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CATALYST PROCESS MODIFICATION AND POLYMERIZATION THEREOF
The present invention describes a process for preparation of catalyst component comprising contacting magnesium based precursor along with an internal donor...
POLYVINYL ALCOHOL AND PURIFICATION METHOD THEREOF
Highly purified polyvinyl alcohol (PVA) which meets the standard of pharmaceutical grade is provided. The PVA has of less than 0.1 wt % of residual methanol,...
REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES
Described are reagents that generate a chemical species initiating a polymerization of at least one kind of monomer by non-resonant multi-photon excitation of...
CURABLE COMPOSITION FOR PHOTOIMPRINT AND METHOD OF PRODUCING FILM, OPTICAL
COMPONENT, CIRCUIT BOARD, OR...
A curable composition for photoimprint at least includes a polymerizable compound component (A) and a photopolymerization initiator component (B) and satisfies...
UNIFIED COOLING IN MULTIPLE POLYOLEFIN POLYMERIZATION REACTORS
A system and method for a polyolefin reactor temperature control system having a first reactor temperature control path, a second reactor temperature control...
A heparan sulphate that binds vitronectin is disclosed.
AQUEOUS IRON CARBOHYDRATE COMPLEXES, THEIR PRODUCTION AND MEDICAMENTS
A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron (III) salt and an aqueous solution of the oxidation product of one or...
MICRO CHIRAL REGULATION CELLULOSE CHROMATOGRAPHY STATIONARY PHASE,
PREPARATION METHOD AND USE THEREOF
The present invention discloses a cellulose derivative shown as formula (I), which is obtained as follows: the hydroxyl at position 6 of microcrystalline...
Reversibly crosslinked cellulose ethers and process for the production
thereof by selective oxidation of...
Reversibly crosslinked, water-soluble cellulose ethers having at least two different ether components is disclosed. At least one ether component is an alkyl,...
CROSS-METATHESIZED POLYSACCHARIDE DERIVATIVES AND PROCESSES FOR PREPARING
Methods for the cross-metathesis of polysaccharides with one or more olefin-terminated side chains and cross-metathesized products are described. In an...
ANTI-CEP ANTIBODY OR FRAGMENT THEREOF
An isolated anti-carboxyethylpyrrole (anti-CEP) antibody or antigen binding portion thereof includes a heavy chain variable domain that includes three CDRs...
ANTHROPOGENIC INSECT-RESISTANT GENE AND CRY1C TOXIN IDIOTYPE SINGLE-CHAIN
ANTIBODY ENCODED THEREBY AND...
An anthropogenic insect-resistant gene having a nucleotide sequence represented by SEQ ID NO.1, and a Cry1C toxin idiotype single-chain antibody encoded by...
NSP4 INHIBITORS AND METHODS OF USE
The invention provides NSP4 inhibitors (such as anti-NSP4 antibodies) and methods of using the same.
Antibodies Specific for Urokinase-Type Plasminogen Activator and Methods
of Use Thereof
The present disclosure relates to antibodies specific for urokinase-type plasminogen activator (uPA). According to certain embodiments, the anti-uPA antibody...
HETERODIMERIC ANTIBODIES THAT BIND CD3 AND CD38
The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
PREPARATION USEFUL FOR, AND METHOD FOR TREATMENT OF NEONATAL ALLOIMMUNE
A preparation useful for, and a method for the prophylactic treatment of women post-childbirth in order to avoid immunization and antibody production, which...
Fc CONTAINING POLYPEPTIDES HAVING INCREASED BINDING TO FcGammaRIIB
The present invention is directed to methods and compositions for the production of Fc-containing polypeptides which are useful as human or animal therapeutic...
CHICKEN ANTIBODY TRANSFORMED INTO CYSTEINE AND SITE-SPECIFIC CONJUGATION
A framework fragment derived from a chicken antibody, in which an amino acid at a particular position is replaced by cysteine, a heavy chain variable region or...
ICOS BINDING PROTEINS
The present invention relates to an ICOS binding protein, or antigen binding portion thereof that is an agonist human ICOS and does not induce complement,...
SINGLE-CHAIN VARIABLE FRAGMENT ANTI-CD133 ANTIBODIES AND USES THEREOF
Disclosed herein are a monoclonal antibody that specifically binds to human CD133 and single-chain variable fragments thereof. Also disclosed herein is a...
METHOD FOR TREATING AND/OR PREVENTING ATRIAL FIBRILLATION
Disclosed herein is a method for treating and/or preventing atrial fibrillation in a subject, comprising administering to the subject a pharmaceutical...
Human Immune Therapies Using a CD27 Agonist Alone or in Combination with
Other Immune Modulators
Methods of inducing T cell proliferation and expansion in vivo for treating conditions wherein antigen-specific T cell immune response are therapeutically...
FasR ANTIBODIES FOR DIAGNOSTIC AND THERAPEUTIC USE
Provided herein are an exogenous antibody that binds selectively to a misfolded form of human FasR, and methods and uses for said antibody. Specifically...
TREATMENT OF DIABETES MELLITUS, METHODS AND COMPOSITIONS THEREFOR
Methods of treatment of diabetes are disclosed. These methods include administration of an inhibitor of chemokine XCL1, and administration of an inhibitor of...
CXCL12 (CHEMOKINE (C-X-C MOTIF) LIGAND 12) AND IGFBP2 INHIBITORS FOR THE
APPLICATION IN THE TREATMENT OF...
The subject of the invention is the application of CXCL12 (Chemokine (C-X-C motif) Ligand 12) and IGFBP2 inhibitors for the treatment of diabetes mellitus...
ANTI-GALECTIN-1 (GAL1) MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF FOR
The present invention is based, in part, on the discovery of galectin 1 (Gal1) epitopes against which anti-Gal1 agents can neutralize Gal1 function, as well as...
The present invention relates to methods of minimizing the aggregation of BiTE.RTM. molecules in solution. In one embodiment, a method of the invention is used...
The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies...
HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding...
IL-18 BINDING PROTEIN (IL-18BP) IN INFLAMMATORY DISEASES
The present invention provides means and methods for treating Interleukin 18 (IL-18)-associated diseases and disorders. In particular, the present invention...
BISPECIFIC ANTIBODY AGAINST TNF-ALPHA AND SYNOVIAL MICROVASCULATURE OF
The present invention provides bispecific molecule comprising: (i) a first antigen binding portion which specifically targets the synovial microvasculature of...
SIGNATURE OF TL1A (TNFSF15) SIGNALING PATHWAY
The present invention relates to the finding that TL1A enhances differentiation of TH17 cells, and enhance IL17 secretion from TH17 cells. In one embodiment,...
The present invention relates to compounds that bind to human vascular endothelial growth factor A (VEGFA) and human angiopoietin-2 (Ang2), and may be useful...
HIGH CONCENTRATION FORMULATIONS OF ANTI-C5 ANTIBODIES
The present disclosure relates to, inter alia, stable aqueous solutions comprising a high concentration of an antibody that binds to human complement component...
PRODUCT AND METHOD FOR TREATING SARCOPENIA
A method of treating sarcopenia comprises administering to a subject a composition comprising an anti-AGE antibody. The method may also be used for preventing...
METHODS FOR MODULATING IMMUNE RESPONSES DURING CHRONIC IMMUNE CONDITIONS
BY TARGETING METALLOTHIONEINS
Described herein are novel compositions comprising MT1 and/or MT2 modulators (i.e., inhibitors or activators), and methods using these agents for targeting...
Methods of Improving the Therapeutic Efficacy and Utility of Antibody
The present disclosure relates to methods and uses of improving the therapeutic efficacy and utility of antibody fragments by employing anti-epitope-tagging...
Human Antibodies to Ebola Virus Glycoprotein
The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to Ebola virus glycoproteins, pharmaceutical compositions...
AGENTS AND METHODS BASED ON THE USE OF THE EDA DOMAIN OF FIBRONECTIN
This invention relates to the use of a polypeptide in the production of an immunostimulatory agent, said polypeptide comprising a sequence corresponding to the...
SOLUBLE CD33 FOR TREATING MYELODYSPLASTIC SYNDROMES (MDS)
Disclosed are compositions and methods for treating disease or condition caused or exacerbated by S100A9 activity, such as myelodysplastic syndromes (MDS)...
NOVEL DERIVATIVE OF AN INSULIN ANALOGUE
The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.
STABILIZED POLYPEPTIDE INSULIN RECEPTOR MODULATORS
Provided herein are stabilized .alpha.-CT polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of Formula (I-1) or Formula (I-2): ...
INTERLEUKIN-4 RECEPTOR-BINDING FUSION PROTEINS AND USES THEREOF
The present invention relates to interleukin-4 receptor binding fusion proteins. More specifically, the invention provides, in part, fusion proteins that...
WATER-SOLUBLE EXPRESSION AND PURIFICATION METHOD OF HUMAN GCSF RECOMBINANT
PROTEIN HAVING BIOLOGICAL ACTIVITIES
The present invention relates to a water-soluble expression and a purification method of a human granulocyte colony-stimulating factor (hGCSF) recombinant...
Granulocyte Macrophage Colony-Stimulating Factor Compositions
The present invention provides a composition of homogeneously glycosylated GM-CSF or a homogeneously glycosylated fragment thereof, wherein each molecule of...
Influenza Nucleoprotein Vaccines
The present invention is related to a fusion protein comprising a variant of a nucleoprotein antigen from Influenza strain A, B or C, and a variant of a C4bp...
METHOD OF TREATING DISORDERS REQUIRING DESTRUCTION OR REMOVAL OF CELLS
The embodiments include methods of treating conditions requiring removal or destruction of cellular elements, such as benign or malignant tumors in treatment...
Dialysis-Free Process for Aqueous Regenerated Silk Fibroin Solution and
The present invention provides a dialysis-free process for the generation of aqueous regenerated silk fibroin solutions. A degumming reactor is presented that...
Polypeptides Comprising an Ice-Binding Activity
The present invention relates to novel polypeptides comprising an ice-binding capability resulting in an ice crystal formation and/or growth reducing or...
BIOMARKERS FOR MYCOBACTERIUM AVIUM PARATUBERCULOSIS (MAP)
Described are methods and products useful for identifying subjects with Mycobacterium avium subspecies paratuberculosis (MAP). A number of protein antigens...