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TYLOSIN A ANALOGS AND DERIVATIVES
The present invention pertains to derivatives of tylosin A. In particular, the present invention pertains to compounds having a structure of Formula (I). The...
Alkenyl Glycosides and Their Preparation
An alkenyl glycoside is prepared by reacting a metathesis-derived unsaturated fatty alcohol containing 10 to 30 carbon atoms with either (1) a reducible...
GLYCOAMINO ACID AND USE THEREOF
An object of the present invention is to provide glycoamino acid as an amino acid precursor with improved properties (particularly water-solubility, stability...
METHOD FOR EXTRACTING LIGNIN FROM BLACK LIQUOR AND PRODUCTS PRODUCED
The invention relates to a method for extracting undissolved carbonized lignin from black liquor and products produced thereby. The invention further relates...
LIGATED ANIONIC-ELEMENT REAGENT COMPLEXES (LAERCs) AS NOVEL REAGENTS
A novel ligated reagent complex is provided. The ligated reagent includes at least one zero-valent atom, whether metal, metalloid, or non-metal, in complex...
COX-2-TARGETING, PLATINUM-CONTAINING CONJUGATES AND THEIR USE IN THE
TREATMENT OF TUMORS AND CANCERS
The present disclosure provides platinum-containing conjugates that selectively target and kill tumor/cancer cells. The conjugates contain a moiety that...
THIENOPIPERIDINE DERIVATIVE AND USE THEREOF
The present invention relates to a kind of thienopiperidine derivative or pharmaceutically acceptable acid addition salt thereof and a pharmaceutical...
NOVEL CRYSTALLINE FORMS OF CEFTAROLINE FOSAMIL
The present invention relates to novel crystalline forms of ceftaroline fosamil and to methods for their preparation. Furthermore the present invention relates...
BIOLOGICALLY ACTIVE COMPOUNDS SPECIFICALLY DELIVERED INTO MITOCHONDRIA
This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of...
FLUORINATED COMPOUNDS USABLE AS AN ORGANIC SOLVENT FOR LITHIUM SALTS
The disclosure relates to compounds of following formula (I): ##STR00001## where: X corresponds to a repeat unit of following formula (II): ##STR00002## or to a...
PHOSPHORUS-CONTAINING COMPOUND AND CURING EPOXY RESIN COMPOSITION
Provided is a novel phosphorus-containing compound represented by general formula (I). The compound has reactivity with a glycidyl group and is therefore...
TITANIUM (IV) COMPOUNDS AND METHODS OF FORMING HETEROCYCLIC COMPOUNDS
The present disclosure provides Titanium (IV) compounds and methods of making heterocyclic compounds such as pyrroles using Titanium (IV) compounds. In certain...
METHOD FOR PRODUCING CARBAMATOORGANOSILANES
Carbamatoorganosilanes are produced in exceptionally high yield with a high degree of purity, by reacting an aminoorganosilane with a dialkylcarbonate in the...
CONVENIENT PROCESS FOR THE PREPARATION OF STATINS
Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS
Compounds, pharmaceutical formulations, and methods of treating inflammatory conditions are disclosed. (F) ##STR00001##
BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING
Benzodiazepine dimers having a structure represented by ##STR00001## wherein R.sup.1 is ##STR00002## wherein the variables in formulae (I), (Ia), and (Ib) are as...
Novel indazoles for the treatment and prophylaxis of respiratory syncytial
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7, A.sup.1, A.sup.2...
COMPOUND FOR THE TREATMENT OF HUMAN LIVER CANCER AND METHOD FOR
The compound "2-((4-nitrophenyl)amino)-7,8,9,10-tetrahydro cyclohepta[4,5]thieno[2,3-d][1,3,4]thiadiazolo[3,2-a]pyrimidin-11(6H)-one- " and method of...
ALKYNYL ALCOHOLS AND METHODS OF USE
The invention relates to compounds of Formula (0): ##STR00001## wherein Q, A.sup.1-A.sup.8, R.sup.4 and R.sup.5 and each has the meaning as described herein....
FORMS OF RIFAXIMIN AND USES THEREOF
The present invention relates to Rifaximin polymorphic forms, to their use in medicinal preparations and to therapeutic methods using them.
Disclosed herein are maytansinoid drug linker derivatives which can be linked to a antigen binding unit (Abu), and maytansinoid drugs linked with an antigen...
NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions...
THERAPEUTIC PYRAZOLYL THIENOPYRIDINES
The present invention provides for compounds of Formula I, and pharmaceutically acceptable salts thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3,...
CARBOXYLIC ACID COMPOUNDS IN TREATMENT OF DIABETES MELLITUS
The invention relates to compounds for increasing QPR40 receptor activity and application thereof. These compounds include of a compound of Formula (I),...
SUBSTITUTED THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE ANALOGS AS POSITIVE
ALLOSTERIC MODULATORS OF THE MUSCARINIC...
In one aspect, the invention relates to substituted thieno[2,3-b]pyridine-2-carboxamide analogs, derivatives thereof, and related compounds, which are useful...
CARBAZOLE-CONTAINING SULFONAMIDES AS CRYPTOCHROME MODULATORS
The subject matter herein is directed to carbazole-containing sulfonamide derivatives and pharmaceutically acceptable salts or hydrates thereof of structural...
Benzoic Acid, Benzoic Acid Derivatives and Heteroaryl Carboxylic Acid
Conjugates of Hydrocodone, Prodrugs,...
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, ...
POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS
Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase...
NEW CHEMICAL COMPOUNDS (DERIVATIVES) AND THEIR APPLICATION FOR THE
TREATMENT OF ONCOLOGICAL DISEASES
The invention relates to novel chemical compounds of general formula I, in which L.sup.A, L.sup.B, L.sup.C, ring A, ring B, R.sup.A, R.sup.B, R.sup.C, R.sup.D,...
IMIDAZOLE-DERIVED MODULATORS OF THE GLUCOCORTICOID RECEPTOR
Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1,...
PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES OF OMARIGLIPTIN
Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of the active pharmaceutical ingredient named...
METHOD FOR PRODUCING ENDO-9-AZABICYCLO[3.3.1]NONAN-3-OL DERIVATIVE
A 9-azabicyclo[3.3.1]nonan-3-one derivative is reacted with a hydrogen in the presence of a catalyst composed of a ruthenium complex to obtain, at a low cost,...
QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS
Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are...
DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA
Provided are novel compounds of Formula (I): ##STR00001## pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in...
PROCESS FOR PREPARING A COMPOUND
The invention provides processes of preparation thereof useful in the preparation of compounds that can be used as CHK1 inhibitors.
COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY
The present invention is directed to azaindazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in...
AROMATIC HETEROCYCLYLAMINE DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY
The present invention is related to a compound represented by formula (I) ##STR00001## wherein --X-- is --NH-- or --S--; --Z-- is --O-- or --S--; R.sup.3, ...
HETEROARYLPIPERIDINE AND PIPERAZINE DERIVATIVES AS FUNGICIDES
Heteroarylpiperidine and -piperazine derivatives of the formula (I) ##STR00001## in which the symbols R.sup.A1, R.sup.A2, X, Y, L.sup.1, L.sup.2, R.sup.B1,...
CINNOLINE DERIVATIVES USEFUL AS CB-1 RECEPTOR INVERSE AGONISTS
The present invention is directed to cinnoline derivatives pharmaceutical compositions containing them and their use in the treatment of disorders and...
NEW CYCLOHEXYLAMINE DERIVATIVES HAVING 2 ADRENERGIC AGONIST AND M3
MUSCARINIC ANTAGONIST ACTIVITIES
The present invention relates to novel compounds having .beta.2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions...
CERTAIN AMINO-PYRIDINES AND AMINO-TRIAZINES, COMPOSITIONS THEREOF, AND
METHODS FOR THEIR USE
Provided are compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.2, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
COBICISTAT DICHLOHYDRATE SALT
The present invention encompasses Cobicistat dihydrochloride salt, and pharmaceutical compositions thereof. ##STR00001##
PREPARATION AND USE OF 7A-HETEROCYCLE SUBSTITUTED- 6,6-DIFLUORO BICYCLIC
HIMBACINE DERIVATIVES AS PAR-1...
The present invention relates to bicyclic himbacine derivatives of the formula ##STR00001## or a pharmaceutically acceptable salt thereof wherein: R.sup.1...
3-SUBSTITUTED CYCLOPENTYLAMINE DERIVATIVES
Compounds of the formula I ##STR00001## in which R, W, R.sup.1, R.sup.4, X.sup.1, X.sup.2, X.sup.3, X.sup.4 and q have the meanings indicated in claim 1, are...
PREPARATION AND USE OF 3-PYRIDYL SUBSTITUTED- 6,6-DIFLUORO BICYCLIC
HIMBACINE DERIVATIVES AS PAR-1 RECEPTOR...
The present invention relates to bicyclic himbacine derivatives of the formula ##STR00001## or a pharmaceutically acceptable salt thereof wherein: ...
PROCESSES FOR PRODUCING CYCLOALKYLCARBOXAMIDO-PYRIDINE BENZOIC ACIDS
The present invention relates to a process of providing the 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) ...
HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS
The present invention provides, in part, compounds of Formula I: ##STR00001## and pharmaceutically acceptable salts thereof; processes for the preparation of;...
CARBAZOLE CARBOXAMIDE COMPOUNDS
Disclosed are compounds of Formula (I); and salts thereof, wherein: Formula (II); Q is: R.sub.1 is --C(CH.sub.3)2OH, --NHC(=0)C(CH.sub.3).sub.3, --N(CH3)2, or...
INDOLE COMPOUND AS INHIBITOR OF NECROSIS
The present invention relates to an indole compound represented by formula (1), a pharmaceutically acceptable salt or isomer thereof, a composition for...
The invention relates to pyrrolone compounds of the formula (I) wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.a, R.sup.c and R.sup.d are as defined in the...