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Patent # Description
2016/0200707 URAZOLE COMPOUNDS
The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) wherein R.sup.1, R.sup.2, R.sup.3,...
2016/0200706 Imidazole-1-yl pyrimidine derivatives, or pharmacutically acceptable salt thereof, and pharmaceutic composition...
The present invention relates to a novel imidazole-1-yl pyrimidine derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutic composition...
2016/0200705 BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1
The present invention relates to compounds of formula (I): ##STR00001## in which Y, Y.sub.1, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the Summary...
2016/0200704 THERAPEUTIC INHIBITORY COMPOUNDS
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
2016/0200703 NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated...
2016/0200702 SALT, ACID GENERATOR, PHOTORESIST COMPOSITION, AND METHOD FOR PRODUCING PHOTORESIST PATTERN
A salt represented by the formula (I): ##STR00001## wherein R.sup.1 represents a C1 to C12 alkyl group in which a methylene group can be replaced by an oxygen...
2016/0200701 METHODS FOR THE SEPARATION OR PURIFICATION OF VITAMIN E, TOCOPHEROLS AND TOCOTRIENOLS FROM LIPID MIXTURES
This invention generally relates to the isolation of molecules exhibiting vitamin E activity, e.g. tocopherols and/or tocotrienols, from mixed lipid...
2016/0200700 METHODS OF PRODUCING ALKYLFURANS
Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example,...
2016/0200699 GLYCIDOL PREPARATION
This invention relates to an improved one-pot synthetic process for the preparation of glycidol from the reaction of glycerol and dimethyl carbonate. More...
2016/0200698 VORTIOXETINE SALT AND CRYSTAL THEREOF, THEIR PREPARATION METHOD, PHARMACEUTICAL COMPOSITIONS AND USAGE
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a...
2016/0200697 INHIBITION OF WNT, TGF BETA AND HIPPO SIGNALING PATHWAYS TO TREAT CANCER, ORGAN FIBROSIS AND METABOLIC DISORDERS
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R.sup.1-R.sup.5 is individually selected from H,...
2016/0200696 PROCESS FOR THE PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS
A process for the purification of diaminophenothiazinium compounds, and particularly of methylene blue, is described. The process provides for simple and...
2016/0200695 Methods and Compositions for Selective and Targeted Cancer Therapy
Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides,...
2016/0200694 FILTRATION PROCESS FOR PURIFYING LIQUID AZOLE HETEROAROMATIC COMPOUND-CONTAINING MIXTURES
A process for removing impurities from a liquid azole heteroaromatic compound-containing (e.g., triazole-containing) mixture by: (a) providing a liquid azole...
2016/0200693 Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
The present invention provides trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitor compounds of formula (I), which may be...
2016/0200692 Substituted N-(1,2,4-Triazol-3-yl)Arylcarboxamide Compounds and Their Use as Herbicides
The invention relates to N-(1,2,4-triazol-3-yl)arylcarboxamides of formula I and their use as herbicides. In said formula I, X represents N or CR.sup.2,...
2016/0200691 PROCESS FOR THE LARGE SCALE PRODUCTION OF 1H-[1,2,3]TRIAZOLE AND ITS INTERMEDIATE 1-BENZYL-1H-[1,2,3]TRIAZOLE
The present invention provides a process for the large scale production of 1H-[1,2,3]triazole of formula (I) and its intermediate 1-benzyl-1H-[1,2,3]triazole...
2016/0200690 PRODUCTION METHOD FOR 3,3-DIMETHYL-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE DERIVATIVE AND INTERMEDIATE FOR SAID...
An object is to provide a novel production method suitable for industrial production of a 3,3-dimethyl-3,4-dihydro-1H-quinoxalin-2-one derivative and a...
2016/0200689 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS
Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor...
2016/0200688 Process of Preparing a Quinazoline Derivative
A concise, efficient and cost- and time-saving process for the preparation of a quinazoline derivative of formula A given below: ##STR00001## which is an...
2016/0200687 Methods for Preparing Azoxystrobin and Intermediate Thereof
The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound...
2016/0200686 BENZIMIDAZOLYL-METHYL UREA DERIVATIVES AS ALX RECEPTOR AGONISTS
The present invention relates to benzimidazolyl-methyl urea derivatives of formula (I), ##STR00001## wherein n, D, E, R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
2016/0200685 SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES
Provided are compounds of general formula A and A', wherein X.sub.1 and X.sub.2 are each C, CH or N; R.sub.3 and R.sub.4 are each H, optionally substituted...
2016/0200684 Pharmaceutical Compositions for the Treatment of CFTR-Mediated Disorders
The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide (Compound 1), solids...
2016/0200683 ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
2016/0200682 2-Piperidinyl Substituted N,3-Dihydroxybutanamides
Disclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, Y, and Z are defined herein....
2016/0200681 Tetrahydrocyclopentapyrrole Derivatives and a Method for Preparing the Same
The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux...
2016/0200680 Methods and Intermediates Useful for the Preparation of alpha-Branched Aryl Phthalimides and alpha-Branched...
The invention provides methods and intermediates that are useful for preparing .alpha.-branched aryl phthalimides and .alpha.-branched aryl amines.
2016/0200679 NOVEL CRYSTALLINE ARYLALKYLAMINE COMPOUND AND PROCESS FOR PRODUCING THE SAME
The present invention provides novel crystal forms of arylalkylamine compounds. Specifically, the novel crystal forms of ...
2016/0200678 HETEROCYCLE ANALOGS OF CAI-1 AS AGONISTS OF QUORUM SENSING IN VIBRIO
A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small...
2016/0200677 PREPARATION OF CAPROLACTAM FROM 6-AMINO CAPROIC ACID OBTAINED IN A FERMENTATION PROCESS
The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising...
2016/0200676 METALLOPROTEASE INHIBITORS, METHODS FOR PRODUCING SAME, AND THERAPEUTIC USES THEREOF
The invention relates to new .alpha.-vinyl carbonylated compounds corresponding to general formula (I), wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and...
2016/0200675 3, 4-BIS-BENZYLSULFONYLBUTYRONITRILE AND ITS PHARMACEUTICAL USE
The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method...
2016/0200674 IDO INHIBITORS
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
2016/0200673 Antibacterial Compounds
Disclosed are compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, Y, Z, X,...
2016/0200672 NEW PROCESS
A process for the preparation of a compound of formula (I): ##STR00001## which is useful as an intermediate in the preparation of pharmaceutically active compounds.
2016/0200671 CRYSTALLINE SALTS OF (4S, 4AS, 5AR, 12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-- ...
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(me- ...
2016/0200670 RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed...
2016/0200669 METHOD FOR RECOVERING FLUORINATED EMULSIFIER
To provide a method for recovering, from a liquid to be treated containing a fluorinated polymer and a fluorinated emulsifier, the fluorinated emulsifier...
2016/0200668 PREPARATION METHOD AND USE OF N-ACYL ACIDIC AMINO ACID OR SALT THEREOF
The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an...
2016/0200667 NOVEL PROCESS FOR MAKING OMEGA-AMINOALKYLENIC ALKYL ESTER
A method for making a compound of formula (V): ##STR00001## is provided. The method comprises converting a compound of formula (III): ##STR00002## to the compound...
2016/0200666 CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
Cyclic vinylogous amides of Formula I are disclosed ##STR00001## The compounds are useful for treating diseases that arise from inappropriate activity of...
2016/0200665 SYNTHESIS OF BIPHENYLALANINOL VIA NOVEL INTERMEDIATES
The invention relates to a novel synthesis route towards R-biphenylalaninol and to the intermediates applied in this synthesis route. The process according to...
2016/0200664 Process for Preparing Cinacalcet and Pharmaceutically Acceptable Salts Thereof
The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting...
2016/0200663 Method and Device for Removing Contaminants Arising During the Production of Aliphatic Nitrate Esters
The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in...
2016/0200662 COMPOUNDS HAVING NEGATIVE OPTICAL DISPERSION, NEGATIVE OPTICAL DISPERSION COMPOSITION COMPRISING THE COMPOUNDS,...
The present invention relates to a reverse wavelength dispersion compound, a reverse wavelength dispersion composition including the same, and an optically...
2016/0200661 NEW SALVIANOLIC ACID COMPOUND T, PREPARATION METHOD THEREFOR, AND USE THEREOF
The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a...
2016/0200660 METHOD FOR PRODUCING METHACROLEIN AND THE CONDITIONING/DRAINING THEREOF FOR DIRECT OXIDATIVE ESTERIFICATION
The present invention relates to a process for preparing methyl methacrylate by direct oxidative esterification of methacrolein and the preparation of...
2016/0200659 Esters with antimicrobial, bioresistant and fungal resistant properties
A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and...
2016/0200658 PROCESS FOR RECOVERING WATER, METAL AND ORGANICS FROM THE PRODUCTION OF POLYCARBOXYLIC ACID
In a process for recovering water, metals, soluble organics and insoluble organics from a process for the production of a polycarboxylic acid, the stream is...
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