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The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, (I) wherein R.sup.1, R.sup.2, R.sup.3,...
Imidazole-1-yl pyrimidine derivatives, or pharmacutically acceptable salt
thereof, and pharmaceutic composition...
The present invention relates to a novel imidazole-1-yl pyrimidine derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutic composition...
BENZAMIDE DERIVATIVES FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND
The present invention relates to compounds of formula (I): ##STR00001## in which Y, Y.sub.1, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are defined in the Summary...
THERAPEUTIC INHIBITORY COMPOUNDS
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma...
NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID
The present disclosure is generally directed to compositions and methods for treating diseases that are ameliorated by the inhibition of CYP26 mediated...
SALT, ACID GENERATOR, PHOTORESIST COMPOSITION, AND METHOD FOR PRODUCING
A salt represented by the formula (I): ##STR00001## wherein R.sup.1 represents a C1 to C12 alkyl group in which a methylene group can be replaced by an oxygen...
METHODS FOR THE SEPARATION OR PURIFICATION OF VITAMIN E, TOCOPHEROLS AND
TOCOTRIENOLS FROM LIPID MIXTURES
This invention generally relates to the isolation of molecules exhibiting vitamin E activity, e.g. tocopherols and/or tocotrienols, from mixed lipid...
METHODS OF PRODUCING ALKYLFURANS
Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example,...
This invention relates to an improved one-pot synthetic process for the preparation of glycidol from the reaction of glycerol and dimethyl carbonate. More...
VORTIOXETINE SALT AND CRYSTAL THEREOF, THEIR PREPARATION METHOD,
PHARMACEUTICAL COMPOSITIONS AND USAGE
The present invention relates to the novel vortioxetine salts, solvates and crystalline forms thereof, specifically, vortioxetine hemihydrobromide and a...
INHIBITION OF WNT, TGF BETA AND HIPPO SIGNALING PATHWAYS TO TREAT CANCER,
ORGAN FIBROSIS AND METABOLIC DISORDERS
Compounds, or pharmaceutically acceptable salts or esters thereof, having a structure of: wherein each of R.sup.1-R.sup.5 is individually selected from H,...
PROCESS FOR THE PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS
A process for the purification of diaminophenothiazinium compounds, and particularly of methylene blue, is described. The process provides for simple and...
Methods and Compositions for Selective and Targeted Cancer Therapy
Provided herein are methods and compositions for selective and targeted cancer therapy, in particular certain benzothiophenes, benzothiazoles, oxalamides,...
FILTRATION PROCESS FOR PURIFYING LIQUID AZOLE HETEROAROMATIC
A process for removing impurities from a liquid azole heteroaromatic compound-containing (e.g., triazole-containing) mixture by: (a) providing a liquid azole...
Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase
The present invention provides trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitor compounds of formula (I), which may be...
Substituted N-(1,2,4-Triazol-3-yl)Arylcarboxamide Compounds and Their Use
The invention relates to N-(1,2,4-triazol-3-yl)arylcarboxamides of formula I and their use as herbicides. In said formula I, X represents N or CR.sup.2,...
PROCESS FOR THE LARGE SCALE PRODUCTION OF 1H-[1,2,3]TRIAZOLE AND ITS
The present invention provides a process for the large scale production of 1H-[1,2,3]triazole of formula (I) and its intermediate 1-benzyl-1H-[1,2,3]triazole...
PRODUCTION METHOD FOR 3,3-DIMETHYL-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
DERIVATIVE AND INTERMEDIATE FOR SAID...
An object is to provide a novel production method suitable for industrial production of a 3,3-dimethyl-3,4-dihydro-1H-quinoxalin-2-one derivative and a...
DELTA OPIOID RECEPTOR AGONIST COMPOUNDS
Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor...
Process of Preparing a Quinazoline Derivative
A concise, efficient and cost- and time-saving process for the preparation of a quinazoline derivative of formula A given below: ##STR00001## which is an...
Methods for Preparing Azoxystrobin and Intermediate Thereof
The present invention discloses a method for preparing azoxystrobin intermediates represented by formulae (1) and (2), comprising: controlling a compound...
BENZIMIDAZOLYL-METHYL UREA DERIVATIVES AS ALX RECEPTOR AGONISTS
The present invention relates to benzimidazolyl-methyl urea derivatives of formula (I), ##STR00001## wherein n, D, E, R.sup.1, R.sup.2, R.sup.3, R.sup.4,...
SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES FOR THE TREATMENT
OF HORMONE-DEPENDENT DISEASES
Provided are compounds of general formula A and A', wherein X.sub.1 and X.sub.2 are each C, CH or N; R.sub.3 and R.sub.4 are each H, optionally substituted...
Pharmaceutical Compositions for the Treatment of CFTR-Mediated Disorders
The present invention relates to the use of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline- -3-carboxamide (Compound 1), solids...
ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
2-Piperidinyl Substituted N,3-Dihydroxybutanamides
Disclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R.sub.1, R.sub.2, Y, and Z are defined herein....
Tetrahydrocyclopentapyrrole Derivatives and a Method for Preparing the
The present invention provides tetrahydrocyclopentapyrrole derivatives that can be used for preventing or treating peptic ulcer, gastritis or reflux...
Methods and Intermediates Useful for the Preparation of alpha-Branched
Aryl Phthalimides and alpha-Branched...
The invention provides methods and intermediates that are useful for preparing .alpha.-branched aryl phthalimides and .alpha.-branched aryl amines.
NOVEL CRYSTALLINE ARYLALKYLAMINE COMPOUND AND PROCESS FOR PRODUCING THE
The present invention provides novel crystal forms of arylalkylamine compounds. Specifically, the novel crystal forms of ...
HETEROCYCLE ANALOGS OF CAI-1 AS AGONISTS OF QUORUM SENSING IN VIBRIO
A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small...
PREPARATION OF CAPROLACTAM FROM 6-AMINO CAPROIC ACID OBTAINED IN A
The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising...
METALLOPROTEASE INHIBITORS, METHODS FOR PRODUCING SAME, AND THERAPEUTIC
The invention relates to new .alpha.-vinyl carbonylated compounds corresponding to general formula (I), wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and...
3, 4-BIS-BENZYLSULFONYLBUTYRONITRILE AND ITS PHARMACEUTICAL USE
The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method...
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
Disclosed are compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R.sub.1, R.sub.2, R.sub.3, Y, Z, X,...
A process for the preparation of a compound of formula (I): ##STR00001## which is useful as an intermediate in the preparation of pharmaceutically active compounds.
CRYSTALLINE SALTS OF (4S, 4AS, 5AR,
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(me- ...
RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed...
METHOD FOR RECOVERING FLUORINATED EMULSIFIER
To provide a method for recovering, from a liquid to be treated containing a fluorinated polymer and a fluorinated emulsifier, the fluorinated emulsifier...
PREPARATION METHOD AND USE OF N-ACYL ACIDIC AMINO ACID OR SALT THEREOF
The invention provides a preparation method of N-acyl acidic amino acid or a salt thereof, comprising subjecting a fatty acyl chloride and an amino acid to an...
NOVEL PROCESS FOR MAKING OMEGA-AMINOALKYLENIC ALKYL ESTER
A method for making a compound of formula (V): ##STR00001## is provided. The method comprises converting a compound of formula (III): ##STR00002## to the compound...
CYCLIC VINYLOGOUS AMIDES AS BROMODOMAIN INHIBITORS
Cyclic vinylogous amides of Formula I are disclosed ##STR00001## The compounds are useful for treating diseases that arise from inappropriate activity of...
SYNTHESIS OF BIPHENYLALANINOL VIA NOVEL INTERMEDIATES
The invention relates to a novel synthesis route towards R-biphenylalaninol and to the intermediates applied in this synthesis route. The process according to...
Process for Preparing Cinacalcet and Pharmaceutically Acceptable Salts
The present patent application relates to a process for preparing cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting...
Method and Device for Removing Contaminants Arising During the Production
of Aliphatic Nitrate Esters
The invention relates to a method and to a device for removing contaminants arising during the production of aliphatic or alicyclic nitric acid esters, in...
COMPOUNDS HAVING NEGATIVE OPTICAL DISPERSION, NEGATIVE OPTICAL DISPERSION
COMPOSITION COMPRISING THE COMPOUNDS,...
The present invention relates to a reverse wavelength dispersion compound, a reverse wavelength dispersion composition including the same, and an optically...
NEW SALVIANOLIC ACID COMPOUND T, PREPARATION METHOD THEREFOR, AND USE
The present invention relates to the medical field, specifically a salvianolic acid T as described in structural formula (I), a chiral isomer thereof, a...
METHOD FOR PRODUCING METHACROLEIN AND THE CONDITIONING/DRAINING THEREOF
FOR DIRECT OXIDATIVE ESTERIFICATION
The present invention relates to a process for preparing methyl methacrylate by direct oxidative esterification of methacrolein and the preparation of...
Esters with antimicrobial, bioresistant and fungal resistant properties
A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and...
PROCESS FOR RECOVERING WATER, METAL AND ORGANICS FROM THE PRODUCTION OF
In a process for recovering water, metals, soluble organics and insoluble organics from a process for the production of a polycarboxylic acid, the stream is...