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SPARC (Secreted Protein, Acidic and Rich in Cysteine), A New Target for
the Treatment and Prevention of Acute...
The invention relates to the identification of Secreted Protein, Acidic and Rich in Cysteine (SPARC) as a new therapeutic target in patients with fulminant...
MICRO-RNA REGULATION OF BONE LOSS
The use of miR-34a and agonists thereof in the treatment of bone loss diseases is described. Such conditions include osteoporosis, rheumatoid arthritis and...
METHODS, SYSTEMS, AND COMPOSITIONS RELATING TO MIRNA-146A
Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or...
METHOD OF OBTAINING ANTIBODIES OF INTEREST AND NUCLEOTIDES ENCODING SAME
The invention is a methodology which makes it possible to select from a very large number of cells, a single cell or cells of interest and obtain specific...
Inducible mutagenesis of target genes
The present invention relates generally to mutagenesis of target genes that takes advantage of the natural mutagenic capabilities of B cells, and enhances...
METHODS FOR RETRIEVING SEQUENCE-VERIFIED NUCLEIC ACID FRAGMENTS AND
APPARATUSES FOR AMPLIFYING SEQUENCE...
A method for retrieving nucleic acid fragments, including: providing reduced DNA libraries during sequencing; amplifying nucleic acid fragments from the...
SYSTEMS AND METHODS FOR QUANTIFYING AN ANALYTE EXTRACTED FROM A SAMPLE
The invention generally relates to systems and methods for quantifying an analyte extracted from a sample. In certain embodiments, the invention provides...
ENCAPSULATING DEVICE AND ENCAPSULATING METHOD FOR ENCAPSULATING A SAMPLE
IN A POLYMER CAPSULE
The invention relates to an encapsulating device (100), which is designed to encapsulate a sample (1, 2) in a polymer capsule, comprising a drop generator...
METHODS OF MODULATING UBIQUITIN LIGASE ACTIVITY
Methods are provided for modulating the activity of multimeric ubiquitin-protein E3 ligases including, but not limited to, E6AP ligase activities. The methods...
STABILIZED RECOMBINANT EXPRESSION PLASMID VECTOR IN HAFNIA ALVEI AND
One aspect of the present disclosure relates to a stabilized recombinant expression plasmid vector comprising a polynucleotide encoding an antitoxin gene which...
MODIFIED FACTOR IX POLYPEPTIDES AND USES THEREOF
Nucleic acid molecules encoding modified factor IX (FIX) polypeptides and uses thereof are provided. Such modified FIX polypeptides include FIXa and other...
DEGRADABLE CLOSTRIDIAL TOXINS
The specification discloses Clostridial toxins or Clostridial toxin chimeras comprising an inactivation cleavage site, polynucleotide molecules encoding such...
Endo-xylanase and Coding Gene and Use Thereof
Provided are an endo-xylanase and a coding gene and the use thereof. Also provided are an expression vector and a host cell containing the coding gene, a...
NOVEL INSECTICIDAL CHITINASE PROTEIN ITS ENCODING NUCLEOTIDE AND
A novel insecticidal chitinase protein from fern Tectaria sp., a process for preparation of the insecticidal protein and nucleic acid sequence encoding for...
CELLULASE ENZYMES HAVING A MODIFIED LINKER AND REDUCED LIGNIN BINDING
Provided are modified cellulase enzymes exhibiting increase cellulose-hydrolyzing activity in the presence of lignin and/or reduced binding to lignin...
ALPHA-AMYLASE VARIANTS AND POLYNUCLEOTIDES ENCODING SAME
The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs,...
ENZYME COMPOSITION AND USES THEREOF
The invention relates to enzyme compositions comprising a glucoamylase, an alpha-amylase, and optionally a cellulolytic composition and/or a protease. The...
ENGINEERED TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR (TALE) DOMAINS AND USES
Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts....
Manufacture of Active Highly Phosphorylated Human Lysosomal Sulfatase
Enzymes and Uses Thereof
This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and...
NOVEL POLYENE-SPECIFIC GLYCOSYLTRANSFERASE DERIVED FROM PSEUDONOCARDIA
Disclosed is a novel polyene-specific glycosyltransferase derived from Pseudonocardia autotrophica. The glycosyltransferase includes an amino acid sequence of...
MODULAR, MICROFLUIDIC, MECHANICALLY ACTIVE BIOREACTOR FOR 3D,
MULTI-TISSUE, TISSUE CULTURE
Disclosed herein are various bioreactor devices and systems for growing cellular material, and related methods of growing cellular material. In some cases, a...
Induction Medium and Methods for Stem Cell Culture and Therapy
Novel MSC stem-cell culture and therapy methods and culture medium compositions for the purpose of inducing, activating, or priming discrete uniform cell...
Methods for Accelerated and Enhanced Cardiac Differentiation of IPS Cells
by Electrical Stimulation
Methods of generating cardiomyocytes from induced pluripotent stem cells (IPSCs) are provided. More specifically, the present disclosure relates to methods of...
METHOD FOR PRODUCING ENGINEERED HEART MUSCLE (EHM)
The present invention provides a new method for producing Engineered Heart Muscle (EHM) under chemically fully defined conditions and compounds all compatible...
HEMATOPOIETIC CELL E-SELECTIN/L-SELECTIN LIGAND POLYPEPTIDES AND METHODS
OF USE THEREOF
The invention feature methods and compositions for treating hematopoietic disorders, inflammatory conditions, and cancer and providing stem cell therapy in a...
METHOD OF NOCICEPTOR DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS AND
The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells,...
COMPOSITION AND METHODS FOR CULTURING CELLS
The present disclosure provides compositions for in vitro culture of cells. The present disclosure provides methods for in vitro culture of cells. The present...
NANOTUBE STRUCTURES, METHODS OF MAKING NANOTUBE STRUCTURES, AND METHODS OF
ACCESSING INTRACELLULAR SPACE
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect,...
SCAFFOLD AND METHOD FOR IMPLANTING CELLS
The disclosure provides for a bone implant for replacing at least a portion of a bone of a patient. The bone implant includes a support structure being a...
CELL CULTURE MEDIUM AND PROCESS FOR CONTROLLING a-AMIDATION AND/OR
C-TERMINAL AMINO ACID CLEAVAGE OF POLYPEPTIDES
The present invention is related to a cell culture medium for reducing the C-terminal heterogeneity of a polypeptide expressed in cell-culture, wherein the...
METHODS OF MAKING SPHEROIDS INCLUDING BIOLOGICALLY-RELEVANT MATERIALS
Methods of making a spheroid are provided whereby a suspension is first produced including one or more biologically-relevant materials dispersed within a...
MICROBIAL CONSORTIA FOR PROGRAMMABLE OUTPUT VIA PHOTOAUTOTROPH-HETEROTROPH
Self-sustained, safe, stable and scalable microbial consortia (S.sup.5MicroCon) are described. The microbial consortia are regulated by ...
METHODS FOR THE PRODUCTION OF DIATOM BIOMASS
The invention relates to methods of producing a diatom biomass. More particularly, the invention relates to methods to produce a diatom biomass using a...
MICROFLUIDIC DEVICES AND/OR EQUIPMENT FOR MICROFLUIDIC DEVICES
A biomedical microfluidic device (MD) for separating a sub-population of particles from a biological fluid has elements for separation and/or filtration of the...
CULTURE SYSTEM AND CULTURE METHOD
A culture system comprises: a preparatory culture vessel and a main culture vessel that accommodate cells and a solution; a main stage that holds the...
AUTOMATIC CULTURE SYSTEM AND AUTOMATIC CULTURE DEVICE
An automatic culture system includes a transfer part configured to transfer a first airtight container which accommodates cells in a sealed state, and an...
DEVICE FOR THE ASEPTIC EXPANSION OF CELLS
A closed system suitable for the aseptic culturing of therapeutic cells. The present system facilitates the aseptic manufacturing of cells for use in therapy,...
PHOTOBIOREACTOR WITH LATERALLY LIGHT-EMITTING LIGHT CONDUCTOR MATS
A photobioreactor and a photobioreactor system are proposed in order to cultivate phototrophic organisms for the purpose of generating fuels, for example. The...
WINE PACKAGED IN ALUMINIUM CONTAINERS
A method of filling an aluminium container with wine, and a filled aluminium container containing a wine characterised in that the maximum oxygen content of...
A BEVERAGE APPARATUS AND METHOD
A beverage apparatus, system and methods for use are provided. The apparatus includes a pressure vessel configured to receive a flexible bag for containing a...
LAUNDRY DETERGENT, FABRIC SOFTENER AND CLEANING FORMULATIONS, SYSTEMS, AND
Water soluble packets containing cleaning concentrates in gel form in unit dose, ready-to-use and pouches to be reconstituted in ready-to-use cleaners and...
CLEANING COMPOSITION AND METHOD FOR CLEANING SEMICONDUCTOR WAFERS AFTER
The invention provides a composition for cleaning contaminants from semiconductor wafers following chemical-mechanical polishing. The cleaning composition...
The present application relates to encapsulated benefit agents, compositions comprising such encapsulated benefit agents and processes for making and using...
AQUEOUS LIQUID COMPOSITION
An aqueous liquid composition, which may be used as a light duty hand dishwashing composition, comprising (i) at least one surfactant, (ii) at least one...
FAST DISSOLVING SOLID DETERGENT
A solid block or unit dosed detergent composition as described which can be utilized in a variety of applications for cleaning surfaces and objects, removing...
AUTOMATIC DISHWASHING DETERGENT
Described are automatic dishwashing detergents, comprising a builder, a surfactant, and a polymer comprising units derived from at least one carboxylic acid...
INTERESTERIFICATION CATALYST AND PROCESS
A process for the production of an ester product from a mixture of at least two different ester compounds includes the steps of mixing together at least two...
METHODS AND INDUSTRIAL PROCESSES FOR THE PRODUCTION OF FREE FATTY ACIDS
AND DERIVATIVES THEREOF FROM SOAP STOCKS
This invention generally relates to the production of free fatty acids and/or derivatives thereof, e.g. fatty acid alkyl esters, from soapstock comprising...
INTEGRATED OIL EXTRACTION APPARATUS
The invention provides a method for extracting oil from a starting plant material. The method includes passing a solvent through the plant material to obtain a...
System and Process for Palm Oil Extraction by Cracking, Threshing and
Dynamic Sterilization of the Fresh Fruit
The present invention patent application belongs to the field of mechanical engineering and consists of a system and process for palm oil extraction integrally...