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Patent # Description
2016/0168195 OLIGOPEPTIDES AND PROCESS FOR PREPARATION THEREOF
This invention relates to oligopeptides having general formula (I). The invention also relates to the process of preparation thereof, wherein the said...
2016/0168194 CHROMATOGRAPHY MATRICES INCLUDING NOVEL STAPHYLOCOCCUS AUREUS PROTEIN A BASED LIGANDS
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as,...
2016/0168193 Isolation of Cyclopamine
Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum...
2016/0168192 PROCESS FOR THE PREPARATION OF ABIRATERONE AND ABIRATERONE ACETATE
##STR00001## The present invention relates to a novel process for the synthesis of abiraterone, and in particular of abiraterone acetate, compound of formula...
2016/0168191 PROCESS FOR THE PREPARATION OF ABIRATERONE OR ABIRATERONE ACETATE
The present invention relates to a novel process for the synthesis of abiraterone and in particular abiraterone acetate, a compound of formula (I) reported...
2016/0168190 C-20 STEROID COMPOUNDS, COMPOSITIONS AND USES THEREOF TO TREAT TRAUMATIC BRAIN INJURY (TBI), INCLUDING CONCUSSIONS
The present invention relates to C-20 steroid compounds, compositions and methods of use thereof to treat, minimize and/or prevent traumatic brain injury...
2016/0168189 DEUTERATED BILE ACIDS
This disclosure relates to deuterated bile acid compositions. A deuterated compound is selected from the disclosed groups of bile acids and their derivatives,...
2016/0168188 SYNTHESIS OF ENT-PROGESTERONE AND INTERMEDIATES THEREOF
The present invention relates to the synthesis of ent-progesterone and intermediates thereof.
2016/0168187 A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL...
Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during DNA...
2016/0168186 Method of Treating Dengue Fever
The application provides methods for treatment or prophylaxis of dengue virus mediated diseases with compounds of Formula I ##STR00001## wherein R.sup.1,...
2016/0168185 NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT
A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: ##STR00001## wherein R.sub.1 is H, methyl, or...
2016/0168184 METHODS OF PREPARING NICOTINAMIDE RIBOSIDE AND DERIVATIVES THEREOF
The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a...
2016/0168183 Conjugates Containing Hydrophilic Spacer Linkers
Described herein are compositions and methods for use in targeted drug delivery using cell receptor binding drug delivery conjugates containing hydrophilic...
2016/0168182 METHOD FOR THE PURIFICATION OF DECITABINE
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and...
2016/0168181 RECYCLABLE METATHESIS CATALYSTS
Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are...
2016/0168180 Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins
N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, N.sup.2-phosphinyl amidinate metal salt...
2016/0168179 CYCLOPOLYARYLENE METAL COMPLEX
If a method for directly functionalizing cycloparaphenylene compounds is developed, such a method is expected to be applied to any cycloparaphenylene compound,...
2016/0168178 MULTIMERIC DUAL-MODALITY BREAST CANCER DIAGNOSTIC AGENTS
The present invention describes dual-modality probes. In particular, the present invention discloses hydroxyapatite specific multimeric bisphosphonate...
2016/0168177 LIQUID BISACYLPHOSPHINE OXIDE PHOTOINITIATOR
A photoinitiator mixture comprising the components (a) a compound of the formula (I) ##STR00001## wherein Ar and Ar.sub.2 independently of each other are ...
2016/0168176 HETERO-FUSED CYCLIC COMPOUND
A compound represented by the formula (I) or a salt thereof: ##STR00001## wherein a ring Z is a 5 to 6-membered heteroaromatic ring having one or two heteroatoms...
2016/0168175 SILYLATED POLYISOCYANATES
The present invention relates to silylated polyisocyanates, to processes for preparing them, to their use, and to coating compositions comprising them.
2016/0168174 ORGANOSILICA MATERIALS AND USES THEREOF
Organosilica materials, which are a polymer of at least one independent monomer of Formula [Z.sup.1OZ.sup.2OSiCH.sub.2].sub.3 (I), wherein Z.sup.1 and Z.sup.2...
2016/0168173 ORGANOSILICA MATERIALS AND USES THEREOF
Provided herein are organosilica materials, which is a polymer of at least one monomer of Formula [Z.sup.1OZ.sup.2OSiCH.sub.2].sub.3 (I), wherein each Z.sup.1...
2016/0168172 ORGANOSILICA MATERIALS AND USES THEREOF
Organosilica materials, which are a polymer of at least one independent monomer of Formula [Z.sup.1OZ.sup.2SiCH.sub.2].sub.3 (I), wherein each Z.sup.1...
2016/0168171 METHODS OF PRODUCING ORGANOSILICA MATERIALS AND USES THEREOF
Methods of preparing organosilica materials, which is a polymer comprising independent siloxane units of Formula [Z.sup.3Z.sup.4SiCH.sub.2].sub.3 (I), wherein...
2016/0168170 PROCESS FOR THE PREPARATION OF HETEROCYCLIC ESTER DERIVATIVES
The present invention is directed to a process for the preparation of heterocyclic ester derivatives of formula I ##STR00001## wherein A.sup.1, SEM, and...
2016/0168169 ORGANOAMINOSILANES AND METHODS FOR MAKING SAME
Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as...
2016/0168168 PROCESS FOR PREPARING BENZOXABOROLES
The present invention is a process comprising contacting a compound of formula 6: ##STR00001## or a pharmaceutically acceptable salt thereof; with a...
2016/0168167 Tricyclic Benzoxaborole Compound, Preparation Method and Use Thereof
The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition...
2016/0168166 A PROCESS FOR PREPARING RIFAXIMIN K
The present invention relates to a process for obtaining rifaximin .kappa. comprising the following steps: a) reacting rifamycin O with 2-amino-4-picoline in...
2016/0168165 MYC MODULATORS AND USES THEREOF
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc...
2016/0168164 THIENO[3,2-d]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS
This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral...
2016/0168163 PROCESS FOR THE MANUFACTURE OF SPIROCYCLIC SUBSTITUTED BENZOFUROQUINOLIZINES
The present invention relates to a process for the manufacture of N-(2-((2R,12bS)-2'-oxo-1,3,4,6,7,12b-hexahydrospiro[benzofuro[2,3-a]quino- ...
2016/0168162 LUMINESCENT COMPOUND AND ELECTROLUMINESCENT DEVICE EXHIBITING THERMALLY ACTIVATED DELAYED FLUORESCENCE
A chemical compound is provided having a structure that includes at least one donor moiety covalently bonded to at least one acceptor moiety. For example, the...
2016/0168161 METHOD FOR PRODUCING HETEROCYCLIC COMPOUND
There is provided a method for producing with a high efficiency a heterocyclic compound that is useful as a raw material for pharamaceuticals. A novel...
2016/0168160 BENZOIC ACID, BENZOIC ACID DERIVATIVES AND HETEROARYL CARBOXYLIC ACID CONJUGATES OF OXYCODONE, PRODRUGS,...
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxycodone...
2016/0168159 PREPARATION OF SATURATED KETONE MORPHINAN COMPOUNDS BY CATALYTIC ISOMERISATION
There is provided a novel process for the preparation of a compound of formula I, wherein R.sup.1, R.sup.2 and R.sup.3 are as described in the description, by...
2016/0168158 NOVEL TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES
The invention relates to a compound of formula (I) ##STR00001## wherein R.sup.1 to R.sup.4 are defined as in the description and in the claims. The compound of...
2016/0168157 HETEROCYCLIC KINASE INHIBITORS
The present invention provides heterocyclic compounds for use as kinase inhibitors and in other applications. Also provided are pharmaceutical compositions and...
2016/0168156 FUSED RING HETEROARYL COMPOUNDS AND THEIR USE AS TRK INHIBITORS
The disclosure provides novel chemical compounds represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug...
2016/0168155 POLYMORPH OF SYK INHIBITORS
Polymorphs of a bis-mesylate salt of a compound of Formula (I): or a hydrate thereof, are provided. The bis-mesylate salt may also be depicted as a compound of...
2016/0168154 INHIBITORS OF TRANSCRIPTION FACTORS AND USES THEREOF
The present invention provides novel compounds of any one of Formulae (I) to (IV), and pharmaceutically compositions thereof. Compounds of any one of Formulae...
2016/0168153 NOVEL CRYSTALLINE FORMS OF PEMETREXED TROMETHAMINE SALTS
The present invention is directed to novel crystalline forms of pemetrexed tromethamine salts and processes for preparation thereof.
2016/0168152 N-ALKYL TRYPTANTHRIN DERIVATIVE, PREPARATION METHOD FOR SAME, AND APPLICATION THEREOF
An N-alkyl tryptanthrin derivative, a preparation method for same, and an application thereof are provided. The structure of the derivative is as represented...
2016/0168151 PYRAZOLO PYRIMIDINE DERIVATIVES AND METHODS OF USE THEREOF
This invention generally relates to pyrazolo pyrimidine derivatives useful as, inter alia, inhibitors of short chain dehydrogenase/reductase (SDR) family of...
2016/0168150 PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES
This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or...
2016/0168149 PURINONE COMPOUNDS AS KINASE INHIBITORS
Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. In addition,...
2016/0168148 TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS
The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the...
2016/0168147 ISOTOPICALLY ENRICHED AZAINDOLES
The present invention relates to deuterated compounds that are useful for inhibiting Janus kinases and processes and intermediates useful for preparing such...
2016/0168146 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant...
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