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Patent # Description
2016/0194417 DEGRADABLE POLYMER RESINS AND METHODS FOR THEIR PREPARATION
Disclosed are polymers having one or more two-photon absorbing chromophores in a backbone of the polymers. The polymers degrade upon two-photon excitation,...
2016/0194416 DISPERSION STABILIZER FOR SUSPENSION POLYMERIZATION AND METHOD FOR PRODUCING VINYL RESIN
The present invention provides a highly water-soluble and easy-to-handle dispersion stabilizer for suspension polymerization that meets the following...
2016/0194415 CATECHOL-RICH POLYMERS FROM N-SUBSTITUTED MALEIMIDES
Disclosed are monomers, polymers and a method of making polymers that retain the ability of the polymer to from reversible and irreversible bonds. Gels...
2016/0194414 PROCESS FOR THE PREPARATION OF 2,2'-BIS-INDENYL BIPHENYL LIGANDS AND THEIR METALLOCENE COMPLEXES
The invention relates to a novel process for the preparation of 2,2'-bis indenyl biphenyl ligands of following formula (3): The invention also relates to...
2016/0194413 CATALYST WITH AL-ALKOXY COMPONENT
The invention refers to a process for preparing a Group 2 metal/transition metal olefin polymerization catalyst component in particulate form having an...
2016/0194412 DISPERSION STABILIZER FOR SUSPENSION POLYMERIZATION AND METHOD FOR PRODUCING VINYL RESIN
The present invention provides an easy-to-handle dispersion stabilizer for suspension polymerization that meets the following requirements: even if the amount...
2016/0194411 END-FUNCTIONAL CONJUGATED DIENE-BASED POLYMER AND MANUFACTURING METHOD THEREFOR
Disclosed are an end-functionalized conjugated diene-based polymer represented by Chemical Formula 1 and a method of preparing the same.
2016/0194410 BINDING AGENT
A binding agent of the Formula A-a':a-S-b:b'-B:X(n), wherein A as well as B is a monovalent binder, a':a as well as b:b' is a binding pair wherein a' and a do...
2016/0194409 Bispecific CD33 and CD3 Binding Proteins
Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human...
2016/0194408 ANTI-PCSK9 ANTIBODIES AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the...
2016/0194407 BINDING MOLECULES SPECIFIC FOR CD73 AND USES THEREOF
The present disclosure provides anti-CD73 binding molecules, e.g., antibodies and antigen binding fragments thereof. Also provided are pharmaceutical...
2016/0194406 MODULATION OF EFFEROCYTOSIS PATHWAYS FOR TREATMENT OF ATHEROSCLEROTIC DISEASE
Smooth muscle cells (SMC) from subjects carrying at least one 9p21 risk factor, can be resistant to efferocytosis, leading to the retention of such cells in...
2016/0194405 ANTI-TISSUE FACTOR ANTIBODIES AND COMPOSITIONS
Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as...
2016/0194404 Compositions and Methods for Treatment of Cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified...
2016/0194403 MODULATION OF GAMMA DELTA T CELLS
The present invention relate to the discovery that BTLA, IL-7 and ROR.gamma.t modulate the activity and expression of .gamma..delta.T cells. Specifically, the...
2016/0194402 CD70-BINDING PEPTIDES AND METHOD, PROCESS AND USE RELATING THERETO
The invention relates to a method for obtaining CD70-binding peptides. With this method CD70-binding peptides may be obtained and/or selected. Further aspects...
2016/0194401 THERAPEUTIC AGENT FOR CHRONIC ARTHRITIDES DISEASES OF CHILDHOOD-RELATED DISEASES
A therapeutic agent for chronic arthritides diseases of childhood-related diseases, for example chronic arthritides diseases of childhood, Still's disease and...
2016/0194400 ANTIBODY WHICH SPECIFICALLY REACTS WITH HUMAN INTEGRIN A6B4
It is an object of the present invention to provide an anti-ITGA6/B4 human antibody, which specifically recognizes ITGA6B4 complex expressed on a cell membrane...
2016/0194399 ANTI-CD3 ANTIBODIES, ACTIVATABLE ANTI-CD3 ANTIBODIES, MULTISPECIFIC ANTI-CD3 ANTIBODIES, MULTISPECIFIC...
The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically...
2016/0194398 Humanized Monoclonal Antibodies and Methods of Use for the Diagnosis and Treatment of Colon and Pancreas Cancer
This invention relates to humanized antibodies that selectively bind the 31.1 epitope on the A33 protein differentially expressed in cancers including, lung...
2016/0194397 FC RECEPTOR BINDING PROTEINS
This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding...
2016/0194396 Bi-Specific Monovalent Fc Diabodies That Are Capable of Binding CD32B and CD79b and Uses Thereof
The present invention is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain ("bi-specific monovalent Fc diabodies") and are...
2016/0194395 Fusion proteins and their related methods
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated...
2016/0194394 ANTIBODIES AGAINST FRIZZLED PROTEINS AND METHODS OF USE THEREOF
This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal...
2016/0194393 METHODS AND COMPOSITIONS FOR MODULATING VOLTAGE-GATED CALCIUM CHANNEL FUNCTION
Therapeutic agents targeted to voltage gated calcium channels and compositions comprising such therapeutic agents are provided, as is the use of such agents...
2016/0194392 ANTIBODIES AGAINST IL-1 BETA
The present invention relates to anti-IL-1 beta antibodies and in particular to monovalent high potency IL-1 beta-binding antibody fragments being highly...
2016/0194391 ANTIBODY DERIVATIVES
The invention relates inter alia to a bivalent, bispecific construct comprising an anti-IL-6 antibody, or derivative thereof, and an anti-IL-23 antibody, or...
2016/0194390 LOW ACIDIC SPECIES COMPOSITIONS AND METHODS FOR PRODUCING AND USING THE SAME
The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods,...
2016/0194389 FC-RECEPTOR BINDING MODIFIED ASYMMETRIC ANTIBODIES AND METHODS OF USE
The present invention relates to antibodies and Fc-region fusion polypeptides which are asymmetrically modified with respect to their Fc-receptor, especially...
2016/0194388 MONOCLONAL ANTIBODIES TO HUMAN 14-3-3 EPSILON AND HUMAN 14-3-3 EPSILON SV
The present invention provides isolated antibodies that bind to 14-3-3 epsilon that are useful in the recognition of tumor cells and tumor specific delivery of...
2016/0194387 Methods Of Treating Inflammation Associated Airway Diseases And Viral Infections
The present disclosure provides methods of treating a pathogen-induced lung inflammation in a subject are provided in which an anti-S100A9 antibody is...
2016/0194386 COMPOSITIONS AND METHODS FOR TREATMENT OF HSCT-ASSOCIATED THROMBOTIC MICROANGIOPATHY
Disclosed are drugs capable of inhibiting the complement pathway for use for treating hematopoietic stem cell transplant (HSCT) associated thrombotic...
2016/0194385 An Antibody Therapy for Amyloid Beta Disease
The present disclosure relates generally to a protocol to treat or prevent diseases or conditions associated with pathological forms of amyloid beta (A.beta.),...
2016/0194384 COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS
This disclosure provides isolated or recombinant polypeptides that are useful to vaccinate individuals suffering from chronic/recurrent biofilm disease or as a...
2016/0194383 ANTI-HUMAN RESPIRATORY SYNCYTIAL VIRUS (RSV) ANTIBODIES AND METHODS OF USE
Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus...
2016/0194382 MEANS AND METHODS FOR PRODUCING HIGH AFFINITY ANTIBODIES
The invention provides means and methods for modulating the occurrence of somatic hypermutations in antibody producing plasmablast-like B-cells.
2016/0194381 METHODS AND COMPOSITIONS FOR TREATMENT OF RETINOID-RESPONSIVE CONDITIONS
Methods and composition for treating a retinoid-responsive condition in a subject are provided according to embodiments of the present invention which include...
2016/0194380 POTENT INHIBITORS OF HUMAN MATRIPTASE DERIVED FROM MCOTI-II VARIANTS
The present invention pertains to highly potent Matriptase inhibitors derived from the miniprotein McotI-II.
2016/0194379 Regeneration of Damaged Tissue
A method of healing a wound including contacting a wound edge with a tropoelastin or elastin derived peptide in conditions for enabling a sustained contact of...
2016/0194378 PEPTIDES AND USES THEREOF
Provided is a peptide and a hydrogel prepared therefrom. The peptide comprises the sequence Gly-(A)-(Gly-X-Y).sub.m-M-(Gly-X-Y).sub.n-Gly-(B)-Gly, wherein A...
2016/0194377 Crystal Structure of Staphylococcus Aureus Clumping Factor A in Complex with Fibrinogen Derived Peptide and...
The present invention discloses crystal structure of Staphylococcus aureus Clumping factor A (ClfA) in complex with fibrinogen (Fg) derived peptide. Also, the...
2016/0194376 HEMATOPOIETIC CELL SELECTIN LIGAND POLYPEPTIDES AND METHODS OF USE THEREOF
The invention feature methods and compositions for treating inflammatory disorders, hematopoietic disorders and non-hematopoietic disorders (e.g., ...
2016/0194375 Engineering Antiviral T Cell Immunity through Stem Cells and Chimeric Antigen Receptors
The HIV-specific cytotoxic T lymphocyte (CTL) response is a critical component in controlling HIV replication and is an important part of the ultimate failure...
2016/0194374 RECOMBINANT AAV-CRUMBS HOMOLOGUE COMPOSITION AND METHODS FOR TREATING LCA-8 AND PROGRESSIVE RP
The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a medicament or in a method of treatment or prophylaxis, for example in the...
2016/0194373 TREATING TYPE I AND TYPE II DIABETES
This document provides methods and materials for treating diabetes. For example, methods and materials for using nucleic acid encoding human preproinsulin to...
2016/0194372 CELL COMPOSITIONS DERIVED FROM DEDIFFERENTIATED REPROGRAMMED CELLS
Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent...
2016/0194371 Fusion proteins comprising FGF-21 and GLP-1R agonist
The invention is directed to a fusion protein comprising at least one FGF-21 (fibroblast growth factor-21) compound and at least one GLP-1R (glucagon-like...
2016/0194370 FUSION PROTEIN OF THERAPEUTIC POLYPEPTIDE WITH IMPROVED PHARMACOKINETIC PROFILE AND USE THEROF
The present invention provides a fusion protein comprising a therapeutic polypeptide fused to one or more flexible unstructured polypeptides and a trimeric...
2016/0194369 METHODS AND COMPOSITIONS FOR CO-EXPRESSION OF POLYPEPTIDES OF INEREST AND IL6
The present invention provides a CHO cell that includes a polynucleotide encoding a polypeptide of interest. The CHO cell may include a heterologous...
2016/0194368 CIRCULAR POLYNUCLEOTIDES
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of circular polynucleotides.
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