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Patent # Description
2016/0184319 Method of Treating Mixed Lineage Leukemia Gene-Rearranged Acute Lymphoblastic Leukemias
The present invention relates to a method of treating a warm-blooded animal, especially a human, having Mixed Lineage Leukemia (MLL rearranged ALL) comprising...
2016/0184318 AUTOTAXIN INHIBITORS
The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments...
2016/0184317 Aminopyridine Derived Compounds as LRRK2 Inhibitors
The present invention is directed to aminopyridine derived compounds of formula (A) ##STR00001## The compounds are considered useful for the treatment of...
2016/0184316 NEPRILYSIN INHIBITORS
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1-R.sup.6, a, b, and X are as defined in the specification, or a...
2016/0184315 METHOD OF IMPROVING COGNITION AND SOCIAL BEHAVIOR IN HUMANS HAVING DEFICITS THEREIN DUE TO NEURODEGENERATIVE...
A .beta..sub.1-ADR agonist prodrug compound, which is hydrolysable in vivo to release a .beta.1-ADR agonist compound, and which prodrug compound contains a...
2016/0184314 Drug Combinations and Uses in Treating a Coughing Condition
The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a...
2016/0184313 Drug Combinations and Uses in Treating a Coughing Condition
The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a...
2016/0184312 TRANSDERMAL ADMINISTRATION SYSTEM FOR USE IN THE TREATMENT OF CHRONIC BRONCHOPULMONARY DISEASES
Transdermal administration system comprising doxofylline as the active ingredient, for use in the treatment of bronchopulmonary diseases having a...
2016/0184311 Combination Therapy for the Treatment of Cancer
The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt...
2016/0184310 OXOQUINAZOLINYL-BUTANAMIDE DERIVATIVES
Compounds of the formula I ##STR00001## in which R.sup.1-R.sup.3 and Z have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed,...
2016/0184309 METHODS OF TREATING VARIOUS CANCERS USING AN AXL/cMET INHIBITOR ALONE OR IN COMBINATION WITH OTHER AGENTS
This application describes the use of the compound (I) or a salt thereof, either alone or in combination with other therapeutically active agents, for the...
2016/0184308 AMINOPYRIMIDINE DERIVATIVES FOR USE AS MODULATORS OF KINASE ACTIVITY
The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative...
2016/0184307 Heterocyclyl Pyrimidine Analogues As TYK2 Inhibitors
The present invention relates to compounds of formula (I) ##STR00001## wherein R, R.sup.1, X.sup.1 to X.sup.5 have the meaning as cited in the description and...
2016/0184306 Novel Pyrimidinyl-DiazoSpiro Compounds
The invention relates to spiro derivatives, to the use of said derivatives in treating diseases and conditions mediated by modulation of voltage-gated sodium...
2016/0184305 1,4-DISUBSTITUTED PYRIDAZINE QUINOLNE ANALOGS THERE OF AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS
The present invention provides a compound of formula IA or a pharmaceutically acceptable salt thereof; 5 (IA) a method for manufacturing the compounds of the...
2016/0184304 COMPOSITION FOR REDUCING NERVOUS SYSTEM INJURY AND METHOD OF MAKING AND USE THEREOF
This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system...
2016/0184303 COMPOUNDS AND THEIR USE AS BACE INHIBITORS
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic...
2016/0184302 LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of...
2016/0184301 LIPID-BASED COMPOSITIONS OF ANTIINFECTIVES FOR TREATING PULMONARY INFECTIONS AND METHODS OF USE THEREOF
A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of...
2016/0184300 COMPOSITION CONTAINING A DPP-IV INHIBITOR FOR PREVENTING OR TREATING RENAL DISEASES
The present invention relates to a composition for preventing or treating renal diseases. The composition of the present invention improves lipid metabolism,...
2016/0184299 COMBINATION COMPOSITION COMPRISING OXYCODONE AND ACETAMINOPHEN FOR RAPID ONSET AND EXTENDED DURATION OF ANALGESIA
The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia,...
2016/0184298 INHIBITORS AND ENHANCERS OF URIDINE DIPHOSPHATE-GLUCURONOSYLTRANSFERASE 2B (UGT2B)
A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is...
2016/0184297 CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or...
2016/0184296 COMPOSITIONS COMPRISING BUPRENORPHINE
This disclosure relates to a buprenorphine sustained release delivery system for treatment of conditions ameliorated by buprenorphine compounds. The sustained...
2016/0184295 ABUSE-PROOFED ORAL DOSAGE FORM
The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it...
2016/0184294 NASAL DRUG PRODUCTS AND METHODS OF THEIR USE
Drug products adapted for nasal delivery, comprising a pre-primed device filled with a pharmaceutical composition comprising an opioid receptor antagonist, are...
2016/0184293 A COMBINATION OF OXYCODONE AND NALOXONE FOR USE IN TREATING PAIN IN PATIENTS SUFFERING FROM PAIN AND A DISEASE...
The present invention is concerned with an oral pharmaceutical dosage form comprising oxycodone or a pharmaceutically acceptable salt thereof and naloxone or a...
2016/0184292 SUBLINGUAL AND BUCCAL FILM COMPOSITIONS
The present invention relates to products and methods for treatment of various symptoms in a patient, including treatment of pain suffered by a patient. The...
2016/0184291 TREATMENT FOR COLLAPSING TRACHEA
The present invention provides pharmaceutical methods and formulations for treating collapsing trachea and related disorders.
2016/0184290 METHOD OF TREATING SCHIZOPHRENIA
A method of treating symptoms of schizophrenia includes enterically administering to a subject a pharmacological agent that inhibits presynaptic glutamate...
2016/0184289 COMPOSITIONS CONTAINING AROMATIC ALDEHYDES AND THEIR USE IN TREATMENTS
Disclosed are pharmaceutical and cosmetic compositions containing aromatic aldehyde compounds. Some of the disclosed compositions are useful as topical...
2016/0184288 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS
The invention relates to compounds of formula I: ##STR00001## where a, R.sup.1, and R.sup.3-6 are as defined in the specification, or a pharmaceutically...
2016/0184287 TREATMENT FOR NICOTINE-INDUCED LUNG DISEASE USING PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA AGONISTS
This invention pertains to the discovery that nicotine interrupts molecular signaling between endodermal and mesodermal cells of the lung alveolus. Treatment...
2016/0184286 DURABLE TREATMENT WITH 4-AMINOPYRIDINE IN PATIENTS WITH DEMYELINATION
Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a...
2016/0184285 PIPERIDINE UREA DERIVATIVES
Compounds of the formula I ##STR00001## in which R.sup.1-R.sup.3 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter...
2016/0184284 LIQUID PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION COMPRISING FEXOFENADINE
The present invention relates to a liquid pharmaceutical composition for oral administration comprising fexofenadine and/or a pharmaceutically acceptable salt...
2016/0184283 ANTIBACTERIAL COMPOUNDS
Disclosed are compounds of formula (I): ##STR00001## which are of use in the treatment of bacterial diseases and infections, to compositions containing those...
2016/0184282 NAMPT INHIBITORS
Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is...
2016/0184281 NAMPT INHIBITORS
Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is...
2016/0184280 METHODS OF PREVENTING THE DEVELOPMENT OF MUCOSITIS AND RELATED DISORDERS
Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof...
2016/0184279 METHODS OF TREATING PAIN AND/OR ITCH WITH SMALL MOLECULE INHIBITORS TARGETING AN mTOR PATHWAY
Methods of treating pain and/or itch in a targeted region of a subject and compositions and dosage forms therefor are described herein. Such methods can...
2016/0184278 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE VASCULAR DISORDERS
The technology described herein is directed to methods and compositions for the treatment of proliferative vascular disorders, e.g. hemangioma. In some...
2016/0184277 Use of Metformin in Combination with a Glucokinase Activator and Compositions Comprising Metformin and a...
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose,...
2016/0184276 Sphingosine kinase inhibition for the treatment and prevention of obstetrical disorders
The subject invention is directed to the treatment of obstetrical disorders by administration of a sphingosine kinase inhibitor. Spingosine kinase inhibitors...
2016/0184275 PHARMACEUTICAL COMPOSITION FOR MODIFIED USE
A pharmaceutical composition for modified release, comprising (1) (R)-2-(2-aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]a- cetic acid anilide,...
2016/0184274 Methods for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition
Methods of using inhibitors of Goodpasture Antigen Binding Protein for inhibiting mesenchymal phenotype after epithelial-to-mesenchymal transition (EMT),...
2016/0184273 NOVEL SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS
The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical...
2016/0184272 Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably...
2016/0184271 Amino Acid Composition for Use in the Treatment of a PDD
The invention relates to the use of at least one amino acid, selected from the group of histidine, lysine, and threonine in the manufacture of a composition...
2016/0184270 SUBSTITUTED 2-IMIDAZOLIDINONES AND 2-IMIDAZOLONES AND THEIR USE IN THE TREATMENT OF CANCER
Compounds of formula (I) wherein R.sub.1, R.sub.4, R.sub.8, X and Y as defined herein are provided as useful for the inhibition of certain types of cancer...
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