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Patent # Description
2016/0176943 NOVEL ALTERNATIVE SPLICE TRANSCRIPTS FOR MHC CLASS I RELATED CHAIN ALPHA (MICA) AND USES THEREOF
The present invention relates to novel alternative splice transcripts (AST) for MICA (MHC class I related chain alpha) encoding novel MICA protein isoforms and...
2016/0176942 Reversible Covalent Linkage of Functional Molecules
The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R.sub.1--H which...
2016/0176941 CD40L COLLECTIN FUSION PROTEINS
The present invention refers to a fusion protein comprising a TNF-superfamily (TNFSF) cytokine or a receptor binding domain thereof fused to a collectin...
2016/0176940 RECOMBINANT PROTEIN
A recombinant protein is provided. The recombinant protein of the invention comprises an erythropoietin and a highly glycosylated peptide, and has a longer...
2016/0176939 CANCER ANTIGEN HELPER PEPTIDE
The present invention relates to a WT1 peptide which has an amino acid sequence consisting of contiguous amino acids derived from a WT1 protein and induces...
2016/0176938 Partial Region Polypeptide of REIC/Dkk-3 Protein
A polypeptide capable of strongly inducing and activating dendritic-cell-like cells for treating or prevent cancer by immunotherapy, and DNA encoding the...
2016/0176937 SHORT PEPTIDES DERIVED FROM VDAC1, COMPOSITIONS AND METHODS OF USE THEREOF
The present invention relates to short peptides based on the amino acids sequence of the N-terminal domain of the human mitochondrial protein voltage-dependent...
2016/0176936 MPS PEPTIDES AND USE THEREOF
This disclosure provides an isolated polypeptide comprising no more than 35 amino acids, wherein the amino acid sequence comprises, or alternatively consists...
2016/0176935 FILIP1L compositions and methods for treating cancer
A purified DOC1 polypeptide comprising a fragment of SEQ ID NO: 1 is provided, wherein the DOC1 polypeptide is not the full-length DOC1 polypeptide sequence. A...
2016/0176934 Ang-2 Binding Complexes and Uses Thereof
Complexes containing one or more modular recognition domains (MRDs) and MRDs attached to scaffolds including antibodies are described. The manufacture of these...
2016/0176933 MUTANT CHANNELRHODOPSINS WITH ALTERED ION SELECTIVITY
The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant...
2016/0176932 STABILIZED SOLUBLE PRE-FUSION RSV F POLYPEPTIDES
This disclosure provides stable pre-fusion respiratory syncytial virus (RSV) F polypeptides, immunogenic compositions comprising the polypeptides, and uses...
2016/0176931 RED GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE
Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green...
2016/0176930 MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS
The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain....
2016/0176929 BRADYKININ RECEPTOR MODULATORS AND USE THEREOF
The present invention relates generally to novel biological and purified peptides as bradykinin receptor modulators for use in the treatment and/or prevention...
2016/0176928 Immunomodulators
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
2016/0176927 PEPTIDE FOR SUPPRESSING OSTEOCLAST DIFFERENTIATION AND USE THEREOF
The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin...
2016/0176926 PEPTIDES AND RELATED MOLECULES THAT BIND TO TALL-1
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may...
2016/0176925 MELANOCORTIN RECEPTOR LIGANDS MODIFIED WITH HYDANTOIN
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the...
2016/0176924 MODIFIED PEPTIDES AS POTENT INHIBITORS OF THE PSD-95/NMDA RECEPTOR INTERACTION
The present invention is directed to the provision of small molecule inhibitors of the PSD-95/NMDA receptor interaction, employing an undecapeptide...
2016/0176923 NONAPEPTIDE WITH ANTI-TUMOUR ACTIVITY
The present invention relates to peptides or peptide like molecules and their uses in therapy, in particular as anti-tumour agents.
2016/0176922 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of...
2016/0176921 METHODS OF PURIFYING RECOMBINANT PROTEINS
Provided herein are methods of purifying a recombinant protein and methods of manufacturing a recombinant protein product that include capturing a recombinant...
2016/0176920 MAGNETIC SEPARATION OF LIPOPROTEINS USING DEXTRAN SULFATE
The invention provides apparatus and methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic...
2016/0176919 CELL SPECIFIC LABELING OF NEWLY SYNTHESIZED PROTEINS
Disclosed herein are compositions comprising blocked puromycin analogs that are converted into active puromycin analogs upon the activity of a penicillin...
2016/0176918 COUPLING METHOD FOR PEPTIDE SYNTHESIS AT ELEVATED TEMPERATURES
An improved method for coupling carboxylic acids and amines is disclosed that includes the steps of combining a hyper-acid sensitive linker connecting an amine...
2016/0176917 Bile Acid Derivatives as FXR/TGR5 Agonists and Methods of Use Thereof
The present invention provides compounds of Formula I, ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2016/0176916 METHODS TO INDUCE TARGETED PROTEIN DEGRADATION THROUGH BIFUNCTIONAL MOLECULES
The present application provides bifunctional compounds which act as protein degradation inducing moieties. The present application also relates to methods for...
2016/0176915 PROCESS FOR PREPARATION OF ABIRATERONE ACETATE
The present invention relates to improvement in the process of preparation of abiraterone acetate or a pharmaceutically acceptable salt thereof wherein the...
2016/0176914 GLYCOSYLATED CARDIOTONIC STEROIDS
Compounds which are glycosylates of an A-ring of a cardiotonic steroid, wherein the steroid is attached to the anomeric position of (a) a monosaccharide...
2016/0176913 Preparation and Uses of Obeticholic Acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid...
2016/0176912 Novel Ticagrelor Co-Crystal
The present invention relates to a novel co-crystal of the compound of formula (I): wherein the co-former molecule is acetyl salicylic acid, to processes for...
2016/0176911 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection...
2016/0176910 SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
Disclosed herein are nucleosides, nucleotides and nucleotide analogs, methods of synthesizing the same and methods of treating diseases and/or conditions such...
2016/0176909 REGIOSELECTIVE SILYL EXCHANGE OF PER-SILYLATED OLIGOSACCHARIDES
The present invention provides novel, regioselectively-acylated oligosaccharide compounds and methods for preparing them. In another aspect, the. invention...
2016/0176908 FIRST-ROW TRANSITION METAL HYDROGENATION AND HYDROSILYLATION CATALYSTS
Transition metal compounds, and specifically transition metal compounds having a tetradentate and/or pentadentate supporting ligand are described, together...
2016/0176907 Photolabile Compounds
The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be...
2016/0176906 Chemical Compounds
The present invention relates to compounds of Formula (I): ##STR00001## and to their salts, pharmaceutical compositions, methods of use, and methods for their...
2016/0176905 FORMS OF R)-3-(4-(2-(2-METHYLTETRAZOL-5-YL)PYRIDIN-5-YL)-3-FLUOROPHENYL)-5- -HYDROXYMETHYL OXAZOLIDIN-2-ONE...
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,...
2016/0176904 Preparation of Graphitic C3N3P Material
A new graphitic material has the empirical formula C.sub.3N.sub.3P and comprises triazine rings bound together by phosphorus atoms, and/or other 5- or...
2016/0176903 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI
The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties...
2016/0176902 SYNTHESIS OF ANTIMICROBIAL SILSESQUIOXANE-SILICA HYBRIDS
One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a...
2016/0176901 Reagents and Methods for Fluorinating a Substrate
Described herein are perfluoroalkylated zinc compounds having the structure of Formula (I) or Formula (II), which can be used to perfluoroalkylate organic,...
2016/0176900 SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase...
2016/0176899 CO-CRYSTALS OF 5-AMINO-2-OXOTHIAZOLO[4,5-D]PYRIMIDIN-3(2H)-YL-5-HYDROXYMETHYL TETRAHYDROFURAN-3-YL ACETATE...
Co-crystals of Formula I compounds and their pharmaceutical compositions are novel therapeutics for the treatment of diseases, such as human immunodeficiency...
2016/0176898 IMIDAZOTHIAZOLE SUFONAMIDES AS NEMATICIDES
Disclosed are compounds of formula (I) which possess nematicidal properties ##STR00001## wherein the structural elements have the meaning as indicated in the ...
2016/0176897 7-AMINOCEPHEM DERIVATIVE COMPOUNDS
This disclosure provides methods of making certain 7-aminocephem derivatives useful in the manufacture of cephalosporin antibiotic compounds.
2016/0176896 ERK INHIBITORS
The present invention provides thieno[2,3-c]pyrrol-4-one compounds that inhibit activity of extracellular-signal-regulated kinase (ERK) and may be useful in...
2016/0176895 METHODS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS
In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically...
2016/0176894 TAXANE AND ABEO-TAXANE ANALOGS
The present application discloses new taxane analogs, intermediates and methods for producing them. The present application is also directed to pharmaceutical...
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