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Patent # Description
2016/0207925 L-METHYLFOLATE SALT PREPARATIONS, MEDICAMENTS, AND NUTRITIONAL SUPPLEMENTS COMPRISING SUCH SALTS THEREOF
The present invention provides salts of L-methylfolate of formula I, ##STR00001## wherein X and Y both are elected from H, amino acids, and amine compounds,...
2016/0207924 2, 6-Di-Nitrogen-Containing Substituted Purine Derivative, And Preparation Method, Pharmaceutical Composition...
The present invention provides a 2, 6-di-nitrogen-containing substituted purine derivative having a formula (I) structure, or pharmaceutical salt or hydrate...
2016/0207923 AZASPIRO[4.5] DECANE DERIVATIVES AND USE THEREOF
The invention provides azaspiro[4.5]decane derivatives of Formula (A): and pharmaceutically acceptable salts, solvates, hydrates, N-oxides, and diastereomers...
2016/0207922 Inhibitors of the Renal Outer Medullary Potassium Channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1)...
2016/0207921 ERGOLINE COMPOUNDS AND USES THEREOF
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or...
2016/0207920 ISOERGOLINE COMPOUNDS AND USES THEREOF
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention,...
2016/0207919 IMIDAZO[1,2-a]PYRIDIN-7-AMINE
The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, for example,...
2016/0207918 SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASEINHIBITORS
This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention...
2016/0207917 BENZOQUINOLONE INHIBITORS OF VMAT2
The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof represented by...
2016/0207916 NAPHTHYLUREA DERIVATIVES AND MEDICAL APPLICATIONS THEREOF
The present invention relates to naphthylurea derivatives. Such substances can significantly inhibit VEGFR2 and PDGFR-.beta. receptor tyrosine kinase...
2016/0207915 PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES
The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or...
2016/0207914 Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection
The invention provides novel compounds having the general formula: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described...
2016/0207913 PRODRUGS OF AMINO QUINAZOLINE KINASE INHIBITOR
Disclosed are compounds having the formula: ##STR00001## wherein X is as defined herein, and methods of making and using the same.
2016/0207912 HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods...
2016/0207911 Crystal Form of Dabrafenib and Preparation Method and Use Thereof
The invention relates to a new crystal form of dabrafenib and preparation method thereof. With respect to known crystal forms, the new crystal form has the...
2016/0207910 Fluorinated 2-arylbenzo heterocyclic compound with high affinity to A beta 946; plaques and containing chiral...
A fluorinated 2-arylbenzo heterocyclic compound with high affinity to A.beta. plaques and containing a chiral side chain substituent, has a general formula (I)...
2016/0207909 Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof
A synthesis method of anti-cancer drug UK-1 includes: mixing methyl 2-amino-3-hydroxybenzoate, aldehyde and molecular sieves to form a mixture and firstly...
2016/0207908 BROAD SPECTRUM ANTIVIRAL AND ANTIPARASITIC AGENTS
The invention provides compounds represented by the formulae: (I) and (II) where the compounds are useful in treating, for example, viral and/or parasitic...
2016/0207907 Crystalline Forms of Afatinib Monomaleate, Preparation Methods and Pharmaceutical Compositions Thereof
The present invention relates to the novel solid forms of Afatinib monomaleate and preparation methods thereof; the solid forms of Afatinib monomaleate of the...
2016/0207906 NOVEL 2,6-DIAMINOPYRIMIDINE DERIVATIVE
To provide a novel 2,6-diaminopyrimidine derivative by the following formula (I): A 2,6-diaminopyrimidine derivative is represented by the formula (I): ...
2016/0207905 SUBSTITUTED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF
The present disclosure relates to pyrimidine compounds of formula (I), their stereoisomers, tautomers, pharmaceutically acceptable salts, polymorphs, solvates,...
2016/0207904 CRYSTALLINE 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALD- EHYDE ANSOLVATE SALTS
Disclosed are crystalline ansolvate salts of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzald- ehyde (or Compound 1), such as the...
2016/0207903 Photochromic Compounds
Described are novel photochromic naphthopyran compounds which exhibit a red coloring when in a red-colored state achieved upon exposure to ultraviolet light,...
2016/0207902 TOCOPHEROL AND TOCOPHERYL QUINONE DERIVATIVES AS CORRECTORS OF LYSOSOMAL STORAGE DISORDERS
The subject invention relates to improved tocopheryl quinone derivatives and tocopherol derivatives having improved pharmacokinetics in vivo that can, in some...
2016/0207901 COMPOUND, MEDICINE, ANTI-INFLAMMATORY, COSMETIC, FOOD AND DRINK, AND METHOD FOR PRODUCING COMPOUND
A compound is represented by Formula (I) or (II) described below. ##STR00001## A medicine includes, as an active ingredient, a compound represented by Formula...
2016/0207900 PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS
The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions...
2016/0207899 CONVERSION AND PURIFICATION OF BIOMASS
The present invention relates to a method for synthesizing an optionally substituted furoic acid by dehydrating a biomass and oxidizing the optionally...
2016/0207898 PROCESS FOR PURIFYING AN ACID COMPOSITION COMPRISING 2-FORMYL-FURAN-5-CARBOXYLIC ACID AND 2,5-FURANDICARBOXYLIC...
An acid composition comprising 2-formyl-furan-5-carboxylic acid and 2,5-furandicarboxylic acid is purified in a process which comprises; contacting the acid...
2016/0207897 METHODS FOR PRODUCING 5-(HALOMETHYL)FURFURAL
The present disclosure provides methods to produce 5-(halomethyl)furfural, including 5-(chloromethyl)furfural, by acid-catalyzed conversion of C6 saccharides,...
2016/0207896 METHOD FOR PREPARING 5-HYDROXYMETHYL-2-FURFURAL USING ACID CATALYST IN PRESENCE OF ETHYLENE GLYCOL-BASED...
Provided is a method for preparing 5-hydroxymethyl-2-furfural using an acid catalyst in the presence of an ethylene glycol-based solvent. The method for...
2016/0207895 SYNTHESIS OF ALKYLFURANS
The invention provides a method for preparing a 2,5-dialkyl furan. The method includes forming a reaction mixture containing a catalyst, a hydrogen source, and...
2016/0207894 Synthesis of Diacids, Dialdehydes, or Diamines from THF-Diols
A simple and elegant chemical process for the synthesis of oxygenated products, such as acids and aldehydes, or other derivative products, such as amines and...
2016/0207893 NOVEL CALCIUM MODULATORS
Disclosed are novel calcium modulators having formula I: ##STR00001## or a pharmaceutically acceptable salt, and including deuterated forms thereof, wherein:...
2016/0207892 FACILE METHOD FOR PREPARATION OF SODIUM 5-NITROTETRAZOLATE USING A FLOW SYSTEM
Described are methods for preparing salts of 5-nitrotetrazolate that include reacting aqueous solutions of 5-aminotetrazole, an acid, and sodium nitrite in a...
2016/0207891 MALIGNANT AND NON-MALIGNANT DISEASE TREATMENT WITH RAS ANTAGONISTS
The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular...
2016/0207890 ETHYNYL DERIVATIVES
It has been surprisingly been found that the compounds of general formula I are positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4...
2016/0207889 APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF
This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.
2016/0207888 PYRAZOLOCHALCONES AS POTENTIAL ANTICANCER AGENTS
The present invention relates to a pyrazolochalcone of formula A useful as potential antitumor agent against human cancer cell lines and a process for the...
2016/0207887 ANTIDIABETIC TRICYCLIC COMPOUNDS
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
2016/0207886 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATION AND PAIN
The invention relates to the compounds of formula V or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The...
2016/0207885 INDOL AND INDAZOL DERIVATIVES
The present invention relates to compounds of formula ##STR00001## wherein A is ##STR00002## R is lower alkyl, --(CH.sub.2).sub.z-C.sub.3-7-cycloalkyl...
2016/0207884 POLYMORPHIC FORM OF PYRROLE DERIVATIVE AND INTERMEDIATE THEREOF
The present invention relates to Saroglitazar free acid of Formula (IA) or its pharmaceutically acceptable salts, pharmaceutically acceptable solvates,...
2016/0207883 NOVEL AROMATIC COMPOUND AND USE THEREOF
Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a ...
2016/0207882 METHOD FOR PREPARING ORGANIC PEROXIDES
A method for preparing peroxide, including a step of treating, in a reaction medium, a component having at least one tertiary alcohol grouping with a compound...
2016/0207881 4-METHYLSULFONYL-2-BUTENENITRILE AND ITS PHARMACEUTICAL USE
The present invention is directed to a method of treating an inflammatory skin disease or disorder, such as dermatitis, psoriasis, acne, or rosacea. The method...
2016/0207880 AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, ##STR00001## wherein R.sup.1, X, m, R.sup.2, Y, R.sup.3,...
2016/0207879 METHODS AND INDUSTRIAL PROCESSES FOR THE GENERATION OF FREE FATTY ACIDS AND DERIVATIVES THEREOF FROM OIL GUMS
This invention generally relates to the generation of free fatty acids and/or derivatives thereof, e.g. fatty alkyl esters, and/or fatty amides, from...
2016/0207878 MAO-B Selective Inhibitor Compounds, Pharmaceutical Compositions Thereof and Uses Thereof
Described herein are a series of compounds having the structure of Formula I: ##STR00001## for use in the inhibition of MAO and uses thereof for the treatment of...
2016/0207877 ISOMERIZATION METHOD FOR BIS (AMINOMETHYL) CYCLOHEXANE
A method for isomerizing a bis(aminomethyl)cyclohexane, including an isomerization step of isomerizing the bis(aminomethyl)cyclohexane in the presence of an...
2016/0207876 CATALYST USED FOR RESOURCE UTILIZATION OF A FIXED BED ANILINE DISTILLATION RESIDUE AND METHOD FOR PREPARING...
The present invention relates to a catalyst for fixed bed aniline rectification residue recycling and preparation method thereof. Based on the total weight of...
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