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METHODS FOR TREATING CANCER USING AN IMMUNOTOXIN
The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a...
COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein...
PEPTIDES AND PEPTIDE/ACTIVE COMPOUND CONJUGATES FOR RENAL TARGETING
The present invention relates to a peptide which consists of more than 50% of sequence sections of the formula -(A.sub.n-B.sub.m-C.sub.o)-, and to a conjugate...
Development of Novel Macromolecule Transduction Domain with Improved Cell
Permeability and Method for Using Same
The present invention relates to an improved macromolecule transduction domain (MTD), which facilitates permeating the cell membrane of a biologically active...
MODIFIED BLOOD FACTORS COMPRISING A LOW DEGREE OF WATER SOLUBLE POLYMER
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble...
Graft Copolymer Polyelectrolyte Complexes for Drug Delivery
Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological...
FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
COMPOSITIONS COMPRISING VITAMIN B12 AND INTRINSIC FACTOR AND METHODS OF
A system for detecting cancer cells that targets the cubilin receptor for the vitamin B12 binding protein, intrinsic factor. A B12 conjugate and intrinsic...
USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS
The invention provides uses for phospholipid conjugates of TLR agonists as enhancers of an innate immune response. Specifically, purine derivatives which are...
PEPTIDES FOR ENHANCING TRANSDERMAL DELIVERY
Skin penetration enhancers comprising peptides are disclosed. Compositions comprising the skin penetration enhancers are also provided. The compositions...
Cholesterol Ester-Depleting Nanomedicine for Non-toxic Cancer Chemotherapy
The present invention provides a formulation for reducing the hydrophobicity of ACAT-1 inhibitors. Methods for using the formulation of the present invention...
Stable Aqueous Formulations of Adenovirus Vectors
The present invention is based on the surprising discovery that the inclusion of an anionic polymer in the adenovirus formulation enhances long-term stability...
Polymer Compositions in Biomedical Applications
The present invention relates to compositions useful for biomedical procedures. More specifically the compositions are useful in procedures involving vascular...
COMPOSITIONS AND METHODS FOR STABILIZING PROTEIN-CONTAINING FORMULATIONS
The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in...
TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID
Topical compositions comprising a corticosteroid and at least one penetration enhancing agent, wherein the composition is substantially free of propylene glycol.
DIFFUSION PIGMENTS IN PHOTOTHERAPY
The present invention relates to the use of microfine pigments in medical and cosmetic phototherapy.
Compounds compositions and methods including thermally labile moieties
The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods...
TRANS CAROTENOIDS, THEIR SYNTHESIS, FORMULATION AND USES
The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These...
Etanercept Formulations Stabilized with Combinations of Sugars and Polyols
The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these...
Combination therapy for neoplasia treatment
The present invention relates to an insulin-like growth factor (IGF) receptor antagonist for use in the treatment of prostate neoplasia, including benign...
MODULATION OF TUMOR IMMUNITY
Methods of treating proliferative disorders are described. In particular, combination treatment with a GITR agonist and a PD-1 antagonist are provided.
ARRANGING INTERACTION AND BACK PRESSURE CHAMBERS FOR MICROFLUIDIZATION
An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidisation device whose interaction chamber comprises a plurality...
NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular,...
Fowl Adenovirus Vaccine
Disclosed is a vaccine comprising a fiber protein, selected from fiber-2 protein of Fowl Adenovirus C (FAdV-C), fiber-2 protein of Fowl Adenovirus A (FAdV-A),...
RECOMBINANT CDV COMPOSITIONS AND USES THEREOF
The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal...
HENDRA AND NIPAH VIRUS G GLYCOPROTEIN IMMUNOGENIC COMPOSITIONS
This invention relates to Hendra virus and Nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions...
COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOGEN EVOLUTION AND USES THEREOF
The present disclosure relates to compositions and methods for using a modified virus that infects a cell only if the virus presents a candidate antigen that...
METHOD FOR PREPARING VIROSOMES
Described are methods for preparing virosomes comprising the steps of: (a) providing an enveloped virus, and optionally inactivating the virus; (b)...
T cell receptors
The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted CLGGLLTMV peptide (SEQ ID NO: 1) derived from the LMP2A protein from...
ENVELOPED VIRUS VACCINE AND METHOD FOR PRODUCTION
The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV)...
Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use
The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said...
DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES
A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides...
LIVE-ATTENUATED VACCINE AGAINST PLAGUE
Provided herein is a genetically modified Y. pestis that includes three alterations compared to a control Y. pestis. Two alterations include decreased mRNA,...
INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS PRODUCED BY
The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to...
Mesothelin Vaccines and Model Systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are...
HLA-A* 1101-RESTRICTED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION
COMPRISING THE SAME
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein,...
VARIABLE EPITOPE LIBRARY COMPOSITIONS AND METHODS OF THERAPEUTIC AND
The present disclosure relates to compositions and methods for targeting antigenically variable pathogens and diseases. Embodiments of the present disclosure...
METHODS OF MODULATING THE NEGATIVE CHEMOTAXIS OF IMMUNE CELLS
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a ...
A pharmaceutical composition comprising at least two peptides of from 20 to 60 amino acids in length, selected from peptides comprising a sequence of at least...
Inotropic Antibodies and Therapeutic Uses Thereof
Antibodies binding to sites on the alpha-subunit of the (Na.sup.++K.sup.+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In...
REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE
VACCINE IMMUNOGENICITY AND/OR SAFETY
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated...
Methods For Treating Tissue Fibrosis
The present invention includes methods for reducing tissue damage in patients undergoing radiation treatment or with idiopathic pulmonary fibrosis or...
Compositions and method for utilization of thioretinamide in therapy of
degenerative diseases of aging
A process for the endogenic catabolism of homocysteine and the control of homocysteine levels for treating disease and the degenerative diseases of aging is...
ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE
The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention...
HDAC2 DEFENDS VASCULAR ENDOTHELIUM FROM INJURY
The invention features compositions comprising HDAC2 and methods for protecting the vascular endothelium from injury.
METHOD FOR PROPHYLAXIS AND/OR TREATMENT OF ERBB2 POSITIVE CANCERS
Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that...
Treatment of Synucleinopathies
This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as...
COMPOSITIONS FOR REDUCING THE DELETERIOUS EFFECTS OF STRESS AND AGING
The invention provides a formulation for treating stress and lessening fatigue. The formulation can be combined with water or another suitable liquid to...
COMPOSITIONS AND KITS FOR TREATING PRURITUS AND METHODS OF USING THE SAME
A treatment for pruritus is described that is based upon amylase. The amylases (.alpha.-, .beta.-, .gamma.-amylase) are noted for the cleavage of the...
METHODS OF PROMOTING FAT LOSS COMPRISING ADMINISTERING AN ALK7 INHIBITOR
The invention relates to ALK7 soluble receptors and their uses as antagonists of the function of certain ligands such as GDF-8 (Myostatin) and GDF-11. The ALK7...