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Patent # Description
2016/0208025 BRIDGED METALLOCENE COMPLEX FOR OLEFIN POLYMERIZATION
The invention relates to a metallocene complex according to formula (1) wherein M is a metal selected from lanthanides or transition metals from group 3, 4, 5...
2016/0208024 END-FUNCTIONALIZED CONJUGATED DIENE-BASED POLYMER AND PROCESS FOR PRODUCING SAME
Disclosed are a modified conjugated diene-based polymer represented by Chemical Formula 1, a method of preparing the same, and a rubber composition including...
2016/0208023 MODIFIED CONJUGATED DIENE-BASED POLYMER, PREPARATION METHOD THEREFOR, AND RUBBER COMPOSITION COMPRISING SAME
Disclosed is a method of preparing a modified conjugated diene-based polymer, including (a) polymerizing a conjugated diene monomer, or a conjugated diene...
2016/0208022 METHOD FOR PREPARING SUPER ABSORBENT POLYMER
This disclosure relates to a method for preparing super absorbent polymer. The method for preparing super absorbent polymer according to the present invention...
2016/0208021 Molecular constructs with targeting and effector moieties
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
2016/0208020 Peptide core-based multi-arm linkers
The present disclosure provides various molecular constructs having a targeting element and/or an effector element. Methods for treating various diseases using...
2016/0208019 T CELL ACTIVATING BISPECIFIC ANTIGEN BINDING MOLECULES
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In...
2016/0208018 ANTIBODIES AND CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR ROR1
Provided are ROR1 binding molecules, including anti-ROR1 antibodies, including antibody fragments such as variable heavy chain (VH) regions, single-chain...
2016/0208017 MUTANT INTERLEUKIN-2 POLYPEPTIDES
The present invention generally relates to mutant interleukin-2 polypeptides that exhibit reduced affinity to the .alpha.-subunit of the IL-2 receptor, for use...
2016/0208016 Anti-ADAM12 antibodies for the treatment of cancer
The present disclosure concerns monoclonal antibodies directed to the pro-domain of ADAM 12 and their use in the treatment of cancer.
2016/0208015 HUMAN MONOCLONAL ANTIBODIES SPECIFIC FOR GLYPICAN-3 AND USE THEREOF
Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies...
2016/0208014 PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF CANCERS
The present invention relates to a pharmaceutical composition for treatment and/or prevention of cancer, which comprises, as an active ingredient, an antibody...
2016/0208013 METHODS AND COMPOSITIONS FOR REDUCING CARDIAC DAMAGE AND OTHER CONDITIONS
Endoglin has been identified to play a functional role as a regulator of TGF.beta.1 signaling, particular in TGF.beta.1-mediated calcineurin expression. The...
2016/0208012 Compositions and Methods for Treatment of Cancer
The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified...
2016/0208011 CCR3 MODULATION IN THE TREATMENT OF AGING-ASSOCIATED IMPAIRMENTS, AND COMPOSITIONS FOR PRACTICING THE SAME
Methods of treating an adult mammal for an aging-associated impairment are provided. Aspects of the methods include modulating CCR3, e.g., by modulating...
2016/0208010 ANTI-HUMAN CD52 IMMUNOGLOBULINS
The present invention relates to humanized immunoglobulins, mouse monoclonal antibodies and chimeric antibodies that have binding specificity for human CD52....
2016/0208009 Glycosylation Engineering of Antibodies for Improving Antibody-Dependent Cellular Cytotoxicity
The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation...
2016/0208008 MONOCLONAL ANTIBODIES TO TRANSFERRIN AND TRANSFERRIN RECEPTOR ANTIGENS, AND USES THEREOF
Some embodiments are directed to monoclonal antibodies (mAbs) that bind to transferrin (TF) and transferrin receptor 1 (TFRC), hybridoma lines that secrete...
2016/0208007 ANTI-CD40 ANTIBODIES AND METHODS OF USE
The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic...
2016/0208006 METHODS AND COMPOSITIONS FOR INCREASING N-ACETYLGLUCOSAMINIDASE ACTIVITY IN THE CNS
Provided herein are methods and compositions for treating a subject suffering from an enzyme deficiency in the central nervous system (CNS). The bifunctional...
2016/0208005 NOVEL ANTI-HUMAN TSLP RECEPTOR ANTIBODY
An anti-human TSLP receptor antibody that specifically binds to human TSLP receptor and inhibits an action of human TSLP through human TSLP receptor. A method...
2016/0208004 IL-17RA-IL-17RB Antagonists and Uses Thereof
The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a...
2016/0208003 Antibodies
The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of...
2016/0208002 Compositions Associated with and Methods of Managing Neutrophil Movement
The disclosure also relates to a method of reducing the number of neutrophils in a body region by administering a CD209-binding compound or antibody in an...
2016/0208001 MEANS AND METHODS FOR TREATING DLBCL
The present invention provides means and methods for treating diffuse large B cell lymphoma (DLBCL). Specifically, a bispecific CD19.times.CD3 antibody which...
2016/0208000 IMMUNORECEPTOR MODULATION FOR TREATING CANCER AND VIRAL INFECTIONS
A method of reducing or relieving immune inhibition in a mammal includes the step of at least partly inhibiting or reducing CD96 activity in one or more cells...
2016/0207999 ANTI-HUMAN FOLATE RECEPTOR BETA ANTIBODIES AND METHODS OF USE
Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments...
2016/0207998 ANTI-RICIN ANTIBODIES AND USES THEREOF
The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments...
2016/0207997 ANTI-C5A ANTIBODIES
The present disclosure relates to, inter alia, antibodies, or antigen-binding fragments thereof, that bind to C5a and to use of the antibodies in methods for...
2016/0207996 ANTIBODIES TO COMPLEX TARGETS
The present invention relates to antibodies and antigen binding fragments thereof derived from antibodies raised by DNA immunization of host animals,...
2016/0207995 ANTI-IL-4 ANTIBODIES AND BISPECIFIC ANTIBODIES AND USES THEREOF
The invention provides anti-IL-4 antibodies and bispecific antibodies and methods of using the same.
2016/0207994 MODULATORS OF IL-12 AND/OR IL-23 FOR THE PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE
The invention provides antibody against p40, IL-12 or IL-23 for the prevention or treatment of Alzheimer's disease. It further provides ligands to the pair of...
2016/0207993 ANTIGEN-BINDING CONSTRUCTS
The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the...
2016/0207992 METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention...
2016/0207991 Therapeutic Antibody
The present invention relates to antibodies that bind brain-derived neurotrophic factor (BDNF). The invention further relates to nucleic acid sequences coding...
2016/0207990 ANTIBODIES TO ENDOPLASMIN AND THEIR USE
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant...
2016/0207989 CONDITIONALLY ACTIVE CHIMERIC ANTIGEN RECEPTORS FOR MODIFIED T-CELLS
This disclosure relates to a chimeric antigen receptor for binding with a target antigen. The chimeric antigen receptor comprises at least one antigen specific...
2016/0207988 A NOVEL HORMONE THAT PROMOTES BONE RESORPTION AND USES THEREOF
The disclosure describes the use of anti-IGFBP1 antibodies to inhibit the bone loss-inducing properties of FGF21. This can be applied in the context of FGF21...
2016/0207987 ALTERNATIVE PATHWAY SPECIFIC ANTIBODIES FOR TREATING ARTHRITIS
A method of selecting a genus of therapeutic antibodies includes selecting antibodies with the following criteria; a) do inhibit cell lysis under conditions...
2016/0207986 Immobilized Single Domain Antigen-Binding Molecules
The immobilisation of single domain antigen binding fragments of antibodies naturally devoid of light chains, or protein domains functionally equivalent...
2016/0207985 ANTI-HIV DOMAIN ANTIBODIES AND METHOD OF MAKING AND USING SAME
The invention provides single domain antibodies and derivatives thereof that bind antigens of interest, which are stable, soluble, and do not tend to...
2016/0207984 HIGH AFFINITY SYNBODIES FOR INFLUENZA
Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.
2016/0207983 Methods, Cells & Organisms
The invention relates to an approach for introducing one or more desired insertions and/or deletions of known sizes into one or more predefined locations in a...
2016/0207982 Fusion Partner for Production of Monoclonal Rabbit Antibodies
The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody....
2016/0207981 NON-IMMUNOGENIC SINGLE DOMAIN ANTIBODIES
The invention provides modifications within human or humanized single domain antibody fragments (sdAbs) that prevent recognition by pre-existing antibodies, to...
2016/0207980 FC-CONTAINING MOLECULES EXHIBITING PREDICTABLE, CONSISTENT, AND REPRODUCIBLE GLYCOFORM PROFILES
The present invention relates to variant Fc-containing molecules, such as antibodies and Fc-fusion molecules, having glycosylation characteristics favorable to...
2016/0207979 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS
Provided herein are multifunctional heteromultimer proteins. In specific embodiments is a heteromultimer comprising: at least two polypeptide constructs, each...
2016/0207978 METHODS AND COMPOSITIONS RELATED TO LARGE SCALE PRODUCTION OF PROTEINS
Disclosed herein are methods and compositions related to synthetic fusion proteins and engineered cells.
2016/0207977 Compounds Suitable for Treatment of Haemophilia
The present invention relates to Von Willebrand (VWF) compounds as well as compositions suitable for treatment of blood clotting diseases. The present...
2016/0207976 RECOMBINANT PLATELET COLLAGEN RECEPTOR GLYCOPROTEIN VI AND ITS PHARMACEUTICAL USE
The invention relates to Glycoprotein VI (GPVI), its isolation, purification, and methods for recombinant production. Especially, the invention relates to the...
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