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Patent # Description
2016/0207975 CGRP AGONIST PEPTIDES
The embodiments provide a calcitonin gene-related peptide (CGRP) agonist peptide or pharmaceutically acceptable salt thereof, including pharmaceutical...
2016/0207974 ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION AND REDUCED IMMUNOGENICITY
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including once weekly administration. The...
2016/0207973 DESIGNER OSTEOGENIC PROTEINS
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use...
2016/0207972 RECOMBINANT PROTEINS AND THEIR THERAPEUTIC USES
A recombinant protein expressing one or more human growth factors, tumor antigens, and/or receptors or epitopes thereof on or within an immunogenic expression...
2016/0207971 HSP20 Inhibits Amyloidogenesis and Neurotoxicity
The present inventions are compositions and methods of using at least a portion of an isolated and purified .alpha.-crystallin polypeptide that includes one or...
2016/0207970 POLYPEPTIDE FOR THE PROTECTION AGAINST HEART ISCHEMIA-REPERFUSION INJURY
A peptide of the formula R.sup.1--NH-HAEGTFTSDVSSYLEGQAAKEFIAWLVK-CONR.sup.2R.sup.3 wherein R.dbd.H or an organic compound comprising from 1 to 10 carbon atoms...
2016/0207969 CLOSTRIDIUM DIFFICILE TARGETING MOIETIES AND CONSTRUCTS COMPRISING SAID MOIETIES
In certain embodiments, constructs are provided that selectively/preferentially inhibit and/or kill Clostridium difficile. In certain embodiments the...
2016/0207968 TARGETING OF PODOPLANIN WITH LECTIN FOR USE IN THE PREVENTION AND TREATMENT OF CANCER
Lectin compositions and methods for reducing tumor cell growth and preventing or treating cancer are provided.
2016/0207967 PHL P 5A DERIVATIVES HAVING REDUCED ALLERGENEITY AND RETAINED T-CELL REACTIVITY
The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity...
2016/0207966 MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES
A polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A, as specified by SEQ ID NO...
2016/0207965 PROTEIN PRODUCTION SYSTEMS AND METHODS THEREOF
Disclosed herein is a protein purification system and methods of using the system. In particular, disclosed is a split intein comprising an N-terminal intein...
2016/0207964 DESIGNING A SOLUBLE FULL-LENGTH HIV-1 GP41 TRIMER
Described herein is a soluble HIV-1 retrovirus transmembrane glycoprotein gp41 trimer (Soc-gp41M-Fd) containing a partial ectodomain and the cytoplasmic...
2016/0207963 NOVEL INFLUENZA ANTIGENS AND ANTIBODIES
Novel influenza antigens, novel immunogenic or vaccine compositions, as well as uses of and methods for producing said antigens and compositions, are described.
2016/0207962 ELECTRON SPIN LABELED ICE BINDING COMPOUNDS USED FOR CARRYING PARAMAGNETIC CENTERS FOR DYNAMIC NUCLEAR POLARIZATION
Spin labeled ice binding compounds (IBCs) including ice binding proteins (IBPs), also called antifreeze proteins (AFPs) and their analogs are exploited to...
2016/0207961 Cyclosporine Analogue Molecules Modified At Amino Acid 1 and 3
Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following...
2016/0207960 PEPTIDES INHIBITING COLD-INDUCIBLE RNA BINDING PROTEIN ACTIVITY
Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. Methods of treating a subject suffering from an inflammatory condition comprising...
2016/0207959 METHODS AND COMPOSITIONS FOR TREATMENT OF CARTILAGE AND DISC TISSUE PATHOLOGIES
An isolated polypeptide comprising a peptide selected from: i) DHX.sub.1SDNYT, wherein X.sub.1 is L or H (SEQ ID NO:3); ii) a conservative variant of i) iii) a...
2016/0207958 METHOD FOR PRODUCING DIPEPTIDE DERIVATIVE CONTAINING DISUBSTITUTED AMINO ACID RESIDUE
A method for producing a dipeptide that has a protected N-terminal and is represented by formula (1) or a salt of the dipeptide, said method comprising...
2016/0207957 AMINO DIACIDS CONTAINING PEPTIDE MODIFIERS
The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to...
2016/0207956 NOVEL SALTS AND POLYMORPHS OF SCY-078
SCY-078 is a glucan synthase inhibitor with antimicrobial activity. Novel salts and polymorph forms of SCY-078 are disclosed herein. The disclosure also...
2016/0207955 MULTIVALENT SIALIC ACID DERIVATIVES
Disclosed is tri- or tetravalent sialic acid derivatives comprising a core moiety to which 3 or 4 sialic acid residues are connected via a linker. Such...
2016/0207954 A NON-CALORIC SWEETENER
Disclosed is a steviol glycoside referred to as rebaudioside D2. Rebaudioside D2 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
2016/0207953 SUBSTITUTED-6,8-DIOXABICYCLO[3.2.1]OCTANE-2,3-DIOL COMPOUNDS AS TARGETING AGENTS OF ASGPR
Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical...
2016/0207952 PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS
Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic...
2016/0207951 ORGANOMETALLIC COMPOUNDS FOR USE AS ANTHELMINTICS
The Invention comprises a compound characterized by a general formula (1), R.sup.L--OM-R.sup.R (1) wherein OM is an organometallic compound independently...
2016/0207950 ORGANOMETALLIC N-2-CYANO-1-HYDROXYPROPAN-2-YL FOR USE AS ANTHELMINTICS
The invention relates to a compound characterized by a general formula, ##STR00001## wherein OM is an organometallic compound independently selected from the ...
2016/0207949 NOVEL CYTOTOXIC AGENTS FOR CONJUGATION TO A CELL BINDING MOLECULE
The present invention is related to novel cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent,...
2016/0207948 PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES
The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating...
2016/0207947 METHOD FOR PREPARING TRISHYDROXYMETHYL PHOSPHINE
A method for preparing trishydroxymethyl phosphine from tetrakishydroxymethyl phosphonium salt, the method including at least the steps of continuously feeding...
2016/0207946 LIGAND COMPOUND, CATALYST SYSTEM FOR OLEFIN OLIGOMERIZATION, AND METHOD FOR OLEFIN OLIGOMERIZATION USING THE SAME
This disclosure relates to a ligand compound, a catalyst system for olefin oligomerization, and a method for olefin oligomerization using the same. The...
2016/0207945 Novel chiral aryl or aryl-alkyl phosphoramidate dexamphetamine precursors having a regioisomeric purity >99%
The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel...
2016/0207944 METHODS FOR PRODUCING FUNCTIONALIZED GRAPHENES
Methods for producing functionalized graphene from graphite oxide or graphite are disclosed in which ionic liquids are used as a reaction medium to promote...
2016/0207943 Apparatus and Methods for the Automated Synthesis of Small Molecules
Provided are methods for purifying N-methyliminodiacetic acid (MIDA) boronates from solution. Also provided are methods for deprotection of boronic acids from...
2016/0207942 METHOD FOR PRODUCING ALKYL-INDIUM COMPOUNDS AND THE USE THEREOF
The invention relates to a method for the cost-effective and environmentally friendly production of alkyl indium sesquichloride in high yield and with high...
2016/0207941 METHOD FOR PRODUCING ALKYL-INDIUM COMPOUNDS AND THE USE THEREOF
The invention relates to a method for the cost-effective and environmentally friendly production of dialkyl indium chloride in high yield and with high...
2016/0207940 HETEROCYCLIC COMPOUNDS AND USES THEREOF
Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods...
2016/0207939 POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a...
2016/0207938 QUINAZOLINE DERIVATIVES
The present invention concerns the compounds of formula ##STR00001## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically...
2016/0207937 NOVEL MICROBIAL PRODUCT HAVING ANTIFUNGAL ACTIVITY
Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a...
2016/0207936 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
Compounds of the formula I or II: ##STR00001## wherein X, m, Ar, R.sup.1 and R.sup.2 are as defined herein. The subject compounds are useful for treatment of...
2016/0207935 SUBSTITUTED THIENO[2,3-C]PYRIDAZINE-6-CARBOXAMIDE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC...
In one aspect, the invention relates to substituted 5-aminothieno[2,3-c]pyridazine-6-carboxamide analogs, derivatives thereof, and related compounds, which are...
2016/0207934 Herbicidally active (alkynyl-phenyl)-substituted cyclic dione compounds and derivatives thereof
The present invention relates to a compound of formula (I): wherein: X is methyl or chlorine; R.sup.1 is fluorine or bromine; R.sup.2 is ethynyl, ...
2016/0207933 GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either...
2016/0207932 NOVEL TRICYCLIC CHIRAL COMPOUNDS AND THEIR USE IN ASYMMETRIC CATALYSIS
The present invention relates to a compound of general Formula (VIII), ##STR00001## the compound having a bowl-shaped conformation, its formation and its use in...
2016/0207931 PROTEIN KINASE INHIBITOR CONTAINING PYRROLOPYRIDAZINE DERIVATIVE
The present invention relates to a pyrrolopyridazine derivative represented by Formula 1 of the detailed description, or a pharmaceutically acceptable salt...
2016/0207930 NOVEL NEUROKININ 1 RECEPTOR ANTAGONIST COMPOUNDS II
The invention relates novel NK1 receptor antagonists represented in formula A, wherein R.sub.1 and R.sub.2 independently are selected from the group consisting...
2016/0207929 PI3K PROTEIN KINASE INHIBITORS, PARTICULARLY DELTA AND/OR GAMMA INHIBITORS
The present disclosure provides novel compounds useful as PI3K protein kinase modulators, in particular as PI3K delta (.delta.) and/or gamma (.gamma.) protein...
2016/0207928 NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER
The present invention relates to novel compounds showing an inhibitory effect on Mps-1 kinase, to methods of preparing said compounds, to pharmaceutical...
2016/0207927 PYRIMIDINE SUBSTITUTED PURINE COMPOUNDS AS KINASE (S) INHIBITORS
The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure: ##STR00001## or a pharmaceutically acceptable...
2016/0207926 PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases...
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