices and...
2016/0168213 GROWTH DIFFERENTIATION FACTOR 15 (GDF-15) CONSTRUCTS
Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in...
2016/0168212 COMPOSITIONS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
Isolated peptides are provided, being less than 20 amino acids in length. The peptides comprising an amino acid sequence GVLYVGSKTREGV (SEQ ID NO: 12)...
2016/0168211 MULTIMERIZATION TECHNOLOGIES
The present invention provides, among other things, dimeric multispecific binding agents (e.g., fusion proteins comprising antibody components) that have...
2016/0168210 DERIVATIVES OF COLLAGEN-BINDING HAIRPIN PEPTIDES
Compounds of interest, for example active pharmaceutical ingredients, probes or inactive carriers, may be delivered to a site of interest by conjugating the...
2016/0168209 PROTEIN LIGAND FOR AFFINITY ISOLATION MATRIX
An object of the present invention is to develop techniques to create novel engineered protein ligands that maximize the binding capacity and binding...
2016/0168208 Peptides derived from Campylobacter jejuni and their use in vaccination
Disclosed are polypeptides for Campylobacter jejuni that are useful as immunogenic agents for vaccine use. Also disclosed are nucleic acid fragments encoding...
2016/0168207 RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE
The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory...
2016/0168206 FINE EPITOPE PEPTIDE CAPABLE OF INDUCING CROSS-REACTIVE ANTIBODIES AMONG HOMOLOGOUS PROTEINS IN HUMAN PAPILLOMA...
This invention relates to the minimal motif of an epitope on the E6 protein from human papilloma virus (HPV), and this minimal motif of the epitope induces a...
2016/0168205 METHODS AND COMPOSITIONS FOR LABELING POLYPEPTIDES
Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and...
2016/0168204 METHOD FOR PURIFYING OLIGOSACCHARIDE PEPTIDE
The present invention provides a method for conveniently purifying sialyl glycopeptide from an egg yolk component, comprising the step of mixing a ...
2016/0168203 Cyclic Antimicrobial Peptides
The present invention relates to cyclic cationic peptides and their use in the treatment of microbial infections.
2016/0168202 Cyclic peptides as ADAM protease inhibitors
The invention relates to a method for inhibiting an ADAM protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the...
2016/0168201 Methods and Compositions for the Treatment of Gastrointestinal Disorders
Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional...
2016/0168200 IMMUNOTHERAPY AGAINST SEVERAL TUMORS, SUCH AS LUNG CANCER, INCLUDING NSCLC
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
2016/0168199 TISSUE PROTECTIVE PEPTIDES AND PEPTIDE ANALOGS FOR PREVENTING AND TREATING DISEASES AND DISORDERS ASSOCIATED...
The present invention provides peptides and peptide analogs that have tissue protective activities while having little or no potentially undesirable...
2016/0168198 SIGNAL SEQUENCE FOR PROTEIN EXPRESSION IN PICHIA PASTORIS
The present invention relates to a signal sequence from a unique Pichia pastoris protein. Further the invention discloses use of signal sequence for the...
2016/0168197 METHOD FOR CANCER IMMUNOTHERAPY
A novel compound of the formula (1): ##STR00001## wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R.sup.1...
2016/0168196 COMPOUND FOR LABELING SUGAR CHAIN SAMPLE
A compound having the following structure has been found out: ##STR00001## (R.sup.1 and R.sup.2 each independently represent any one of a hydrogen atom and an...
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