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Patent # Description
2016/0185819 PEPTIDES FOR THE STIMULATION OF COLLAGEN FORMATION
The present invention relates to a compound of formula (I) and to compositions comprising said compound, as well as the use of said compound and/or said...
2016/0185818 BIDENTATE-BINDING MODULATORS OF LRRK2 AND JNK KINASES
Both JNK and LRRK2 are associated with Parkinson's disease (PD), myocardial infarction (MI), and other medical disorders. Here we report a reasonably selective...
2016/0185817 PURIFICATION OF CHIMERIC FVIII MOLECULES
The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity...
2016/0185816 METHOD OF PURIFYING POLYPEPTIDES
The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an...
2016/0185815 BILE ACID DERIVATIVES AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
The present invention provides compounds of Formula I, ##STR00001## pharmaceutical compositions comprising these compounds and methods of using these compounds...
2016/0185814 VIRUS DETECTION
The invention provides methods and materials for use in the detection of influenza viruses which utilise a nanoparticle, for example gold nanoparticle, probe...
2016/0185813 RECOVERY OF STEVIOL GLYCOSIDES
The present invention relates a process for the recovery of one or more steviol glycosides from a steviol glycoside-containing fermentation broth, which method...
2016/0185812 PROCESS FOR SYNTHESIZING HIGHLY OPTICALLY ACTIVE 1,3-DISUBSTITUTED ALLENES
The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for...
2016/0185811 Spiroannulated nucleosides and process for the preparation thereof
We claim a simple strategy for the synthesis of a collection of C(3')-spirodihydroisobenzo-furannulated and C(3')-spirodihydroisobenzo-furannulated nucleosides...
2016/0185810 RESIN COMPOSITIONS COMPRISING LIGNIN DERIVATIVES
The present invention provides derivatives of native lignin having a certain ethoxy content. Surprisingly, it has been found that phenolic resins comprising...
2016/0185809 METHOD FOR LIGNIN RECOVERY
The present invention primarily relates to a method for isolating lignin, preferably unmodified lignin, from a mixture, in particular a pulping slurry,...
2016/0185808 PLATINUM DERIVATIVES FOR HYDROPHOBIC FORMULATIONS
New derivatives of a Pt (II) complex provided which are liposoluble and useful as anticancer agents. Also disclosed are platinum II complexes in delivery...
2016/0185807 Manganese Complexes And Use Thereof For Preparing Thin Films
Manganese complexes, methods of making the same, and use thereof in thin film deposition, such as CVD and ALD are provided herein.
2016/0185806 PROCESS FOR OBTAINING METAL-ORGANIC MATERIALS WITH STRUCTURE TYPE MIL-101 (Cr) AND MIL-101-Cr-Mx+
The present invention relates to a process for obtaining materials with Metal Organic atomic structure and called MOF (MOF: Metal Organic Framework) type...
2016/0185805 PROBE FOR IMAGING PARP-1 ACTIVITY
Provided are embodiments of a small molecule tracer for positron emission tomography (PET) imaging of the enzyme activity of PARP-1 that is responsible for...
2016/0185804 SILANE AND SILICIC ACID (HETERO)POLYCONDENSATE HAVING AROMATIC COMPOUNDS LINKED VIA COUPLING GROUPS WHICH ARE...
The present invention relates to compounds and silicic acid (hetero)polycondensates comprising structures of formulas (1) and/or (2), ##STR00001## R.sup.2 is a...
2016/0185803 PROCESS FOR THE PREPARATION OF MACROCYCLIC POLYAZACARBOXYLATE LIGANDS AND CHELATES
The present disclosure relates generally to a process for the synthesis of 1,4,7,10-tetraazacyclododecane ligands, chelates, and derivatives thereof. In...
2016/0185802 ANTIMICROBIAL COMPOSITE MATERIAL AND METHOD FOR FABRICATING THE SAME
An antimicrobial composite material and a method for fabricating the same are provided. The antimicrobial composite material includes a porous material, a...
2016/0185801 5-HT3 RECEPTOR ANTAGONISTS
The present invention provides compounds of the formula: ##STR00001## that are 5HT3 receptor antagonists and are therefore useful for the treatment of diseases...
2016/0185800 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS
Chemical entities that modulate PI3 kinase activity, and chemical entities, pharmaceutical compositions, and methods of treatments of diseases and conditions...
2016/0185799 ACC INHIBITORS AND USES THEREOF
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
2016/0185798 HETEROCYCLYLALKYNE DERIVATIVES AND THEIR USE AS MODULATORS OF mGluR5 RECEPTORS
This invention relates to compounds of formula I, ##STR00001## their use as allosteric modulators of mGluR5 receptor activity, pharmaceutical compositions...
2016/0185797 ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): ##STR00001## wherein A.sup.1-A.sup.8, R.sup.4 and R.sup.5 each has the meaning as described herein. Compounds...
2016/0185796 PHOSPHOINOSITIDE 3-KINASE INHIBITOR WITH A ZINC BINDING MOIETY
The invention provides a compound of Formula I, ##STR00001## Pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment...
2016/0185795 UREA DERIVATIVES AND THEIR USE AS FATTY-ACID BINDING PROTEIN (FABP) INHIBITORS
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, W, A and B are as described ...
2016/0185794 METHOD FOR SELECTIVELY PREPARING EVOGLUCOSENONE (LGO) AND OTHER ANHYDROSUGARS FROM BIOMASS IN POLAR APROTIC...
A method to produce 5-hydroxymethylfurfural (HMF) is described in which a reactant including cellulose, lignocellulose, or a combination thereof, in a reaction...
2016/0185793 METHOD FOR THE PURIFICATION OF EPOTHILONES VIA CRYSTALLIZATION
The present invention provides a new method of separating epothilones from one another that can be used on an industrial scale for the selective enrichment of...
2016/0185792 METHOD FOR THE PURIFICATION OF EPOTHILONES VIA CRYSTALLIZATION
The present invention provides a new method of separating epothilones from one another that can be used on an industrial scale for the selective enrichment of...
2016/0185791 DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic...
2016/0185790 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0185789 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0185788 PROCESS FOR PREPARING OXYCODONE COMPOSITIONS
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
2016/0185787 NEW STABLE SALT OF 5,10-METHYLENE-(6R)-TETRAHYDROFOLIC ACID
The present invention is directed towards the hemisulfate salt of 5,10-methylene-(6R)-tetrahydrofolic acid, preferably in substantially crystalline form, as...
2016/0185786 PYRROLOTRIAZINONES AND IMIDAZOTRIAZINONES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
2016/0185785 PYRROLO AND PYRAZOLOPYRIMIDINES AS UBIQUITIN-SPECIFIC PROTEASE 7 INHIBITORS
The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
2016/0185784 BICYCLIC UREAS AND THIADIAZOLIDINE-1, 1-DIOXIDES AS CETP INHIBITORS
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is --C(.dbd.O) or --S(O).sub.2--, are CETP...
2016/0185783 ACC INHIBITORS AND USES THEREOF
The present invention provides for compounds of formula I as acetyl-CoA carboxylase (ACC) inhibitors. The ACC inhibitors are useful for the prevention or...
2016/0185782 COMPOUNDS AND METHODS FOR INHIBITING MITOTIC PROGRESSION
This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase,...
2016/0185781 1,9-DIAZAPHENALENE DERIVATIVE AND PROCESS FOR MANUFACTURING THE SAME
A 1,9-diazaphenalene derivative is represented by ##STR00001## where R, R.sup.1, R.sup.2, R.sup.3, Y.sup.1, and Y.sup.2 are as defined in the specification and...
2016/0185780 TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
2016/0185779 DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2016/0185778 DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2016/0185777 DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
2016/0185776 IMIDE AND ACYLUREA DERIVATIVES AS MODULATORS OF THE GLUCOCORTICOID RECEPTOR
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1,...
2016/0185775 SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF
The present application relates to novel pyrazolo[1,5-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in...
2016/0185774 Anti-Infective Compounds
The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.
2016/0185773 BICYCLIC INHIBITORS
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
2016/0185772 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein...
2016/0185771 Conjugate of Benzofuranone and Indole or Azaindole, and Preparation and Uses Thereof
The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes,...
2016/0185770 SALTS, CO-CRYSTALS, AND POLYMORPHS OF AN ANXIOLYTIC COMPOUND
The present invention provides amorphous arid crystalline forms of 1-ethyl-6-(indan-2-ylamino)-3-(morpholine-4-carbonyl)-1,8-naphthyridin-4-- one (compound 1),...
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