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Patent # Description
2016/0186169 Effective method for specific gene silencing using artificial small RNA
A nucleic acid molecule comprising a stem-loop structure, a nucleic acid complex comprising the nucleic acid molecule, a composition for delivering a target...
2016/0186168 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING
The present disclosure provides compositions and methods for genomic engineering.
2016/0186167 Method and Device for Processing a Sample of Biological Material Containing Target Cells and Companion Cells in...
A method for processing a sample of biological material containing target cells and companion cells in order to extract nucleic acids of the target cells...
2016/0186166 HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS
The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the...
2016/0186165 Multisort cell separation method
The invention is directed to a method for enriching target cells from a sample of cells characterized by: a) contacting the sample with a cell aggregation...
2016/0186164 THERMOSTABLE BLUNT-END LIGASE AND METHODS OF USE
Thermostable blunt-end ligases suitable for use in nucleic acid ligation reactions at elevated temperatures are provided. The ligases comprise fusion proteins...
2016/0186163 ENGINEERED MICROBES AND METHODS FOR MICROBIAL OIL OVERPRODUCTION FROM CELLULOSIC MATERIALS
The invention relates to engineering microbial cells for utilization of cellulosic materials as a carbon source, including xylose.
2016/0186162 ALDOLASE, ALDOLASE MUTANT, AND METHOD AND COMPOSITION FOR PRODUCING TAGATOSE BY USING SAME
This disclosure relates to aldolase, an aldolase mutant, and a method and a composition for producing tagatose by using the same. The feature of the disclosure...
2016/0186161 Alkenol dehydratase variants
Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of a compound corresponding to the general formula...
2016/0186160 ASPARTIC PROTEASES
The invention relates to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic proteases, and methods...
2016/0186159 SOLID TEXTILE DETERGENT WITH IMPROVED PROTEASE PERFORMANCE
The aim of the invention is to improve the detergent power of solid textile detergents having a pH value ranging from 4 to under 10 in a solution containing 1...
2016/0186158 VACCINES COMPRISING LEISHMANIA POLYPEPTIDES FOR THE TREATMENT AND DIAGNOSIS OF LEISHMANIASIS
Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising...
2016/0186157 INTEIN-MODIFIED ENZYMES, THEIR PRODUCTION AND INDUSTRIAL APPLICATION
A method of predicting an intein insertion site in a protein that will lead to a switching phenotype is provided. The method includes identifying a plurality...
2016/0186156 ARTIFICIAL CELLULOSOMES COMPRISING MULTIPLE SCAFFOLDS AND USES THEREOF IN BIOMASS DEGRADATION
Multi-enzyme complexes comprising an array of scaffold subunits designed for efficient integration of a plurality of carbohydrate-active enzymes are provided.
2016/0186155 VARIANT ENZYMES
Disclosed are glycosyl hydrolase enzyme variants, particularly variants of certain oxidoreductases of glycosyl hydrolase family 61. Nucleic acids encoding the...
2016/0186154 GENETICALLY MODIFIED RUMEN MICROBES FOR PRODUCTION OF ALCOHOL AND ALLIED DOWNSTREAM PRODUCTS FROM...
The present invention relates to genetically modified rumen microbes which has been transformed by inserting into it a plasmid vector containing a gene of...
2016/0186153 B-1,3-GLUCANASE, POLYNUCLEOTIDE, RECOMBINANT VECTOR, TRANSFORMANT, PRODUCTION METHOD FOR B-1,3- GLUCANASE,...
A .beta.-1,3-glucanase that exhibits decomposition activity with respect to paramylon derived from the genus Euglena. The .beta.-1,3-glucanase is derived from...
2016/0186152 MODIFIED CASCADE RIBONUCLEOPROTEINS AND USES THEREOF
A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex...
2016/0186151 Polypeptide Containing DNA-Binding Domain
The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting...
2016/0186150 SIRP-ALPHA VARIANT CONSTRUCTS AND USES THEREOF
The invention relates to compositions and methods of constructs comprising a SIRP-.alpha. polypeptide, including SIRP-.alpha. variants. The constructs may be...
2016/0186149 Manufacture of Active Highly Phosphorylated Human N-Acetylgalactosamine-6-Sulfatase and Uses Thereof
This invention provides compositions of active highly phosphorylated human N-acetylgalactosamine-6-sulfatase (GALNS), and pharmaceutical compositions and...
2016/0186148 TRUNCATED ACTRIIB-FC FUSION PROTEIN
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone,...
2016/0186147 COMPOSITIONS OF AND METHODS FOR IN VITRO VIRAL GENOME ENGINEERING
The present disclosure relates to a method of in vitro engineering of nucleic acids. This disclosure further relates to in vitro engineering of viral genomes...
2016/0186146 HUMAN PLURIPOTENT STEM CELL-BASED MODELS FOR PREDICTIVE DEVELOPMENTAL NEURAL TOXICITY
The present invention relates to three-dimensional (3D) tissue constructs and methods of using such 3D tissue constructs to screen for neurotoxic agents. In...
2016/0186145 Process for Enhancing Stem Cell Bioactivity Using Tauroursodeoxycholic Acid
The present invention relates to a process for enhancing stem cell bioactivity using tauroursodeoxycholic acid (TUDCA) or a pharmaceutical acceptable salt...
2016/0186144 EPITHELIAL CELL DIFFERENTIATION OF HUMAN MESENCHYMAL STROMAL CELLS
The present invention relates to the discovery that different stem cell types (e.g., bone marrow-derived mesenchymal stem cells (BM-MSC) and adipose-derived...
2016/0186143 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF
Disclosed herein are methods for generating SC-.beta. cells, and isolated populations of SC-.beta. cells for use in various applications, such as cell therapy.
2016/0186142 MAMMALIAN MUSCLE-DERIVED STEM CELLS
The present invention provides a new method of obtaining muscle-derived mesenchymal stem cells from microbiopsies of mammalian origin. The invention provides...
2016/0186141 SMALL MOLECULE CELLULAR REPROGRAMMING TO GENERATE CARDIOMYOCYTES
Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become cardiac progenitor cells or...
2016/0186140 COMPOSITIONS FOR MESODERM DERIVED ISL1+ MULTIPOTENT CELLS (IMPs), EPICARDIAL PROGENITOR CELLS (EPCs) AND...
The present invention relates to inter alia, methods for the generation and maintenance of Mesoderm-derived ISL1+ Multipotent Progenitors (IMPs), the...
2016/0186139 CELL AND GENE BASED METHODS TO IMPROVE CARDIAC FUNCTION
Compositions and methods for improving cardiac function, myocardial contractility and relaxation in a mammal are provided. Cardiomyocytes transfected with one...
2016/0186138 Natural Killer Cells and Methods for Enhancing Viability, Proliferation and Cytotoxicity of Same Following...
The invention provides Natural Killer cells and improved methods for increasing Natural Killer cell viability, proliferation and cytotoxicity following...
2016/0186137 DERIVATION OF HUMAN MICROGLIA FROM PLURIPOTENT STEM CELLS
The present invention relates to methods for deriving human hematopoietic progenitors, primitive macrophages, and microglial cells from human pluripotent stem...
2016/0186136 METHOD FOR PRODUCING ANTERIOR EYE SEGMENT TISSUE
The present invention provides a production method of a cell aggregate containing an anterior eye segment tissue or a partial structure thereof, or a precursor...
2016/0186135 HUMAN PLURIPOTENT STEM CELL-BASED SYSTEM FOR GENERATING ENDOTHELIAL CELLS
The present invention relates to chemically defined and xenogeneic material-free methods for deriving endothelial cells from human pluripotent stem cells. In...
2016/0186134 MESODERM AND DEFINITIVE ENDODERM CELL POPULATIONS
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell...
2016/0186133 PATIENT-SPECIFIC STEM CELL LINES DERIVED FROM HUMAN PARTHENOGENETIC BLASTOCYSTS
Methods are disclosed for generating HLA homozygous parthenogenetic human stem cell (hpSC-Hhom) lines from both HLA homozygous and HLA heterozygous donors....
2016/0186132 PROCESS FOR PRODUCING MULTIPOTENT STEM CELLS AND PROGENITORS
The present invention relates to a non-enzymatic process for producing multipotent stem cells and progenitors from the cultivation of stem cell niches.
2016/0186131 THREE DIMENSIONAL PURIFIED COLLAGEN MATRICES
Cell culture scaffolds presenting a more biologically relevant microenvironment are disclosed. More particularly, these cell culture scaffolds comprise...
2016/0186130 CELL CULTURE IMPROVEMENTS
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the...
2016/0186129 METHOD OF TREATING BACTERIAL CONTAMINATION IN A MICROALGAE CULTURE WITH PH SHOCK
Methods of treating contamination, particularly bacterial contamination, in an open culture of microalgae with organic carbon are described herein. The methods...
2016/0186128 USE OF THERMOPHILIC NUCLEASES FOR DEGRADING NUCLEIC ACIDS
The present invention relates to the use of a thermophilic nuclease for degrading nucleic acids in vivo and/or in situ, wherein the thermophilic nuclease is...
2016/0186127 CAPTURE AND ELUTION OF BIO-ANALYTES VIA BEADS THAT ARE USED TO DISRUPT SPECIMENS
Lysing may include agitating a specimen in a chamber along with a medium that includes a particulate lysing material that has an affinity for a biological...
2016/0186126 ACOUSTIC ENERGY TREATMENT USING PHASE CHANGE COUPLANT
Method and apparatus for transmitting acoustic energy to a sample for treatment by employing a phase change couplant at least adjacent a sample vessel. The...
2016/0186125 SYSTEM AND METHOD TO DIVIDE LIPOSUCTION FAT INTO ALIQUOTS
A system (1) to divide liposuction fat into aliquots, comprising taking means (2, 3) to take from a container a quantity of adipose material, made available by...
2016/0186124 CELL CULTURING SYSTEM FOR CULTIVATING ADHERENT CELLS AND LIQUID SUPPLY INTERFACE COMPRISING A CELL CULTURE...
The invention relates to a liquid supply interface (62, 62', 62'', 62''') for a cell culture system for supplying cell cultures found in different cell culture...
2016/0186123 CELL CULTURE APPARATUS AND CELL CULTURE METHOD
A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a...
2016/0186122 CULTURE APPARATUS
A culture apparatus that cultivates a culture, which includes an outer case, an inner case configured with metal plates inside the outer case, a heater outside...
2016/0186121 FERMENTATION APPARATUS
A fermentation apparatus in a standard pressure, comprising a mixer and a ventilation pore; a water filter, connecting to at least one pipe; a heater,...
2016/0186120 BIOLOGICAL STERILIZATION INDICATOR
A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at...
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