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Patent # Description
2016/0194317 T-BOX RIBOSWITCH-BINDING ANTI-BACTERIAL COMPOUNDS
The present disclosure identifies compounds that bind to a t-RNA-dependent riboswitch of aaRS gene expression unique to Gram-positive bacteria. The compounds...
2016/0194316 SUBSTITUTED BENZENE COMPOUNDS
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds...
2016/0194315 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
2016/0194314 PI-KINASE INHIBITORS WITH ANTI-INFECTIVE ACTIVITY
Compounds and methods are provided for the treatment of pathogen infections. In some embodiments, the anti-infective compounds have broad spectrum activity...
2016/0194313 INDOLE AMIDE COMPOUND AS INHIBITOR OF NECROSIS
The present invention relates to an indole amide compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for...
2016/0194312 ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION...
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing...
2016/0194311 SUBSTITUTED NICOTINAMIDE DERIVATIVES AS KINASE INHIBITORS
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
2016/0194310 ANHYDROUS CRYSTALLINE FREE BASE FORM OF 6--3-ETHOXY-1,2-BENZISOXAZOLE
A crystalline form of 6-{2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy}-3-ethoxy-1,2-benzo- xazole is provided which is useful in the treatment of...
2016/0194309 A Process For The Preparation Of Rivaroxaban
Described is an improved, industrially feasible and environmental friendly process for the preparation of Rivaroxaban. Also described are novel compounds which...
2016/0194308 NOVEL PIPERIDINYL BENZOIMIDAZOLE DERIVATIVES AS MPGES-1 INHIBITORS
The compounds 1-(5-chloro-6-methyl-1-(6-(trifluoromethyl)pyridin-2-yl)-1H-benzo[d]imida- ...
2016/0194307 COMPOUNDS USEFUL AS IMMUNOMODULATORS
Disclosed are compounds of Formula (I): (I). Also disclosed are methods of using such compounds as immunomodulators, and pharmaceutical compositions comprising...
2016/0194306 HISTONE DEMETHYLASE INHIBITORS
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted ...
2016/0194305 THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE
Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a...
2016/0194304 ISOINDOLINE OR ISOQUINOLINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS...
Compounds of formula (I): ##STR00001## wherein Het, R.sub.3, R.sub.4, R.sub.5, R.sub.7, R.sub.8, R.sub.9, T, p, p', q, and q' are as defined in the description. ...
2016/0194303 HETEROCYCLES CAPABLE OF MODULATING T-CELL RESPONSES, AND METHODS OF USING SAME
The present disclosure is directed in part to heterocycles, and their use in treating medical disorders, such as immune inflammatory disorders such as Crohn's...
2016/0194302 CYCLIC AMINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
A compound exerts a strong analgesic effect against pain, in particular, neuropathic pain and/or fibromyalgia syndrome. The cyclic amine derivative is...
2016/0194301 PREPARATION OF LENALIDOMIDE
Processes for the preparation of substantially pure lenalidomide. The application also relates to an enriched, substantially pure, and pure amorphous form of...
2016/0194300 REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES
A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.
2016/0194299 COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS
Described herein are compounds and compositions for treating drug resistant and persistent tuberculosis. Also described herein is a method of screening for...
2016/0194298 PROCESS FOR PRODUCTION OF HEXANETRIOL FROM 5-HYDROXYMETHYLFURFURAL
Industrial scale conversions of 5-hydroxymethylfurfural to commodity chemicals such as 1,2,6-hexanetriol and 1,6-hexanediol by chemocatalytic conversions using...
2016/0194297 GLYCIDYL ETHERS OF LIMONENE DERIVATIVES AND OLIGOMERS THEREOF AS CURABLE EPOXY RESINS
Cured epoxy resins are widespread because of their excellent mechanical and chemical properties. Typically, epoxy resins based on bisphenol A diglycidyl ethers...
2016/0194296 PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF...
The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof ##STR00001## wherein Ar', R.sub.1, R.sub.2, R.sub.3, R.sub.4, X,...
2016/0194295 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Derivatives as Immunomodulators
The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1)...
2016/0194294 OLIGOMER-CONTAINING SUBSTITUTED AROMATIC TRIAZINE COMPOUNDS
The invention relates to (among other things) methods for treatment comprising administering oligomer-containing substituted aromatic triazine compounds. A...
2016/0194293 Integrated Process for Urea and Melamine Production
In an integrated process for urea and melamine production, urea is produced in a urea plant (10) comprising a high pressure urea synthesis section (11) from...
2016/0194292 TRIAZOLONE COMPOUNDS AND USES THEREOF
The invention disclosed herein is directed to compounds of Formula (1a) and (1b) and pharmaceutically acceptable salts thereof, which are useful in the...
2016/0194291 STYRYL QUINAZOLINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE AGENTS
The present invention relates to styryl quinazoline derivatives of the general formula (I) and pharmaceutically acceptable solvates, hydrates, salts,...
2016/0194290 DIHYDROPYRIMIDIN-2-ONE COMPOUNDS AND MEDICAL USE THEREOF
A compound of Formula [I] or a pharmaceutically acceptable salt thereof: ##STR00001## wherein each symbol is defined as in the specification.
2016/0194289 PROCESS FOR DRYING BENDAMUSTINE HYDROCHLORIDE MONOHYDRATE
Wet bendamustine hydrochloride monohydrate may be dried by a two stage process wherein rapid drying is first carried out to provide a partially dried product,...
2016/0194288 INHIBITION OF BACTERIAL BIOFILMS AND MICROBIAL GROWTH WITH IMIDAZOLE DERIVATIVES
Disclosure is provided for imidazole derivative compounds useful to inhibit the formation of biofilms and/or inhibit microbial growth, compositions including...
2016/0194287 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION AND PAIN
The invention relates to the compounds of formula I, formula II, formula III, formula IV and formula V or its pharmaceutical acceptable polymorphs, solvates,...
2016/0194286 NEW ANTI-MALARIAL AGENTS
The present invention is related to a use of pyrazole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the...
2016/0194285 PROCESS FOR MAKING ISOQUINOLINE COMPOUNDS
The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to...
2016/0194284 ALLOSTERIC MODULATORS OF THE CANNABINOID 1 RECEPTOR
The present technology relates to compounds and compositions of Formulas I, II, VII, and VIII, and methods using such compounds. The compounds and compositions...
2016/0194283 Biological Buffers with Wide Buffering Ranges
Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be...
2016/0194282 A Process For Preparation Of Saxagliptin And Its Hydrochloride Salt
Described is an improved and industrially feasible process for the preparation of Saxagliptin or its hydrochloride salt. Also described are the novel...
2016/0194281 CRYSTALLINE FORMS OF SILODOSIN
The present disclosure is directed to novel crystalline forms of silodosin and compositions comprising any of the novel crystalline forms of silodosin. Also...
2016/0194280 IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES
The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In...
2016/0194279 ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS
The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of...
2016/0194278 DITHIOL MUCOLYTIC AGENTS
Provided are dithiol mucolytic agents. These agents increase the liquefaction of mucus in a patient with excessive mucus or mucus with increased viscoelastic,...
2016/0194277 ZINC CLUSTER COMPOUNDS AND THEIR USE AS CATALYSTS IN THE REACTION OF AMINES WITH DIALKYL CARBONATES
The present invention relates to metallic zinc cluster compounds which are suitable as catalysts in the reaction of amines with dialkyl carbonates to produce...
2016/0194276 CATALYTIC ESTER DECARBONYLATION
A process of preparing olefins of the formula (I) is described herein: ##STR00001## with R.sup.1 being a substituted or unsubstituted ...
2016/0194275 BIS(PERFLUOROETHER CARBOXYLIC ACID ALKYL)AMINO ESTER AND METHOD FOR PRODUCING THE SAME
A bis(perfluoroether carboxylic acid alkyl)amino ester represented by the general formula: ...
2016/0194274 PHENANTHRENE DERIVATIVES FOR USE AS MEDICAMENTS
The present invention refers to phenanthrene derivatives for use as medicaments, mainly in the prevention and/or treatment of Myotonic Dystrophy Type 1,...
2016/0194273 PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS WITH METAL ALCOHOLATES
Process for the etherification of amino alcohols with metal alcoholates A process for the preparation of the ether of formula I ##STR00001## where R.sub.1 and...
2016/0194272 PROCESS FOR THE ETHERIFICATION OF AMINO ALCOHOLS
A process for the preparation of the ether of formula I ##STR00001## where R.sub.1 and R.sub.2 independently from one another are hydrogen or an alkyl group with...
2016/0194271 PROCESS FOR PREPARING ALKYL PYROGLUTAMIC ACIDS
This disclosure relates to methods for limiting the undesired reverse Mannich reaction during the hydrogenation reduction of one or more nitro functional...
2016/0194270 METHOD FOR REMOVING HCN FROM CRUDE DINITRO TOLUENE
A process for the preparation of dintrotoluene which comprises (a) nitrating toluene with a nitrating acid, wherein said nitrating acid is a mixture of nitric...
2016/0194269 PURIFICATION METHOD OF PHOTOREACTIVE COMPOUND AND PHOTOREACTIVE COMPOUND (As Amended)
Provided is a purification method of a photoreactive compound, and a photoreactive compound. According to the purification method of the present invention, a...
2016/0194268 PRODUCTION METHOD OF KETOMALONIC ACID COMPOUND
Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more...
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