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Patent # Description
2016/0199507 METHODS FOR TREATING CANCER USING AN IMMUNOTOXIN
The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a...
2016/0199506 COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF
The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein...
2016/0199505 PEPTIDES AND PEPTIDE/ACTIVE COMPOUND CONJUGATES FOR RENAL TARGETING
The present invention relates to a peptide which consists of more than 50% of sequence sections of the formula -(A.sub.n-B.sub.m-C.sub.o)-, and to a conjugate...
2016/0199504 Development of Novel Macromolecule Transduction Domain with Improved Cell Permeability and Method for Using Same
The present invention relates to an improved macromolecule transduction domain (MTD), which facilitates permeating the cell membrane of a biologically active...
2016/0199503 MODIFIED BLOOD FACTORS COMPRISING A LOW DEGREE OF WATER SOLUBLE POLYMER
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble...
2016/0199502 Graft Copolymer Polyelectrolyte Complexes for Drug Delivery
Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological...
2016/0199501 FACTOR VIII ZWITTERIONIC POLYMER CONJUGATES
The present invention provides multi-armed high MW polymers containing hydrophilic groups conjugated to Factor VIII, and methods of preparing such polymers.
2016/0199500 COMPOSITIONS COMPRISING VITAMIN B12 AND INTRINSIC FACTOR AND METHODS OF USE THEREOF
A system for detecting cancer cells that targets the cubilin receptor for the vitamin B12 binding protein, intrinsic factor. A B12 conjugate and intrinsic...
2016/0199499 USES OF PHOSPHOLIPID CONJUGATES OF SYNTHETIC TLR7 AGONISTS
The invention provides uses for phospholipid conjugates of TLR agonists as enhancers of an innate immune response. Specifically, purine derivatives which are...
2016/0199498 PEPTIDES FOR ENHANCING TRANSDERMAL DELIVERY
Skin penetration enhancers comprising peptides are disclosed. Compositions comprising the skin penetration enhancers are also provided. The compositions...
2016/0199497 Cholesterol Ester-Depleting Nanomedicine for Non-toxic Cancer Chemotherapy
The present invention provides a formulation for reducing the hydrophobicity of ACAT-1 inhibitors. Methods for using the formulation of the present invention...
2016/0199496 Stable Aqueous Formulations of Adenovirus Vectors
The present invention is based on the surprising discovery that the inclusion of an anionic polymer in the adenovirus formulation enhances long-term stability...
2016/0199495 Polymer Compositions in Biomedical Applications
The present invention relates to compositions useful for biomedical procedures. More specifically the compositions are useful in procedures involving vascular...
2016/0199494 COMPOSITIONS AND METHODS FOR STABILIZING PROTEIN-CONTAINING FORMULATIONS
The present invention relates to use of certain alkylglycoside compositions for the prevention of aggregation and oxidation of antibodies and other proteins in...
2016/0199493 TOPICAL COMPOSITIONS COMPRISING A CORTICOSTEROID
Topical compositions comprising a corticosteroid and at least one penetration enhancing agent, wherein the composition is substantially free of propylene glycol.
2016/0199492 DIFFUSION PIGMENTS IN PHOTOTHERAPY
The present invention relates to the use of microfine pigments in medical and cosmetic phototherapy.
2016/0199491 Compounds compositions and methods including thermally labile moieties
The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods...
2016/0199490 TRANS CAROTENOIDS, THEIR SYNTHESIS, FORMULATION AND USES
The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These...
2016/0199489 Etanercept Formulations Stabilized with Combinations of Sugars and Polyols
The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these...
2016/0199488 Combination therapy for neoplasia treatment
The present invention relates to an insulin-like growth factor (IGF) receptor antagonist for use in the treatment of prostate neoplasia, including benign...
2016/0199487 MODULATION OF TUMOR IMMUNITY
Methods of treating proliferative disorders are described. In particular, combination treatment with a GITR agonist and a PD-1 antagonist are provided.
2016/0199486 ARRANGING INTERACTION AND BACK PRESSURE CHAMBERS FOR MICROFLUIDIZATION
An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidisation device whose interaction chamber comprises a plurality...
2016/0199485 NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular,...
2016/0199484 Fowl Adenovirus Vaccine
Disclosed is a vaccine comprising a fiber protein, selected from fiber-2 protein of Fowl Adenovirus C (FAdV-C), fiber-2 protein of Fowl Adenovirus A (FAdV-A),...
2016/0199483 RECOMBINANT CDV COMPOSITIONS AND USES THEREOF
The present invention provides vectors that contain and express in vivo or in vitro CDV polypeptides or antigens that elicit an immune response in animal...
2016/0199482 HENDRA AND NIPAH VIRUS G GLYCOPROTEIN IMMUNOGENIC COMPOSITIONS
This invention relates to Hendra virus and Nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions...
2016/0199481 COMPOSITIONS AND METHODS FOR DIRECTED IMMUNOGEN EVOLUTION AND USES THEREOF
The present disclosure relates to compositions and methods for using a modified virus that infects a cell only if the virus presents a candidate antigen that...
2016/0199480 METHOD FOR PREPARING VIROSOMES
Described are methods for preparing virosomes comprising the steps of: (a) providing an enveloped virus, and optionally inactivating the virus; (b)...
2016/0199479 T cell receptors
The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted CLGGLLTMV peptide (SEQ ID NO: 1) derived from the LMP2A protein from...
2016/0199478 ENVELOPED VIRUS VACCINE AND METHOD FOR PRODUCTION
The present invention provides methods of production of a purified enveloped virus antigen. In particular, it provides purified Ross River Virus (RRV)...
2016/0199477 Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use
The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said...
2016/0199476 DEVELOPMENTS IN MENINGOCOCCAL OUTER MEMBRANE VESICLES
A first aspect of the invention provides meningococcal outer membrane vesicles in which NHBA is over-expressed. A second aspect of the invention provides...
2016/0199475 LIVE-ATTENUATED VACCINE AGAINST PLAGUE
Provided herein is a genetically modified Y. pestis that includes three alterations compared to a control Y. pestis. Two alterations include decreased mRNA,...
2016/0199474 INCAPACITATED WHOLE-CELL IMMUNOGENIC BACTERIAL COMPOSITIONS PRODUCED BY RECOMBINANT EXPRESSION
The present invention features incapacitated whole-cell bacterial immunogenic compositions and methods of their production, which compositions are useful to...
2016/0199473 Mesothelin Vaccines and Model Systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are...
2016/0199472 HLA-A* 1101-RESTRICTED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
An HLA-A*1101-restricted WT1 peptide, specifically, a peptide comprising an amino acid sequence consisting of 9 contiguous amino acids from a WT1 protein,...
2016/0199471 VARIABLE EPITOPE LIBRARY COMPOSITIONS AND METHODS OF THERAPEUTIC AND PROPHYLACTIC USE
The present disclosure relates to compositions and methods for targeting antigenically variable pathogens and diseases. Embodiments of the present disclosure...
2016/0199470 METHODS OF MODULATING THE NEGATIVE CHEMOTAXIS OF IMMUNE CELLS
The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a ...
2016/0199469 ONCOLOGY VACCINE
A pharmaceutical composition comprising at least two peptides of from 20 to 60 amino acids in length, selected from peptides comprising a sequence of at least...
2016/0199468 Inotropic Antibodies and Therapeutic Uses Thereof
Antibodies binding to sites on the alpha-subunit of the (Na.sup.++K.sup.+)-ATPase increase cardiac contraction of both ventricular myocytes and mouse heart. In...
2016/0199467 REGULATED EXPRESSION OF ANTIGEN AND/OR REGULATED ATTENTUATION TO ENHANCE VACCINE IMMUNOGENICITY AND/OR SAFETY
The invention relates to compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated...
2016/0199466 Methods For Treating Tissue Fibrosis
The present invention includes methods for reducing tissue damage in patients undergoing radiation treatment or with idiopathic pulmonary fibrosis or...
2016/0199465 Compositions and method for utilization of thioretinamide in therapy of degenerative diseases of aging
A process for the endogenic catabolism of homocysteine and the control of homocysteine levels for treating disease and the degenerative diseases of aging is...
2016/0199464 ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE
The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention...
2016/0199463 HDAC2 DEFENDS VASCULAR ENDOTHELIUM FROM INJURY
The invention features compositions comprising HDAC2 and methods for protecting the vascular endothelium from injury.
2016/0199462 METHOD FOR PROPHYLAXIS AND/OR TREATMENT OF ERBB2 POSITIVE CANCERS
Provided are compositions and methods for prophylaxis and/or therapy of ErbB2-positive cancer. The compositions include pharmaceutical preparations that...
2016/0199461 Treatment of Synucleinopathies
This invention relates generally to treating synucleinopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as...
2016/0199460 COMPOSITIONS FOR REDUCING THE DELETERIOUS EFFECTS OF STRESS AND AGING
The invention provides a formulation for treating stress and lessening fatigue. The formulation can be combined with water or another suitable liquid to...
2016/0199459 COMPOSITIONS AND KITS FOR TREATING PRURITUS AND METHODS OF USING THE SAME
A treatment for pruritus is described that is based upon amylase. The amylases (.alpha.-, .beta.-, .gamma.-amylase) are noted for the cleavage of the...
2016/0199458 METHODS OF PROMOTING FAT LOSS COMPRISING ADMINISTERING AN ALK7 INHIBITOR
The invention relates to ALK7 soluble receptors and their uses as antagonists of the function of certain ligands such as GDF-8 (Myostatin) and GDF-11. The ALK7...
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