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Anti-Myostatin Antibodies, Polypeptides Containing Variant Fc Regions, and
Methods of Use
The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells...
VEGF-binding molecules, preferably VEGF-binding immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing...
Complement Pathway Inhibitors Binding To C5 And C5a Without Preventing The
Formation Of C5b
The invention relates to inhibitors that bind to C5 and C5a, but which do not prevent the activation of C5 and do not prevent formation of or inhibit the...
COMPOSITIONS AND METHODS FOR TREATING ANAPLASTIC THYROID CANCER
Methods of treating a disease or disorder characterized by cells with increased or aberrant expression of cytokeratin-8 (CK8) are disclosed. The methods...
MONOCLONAL ANTIBODIES THAT NEUTRALIZE ANTHRAX TOXINS
The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA)....
ANTIBODIES THAT POTENTLY NEUTRALIZE RSV AND USES THEREOF
The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both group A and group B RSV. The invention also...
Monoclonal Antibodies Capable of Reacting with a Plurality of Influenza
Virus A Subtypes
Monoclonal antibodies directed against the influenza A virus are described, which have the advantageous and unpredicted property of being able to bind a...
ANTIBODIES DIRECTED AGAINST INFLUENZA
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments,...
ANTI-INFLUENZA VIRUS NEUTRALIZING ANTIBODY
It is an object of the present invention to provide a novel antibody having a high binding activity and a high neutralizing activity on influenza viruses. The...
NOVEL MEANS AND METHODS FOR TREATING HBV INFECTION AND ASSOCIATED
The present invention relates to a polypeptide comprising (a) a first set of six complementarity determining regions (CDRs) configured to bind a first antigen;...
Chromatography Ligand Comprising Domain C From Staphylococcus Aureus
Protein A For Antibody Isolation
The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant...
FUSION PROTEIN COMPRISING ALBUMIN AND RETINOL-BINDING PROTEIN
There is provided a fusion protein comprising albumin and retinol-binding protein (RBP), which can be used for preventing or treating fibrotic diseases. The...
FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII
The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a...
The present invention relates to a covalent complex of von Willebrand Factor (VWF) and Factor VIII, wherein the complex is modified such that it has an...
FLT4 (VEGFR-3) AS A TARGET FOR TUMOR IMAGING AND ANTI-TUMOR THERAPY
The present invention provide purified Flt4 receptor tyrosine kinase polypeptides and fragments thereof, polynucleotides encoding such polypeptides, antibodies...
Purification Process for PTH
The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH.sup.1-34 or teriparatide), said process for...
GLP-1 Derivatives, and Uses Thereof
The present invention relates to tri-acylated GLP-1 derivatives, acylated at positions corresponding to positions (18, 22, 30), (18, 26, 37), (18, 27, 37),...
CYSTEINE VARIANTS OF INTERLEUKIN-11 AND METHODS OF USE THEREOF
Disclosed are cysteine variants of interleukin-11 (IL-11) and methods of making and using such proteins in therapeutic applications.
IL4 CONJUGATED TO ANTIBODIES AGAINST EXTRACELLULAR MATRIX COMPONENTS
A conjugate comprising interleukin-4 (IL4) and a specific binding member is disclosed. The specific binding member preferably binds an extra-cellular matrix...
COMPOSITIONS, USES AND METHODS FOR TREATMENT OF METABOLIC DISORDERS AND
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of...
COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
BH3 PEPTIDES AND METHODS OF USE THEREOF
The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods...
ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT
The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen...
FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR
APPLICATION TO TRANSMEMBRANE DRUG...
The present invention comprises a method for delivering pharmaceutical and/or imaging agents within and/or through the dermal, mucosal and other cellular...
USE OF MULTIVALENT SYNTHETIC LIGANDS OF SURFACE NUCLEOLIN FOR TREATING
CANCER OR INFLAMMATION
A method for treating disorders involving deregulation of cell proliferation and/or angiogenesis comprising the administration of an effective amount of a...
FORMULATION OF MK2 INHIBITOR PEPTIDES
The described invention provides pharmaceutical formulations comprising a polypeptide of amino acid sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a...
PEPTIDES AND USES THEREOF
Disclosed herein are zinc finger peptides having at least 4 zinc finger domains, such as 6, 11, 12 or 18 zinc finger domains. The zinc finger peptides may be...
MUTEINS WITH TEAR LIPOCALIN HAVING AFFINITY TO HUMAN C-MET RECEPTOR
TYROSINE KINASE AND METHODS FOR OBTAINING...
The present invention relates to novel muteins derived from human tear lipocalin having affinity to human c-Met receptor tyrosin kinase (c-Met). The invention...
DELIVERY SYSTEM FOR FUNCTIONAL NUCLEASES
Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex...
Pesticidal Nucleic Acids and Proteins and Uses Thereof
The invention provides compositions comprising polynucleotide molecules encoding certain pesticidal polypeptides which exhibit plant parasitic nematode and/or...
METHIONYL TRNA SYNTHETASE FOR BIOSYNTHESIS OF PHOTOMETHIONINE-LABELED
PROTEIN AND METHOD FOR PREPARING...
Provided is a methionyl tRNA synthase (MRS) for the biosynthesis of a photomethionine-labeled protein and a method for preparing a photoactivatable protein G...
Truncated L1 Protein of Human Papillomavirus Type 58
Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like...
VIRUS LIKE PARTICLE COMPRISING MODIFIED ENVELOPE PROTEIN E3
A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from...
PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human...
Molecule Detection Using Boronic Acid Substituted Probes
Provided are polymeric scaffold compositions and methods for detecting or quantitating diols such as carbohydrates or carbohydrate containing molecules (e.g.,...
BINDING POLYPEPTIDES HAVING A MUTATED SCAFFOLD
The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence ...
ANTIBACTERIAL AGENTS: SALINAMIDE DERIVATIVES
The invention provides compounds of formula (I): ##STR00001## and salts thereof, wherein X and Y have any of the values defined herein. The compounds inhibit...
SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the...
Compound, Transitmycin, Effective Against Bacterial and Viral Pathogens
Provided herein is a compound represented by Formula (I) (Transitmycin) effective against bacterial and viral pathogens.
VANCOMYCIN DERIVATIVE, AND PREPARATION METHOD AND APPLICATION THEREOF
The present invention provides a vancomycin derivative, and a preparation method and an application thereof. The vancomycin derivative of the present invention...
CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED
The present invention relates to cyclosporin analogs that are potent inhibitors of cyclophilin D and have low immunosuppressive activity; processes for...
AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL
DISORDERS, INFLAMMATION, CANCER AND...
The invention provides novel guanylate cyclase-C agonist peptides and their use in the treatment of human diseases including gastrointestinal disorder,...
Modified Mini-Hepcidin Peptides and Methods of Using Thereof
Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.
PEPTIDE VACCINES FOR CANCERS EXPRESSING TUMOR-ASSOCIATED ANTIGENS
The present invention provides peptides having an amino acid sequence as set forth in SEQ ID NO: 19, 22, 30, 34, 344, 358, 41, 44, 46, 48, 78, 376, 379, 80,...
GLYCOGEN SYNTHASE KINASE-3 INHIBITORS
Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are converted to inhibitors of...
Bioactive polypeptide DELQ and preparation method as well as application
A milk-derived bioactive polypeptide has in vitro antioxidant activity and an immunity-enhancing function, and an amino acid sequence thereof is DELQ....
BUOYANT PROTEIN HARVESTING DEVICE
A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the...
MICROPARTICLES FOR CELL DISRUPTION AND/OR BIOMOLECULE RECOVERY
The present invention provides novel methods of cell disruption and release of biomolecules from a cell. The invention comprises the use of positively and/or...
HIGHLY EFFICIENT SYNTHESIS OF LONG RNA USING REVERSE DIRECTION APPROACH
The present invention relates to novel process of reverse 5'.fwdarw.3' directed synthesis of RNA oligomers in the range of about 100-mer to about 200-mer has...
1,2,3-TRIAZOLE-TETHERED CARBOHYDRATE-DI AND TRI LIPIDATED CYSTEINE
CONJUGATES USEFUL AS VACCINE ADJUVANTS AND...
The present invention relates to carbohydrate-di and tri lipidated cysteine based 1,2,3-triazoles useful as vaccine adjuvants of formula 1 ##STR00001## The...