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Patent # Description
2016/0208275 MODIFIED EXPRESSION OF PROLYL-4-HYDROXYLASE IN PHYSCOITRELLA PATENS
The field of the invention relates to a method for the production of a recombinant protein in a plant-based system comprising the steps of providing a...
2016/0208274 BLOOD CLOT-DISSOLVING PROTEINS PRODUCED IN SEEDS
Transgenic plants in which blood-clot dissolving proteins are produced in seeds of the plants are provided. Expression of the proteins is driven by a seed...
2016/0208273 System, Method, and Device for the Expression or Repression of Proteins
This invention relates to systems, methods, and devices for inducing and/or repressing the expression of proteins. More particularly, the invention relates to...
2016/0208272 PLANT GENOME MODIFICATION USING GUIDE RNA/CAS ENDONUCLEASE SYSTEMS AND METHODS OF USE
Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell. The methods and compositions employ...
2016/0208271 METHODS FOR PRODUCING GENETIC MODIFICATIONS IN A PLANT GENOME WITHOUT INCORPORATING A SELECTABLE TRANSGENE...
Compositions and methods are provided for genome modification of a target sequence in the genome of a plant or plant cell, without incorporating a selectable...
2016/0208270 YEAST CELL HAVING DECREASED RGT1 ACTIVITY, METHOD OF PRODUCING THE SAME, AND METHOD OF PRODUCING PRODUCT USING...
A recombinant yeast cell having a decreased RGT1 protein activity and an increased ability to produce a glycolytic intermediate or a glycolytic ...
2016/0208269 COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and...
2016/0208268 Production of Recombinant Proteins Utilizing Non-Antibiotic Selection Methods and the Incorporation of...
Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b)...
2016/0208267 Antisense Oligonucleotides Against Neutral Sphingomyelinase and Neutral Sphingomyelinase Inhibitor GW4869 for...
Alzheimer's disease (AD) is the most common human neurodegenerative disease of the CNS resulting in progressive neuronal death and memory loss. Despite intense...
2016/0208266 Methods and Means for Treatment of Osteoarthritis
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically,...
2016/0208265 RNA INTERFERENCE AGENTS FOR GST-PI GENE MODULATION
This invention provides compounds, compositions and methods for modulating the expression of human GST-.pi. using RNA interference. The RNA interference...
2016/0208264 ANTISENSE-INDUCED EXON2 INCLUSION IN ACID ALPHA-GLUCOSIDASE
The present disclosure relates to antisense oligomers and related compositions and methods for inducing exon inclusion as a treatment for glycogen storage...
2016/0208263 LIPOSOME FOR TOPICAL ADMINISTRATION AND APPLICATION THEREOF
This invention provides a novel delivery means that enables efficient delivery of an active ingredient to a target cell. Such novel delivery means is a...
2016/0208262 MCP-1 Binding Nucleic Acids
The present invention is related to a nucleic acid, preferably binding to MCP-1, selected from the group consisting of Type 1A nucleic acids, type 1B nucleic...
2016/0208261 METHODS AND COMPOSITIONS FOR INHIBITING THE FUNCTION OF POLYNUCLEOTIDE SEQUENCES
A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian...
2016/0208260 COMPLEX CONTAINING OLIGONUCLEOTIDE HAVING IMMUNOPOTENTIATING ACTIVITY AND USE THEREOF
The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly...
2016/0208259 TARGETING MICRORNAS FOR METABOLIC DISORDERS
Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of...
2016/0208258 MIR-92 INHIBITORS AND USES THEREOF
The present invention provides oligonucleotide inhibitors of miR-92 and methods of using said inhibitors for inhibiting the function and/or activity of miR-92...
2016/0208257 AAV-BASED TREATMENT OF CHOLESTEROL-RELATED DISORDERS
The invention in some aspects relates to methods and compositions for assessing the effectiveness of miRNA inhibitors. In other aspects of the invention,...
2016/0208256 RNA INTERFERENCE AGENTS FOR P21 GENE MODULATION
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules...
2016/0208255 RNA AGENTS FOR P21 GENE MODULATION
This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules...
2016/0208254 RNA AGENTS FOR GST-PI GENE MODULATION
This invention provides compounds, compositions and methods for modulating the expression of human GST-.pi. using RNA interference. The RNA interference...
2016/0208253 PARENTAL RNAI SUPPRESSION OF KRUPPEL GENE TO CONTROL COLEOPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of...
2016/0208252 PARENTAL RNAI SUPPRESSION OF HUNCHBACK GENE TO CONTROL HEMIPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of hemipteran pests through RNA interference-mediated inhibition of...
2016/0208251 PARENTAL RNAI SUPPRESSION OF CHROMATIN REMODELING GENES TO CONTROL COLEOPTERAN PESTS
This disclosure concerns nucleic acid molecules and methods of use thereof for control of coleopteran pests through RNA interference-mediated inhibition of...
2016/0208250 THERAPEUTIC AGENT FOR CORNEAL EPITHELIAL DISORDER
A therapeutic agent for a corneal epithelial disorder, containing a miR-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells,...
2016/0208249 Compositions and Methods for Inducing Senescence in Cancer Cells
The invention relates to nucleic acid sequences as well as to modified oligonucleotides (ODNs) comprising a p52 binding site derived from the EZH2 promoter...
2016/0208248 Neurocalcin Delta Inhibitors and Therapeutic and Non-Therapeutic Uses Thereof
The present invention relates to an inhibitor of neurocalcin delta (NCALD) for use in a method for the treatment or prevention of a patient suffering from a...
2016/0208247 METHODS OF USE OF SPHINGOLIPID POLYALKYLAMINE OLIGONUCLEOTIDE COMPOUNDS
Provided herein are sphingolipid-polyalkylamine siRNA compounds pharmaceutical compositions comprising such compounds, and methods of use in therapy.
2016/0208246 COMPOSITIONS AND METHODS FOR TREATING A HEMATOLOGICAL MALIGNANCY ASSOCIATED WITH AN ALTERED RUNX1 ACTIVITY OR...
A method of treating a hematological malignancy associated with an altered RUNX1 activity or expression is disclosed. The method comprising administering to a...
2016/0208245 RNA/DNA nanoparticle for siRNA target-specific delivery and vehicle including the same
A RNA/DNA nanoparticle for delivering siRNA where a RNA transcript including at least one hairpin structure hybridizes DNA-cholesterol conjugate and folate-DNA...
2016/0208244 MODULATION OF KCNH2 ISOFORM EXPRESSION BY OLIGONUCLEOTIDES AS A THERAPEUTIC APPROACH FOR LONG QT SYNDROME
Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the...
2016/0208243 NOVEL CRISPR ENZYMES AND SYSTEMS
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or...
2016/0208242 METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS IN AN ARRAY
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation device described can comprise a photomask...
2016/0208241 COMPOSITIONS AND METHODS FOR ENRICHMENT OF NUCLEIC ACIDS
Methods are provided for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids, e.g., sequence...
2016/0208240 NGS WORKFLOW
The present invention relates to improved semi-automated methods that permit the extraction of nucleic acids from samples, preparation of PCR and post-PCR...
2016/0208239 EXPRESSION VECTOR PRODUCTION AND HIGH-THROUGHPUT CELL SCREENING
The present invention relates inter alia to expression vector production as well as application to the production of host cells for protein repertoire...
2016/0208238 Cell-Based Composite Materials with Programmed Structures and Functions
The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to...
2016/0208237 MODIFICATIONS OF PEPTIDE COMPOSITIONS TO INCREASE STABILITY AND DELIVERY EFFICIENCY
The disclosed invention relates to methods of modifying peptide compositions to increase stability and delivery efficiency. Specifically, the disclosed...
2016/0208236 NOVEL METHODS FOR RECOVERY OF LEAF PROTEINS
A novel method for processing soluble plant leaf proteins is described. While leaf proteins are considered potentially the most abundant source of protein in...
2016/0208235 DETECTION AND REMOVAL OF MISFOLDED PROTEINS/PEPTIDES
The invention concerns the field of detecting and quantifying misfolded proteins/peptides. In particular the detection and quantification of misfolded...
2016/0208234 Protease Variants and Polynucleotides Encoding Same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
2016/0208233 EVOLVED SORTASES AND USE THEREOF
Evolved sortases exhibiting enhanced reaction kinetics and/or altered substrate preferences are provided herein, for example evolved sortases that bind...
2016/0208232 NOVEL VARIANT TRICHODERMA REESEI ENDOGLUCANASES
The present invention provides T. reesei endoglucanase I variants exhibiting improved cellulase and/or xylanase activity, in particular at 30.degree. C. and/or...
2016/0208231 DIMERIC BACTERIOPHAGE LYSINS
The present invention provides isolated dimeric Streptococcus-specific phage lysins having two Streptococcus-specific phage lysin monomers covalently linked to...
2016/0208230 Thermostable Alpha-Amylases
The present invention relates to an isolated polynucleotide comprising an open reading frame encoding a polypeptide having alpha-amylase activity, the...
2016/0208229 Polypeptides Having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
2016/0208228 ENGINEERED ENZYME HAVING ACETOACETYL-COA HYDROLASE ACTIVITY, MICROORGANISMS COMPRISING SAME, AND METHODS OF...
The disclosure provides engineered enzymes that are capable of mediating the conversion of acetoacetyl-CoA to acetoacetate that do not react with the same...
2016/0208227 COMPOSITIONS AND METHODS FOR CONTROLLING MICROBIAL GROWTH
Provided are modified microorganisms which are modified such that their growth can be controlled using exogenously provided compounds. The microorganisms can...
2016/0208226 Transaminase Biocatalysts
The present invention relates to pyruvate: .omega.-amino acid transaminases isolated from a Pseudomonas species. The transaminases act on long chain amino...
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