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Patent # Description
2016/0185769 Bromodomain Inhibitors
The present invention provides for compounds of formula (I). wherein R.sup.x, R.sup.y, R.sup.x1, L.sup.1, G.sup.1, A.sup.1, A.sup.2, A.sup.3, and A.sup.4 have...
2016/0185768 THIAZOLE OREXIN RECEPTOR ANTAGONISTS
The present invention is directed to thiazole compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
2016/0185767 SOLID ORAL DOSAGE FORMULATION OF HCV INHIBITOR IN THE AMORPHOUS STATE
Described herein are solid oral dosage forms containing Compound (1) or a pharmaceutically acceptable salt thereof (Formula 1), wherein Compound (1) is in the...
2016/0185766 Novel Salts of Raltegravir
Provided herein are novel salts of raltegravir, viz., meglumine salt, erbumine salt, ammonium salt, tris salt and L-arginine salt of raltegravir and processes...
2016/0185765 ORGANIC METAL COMPLEX, LIGHT EMITTING MATERIAL, DELAYED FLUORESCENT MATERIAL, AND ORGANIC LIGHT EMITTING DEVICE
An organic metal complex represented by the following general formula is useful as a light emitting material for an organic electroluminescent device and...
2016/0185764 PREPARATION AND USE OF 7A-AMIDE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR...
The present invention relates to bicyclic himbacine derivatives of the formula ##STR00001## or a pharmaceutically acceptable salt thereof wherein: R.sup.1...
2016/0185763 LIQUID CRYSTAL STABILIZER, LIQUID CRYSTAL COMPOSITION INCLUDING THE SAME, AND LIQUID CRYSTAL DISPLAY INCLUDING...
A liquid crystal stabilizer according to an exemplary embodiment of the present invention includes at least one of the compounds represented by the following...
2016/0185762 METHOD FOR PRODUCING TRIS-AZIRIDINOMETHANE
A process for preparing trisaziridinomethane (I) ##STR00001## by reacting aziridine with chloroform, wherein the molar ratio of aziridine to chloroform is not...
2016/0185761 Compounds for Enhancing the Cognitive Function
The invention relates to 2-oxo-1-pyrrolidinyl triazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as...
2016/0185760 PROCESS FOR THE PREPARATION OF MALIC ACID SALT OF SUNITINIB
The present invention relates to a process of preparation of malic acid salt of sunitinib.(I). ##STR00001##
2016/0185759 NOVEL INDAZOLE COMPOUNDS AND A PROCESS FOR THE PREPARATION THEREOF
The patent discloses novel indazole compounds of general formula 1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications,...
2016/0185758 2-(Pyridin-2-yl)-1, 7-Diaza-Spiro [4.4] Nonane-6-One Compound as Voltage-Gated Sodium Channel Modulator
The invention relates to spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium...
2016/0185757 INDOLE DERIVATIVES AS MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF
Agents of formulas (I)/(II)/(III) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein. ##STR00001##
2016/0185756 SUBSTITUTED BENZIMIDAZOLES AND BENZOPYRAZOLES AS CCR(4) ANTAGONISTS
Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic...
2016/0185755 1,2-DISUBSTITUTED CYCLOBUTYL COMPOUNDS
The invention refers to compounds of general formula (I) ##STR00001## wherein the variables take various meanings, pharmaceutical compositions containing them...
2016/0185754 Chemical Process for the Synthesis of ...
The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The...
2016/0185753 DEUTERATED DIAMINOPYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS
Deuterated diaminopyrimidine compounds and pharmaceutical compositions containing such compounds are described. In particular, disclosed are deuterated...
2016/0185752 PIPERIDINE AND AZEPINE DERIVATIVES AS PROKINETICIN RECEPTOR MODULATORS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof (Formula (I)) in which m, X, R.sup.1, R.sup.2, R.sup.3...
2016/0185751 METHOD FOR PREPARING BENZAMIDE DERIVATIVE, NOVEL INTERMEDIATE USED IN PREPARATION OF BENZAMIDE, AND METHOD FOR...
The present invention relates to a method for preparing N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chlo- ro-2-methoxybenzamide, which...
2016/0185750 NICOTINE SALTS, CO-CRYSTALS, AND SALT CO-CRYSTAL COMPLEXES
The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular,...
2016/0185749 METHOD FOR THE SYNTHESIS OF 4-(HETEROCYCLOALKYL)-BENZENE-1,3,-DIOL COMPOUNDS
A method is described for the synthesis of 4-(heterocycloalkyl)-benzene-1,3-diol compounds of general formulae (I) and (II): ##STR00001## wherein X can be...
2016/0185748 PYRIDYL REVERSE SULFONAMIDES FOR HBV TREATMENT
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to...
2016/0185747 N-CYCLOALKYL-N-[(FUSEDPHENYL)METHYLENE]-(THIO)CARBOXAMIDE DERIVATIVES
The present invention relates to fungicidal N-cycloalkyl-N-[(fusedphenyl)methylene] carboxamide derivatives and their thiocarbonyl derivatives, their process...
2016/0185746 DIOXOLANE DERIVATIVE, LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL ELEMENT, AND LIQUID CRYSTAL DISPLAY DEVICE
A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane...
2016/0185745 ANALOGS OF VINAXANTHONE AND XANTHOFULVIN, METHODS OF SYNTHESIS, AND METHODS OF TREATMENTS THEREOF
The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.
2016/0185744 COMPOUND FOR INHIBITING SYK ACTIVITY
A compound of formula (I) or a pharmaceutically acceptable salt, hydrate or prodrug thereof for inhibiting Syk activity, ##STR00001##
2016/0185743 15-Oxospiramilactone Derivatives, Preparation Method and Uses Thereof
The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically...
2016/0185742 Method for Preparing Benzopyran Compound and Application thereof in Treating Pulmonary Fibrosis
The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a...
2016/0185741 PROCESS FOR THE PREPARATION OF PROPYLENE OXIDE
A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile,...
2016/0185740 2-BENZOYLAMINOBENZAMIDE DERIVATIVES AS BCL-3 INHIBITORS
The invention relates to a compound of general formula (I): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, m and n are as defined herein. The...
2016/0185739 Solid Forms Of A Transthyretin Dissociation Inhibitor
The present invention relates to solid forms of the N-methyl-D-glucamine (meglumine) salt of 6-carboxy-2-(3,5-dichlorophenyl)-benzoxazole and to methods for...
2016/0185738 PROCESS FOR PRODUCING 2-PHENYL-1,3-BENZOXAZOLES
The present invention relates to a novel method for producing 2-phenyl-1,3-benzoxazoles of formula (I). ##STR00001##
2016/0185737 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More...
2016/0185736 NOVEL, TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
The present invention provides a novel P2X.sub.3 and/or P2X.sub.2/3 receptor antagonist. A compound represented by the formula (I): ##STR00001## wherein...
2016/0185735 FATTY ACID ANALOGS AND THEIR USE
Embodiments of novel fatty acid analogs, precursors of such analogs, pharmaceutical compositions including same, and methods of their use are disclosed. In...
2016/0185734 METHOD FOR PRODUCING OPTICALLY ACTIVE 5-HYDROXY-3-KETOESTER
The object of the present invention is to provide a method for producing in high yield with high stereoselectivity an optically active 5-hydroxy-3-ketoester...
2016/0185733 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
The present invention relates to compounds of formula I: ##STR00001## in which Y, Y.sub.1, Y.sub.4, Y.sub.5, Y.sub.6, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are...
2016/0185732 METHOD AND INDUSTRIAL PROCESS FOR CONTINUOUS SYNTHESIS OF DIFFERENT IONIC LIQUIDS
Producing different ionic liquids industrially currently requires either operating separate plants or continually refitting existing plants. While this is not...
2016/0185731 METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES
The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing...
2016/0185730 DRUG FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR...
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use...
2016/0185729 PROCESSES FOR PREPARING 3-BENZAZEPINES
The present invention provides processes and intermediates for the preparation of 3-benzazepines and salts thereof which can be useful as serotonin (5-HT)...
2016/0185728 CYANOQUINOLINE DERIVATIVES
Disclosed is a compound of formula I, a stereoisomer thereof, a cis-trans-isomer thereof, a tautomer thereof, or a mixture thereof, or a pharmaceutically...
2016/0185727 SUBSTITUTED 4-AMINO-5-(CYCLOHEXYLOXY)QUINOLINE-3-CARBOXYLIC ACIDS AS SWEET FLAVOR MODIFIERS
Disclosed herein are 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acid compounds having useful as sweet flavor modifiers. Also disclosed herein are...
2016/0185726 ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF
The present invention relates to novel anthelmintic compounds of formula (I) below: ##STR00001## wherein Y and Z are independently a bicyclic carbocyclic or a...
2016/0185725 c-Met Modulators and Method of Use
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation,...
2016/0185724 HYDROXYPHENYL DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF
The invention relates to hydroxyphenyl derivatives of formula (I); and uses thereof as anti-bacterial and/or anti-parasitic agents.
2016/0185723 C-H FLUORINATION OF HETEROCYCLES WITH SILVER (II) FLUORIDE
The present invention provides compositions and methods for the selective C--H fluorination of nitrogen-containing heteroarenes with AgF.sub.2, which has...
2016/0185722 METHOD FOR PRODUCING META-XYLYLENEDIAMINES AND METHOD FOR PRODUCING BISAMIDE COMPOUND
A method for producing meta-xylylenediamines includes a reaction step in which monohalogenated benzenes, formaldehydes, and an amide compound having a primary...
2016/0185721 INDOLE-CARBOXAMIDES
The present invention relates to compounds of general formula ##STR00001## wherein R.sup.1 is aryl or heteroaryl, which are optionally substituted by one, two or...
2016/0185720 Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-p- ...
Novel salt forms of [R--(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1-methylethyl- )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid ...
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