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Patent # Description
2016/0194367 IMMUNOGENIC PEPTIDES AND THEIR USE IN IMMUNE DISORDERS
The present invention provides novel peptides and homologues thereof. The peptides of the invention comprise (i) a T-cell epitope of an antigen (self or...
2016/0194366 APPLICATIONS OF AN IMMUNE SYSTEM-RELEASED ACTIVATING AGENT (ISRAA)
The present invention relates to applications of an immune system-released activating agent (ISRAA) polypeptide, which is induced by a nervous stimulus and...
2016/0194365 METHODS FOR TREATMENT OF AND PROPHYLAXIS AGAINST INFLAMMATORY DISORDERS
An isolated and purified peptide, neonatal NET-inhibitory Factor (nNIF), is disclosed. Methods for treatment of and prophylaxis against inflammatory disorders...
2016/0194364 INSECTICIDAL POLYPEPTIDES HAVING BROAD SPECTRUM ACTIVITY AND USES THEREOF
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having...
2016/0194363 Compositions and Methods Related to Protein A (SpA) Variants
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium....
2016/0194362 Recombinant polypeptide construct comprising multiple enterotoxigenic Escherichia coli fimbrial subunits
The inventive subject matter relates to a recombinant polypeptide constructs comprising enterotoxigenic Escherichia coli fimbrial subunits. The recombinant...
2016/0194361 Modular DNA-Binding Domains and Methods of Use
The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically...
2016/0194360 PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS
Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis). Compounds which modulate one or...
2016/0194359 CELL-REACTIVE, LONG-ACTING, OR TARGETED COMPSTATIN ANALOGS AND RELATED COMPOSITIONS AND METHODS
In some aspects, the present invention provides cell-reactive compstatin analogs and compositions comprising cell-reactive compstatin analogs. In some aspects,...
2016/0194358 LINEAR PEPTIDE ANTIBIOTCS
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in...
2016/0194357 Novel NPR-B Agonists
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
2016/0194356 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
Disclosed herein are compositions and methods related to aromatic-cationic peptides. In particular, the compositions and methods relate to aromatic-cationic...
2016/0194355 DIPEPTIDYL PEPTIDASE-IV (DPPIV), INHIBITORY PEPTIDE COMPOUND, COMPOSITION CONTAINING THE SAME, AND PRODUCTION...
A peptide compound having a dipeptidyl peptidase-IV (DPPIV) inhibitory activity or a composition containing the peptide compound that can make a contribution...
2016/0194354 STEREOSELECTIVE SYNTHESIS OF DIOLS AND TRIOLS BY MANNICH REACTION AND THEIR USE IN THE SYNTHESIS OF CARFILZOMIB
It is provided an improved process for preparing Carfilzomib, including novel compounds that can be used as intermediates in the process for preparing...
2016/0194353 IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions...
2016/0194352 AMORPHOUS FORMS OF DACLATASVIR DIHYDROCHLORIDE
The present application relates to the amorphous form of Daclatasvir dihydrochloride and the processes for the preparation thereof. The application further...
2016/0194351 Progesterone Phosphate Analogs and Uses Related Thereto
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed...
2016/0194350 NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS...
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2 and R.sup.3 are as described herein, and their prodrugs or...
2016/0194349 COMPOSITIONS AND METHODS FOR MODULATING ANGIOPOIETIN-LIKE 3 EXPRESSION
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods,...
2016/0194348 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the...
2016/0194347 METHOD FOR PRODUCING P1,P4-DI(URIDINE 5'-) TETRAPHOSPHATE
A method for producing P.sup.1,P.sup.4-di(uridine 5'-) tetraphosphate (UP.sub.4U) that can avoid reduction of the synthetic efficiency without using UTP free...
2016/0194346 METALPORPHYRIN COMPLEX, PREPARATION METHOD THEREFOR AND METHOD FOR PREPARING POLYCARBONATE
The present invention provides a metalporphyrin complex having structure represented by formula (I), wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,...
2016/0194345 PLATINUM (II) COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF
Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method...
2016/0194344 Pyridine-Oxyphenyl Coordinated Iridium (III) Complexes and Methods of Making and Using
Iridium (III) complexes are described together with methods to prepare and use such complexes. Also described are devices that utilize the iridium (III)...
2016/0194343 METATHESIS CATALYSTS AND METHODS THEREOF
The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides...
2016/0194342 PHENICOL ANTIBACTERIALS
The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these...
2016/0194341 SILYLATED POLYISOCYANATES
The present invention relates to silylated polyisocyanates containing allophante groups, to processes for preparing them, to their use, and to coating...
2016/0194340 ARGINASE INHIBITORS AND METHODS OF USE
The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: ##STR00001## or a pharmaceutically acceptable salt thereof,...
2016/0194339 Organic Silver Complexes, Their Preparation Methods and Their Methods for Forming Thin Layers
Provided herein is a method for preparing a silver complex. The method includes reacting a silver oxide with a mixture of ammonium carbamate and isopropyl...
2016/0194338 SUBSTITUTED TETRAHYDROCARBAZOLE AND CARBAZOLES CARBOXAMIDE COMPOUNDS
Disclosed are compounds of Formula (I) ##STR00001## wherein: the two dotted lines represent either two single or two double bonds; Q is: ##STR00002## R.sub.1...
2016/0194337 GLYCOSIDASE INHIBITORS AND USES THEREOF
A locking arrangement secures together first and second panels. The arrangement includes locking tabs (54, 56, 58) projecting from an end edge (64) of the...
2016/0194336 P38 MAPK INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES
The present invention provides new p38 mitogen activated protein (MAP) kinase allosteric inhibitors which are useful for the treatment of p38 mediated diseases...
2016/0194335 POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
2016/0194334 FORM 2 CRYSTALLINE POLYMORPH OF A SALT OF ...
There is provided Form 2 crystalline polymorph consisting of N-[1-6-(ethynyl-3-oxo-hexahydro-furo[3,2-b]pyrrole-4-carbonyl)-3-methyl-b- ...
2016/0194333 CRYSTAL OF 6,7-UNSATURATED-7-CARBAMOYL MORPHINAN DERIVATIVE AND METHOD FOR PRODUCING THE SAME
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the present...
2016/0194332 NOVEL QUINOLINE -SUBSTITUTED COMPOUND
An object to be achieved by the present invention is to provide a novel compound having EGFR inhibitory effects and cell growth inhibitory effects, as well as...
2016/0194331 METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE
The present invention is intended to provide a method for efficiently producing and providing a compound having a spirooxindole skeleton, for example, a...
2016/0194330 PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
Disclosed are compounds of Formula A: (structurally represented) where "RG1", "RG2a", "RG4", "RG5", "MG1", "n" and "m" are defined herein which compounds are...
2016/0194329 Therapeutically Active Pyrazolo-Pyrimidine Derivatives
A series of pyrazolo[3,4-d]pyrimidine derivatives that are substituted at the 4-position by a diaza monocyclic, bridged bicyclic or spirocyclic moiety, are...
2016/0194328 SELECTIVE GRP94 INHIBITORS AND USES THEREOF
The disclosure relates to novel selective Grp94 inhibitors, compositions comprising an effective amount of such compounds, and methods to treat or prevent a...
2016/0194327 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS
The present invention relates to substituted xanthines of general formula ##STR00001## wherein R.sup.1 to R.sup.3 are as defined herein, the tautomers, the ...
2016/0194326 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SYNTHESIS
The present invention provides methods for the preparation of substituted heterocycle fused gamma-carbolines, intermediates useful in producing them and...
2016/0194325 SUBSTITUTED HETEROCYCLE FUSED GAMMA-CARBOLINES SOLID
The present invention relates to toluenesulfonic acid addition salt crystals of specific substituted heterocycle fused gamma-carbolines, the method of making...
2016/0194324 ANTIBACTERIAL CYCLOPENTAL[C]PYRROLE SUBSTITUTED 3,4 DIHYDRO-1H-[1,8]NAPHTHYRIDINONES
The present invention is related to novel compounds of formula (I) that inhibit the activity of the FabI enzyme which are therefore useful in the treatment of...
2016/0194323 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
2016/0194322 SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS
Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and...
2016/0194321 PYRROLOPYRIDINE OR PYRAZOLOPYRIDINE DERIVATIVES
The present invention relates to compounds of formula ##STR00001## wherein R.sup.1 halogen, lower alkyl, lower alkoxy, cyano, phenyl, C(O)NHCH.sub.3,...
2016/0194320 HETEROCYCLIC COMPOUNDS AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 INHIBITORS
The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the...
2016/0194319 PYRIDOPYRIMIDINE BASED DERIVATIVES AS POTENTIAL PHOSPHODIESTERASE 3 (PDE3) INHIBITORS AND A PROCESS FOR THE...
The invention relates to a process for the synthesis of pyridopyrimidine derivatives, which work as PDE3 inhibitors.
2016/0194318 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
The present invention relates to novel 1,2,4-triazolo[4,3-a]pyridine compounds as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor...
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