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Patent # Description
2016/0193367 Imageable Polymers
This invention relates to imageable polymers, particularly those comprising poly vinylalcohol and to methods for making them as well as to embolic microspheres...
2016/0193366 SILICONE-BASED ENTERIC CT CONTRAST MATERIAL
The present invention provides a silicon-based polymer contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric...
2016/0193365 Near-Infrared Fluorescent Surgical Dye Markers
The potential use of a PMMA encapsulated near-infrared fluorescent dye includes endoscopic tattooing of intestinal neoplasms, location visualization of...
2016/0193364 COMPOSITIONS AND METHODS FOR MODULATING MITOCHONDRIAL PYRUVATE CARRIER ACTIVITY
Disclosed herein are methods and compositions for the diagnosis and treatment of conditions associated with aberrant pyruvate metabolism, and symptoms thereof,...
2016/0193363 Imaging Brown Adipose Tissue with Curcumin Derivatives
Methods and compositions for imaging Brown adipose tissue (BAT) in living mammals, e.g., humans.
2016/0193362 NEW CELL-SPECIFICALLY ACTIVE NUCLEOTIDE MOLECULES AND APPLICATION KIT FOR THE APPLICATION THEREOF
Cell-specifically active nucleotide molecules and application kit for the use thereof. The problem to be solved was to modify long molecules in such a way that, ...
2016/0193361 LIPOPHILIC NANOPARTICLES FOR DRUG DELIVERY
Nanostructures having a core, a lipid layer and a lipoprotein which are useful for delivering therapeutic agents are provided herein. Methods of treating...
2016/0193360 POLYFUNCTIONAL RADICAL SCAVENGER HYDROGEL FORMULATION
A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional...
2016/0193359 NEW BINDER-DRUG CONJUGATES (ADCS) AND USE THEREOF
The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active...
2016/0193358 ANTIGEN BINDING PROTEINS
The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA...
2016/0193357 Dosages of Immunoconjugates of Antibodies and SN-38 for Improved Efficacy and Decreased Toxicity
The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. In...
2016/0193356 ENGINEERED POLYPEPTIDE CONJUGATES USING TRANSGLUTAMINASE
The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates) comprising specific acyl donor glutamine-containing tags and...
2016/0193355 Novel linker, preparation method, and application thereof
Provided in the present invention is a linker and a preparation method thereof, wherein one end of the linker may covalently link a small molecule compound and...
2016/0193354 ANTISENSE OLIGONUCLEOTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES
The invention relates to an antisense or siRNA oligonucleotide or conjugate with improved pharmacokinetic properties, methods of producing the same as well as...
2016/0193353 FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a...
2016/0193352 Mono- and Di-Peg IL-10 Production; and Uses
Provided are methods of producing mono- and di-pegylated IL-10.
2016/0193351 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY
Conjugates which comprise a drug and a ligand which includes a first saccharide; wherein the conjugate is characterized in that, when the conjugate is...
2016/0193350 Phosphorylcholine Conjugates and Uses Thereof
The present invention provides phosphorylcholine (PC)-conjugates and pharmaceutical compositions, particularly vaccines comprising same for the prevention or...
2016/0193349 FUCOIDAN NANOGELS AND METHODS OF THEIR USE AND MANUFACTURE
Described herein are polymeric drug-carrying nanogels that are capable of targeting to P-selectin for the treatment of cancer and other diseases and conditions...
2016/0193348 MUCOUS LAYER-ADHESIVE POLY-r-GLUTAMIC ACID NANOMICELLES AND DRUG DELIVERY SYSTEM USING SAME
The present invention relates to nanomicelles composed of a complex of a lipophilic compound and a poly-gamma-glutamic acid wherein a portion of carboxyl...
2016/0193347 MULTI-TARGETED UBENIMEX PRODRUG DERIVATIVE AND PREPARATION METHOD AND USE THEREOF
The present invention relates to the design, synthesis, and biological study of multi-targeted Ubenimex pro-drug derivative. More particularly, provided in the...
2016/0193346 Injectable, Non-Aqueous Suspension with High Concentration of Therapeutic Agent
An injectable, nonaqueous suspension including at least one therapeutic agent suspended in a single component vehicle. The single component vehicle is a single...
2016/0193345 Oral Drug Delivery System
Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of...
2016/0193344 Fragmented Hydrogels
Fragmented polysaccharide based hydrogel compositions and methods of making and using the same are provided. The subject polysaccharide based hydrogel...
2016/0193343 COMPOSITION FOR USE IN TREATING AND PREVENTING INFLAMMATION RELATED DISORDER
The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (HA)...
2016/0193342 Modified Hyaluronic Acid Polymer Compositions and Related Methods
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled...
2016/0193341 SOLID FORMULATIONS OF LIQUID BIOLOGICALLY ACTIVE AGENTS
The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent;...
2016/0193340 NOVEL USES OF ALKYL POLYGLYCOSIDES FOR SOLUBILISING VITAMIN E IN WATER; COMPOSITIONS COMPRISING SAME
A composition represented by formula (I): R--O-(G).sub.p-H (I) in which R represents a radical including 6 to 8 carbon atoms, G represents the residue of a...
2016/0193339 TRANSDERMAL FORMULATIONS
The present disclosure is directed to transdermal and moisturizing compositions.
2016/0193338 BIOPHOTONIC COMPOSITIONS COMPRISING A CHROMOPHORE AND A GELLING AGENT FOR TREATING WOUNDS
The present disclosure provides biophotonic compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure are...
2016/0193337 IRON-SALEN COMPLEX
The present invention provides a drug delivery system that overcomes conventional technical problems and that is readily put to practical use. Iron-salen...
2016/0193336 METHODS FOR USING NITRIC OXIDE IN A PLASMA STATE TO TREAT MEDICAL CONDITIONS AND DISEASES
Methods for administering nitric oxide (NO) in a plasma state to a treatment site are disclosed. A discrete stream of matter is placed in a plasma state, in...
2016/0193335 Identification of Surface-Associated Antigens for Tumor Diagnosis and Therapy
Disclosed is a method of diagnosing and treating a head neck cancer characterized by expressing a tumor-associated antigen having the amino acid sequence shown...
2016/0193334 TREATING CANCER WITH A COMBINATION OF A PD-1 ANTAGONIST AND DINACICLIB
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and the CDK inhibitor dincaciclib, and...
2016/0193333 METHODS OF TREATING GENERALIZED PUSTULAR PSORIASIS (GPP) USING IL-17 ANTAGONISTS
The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP). These methods, treatment...
2016/0193332 Activatable Antibodies That Bind Epidermal Growth Factor Receptor And Methods Of Use Thereof
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically...
2016/0193331 Methods for treating and/or limiting development of diabetes
The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting...
2016/0193330 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about...
2016/0193329 Deletion Mutants of Flagellin and Methods of Use
Compositions that include at least a portion of a flagellin and an antigen can be employed in methods that stimulate an immune response in a subject, in...
2016/0193328 Immunoadjuvant Compositions and uses Thereof
The present invention relates to an immunoadjuvant composition comprising at least adjuvant and at least one MyD88-dependent pathway agonist.
2016/0193327 MUCOSAL VACCINE COMPOSITION
The present invention aims at providing a mucosal vaccine composition that can be administered to an intraoral mucous membrane, ocular mucous membrane, ear...
2016/0193326 Vaccine Compositions for Drug Addiction
The present invention relates generally to vaccines for drug addiction. In particular, the present disclosure provides adjuvants for significantly improving...
2016/0193325 INFECTIOUS HEPACIVIRUS PSEUDO-PARTICLES CONTAINING FUNCTIONAL e1, e2 ENVELOPE PROTEINS
The invention relates to the generation and the use of hepacivirus pseudo-particles containing native functional E1, E2 envelope glycoproteins assembled onto...
2016/0193324 METHODS OF IMMUNIZATION WITH VARICELLA ZOSTER VIRUS ANTIGEN
The present invention relates to a method of vaccinating a patient against varicella zoster virus (VZV) by delivery of an effective amount of a live attenuated...
2016/0193323 Fowl Adenovirus Vaccine
Disclosed is a vaccine comprising fiber (2) protein of Fowl Adeno-virus C (FAdV-C) or an immunogenic fragment thereof for use in preventing ...
2016/0193322 COMBINATION IMMUNOGENIC COMPOSITIONS
Combination immunogenic compositions capable of eliciting protection against both RSV and B. pertussis infection and disease are provided, including...
2016/0193321 MAKING INFLUENZA VIRUS VACCINES WITHOUT USING EGGS
Currently, the steps performed prior to release of influenza strains to vaccine manufacturers involve passaging influenza virus through eggs. The invention...
2016/0193320 USE OF A PCV2 IMMUNOGENIC COMPOSITION FOR LESSENING CLINICAL SYMPTOMS IN PIGS
The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several...
2016/0193319 Flagellin Fusion Proteins and Use Thereof to Induce Immune Responses Against Pseudomonas aeruginosa
The invention provides compositions and fusion proteins comprising a flagellin adjuvant and a Pseudomonas aeruginosa antigen. The invention further provides...
2016/0193318 VACCINE
The invention is based upon the identification of a number of antigens derived from a species of the genus Streptococcus, which are cross reactive and which...
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